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All Journal Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Journal of Islamic Pharmacy Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB Journal of Islamic Medicine Biosel: Biologi Science and Education International Journal of Health and Pharmaceutical (IJHP) SEHAT : JURNAL KESEHATAN TERPADU Journal of Tropical Pharmacy and Chemistry
Rahmi Annisa
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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TOXICITY STUDY OF PARE LEAF EXTRACTS (MOMORDICA CHARANTIA) TO CULEX PIPIENS MOSQUITO LARVAE Annisa, Rahmi; Amir, Muhammad; Kuncoro, Hadi
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4506

Abstract

This study aims to determine the yield, toxicity, and toxic concentration of crude extracts of ethanol, n-hexane fraction extract, ethyl acetate fraction extract and n-butanol fractions extract pare leaf (Momordica charantiaL.) larvae Culex pipiens. The method used to determine the toxicity of extract larvasida test larvae Culex pipiens to obtain the LC99 values obtained using the analysis of Reed and Muench. Extraction and fractionation processis known to yield a ethanol crude extract obtained 8.86%, n-hexane fraction extract of 1%, ethyl acetate fraction extract 1.80% and n-butanol fractions extract of 0.80% and the toxicity obtained test results that pare leaf (Momordica charantia L.) have the potential toxicity larvae larvae of Culex pipiens as indicated by the value by Lethality Concrentation 99 % (LC99) in the crude extract ethanol 7416.52  ppm, n-hexane fraction extract of 2564.48 ppm, ethyl acetate fraction extract 2702.09 ppm and n-butanol fractions extract of 2665.63 ppm. Keywords: Pare leaf (Momordica charantia L.), toxicity, larvae Culex pipiens
Analisis in Silico Senyawa Fitokimia dari Fraksi n-Heksana Daun Semanggi (Marsilea crenata Presl.) sebagai Agen Neuroprotektif Ma'arif, Burhan; Jatmiko, Ricky Arie; Megawati, Dewi Sinta; Annisa, Rahmi; Sugihantoro, Hajar; Muchlisin, Muhammad Artabah; Laswati, Hening; Agil, Mangestuti
Journal of Islamic Pharmacy Vol 5, No 1 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i1.9180

Abstract

Estrogen deficiency causes various health problems in postmenopausal women, including neurodegenerative disease. Phytoestrogens emerged as a group of compounds that can replace the estrogen function in the body, and prevent the neurodegenerative disease to occur. Semanggi (Marsilea crenata Presl.) is a typical plant in Surabaya, Indonesia, that contain phytoestrogens. The aim of this research was to determine the metabolite profile of n-hexane fraction of Semanggi leaves using UPLC-QToF-MS/MS, and then to predict the neuroprotective activity of compounds with in silico study using PyRX 0.8 software. The 100 ppm of n-hexane fraction of Semanggi leaves in DCM and methanol were injected 5 µl each into the UPLC-QToF-MS/MS, and then analyzed by Masslynx 4.1 software to determine the compounds. The compounds from metabolite profiling then prepared with SwissADME webtool and Avogadro 1.90.0 software, molecular docking was done using Autodock Vina and Biovia Discovery Studio Visualizer 2016 to 3OLS protein. Metabolite profiling process shows a total of 34 predictable compounds and 28 unknown compounds. From in silico study, it shows a total of 7 compounds that are predicted to have activities similar to estrogen. This result indicate that n-hexane fraction of Semanggi leaves has potential as a neuroprotective agent for treatment for postmenopausal women who experience estrogen deficiency.Keywords: Marsilea crenata Presl., phytoestrogens, metabolite profiling, in silico, neuroprotective
AKTIVITAS ANTITUSIF KOMBINASI EKSTRAK ETANOL JAHE MERAH (Zingiber officinale var. rubrum) DAN DAUN UNGU (Graptophyllum pictum) PADA MARMUT (Cavia porcellus) Umami, Zahra; Muti'ah, Roihatul; Annisa, Rahmi
Majalah Kesehatan FKUB Vol 7, No 4 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.majalahkesehatan.2020.007.04.1

