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All Journal Jurnal Kesehatan Lingkungan indonesia Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Mandala of Health : A Scientific Journal Linggamas: Jurnal Pengabdian Masyarakat
Widhi, Anriani Puspita Karunia Ning
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Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Residu Antibiotik Serta Keberadaan Escherichia Coli Penghasil ESBL pada Daging Ayam Broiler di Pasar Kota Purwokerto Widhi, Anriani Puspita Karunia Ning; Saputra, Imam Nafi Yana
Jurnal Kesehatan Lingkungan Indonesia Vol 20, No 2 (2021): Oktober 2021
Publisher : Master Program of Environmental Health, Faculty of Public Health, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jkli.20.2.137-142

Abstract

Latar belakang: Pemenuhan kebutuhan pangan asal ternak yang berasal dari unggas memiliki angka konsumsi yang cukup tinggi salah satunya yaitu ayam broiler. Untuk memenuhi tingginya permintaan terhadap ayam broiler pada pakandiberifeed additiveserta antibiotic growth promotor (AGP) dalam bentuk antibiotik untuk mempercepat pertumbuhan dan daya tahan tubuh. Pemanfaatan antibiotik yang tidak bijak akan menimbulkan residu antibiotik serta resistensi Escherichia coli penghasil Extended Spectrum β-lactamase (ESBL).Metode: Penelitian ini termasuk penelitian deskriptif. Data primer diperoleh dari hasil screeningtest. Data ditunjukkan dalam tabel dangambar yang dibahas secara deskriptif. Variabel yang diamati residu antibiotik tetrasiklin serta E. coli penghasil ESBL pada daging ayam broiler.Hasil: Temuan terhadap residu antibiotik tetrasiklin pada daging ayam broiler yaitu sebesar 7,14% dengan rerata zona hambat 12,13 mm, sedangkan hasil identifikasi E. coli penghasil ESBL pada daging ayam broiler diperoleh hasil sebesar 71,4%.Simpulan:Residu antibiotik tetrasiklin dalam daging ayam broiler masih tergolong aman dapat dikonsumsi namun, temuanE. coli penghasil ESBL pada daging ayam broiler menimbulkan masalah kesehatan, baik bagi kesehatan hewan maupun manusia, serta dapat menimbulkan resistensi terhadap antibiotik. ABSTRACT Title: Broiler Chicken Meat Sold at Purwokerto's Market Has Antibiotic Residues and Escherichia Coli That Produces EsblBackground: Poultry, of which broiler chickens are one example, is a food source with a relatively high consumption rate.Feed additives and antibiotic growth promoters (AGP) in the form of antibiotics in the ration are given to increase broilers’ growth and endurance to meet the high demand for them. It is important to note that unwise antibiotic use results in the buildup of antibiotic residues and resistance to the Extended Spectrum Beta-lactamase(ESBL)produced by Escherichia coli bacterium.Method: To collect primary data for this descriptive study, the screening test results were employed as a starting point. Next, the information was presented in the form of tables and figures.Result: According to this study, broiler chickens had a tetracycline residue of 7.14 percent, with an inhibitory zone mean of 12.13 mm, and 71.4 percent of ESBL-producing E. coli.Conclusion:According to the study, broiler chicken meat with tetracycline residue is still safe to consume. E. coli, which is known to develop an antibiotic-resistant strain of E. coli ESBL) can cause serious health problems in both humans and animals.
Examining the Relationship between Infection Control Practices and ESBL Bacterial Carriage in Healthcare Workers Ayunisih, Lintang Sekar; Krisniawati, Nia; Wicaksono, Madya Ardi; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.9

