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All Journal Majalah Kesehatan FKUB Asian Journal of Health Research Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia
Yuniaswan, Anggun Putri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Journal of General-Procedural Dermatology

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Multisystem Langerhans Cell Histiocytosis in high-risk group: A case series of two infants Yuniaswan, Anggun Putri; Safitri, Putri Rachma; Retnani, Diah Prabawati
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Background: Langerhans Cell Histiocytosis (LCH) has diverse manifestations, from asymptomatic to aggressive, which involves many organs. Histopathological examination playsa crucialrole as a basic diagnostic standard for LCH. Writing Group of the Histiocyte Society proposes a guideline for diagnosing LCH, divided into presumptive, designated, and definitive diagnosis. Case Illustration: Two cases of a 14 month-old girl and an 18 month-old girl presented similar clinical manifestation and multi-organ involvement. Dermatological examination revealed red papules and plaques covered by brownish scales and crusts on the scalp and body, erosion in some folds of the body. Histopathological examination of the first case revealed an early purpuric phase. S100 immunostaining just revealed hyperplasia of Langerhans cell but still could not support the diagnosis of LCH. Fine Needle Aspiration Biopsy of the enlarged submandibular lymph node after two months ofobservation suggested LCH. In the second case, histopathological examination revealed proliferation of round-oval nucleated cells, pleomorphic, some reniform nuclei, with amphophilic cytoplasm. S100 and CD1a immunostaining revealed a positive reaction in the proliferative cells. Discussion: Patients aged 14 and 18 monthsoldindicatedalmost similar clinical manifestations leading to LCH diagnosis, with different histopathological pictures. The first patient was presumptively diagnosedas high-risk multisystem LCH, but theinitial histopathology results did not support LCH diagnosis. On the other hand, the second patient was definitively diagnosed with high-risk multisystem LCH. Conclusion: Patientswith clinically suspected LCH without histopathological confirmation should be observed at least six months to reassess the necessity of a follow-up biopsy.
Effects of 5% astaxanthin gel on angiogenesis and granulation tissue in second-degree burn animal model Rofiq, Aunur; Yuniaswan, Anggun Putri; Nugraha, Rizki Hapsari
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 2
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Background: Burn injuries generate more free radicals and lead to complex immune dysfunction, which can delay wound healing compared to other wound types. Angiogenesis, essential for wound healing, requires granulation tissue as a marker for successful wound healing. Low concentrations of reactive oxygen species (ROS) are necessary to initiate this process. Astaxanthin is a potent antioxidant with anti-inflammatory properties, known to activate angiogenesis and modulate ROS signaling during wound healing. Methods: This experimental study aimed to evaluate 5% astaxanthin gel on second-degree burns using 30 male Wistar rats. Simple random sampling was utilized. A total of 6 groups were divided according to the time the lesions were evaluated i.e., I. Normal saline, day 2 (n=5); II. Normal saline, day 5 (n=5); III. Normal saline, day 7 (n=5); IV. 5% astaxanthin gel, day 2(n=5); V. 5% astaxanthin gel, day 5 (n=5); VI. 5% astaxanthin gel, day 7 (n=5). Histological assessment of angiogenesis and granulation tissue was based on the number of blood vessels and the extent of the wound to the dermis, respectively. Result: The mean of angiogenesis in 5% astaxanthin gel group was higher than the control group on day 5 (p-value < 0.05). The positive correlation between angiogenesis and granulation tissue was observed on day 5 (p-value < 0.05). Conclusion: The primary effect of 5% astaxanthin gel is during the proliferative phase of wound healing in second-degree burns.
Co-Authors AUNUR ROFIQ Ekasari, Dhany Prafita Fitriana, Nadia Aprilia Hidayat, Deriel Elka Noor Hidayah Nugraha, Rizki Hapsari Prawitasari, Suci Retnani, Diah Prabawati Safitri, Putri Rachma Sinta Murlistyarini Swanenghyun, Garnis Widiatmoko, Arif