Abstract

Batuk sebagai sebuah sistem perlindungan dengan cara mengeluarkan benda asing pada saluran pernapasan manusia yang bisa menyebabkan infeksi. Perlu dilakukan penelitian terhadap pemanfaatan tanaman sebagai obat yang digunakan untuk mengatasi batuk. Hal tersebut dikarenakan tanaman obat memiliki efek samping minim daripada obat buatan. Jahe merah (Zingiber officinale var. rubrum) serta daun ungu (Graptophylum pictum) telah dimanfaatkan penggunaannya dengan cara tradisional dalam mengatasi batuk. Tujuan penelitian ini yaitu mendapatkan pengetahuan mengenai aktivitas antitusif serta perbandingan optimal kombinasi dari ekstrak etanol 96% jahe merah serta ekstrak etanol 96% daun ungu. Uji aktivitas antitusif dilakukan dengan menilai persentase supresi batuk melalui induksi larutan asam sitrat 7,5% pada hewan coba marmut betina sebanyak 28 ekor dibagikan menjadi tujuh kelompok perlakuan di antaranya perlakuan dengan pemberian CMC-Na (kontrol negatif), kodein 10 mg/kg BB (kontrol positif), dosis tunggal 250 mg/kg BB dari ekstrak etanol 96% jahe merah serta daun ungu, dosis kombinasi ekstrak etanol 96% jahe merah serta daun ungu dengan perbandingan kombinasi 1:1, 0,5:1 dan 1:0,5 selama 5 hari. Penelitian menunjukkan hasil bahwa ekstrak etanol 96% jahe merah serta daun ungu pada dosis tunggal maupun kombinasinya memiliki aktivitas antitusif yang mampu meningkatkan supresi batuk melalui hewan percobaan yaitu marmut. Perbandingan hasil kombinasi ekstrak etanol 96% jahe merah serta ekstrak etanol 96% daun ungu yang optimal adalah 1:0,5 dengan persentase supresi batuk sebesar 73,00 %. 
Metabolite Profiling of Eleutherine palmifolia (L.) Merr. By HPTLC-Densitometry and its Correlation with Anticancer Activities and In Vitro Toxicity Mutiah, Roihatul; Hadya, Chorida Muhjatul; Ma'arif Z.A, Burhan; Bhagawan, Weka Sidha; Annisa, Rahmi; Indrawijaya, Yen Yen Ari; Huwaida, Fadhila Isma; Ramadhani D.A., Ria; Susilowati, Retno; Taufik, Imam
Indonesian Journal of Pharmacy Vol 30 No 3, 2019
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1608.73 KB) | DOI: 10.14499/indonesianjpharm30iss3pp157

Abstract

Eleutherine palmifolia (L.) Merr. (E. palmifolia) is a plant that used as raw material for herbal medicines. The difference of growing location the medicinal plants affects the difference of metabolite content, It also affects the pharmacological activity and toxicity of the plant. This study aims to determine the profile of metabolites (metabolite fingerprinting), anticancer profiles, toxicity/safety profiles from several different regions in Indonesia for the purpose of authentication, efficacy, safety and quality control of these plants. Samples were sampled from 6 different locations in Indonesia, they were West Java, Central Java, East Java, East Borneo, Central Borneo, and South Borneo. Metabolite fingerprinting was determined by HPTLC-densitometry method, the profile of anticancer activity and toxicity was known by the MTT-ELISA method. The difference between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Principal Component Analysis (PCA) and Hierarchical Component Analysis (HCA). Whereas the relation between metabolite fingerprinting, anticancer profile, toxicity/safety profile was analyzed by Partial Least Square (PLS). The results of the metabolite profile analysis with PCA showed that E. palmifolia from 6 different locations gave different metabolite profiles and there were 3 metabolites that had a significant effect on cluster formation. samples are Rf 055, 059, and 044. The results of the HCA analysis showed that the 6 regions are in one cluster the same one. The analysis of PLS-DA showed that the metabolites for anticancer activity are found in Rf 059, 076, 093 and Rf 034. While the metabolites for toxicity are Rf 002, Rf 044 and Rf 059.
PROFILE OF ANTICANCER ACTIVITIES OF BROTOWALI (Tinospora crispa L.) PLANTS OFVARIOUS REGIONS IN EAST JAWA Roihatul Mutiah; Laily Nurul Azizah; Rahmi Annisa; Anik Listyana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 2 (2019)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (531.707 KB) | DOI: 10.24071/jpsc.002020