Abstract

The Enterobacteriaceae family widely produces Extended Spectrum Beta-Lactamase (ESBL), and infection by ESBL-producing bacteria can significantly increase morbidity, complicate therapeutic difficulties, escalating healthcare costs, and increase mortality rates. Transmission of these bacteria within the hospital environment may lead to the prevalence of ESBL-producing bacterial carriers among healthcare workers. Health workers' infection prevention and control (IPC) behavior plays a role in transmitting these pathogenic bacteria. This study aimed to determine the relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital. This research used an observational analytic approach with a cross-sectional method. The sampling technique involved purposive sampling, resulting in a total sample of 61 people. Data were obtained by completing an IPC behavior questionnaire and collecting rectal swab samples cultured on CHROM ESBL Agar media. Statistical analysis was done using the Mann-Whitney test. The research identified a prevalence of 13.1% (8/61) ESBL-producing bacterial carriers among health workers at Banjarnegara Islamic Hospital. However, based on statistical analysis, the p-value was 0.664, leading to the rejection of the hypothesis (accepted if p-value <0.05). In conclusion, there is no significant relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital.
Etiology and Antifungal Sensitivity Test in Otomycosis Caused by Candida Sp Darmawan, Anton Budhi; Krisniawati, Nia; Widhi, Anriani Puspita Karunia Ning; Hestiyani, Rani Afifah Nur; Kurniawan, Dhadhang Wahyu; Darmayan, Bella Jovita
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3337

Abstract

Otomycosis is a common fungal infection of the external auditory meatus frequently diagnosed in otolaryngology outpatient clinics. Resistance to antifungals is currently a significant concern, with intrinsic and acquired resistance increasing among isolates that cause fungal infections. The purpose of this research was to identify Candida species causing otomycosis and determine the pattern of antifungal susceptibility among these Candida species. A prospective study was conducted in the Margono Soekarjo General Hospital and Department of Microbiology, Faculty of Medicine, Universitas Jenderal Soedirman Purwokerto, Indonesia, from April – September 2022. Forty-seven (47) clinical samples of otomycosis were collected from 41 patients and then isolated bedside on fungal culture media and was prepared on an object glass for direct microscopic examination of the specimens. Fungal identification was performed using 10% potassium hydroxide (KOH) to observe fungal elements. Samples were cultured on Saboraud dextrose agar (SDA) media with chloramphenicol and Czapek dox agar. The Germ Tube Test was used to identify Candida while yeast-specific identification and antifungal susceptibility assay using a rapid commercial kit was applied for specific identification of the fungus. Antifungal susceptibility patterns were obtained using the Integral System Yeast Plus (ISYP) media pack. Candida parapsilosis was the most prevalent Candida species discovered in this study, accounting for approximately 41.66%, which was followed by Candida tropicalis (25%) and Candida krusei (12.5%), whereas Candida albicans only accounted for 4.1% of the specimens. All Candida species were sensitive to flucitosine and ketoconazole, whereas the voriconazole sensitivity rate reached 96%.  This study concludes that Candida parapsilosis is the most prevalent species of Candida in otomycosis, and that all Candida species are sensitive to Flucitosine, ketoconazole, and voriconazole.
The Correlation of Infection Prevention and Control Knowledge and ESBL Carriage Rate among Healthcare Workers in a Hospital in Indonesia Fanani, Navalia Azkarifda; Krisniawati, Nia; Wicaksono, Madya Ardi; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.3

Abstract

Extended-spectrum beta-lactamase (ESBL) is an enzyme resulting from bacterial gene mutations that can restrict the activity of beta-lactam antibiotics, such as penicillin, the first, second, and third generation of cephalosporin, and monobactam, except cephamycin and carbapenem. ESBL can cause healthcare-associated infections (HAIs). Infection prevention and control (IPC) is a comprehensive effort to prevent HAIs in healthcare facilities. This research investigated the correlation between IPC knowledge level and the incidence of extended-spectrum beta-lactamase (ESBL) producing bacteria carriers in hospital healthcare workers. This research was conducted as observational analytical research using the quantitative and cross-sectional approaches. The research used purposive sampling, involving 61 healthcare workers at Banjarnegara Islamic Hospital. Research instruments included a 24-item questionnaire assessing IPC knowledge and rectal swabs intended to detect the incidence of ESBL carriers using the CHROMagar™ ESBL medium. Most respondents have a relatively good understanding of IPC, with a median score of 16 (25%). Of the 61 rectal swab samples, eight incidences of ESBL carriers were identified (13%). The isolates of the recognized carriers consist of five Escherichia coli (63%), two Klebsiella pneumoniae (25%), and one Acinetobacter baumannii (12%). Statistical analysis using the Mann-Whitney hypothesis test with the SPSS software showed a significant value of 0.493. Therefore, there is no correlation between IPC knowledge level and the incidence of extended-spectrum beta-lactamase-producing bacteria carriers in hospital healthcare workers.
Skrining dan Penyuluhan Pencegahan Penyakit Diabetes Melitus pada Anggota PKK di Sokaraja Tengah Afifah, Afifah; Setiawati, Setiawati; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.13655

