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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Mandala of Health : A Scientific Journal Medical and Health Journal Linggamas: Jurnal Pengabdian Masyarakat
Krisniawati, Nia
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Age Krisniawati, Nia; Ciptaningtyas, Vincentia Rizke; Reki, Winarto
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 13, No 1 (2022): June 2022
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (423.015 KB) | DOI: 10.30659/sainsmed.v13i1.8663

Abstract

Most blood culture contaminants are coagulase-negative staphylococci (CoNS), which are also the leading cause of nosocomial bloodstream infections. To date, no research in Indonesia has analyzed the potential causes of a CoNS infection in the bloodstream. The goal of this research was to better understand who is at risk for developing a CONS-related bloodstream infection while in a hospital setting. Secondary data from the CONS blood culture results at Dr. Kariadi Hospital Semarang were used in this retrospective cross-sectional study conducted between January 1 and December 31, 2016. The Vitek-2 Compact System (Biomerieux, USA) and the Kirby Bauer method (Clinical & Laboratory Standards Institute (CLSI) of the USA) were used for the antibiotic identification and sensitivity testing, respectively. Multivariate with multiple logistic regressions and the Chi-Square test for categorical variables were used in the analysis. Among the study's 272 participants, 158 (58.1%) developed CONS-related bloodstream infections. Risk factors for central nervous system (CNS) bloodstream infection in 18-year-olds include preterm birth, low birth weight (LBW), compromised immunity, malnutrition, immunosuppressive therapy, and peripheral intravenous use. Age >=18, malnutrition, and immunosuppression therapy all ranked high as risk factors in a multivariate analysis. Risk factors for CONS-causing bloodstream infections in people aged 18 include malnutrition and immunosuppressant therapy.
Examining the Relationship between Infection Control Practices and ESBL Bacterial Carriage in Healthcare Workers Ayunisih, Lintang Sekar; Krisniawati, Nia; Wicaksono, Madya Ardi; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.9

Abstract

The Enterobacteriaceae family widely produces Extended Spectrum Beta-Lactamase (ESBL), and infection by ESBL-producing bacteria can significantly increase morbidity, complicate therapeutic difficulties, escalating healthcare costs, and increase mortality rates. Transmission of these bacteria within the hospital environment may lead to the prevalence of ESBL-producing bacterial carriers among healthcare workers. Health workers' infection prevention and control (IPC) behavior plays a role in transmitting these pathogenic bacteria. This study aimed to determine the relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital. This research used an observational analytic approach with a cross-sectional method. The sampling technique involved purposive sampling, resulting in a total sample of 61 people. Data were obtained by completing an IPC behavior questionnaire and collecting rectal swab samples cultured on CHROM ESBL Agar media. Statistical analysis was done using the Mann-Whitney test. The research identified a prevalence of 13.1% (8/61) ESBL-producing bacterial carriers among health workers at Banjarnegara Islamic Hospital. However, based on statistical analysis, the p-value was 0.664, leading to the rejection of the hypothesis (accepted if p-value <0.05). In conclusion, there is no significant relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital.
ANTIBACTERIAL ACTIVITY OF EGGPLANT ETHYL ACETATE EXTRACT (Solanum melongena L.) AGAINST Escherichia coli Handayani, Mira Syafira; Setiawati, Setiawati; Krisniawati, Nia; Sutrisna, Eman
Medical and Health Journal Vol 2 No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.796 KB) | DOI: 10.20884/1.mhj.2023.2.2.8053

Abstract

Terong ungu mengandung senyawa metanol, flavonoid, saponin dan tanin yang berpotensi sebagai antibakteri. Escherichia coli merupakan salah satu kuman penyebab berbagai macam infeksi dan saat ini banyak dilaporkan telah mengalami resistensi terhadap sejumlah antibiotik onvensional. Tujuan penelitian ini untuk mengeksplorasi aktivitas antibakteri dari ekstrak etil asetat terong ungu terhadap bakteri Escherichia coli (E. coli). Penelitian ini merupakan penelitian eksperimental dengan metode mikrodilusi untuk menentukan nilai konsentrasi hambat minimal (KHM) dan metode spread-plate untuk menentukan konsentrasi bunuh minimal (KBM). Penelitian ini menggunakan berbagai dosis ekstrak etil asetat terong ungu (5-40 mg/mL) sebagai kelompok perlakuan dan kelompok kontrol yang tidak diberikan ekstrak etil asetat terong ungu. Ekstrak etil asetat terong ungu mempunyai nilai KHM sebesar 20 mg/mL dan nilai KBM sebesar 20mg/mL. Semakin tinggi konsentrasi ekstrak etil asetat terong ungu, semakin besar pula persentase hambatan ekstrak etil asetat terong ungu terhadap bakteri E. coli. Ekstrak etil asetat terong ungu mempunyai potensi sebagai antibakteri terhadap E. coli
PREVALENSI Candida albicans PADA PASIEN OTOMIKOSIS DI RSUD MARGONO SOEKARJO Wijaya, Helmi Aditya; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah; Krisniawati, Nia; Rujito, Lantip
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8643