Abstract

Brotowali (Tinosporacrispa L) is a plant which has potential to be a chemopreventive agent. This study aims to determine the profile of anticancer activity of brotowali stem extracts (Tinosporacrispa L.), from several regions in East Java. The extraction was carried out by maceration method using 80% ethanol solvent. Then, anticancer activity test was carried out on MCF-7 breast cancer cell model using the Microtetrazolium (MTT) Assay method. The results of the anticancer activity test showed that 15 brotowali stem extracts taken from 5 locations in East Java had significant differences in anticancer activity (P 0.05). Brotowali extracts from Kanigoro, Blitar city, had the highest anticancer activity with an IC50 value of 30.64 g / mL.
FORMULATION AND CARACTERIZATION OF QUERCETIN NIOSOME WITH CONCENTRATION VARIATIONS OF SPAN 20 SURFACTANT Weka Sidha Bhagawan; Rahmi Annisa; Atiza Fajrin Maulidya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 18, No 2 (2021)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1320.953 KB) | DOI: 10.24071/jpsc.002839

Abstract

Quercetin has low solubility, absorption and bioavailability which limits its practical use as a drug or supplement. Therefore, it is important to formulate a quercetin niosome system with various concentrations of span 20 as a surfactant. This investigation aimed to formulate and analyse a quercetin niosome preparation with span 20 variations to provide optimal quercetin solubility. Niosomes were prepared using various concentrations of span 20. In the present study, the quercetin niosome used the reverse phase evaporation (RPE) method. Quercetin niosome is characterised by its organoleptic properties, pH value, particle morphology comprising the particle shape and size, and encapsulation efficiency. Organoleptic observations of the quercetin niosome included a yellow colour, distinctive quercetin odour and thick consistency for all formulas. The pH remained within the physiological pH range of skin. Quercetin niosome morphology was close to spherical while the niosome particle size results were 2.13 µm (F1), 2.99 µm (F2) and 3.31 µm (F3). The quercetin niosome encapsulation efficiency results were 81.86 ± 0.47% (F1), 84.02 ± 0.26% (F2) and 88.24 ± 0.10% (F3). Quercetin niosome were successfully prepared using multiple span 20 concentrations below the cholesterol concentration characterised by the measurement results of organoleptic, pH, particle morphology and encapsulation efficiency.
Inhibition of Cell Cycle and Induction of Apoptosis y Ethanol Leaves Extract of Chrysanthemum cinerariifolium (Trev.) In T47D Breast Cancer Cells Roihatul Mutiah; Alfiyah Laily Inayatin; Rahmi Annisa; Yen Yen Ari Indrawijaya; Anik Listiyana
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp1

