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All Journal Majalah Kedokteran Bandung Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Global Health research Mandala of Health : A Scientific Journal Medical and Health Journal
Darmawan, Anton Budhi
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PREVALENSI Candida albicans PADA PASIEN OTOMIKOSIS DI RSUD MARGONO SOEKARJO Wijaya, Helmi Aditya; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah; Krisniawati, Nia; Rujito, Lantip
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8643

Abstract

Background: Otomycosis is an infection of the ear caused by various fungi. One of the most common fungi that cause Otomycosis is Candida albicans. Otomycosis is a challenge for the medical world and patients because it requires long-term treatment and has a high recurrence rate. It causes the importance of an overview of the prevalence in a place as planning health services, description of cases, and eradication programs. Banyumas Regency has a climate that supports the growth of mushrooms. One of the major hospitals in Banyumas is RSUD Margono Soekarjo. Objective: Knew the prevalence of Candida albicans on Otomycosis at Margono Soekarjo Hospital. Method: This research is a descriptive observational study on the target population of patients at the ENT clinic at RSUD Margono Soekarjo—sampling technique using a total sampling of as many as 42 subjects with 46 samples. Data analysis techniques use univariate analysis to describe the characteristics of each variable. Results: The results of otomycosis sufferers at Margono Soekarjo Hospital were male compared to female by 50:50, namely 21 of 42 subjects (50.00%), respectively. The age group that suffered the most from Otomycosis was the 26-35 age group, with 12 out of 42 subjects (28.57%). The prevalence of Candida albicans in Otomycosis of 2.17% or 1 of 46 patient samples with a clinical diagnosis of Otomycosis at Margono Soekarjo Hospital was caused by a fungus Candida albicans. Conclusion: Prevalence Candida albicans as a cause of Otomycosis in patients at the ENT polyclinic at Margono Soekarjo Hospital in the Januari-February 2023 period of 2.17%, namely 1 out of 46 samples, with 26 years of age included in the 26-35 years age group and female.
Etiology and Antifungal Sensitivity Test in Otomycosis Caused by Candida Sp Darmawan, Anton Budhi; Krisniawati, Nia; Widhi, Anriani Puspita Karunia Ning; Hestiyani, Rani Afifah Nur; Kurniawan, Dhadhang Wahyu; Darmayan, Bella Jovita
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3337

Abstract

Otomycosis is a common fungal infection of the external auditory meatus frequently diagnosed in otolaryngology outpatient clinics. Resistance to antifungals is currently a significant concern, with intrinsic and acquired resistance increasing among isolates that cause fungal infections. The purpose of this research was to identify Candida species causing otomycosis and determine the pattern of antifungal susceptibility among these Candida species. A prospective study was conducted in the Margono Soekarjo General Hospital and Department of Microbiology, Faculty of Medicine, Universitas Jenderal Soedirman Purwokerto, Indonesia, from April – September 2022. Forty-seven (47) clinical samples of otomycosis were collected from 41 patients and then isolated bedside on fungal culture media and was prepared on an object glass for direct microscopic examination of the specimens. Fungal identification was performed using 10% potassium hydroxide (KOH) to observe fungal elements. Samples were cultured on Saboraud dextrose agar (SDA) media with chloramphenicol and Czapek dox agar. The Germ Tube Test was used to identify Candida while yeast-specific identification and antifungal susceptibility assay using a rapid commercial kit was applied for specific identification of the fungus. Antifungal susceptibility patterns were obtained using the Integral System Yeast Plus (ISYP) media pack. Candida parapsilosis was the most prevalent Candida species discovered in this study, accounting for approximately 41.66%, which was followed by Candida tropicalis (25%) and Candida krusei (12.5%), whereas Candida albicans only accounted for 4.1% of the specimens. All Candida species were sensitive to flucitosine and ketoconazole, whereas the voriconazole sensitivity rate reached 96%.  This study concludes that Candida parapsilosis is the most prevalent species of Candida in otomycosis, and that all Candida species are sensitive to Flucitosine, ketoconazole, and voriconazole.
DESCRIPTION OF DISEASES SUFFERED BY MOTHERS AND CHILDREN AT THE AGE OF 0-3 YEARS WITH HEARING LOSS AT MARGONO SOEKARJO PURWOKERTO HOSPITAL Fahrizal, Eky Danu; Kusdaryanto, Wahyu Dwi; Nafiisah, Nafiisah; Agustina, Nenden Nursyamsi; Darmawan, Anton Budhi
Mandala Of Health Vol 17 No 1 (2024): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.1.7908