Abstract

Diabetes Melitus (DM) masih menjadi salah satu masalah kesehatan di Indonesia, khususnya di Banyumas. Pengobatan jangka panjang dan munculnya komplikasi akibat penyakit DM semakin meningkatkan beban ekonomi dan semakin menurunnya kualitas hidup penderita. Mencegah terjadinya penyakit DM menjadi hal yang sangat penting dalam upaya mencegah morbiditas dan mortalitas akibat DM. Pemberdayaan Kesejahteraan Keluarga (PKK) merupakan organisasi masyarakat yang berperan penting dalam upaya pencegahan penyakit DM. Anggota PKK diharapkan dapat menjadi agen perubahan dalam meningkatkan kesehatan keluarga dan masyarakat sekitar. Artikel ini membahas upaya pencegahan dan skrining penyakit DM yang melibatkan anggota PKK di Banyumas. Kegiatan yang dilakukan meliputi penyuluhan dan pemeriksaan kesehatan yaitu pengukuran berat badan, tinggi badan, tekanan darah, kadar glukosa, asam urat, dan kolesterol. Hasil kegiatan menunjukkan adanya peningkatan pemahaman peserta, yang ditunjukkan dengan kenaikan rerata nilai post-test. Pada kegiatan ini juga berhasil dideteksi beberapa peserta dengan kadar glukosa diatas normal. Kegiatan ini diharapkan dapat menjadi model edukasi kesehatan yang berkelanjutan untuk meningkatkan kesadaran dan deteksi dini faktor risiko diabetes melitus di masyarakat.
TINGKAT POSITIVITAS PEMERIKSAAN KALIUM HIDROKSIDA PADA PASIEN OTOMIKOSIS Widhi, Anriani Puspita Karunia Ning; Krisniawati, Nia; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12096

Abstract

Otomycosis is an opportunistic fungal infection of the external ear canal and is widespread worldwide. The clinical manifestations of otomycosis are non-specific symptoms such as earache, discharge, itching, hearing loss, feeling of fullness in the ear, and tinnitus. The most common etiology found is Aspergillus sp. and Candida sp. The purpose of this study was to assess the positivity level of KOH examination in patients with a clinical diagnosis of otomycosis. The method used in this research uses a descriptive quantitative approach. The research subjects were otomycosis patients at the ENT-KL clinic at Margono Soekarjo Hospital from April to August 2022. Samples were taken using Flexible minitip flocked sterile swabs (Copan, Italy) on white to black ear secretions. Swabs were isolated on Saboraud Dextrose Agar (SDA) mushroom culture media (Himedia, India) and for KOH examination. The results obtained in this study were 48(85.7%) positive KOH, positive culture and 8(14.3%) negative KOH, positive culture. In a sample of 56 patients with a clinical diagnosis of otomycosis the most common isolates were Aspergillus sp 32 (57.1%) and Candida sp (42.9%). KOH sensitivity and specificity test results for Aspergillus sp were 37.7% and 100%, while for Candida sp were 97.7% and 50%. The conclusion of this study is that the KOH examination has a positivity rate of 85.7%. This examination needs to be routinely carried out as an initial screening to support the clinical diagnosis of otomycosis.
Co-Authors Ayunisih, Lintang Sekar Darmawan, Anton Budhi Darmayan, Bella Jovita Dhadhang Wahyu Kurniawan Fanani, Navalia Azkarifda Krisniawati, Nia Madya Ardi Wicaksono, Madya Ardi Muhammad Afif Rani Afifah Nur Histiyani Saputra, Imam Nafi Yana Setiawati Setiawati