Abstract

Chrysanthemum cinerariifolium (C.cinerariifolium) is a plant of the Asteraceae family, which has been applied by the community as an ornamental plant and traditional medicine. In this study, the effect of C. cinerariifolium leaves extract on inhibition of cell cycle and induction of apoptosis in T47D breast cancer cells was tested and compared to the standard chemotherapy agent. The citotoxic activity of C. cinerariifolium leaves extract against T47D cancer cells and Vero normal cells was tested by MTT method. Profile of apoptosis and cell cycle were observed by flow cytometry method. Based on chemical compounds profil which is tested used TLC showed that C.cinerariifolium leaves extracts contained flavonoid and terpenoid chemical compounds. The result of cytotoxic test showed that leaves extract of C. cinerariifolium was able to inhibit the growth of T47D cancer cell at IC50 418.8μg/mL. Doxorubicin, extracted from Streptomyces peucetius used as treatment in several cancers including breast cancer. Doxorubicin could inhibit the growth of T47D cancer cells in 115.1μg/mL. The results of cell cycle analysis showed that the C. cinerariifolium leaves extract inhibited cell cycle in G0-G1 and S phase, whereas doxorubicin was able to inhibit cell cycle in G0-G1 phase but experienced cell accumulation in G2-M phase. The percentage of apoptosis in cycle was showed in M1 (sub G1) and M5 (multinuclear) phase which treatment of C. cinerariifolium leaves extract was higher than doxorubicin. Therefore, C. cinerariifolium leaves extract has potential activity as anticancer agent causes inhibition of cell cycle and induction apoptosis. 
Pengaruh Poliherbal Ekstrak Jeringau, Temu Mangga Dan Bawang Putih Pada Fungsi Hepar Tikus (Rattus norwegicus) Bayyinatul Muchtaromah; Rahmi Annisa; Sofiya Sofiya
BIOSEL (Biology Science and Education): Jurnal Penelitian Science dan Pendidikan Vol 8, No 1 (2019): BIOSEL (Biology Science and Education): Jurnal Penelitian Science dan Pendidikan
Publisher : INSTITUT AGAMA ISLAM NEGERI AMBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (286.819 KB) | DOI: 10.33477/bs.v8i1.848

Abstract

This study aims to determine the effect of polyherbal extract of jeringau (Acorus calamus), temu mangga (Curcuma mangga), and garlic (Allium sativum) on the levels of Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) enzymes in rat hepar. The results of this study can be used as an indicator of the safety of using natural-based drugs on the body. This study used a completely randomized design (CRD) with 9 treatments and 3 replications. Treatment consists of K- (without treatment), K + (clomiphene citrate dose of 0.9 mg/kg BW), P1 (combination 1 at dose 50 mg/kgBB, P2 (combination 1 at a dose of 75 mg/kgBB), P3 (combination 1 at a dose of 100 mg/kgBB, P4 (combination 2 at a dose of 50 mg/kgBB), P5 (combination 2 at a dose of 75 mg/kgBB), P6 (combination 2 at a dose of 100 mg/kgBB), P7 (Subur kandungan herb at dose of 75 mg/kgBB). The results showed the highest levels of GPT enzymes were found in the treatment group 3 with the administration of combination 1 extract with a dose of 100 mg / kg BW of 46.7 U/L and the lowest level at P7 14.4 U / L, while the highest GOT enzyme levels were found in P6 namely 57.6 U / L and the lowest at P4 23.3 U / L. The results of the levels of the two transaminase enzymes are still in the normal category. Keywords: Jeringau, Temu Mangga, Garlic, Hepar, GPT, GOT
Formulation and Characterization on Self Nanoemulsifying Drug Delivery System of Eleutherine Palmifolia Extract Employing Short, Medium, and Long Chain Triglyceride Rahmi Annisa; Yen Yen Ari Indrawijaya; Dewi Sinta Megawati; Ana Fikrotus Zakia
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 2 (2020): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i2.232