Abstract

Hearing loss is difficult to detect in infants and children. It can inhibit cognitive, emotional, language, and communication development. Therefore, hearing loss needs to be immediately examined to minimize its impacts. It is essential to recognize the disease suffered by infants and children, especially those with a history of hearing loss during the pranatal, perinatal, and postnatal periods for early examinations. This study aimed to evaluate diseases characteristic suffered by children with hearing loss aged 0-3 years at RSUD Margono Soekarjo, Purwokerto. This research was descriptive, using secondary data. The analysis used was univariate. Hearing loss in children during; the pranatal (15.4%) could be caused by a family history of the disease, TORCH infection, and preeclampsia; during the perinatal (70,3%) could be caused by low birth weight, prematurity, hyperbilirubinemia, and neonatal asphyxia, and; during the postnatal period (14.3%) could be caused by the use of mechanical ventilators and febrile seizures. The disease character in children aged 0-3 years with hearing loss at RSUD Margono Soekarjo Purwokerto are disease during pranatal, perinatal, and postnatal periods
GAMBARAN KLINIS OTOMIKOSIS DI RS MARGONO SOEKARJO Kinanthi, Rusy; Kusdaryanto, Wahyu Dwi; Darmawan, Anton Budhi; Krisniawati, Nia; Nur Hestiyanti, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11498

Abstract

Otomycosis is a disease of the outer ear canal caused by fungal microorganisms. Signs found in patients with otomycosis may also vary, such as edema, redness of the outer ear canal, tragus pain, discharge, or fungal mass through the clinical examination. This study aimed to determine the clinical features of patients diagnosed with otomycosis at Margono Soekarjo Hospital. This research was a descriptive study with a cross-sectional approach using primary data from July-November 2022 at the ENT clinic, Margono Soekarjo Hospital. An ENT specialist took data through the stages of anamnesis and physical examination. After otomycosis is clinically diagnosed, further documentation is carried out on the patient’s examination sheet regarding the characteristics of the subject and the clinical features in the form of symptoms and signs experienced by the subject. The data analysis performed was a univariate analysis to demonstrate the frequency distribution of clinical features in the study subjects. The total samples obtained are 46 samples from 42 subjects diagnosed with otomycosis with an age range of 17-73 years, and the susceptible age to undergo otomycosis is 26-35 years. The most common symptom is itching (80,43%). Other commonly found symptoms are hearing loss (78,26%) and a sensation of blockage in the ears (73,91%). At the same time, the sign commonly found in the physical examination is a fungal mass (100%). The most typical form of fungal group is white mass. In addition, signs are frequently found in discharge (64,04%) and perforation (60,87%). Otomycosis is a common disease in young adults. Symptoms and signs of otomycosis vary, but the common symptoms are itching, hearing loss, and the sensation of blockage in the ears. At the same time, the common signs are fungal mass in the ear, discharge, and perforation of the ear.
TINGKAT POSITIVITAS PEMERIKSAAN KALIUM HIDROKSIDA PADA PASIEN OTOMIKOSIS Widhi, Anriani Puspita Karunia Ning; Krisniawati, Nia; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12096

Abstract

Otomycosis is an opportunistic fungal infection of the external ear canal and is widespread worldwide. The clinical manifestations of otomycosis are non-specific symptoms such as earache, discharge, itching, hearing loss, feeling of fullness in the ear, and tinnitus. The most common etiology found is Aspergillus sp. and Candida sp. The purpose of this study was to assess the positivity level of KOH examination in patients with a clinical diagnosis of otomycosis. The method used in this research uses a descriptive quantitative approach. The research subjects were otomycosis patients at the ENT-KL clinic at Margono Soekarjo Hospital from April to August 2022. Samples were taken using Flexible minitip flocked sterile swabs (Copan, Italy) on white to black ear secretions. Swabs were isolated on Saboraud Dextrose Agar (SDA) mushroom culture media (Himedia, India) and for KOH examination. The results obtained in this study were 48(85.7%) positive KOH, positive culture and 8(14.3%) negative KOH, positive culture. In a sample of 56 patients with a clinical diagnosis of otomycosis the most common isolates were Aspergillus sp 32 (57.1%) and Candida sp (42.9%). KOH sensitivity and specificity test results for Aspergillus sp were 37.7% and 100%, while for Candida sp were 97.7% and 50%. The conclusion of this study is that the KOH examination has a positivity rate of 85.7%. This examination needs to be routinely carried out as an initial screening to support the clinical diagnosis of otomycosis.
Effect of Excessive Monosodium Glutamate (MSG) Consumption on Brain Function and Structure: A Systematic Review in Animal Models Nurhidayah, Annida; Darmawan, Anton Budhi
Indonesian Journal of Global Health Research Vol 7 No 3 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i3.6073

Abstract

Monosodium glutamate (MSG) is widely used as a flavor enhancer, but excessive consumption has been linked to neurotoxicity. Poor dietary intake affects neurotransmitter balance, oxidative stress levels, and long-term neuronal health. Objective: To evaluate the effects of excessive MSG consumption on brain function and structure using animal models. Method: A systematic review was conducted using PubMed, Google Scholar, and ResearchGate (2014–2024). From 1,692 initially identified articles, 8 were selected using the PICO method, focusing on MSG exposure, neurotoxicity, and structural or functional brain changes in animal models. Results: Studies indicate that MSG exposure contributes to neurotransmitter imbalances, increased oxidative stress, and neuronal degeneration, leading to cognitive impairment and behavioral alterations. Additionally, elevated tau phosphorylation and neuroinflammation were observed, potentially increasing the risk of neurodegenerative conditions such as Alzheimer’s disease. The route of administration (oral vs. intraperitoneal) and duration of exposure influenced the severity of effects. Conclusion: Excessive MSG consumption negatively affects brain function and structure through mechanisms such as excitotoxicity, oxidative stress, and neuroinflammation. Further research is needed to standardize dosage thresholds, explore protective interventions, and assess long-term effects in mammalian models.
Korelasi Feritin dengan Sitokin Proinflamasi pada Pasien Talasemia Beta Di Kota Samarinda Kalimantan Timur Aminuddin, Muhammad Fahmi; Darmawan, Anton Budhi; Rujito, Lantip
Majalah Kedokteran Indonesia Vol 72 No 2 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.2-2022-608

Abstract

Introduction: Ferritin is a routine parameter used in the evaluation of iron overload in thalassemia patients. Excess iron causes the formation of ROS, resulting in an oxidative reaction that triggers inflammation. This study aims to determine the correlation of ferritin levels with proinflammatory cytokines in beta thalassemia. Methods: A cross-sectional analytical study was conducted on 33 beta thalassemia patients who received routine blood transfusions at I.A. Moeis Samarinda. Spearman rank correlation test was used to determine the correlation between ferritin and TNF-α and IL-6. Results: The results of this study showed that there was no relationship between ferritin and TNF- (p=0.580) and IL-6 (p=0.924). Meanwhile, there was a significant relationship between TNF- and IL-6 (p less than 0.0001) which had a strong positive correlation (r=0.621). Conclusion: This study showed that there was no correlation between ferritin levels with TNF-α and IL-6. Meanwhile, proinflammatory cytokines showed a correlation between TNF-α and IL-6 in thalassemia patients in Samarinda City.
Co-Authors Agustina, Nenden Nursyamsi Aminuddin, Muhammad Fahmi Darmayan, Bella Jovita Dhadhang Wahyu Kurniawan Fahrizal, Eky Danu Kinanthi, Rusy Krisniawati, Nia Kusdaryanto, Wahyu Dwi Lantip Rujito Nafiisah, Nafiisah Nur Hestiyanti, Rani Afifah Nurhidayah, Annida Rani Afifah Nur Histiyani Widhi, Anriani Puspita Karunia Ning Wijaya, Helmi Aditya