Abstract

Eleutherine palmifolia (E. palmifolia) is a common plant used as an anticancer drug in Kalimantan, Indonesia. The active compound present in it is naphthoquinone, which has low water solubility and needs to be formulated into SNEDDS preparations to improve its dissolution and bioavailability in the body. The dispersion method is used in the preparation of Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) and PEG 400 cosurfactants. Furthermore, this study aims to ascertain the effects of oil on the SNEDDS preparations. The results showed that the effect of the preparations on olive oil, VCO, and oleic acid in the organoleptic test produced dark red, clear, and non functional emulsion. The average particle sizes obtained in the AGF media were 61,10, 774,33, and 211,70 nm; in AIF media it amounted to 211,70, 123,65, and 830,22 nm. The pH value for each formula was 6,8, while the average emulsification time for the AGF media was 24,10, 22,53, and 25,75 seconds, and, lastly, for the AIF media, they were 20,96, 19,62, and 23,74 second.
Antioxidants Activity of Self-Nanoemulsifying Drug Delivery System on Dayak Onions Extract (Eleutherine palmifolia) using DPPH (2,2 difenil-1- picrylhydrazyl) Method Rahmi Annisa; Tanaya Jati Dharma; Roihatul Mutiah; Sitti Nurjannah
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 4 (2021): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i4.339

Abstract

Dayak onions (Eleutherine palmifolia L. Merr) is one plant that has been proven to have benefits as an antioxidant. The Dayak extract is formulated in the self nano emulsifying drug delivery system (SNEDDS) because the extract has low water solubility. The aims this study to develop the SNEDDS formulation system by testing its antioxidant activity. We determined whether there was an increase in antioxidant activity when formulated in the form of SNEDDS or not. The results were then compared with a solution of Dayak onions extract without using SNEDDS. The obtained formula was the optimal result that has been done before using the D-optimal mixture design method. The results of the components consisted of 50 mg of Dayak extract, 10 % caprylic triglyceride as oil, 1% tween 80, and 6,60 % transcutol as a combination surfactant and 12,40 % propylene glycol as co-surfactant. Antioxidant activity testing was carried out using the DPPH (1,1-Diphenyl-2-picrylhydrazyl) method. The antioxidant test using the DPPH method was done with two samples, namely the extract solution and Dayak onion extract SNEDDS. We elaborated the research by using UV-VIS spectrophotometer. Each sample was made into five concentrations, namely 30 ppm, 60 ppm, 90 ppm, 120 ppm, and 150 ppm, and carried out three times replications. The results showed that the IC50 value in the Dayak onion extract solution was 227,19 ppm (very low), while for the SNEDDS solution for the Dayak onion extract the IC50 value obtained was 38,97 ppm (very strong). The analysis was carried out next using an independent T-Test to obtain the results. There was no significant difference between the extract solution and the SNEDDS solution of Dayak onion extract.
Co-Authors Abdul Hakim Ach. Nashichuddin Afrinis, Nur Alfiyah Laily Inayatin Amir, Muhammad Ana Fikrotus Zakia Ana Rahmawati Anik Listiyana Anik Listyana Atiza Fajrin Maulidya Bayyinatul Muchtaromah Ferry Sandra Hadi Kuncoro Hadya, Chorida Muhjatul Hening Laswati Putra Huwaida, Fadhila Isma Jatmiko, Ricky Arie Juwita Ramadhani Kirana, Farenza Okta Laily Nurul Azizah Lasepa, Wanda M. Artabah Muchlisin Ma'arif Z.A, Burhan Ma'arif, Burhan Mangestuti Agil Muhammad Zainuddin Muliyani Muliyani Mustofa, Muhammad Ragib Muti'ah, Roihatul Nazhipah Isnani Nurlaili Susanti Nurwijayanti Purwaningsih, Fauziyah Eni Ramadhani D.A., Ria Retno Susilowati Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Salsabila, Dhia Fadhilah Samah, Moh.Alfin Sitti Nurjannah Sofiya Sofiya Tanaya Jati Dharma Taufik, Imam Umami, Zahra Weka Sidha Bhagawan Wirda Anggraini Yen Yen Ari Indrawijaya Zahiro, Syayida Roisatus