Abstract

Background: Otomycosis is an infection of the ear caused by various fungi. One of the most common fungi that cause Otomycosis is Candida albicans. Otomycosis is a challenge for the medical world and patients because it requires long-term treatment and has a high recurrence rate. It causes the importance of an overview of the prevalence in a place as planning health services, description of cases, and eradication programs. Banyumas Regency has a climate that supports the growth of mushrooms. One of the major hospitals in Banyumas is RSUD Margono Soekarjo. Objective: Knew the prevalence of Candida albicans on Otomycosis at Margono Soekarjo Hospital. Method: This research is a descriptive observational study on the target population of patients at the ENT clinic at RSUD Margono Soekarjo—sampling technique using a total sampling of as many as 42 subjects with 46 samples. Data analysis techniques use univariate analysis to describe the characteristics of each variable. Results: The results of otomycosis sufferers at Margono Soekarjo Hospital were male compared to female by 50:50, namely 21 of 42 subjects (50.00%), respectively. The age group that suffered the most from Otomycosis was the 26-35 age group, with 12 out of 42 subjects (28.57%). The prevalence of Candida albicans in Otomycosis of 2.17% or 1 of 46 patient samples with a clinical diagnosis of Otomycosis at Margono Soekarjo Hospital was caused by a fungus Candida albicans. Conclusion: Prevalence Candida albicans as a cause of Otomycosis in patients at the ENT polyclinic at Margono Soekarjo Hospital in the Januari-February 2023 period of 2.17%, namely 1 out of 46 samples, with 26 years of age included in the 26-35 years age group and female.
Etiology and Antifungal Sensitivity Test in Otomycosis Caused by Candida Sp Darmawan, Anton Budhi; Krisniawati, Nia; Widhi, Anriani Puspita Karunia Ning; Hestiyani, Rani Afifah Nur; Kurniawan, Dhadhang Wahyu; Darmayan, Bella Jovita
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3337

Abstract

Otomycosis is a common fungal infection of the external auditory meatus frequently diagnosed in otolaryngology outpatient clinics. Resistance to antifungals is currently a significant concern, with intrinsic and acquired resistance increasing among isolates that cause fungal infections. The purpose of this research was to identify Candida species causing otomycosis and determine the pattern of antifungal susceptibility among these Candida species. A prospective study was conducted in the Margono Soekarjo General Hospital and Department of Microbiology, Faculty of Medicine, Universitas Jenderal Soedirman Purwokerto, Indonesia, from April – September 2022. Forty-seven (47) clinical samples of otomycosis were collected from 41 patients and then isolated bedside on fungal culture media and was prepared on an object glass for direct microscopic examination of the specimens. Fungal identification was performed using 10% potassium hydroxide (KOH) to observe fungal elements. Samples were cultured on Saboraud dextrose agar (SDA) media with chloramphenicol and Czapek dox agar. The Germ Tube Test was used to identify Candida while yeast-specific identification and antifungal susceptibility assay using a rapid commercial kit was applied for specific identification of the fungus. Antifungal susceptibility patterns were obtained using the Integral System Yeast Plus (ISYP) media pack. Candida parapsilosis was the most prevalent Candida species discovered in this study, accounting for approximately 41.66%, which was followed by Candida tropicalis (25%) and Candida krusei (12.5%), whereas Candida albicans only accounted for 4.1% of the specimens. All Candida species were sensitive to flucitosine and ketoconazole, whereas the voriconazole sensitivity rate reached 96%.  This study concludes that Candida parapsilosis is the most prevalent species of Candida in otomycosis, and that all Candida species are sensitive to Flucitosine, ketoconazole, and voriconazole.
The Correlation of Infection Prevention and Control Knowledge and ESBL Carriage Rate among Healthcare Workers in a Hospital in Indonesia Fanani, Navalia Azkarifda; Krisniawati, Nia; Wicaksono, Madya Ardi; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.3

Abstract

Extended-spectrum beta-lactamase (ESBL) is an enzyme resulting from bacterial gene mutations that can restrict the activity of beta-lactam antibiotics, such as penicillin, the first, second, and third generation of cephalosporin, and monobactam, except cephamycin and carbapenem. ESBL can cause healthcare-associated infections (HAIs). Infection prevention and control (IPC) is a comprehensive effort to prevent HAIs in healthcare facilities. This research investigated the correlation between IPC knowledge level and the incidence of extended-spectrum beta-lactamase (ESBL) producing bacteria carriers in hospital healthcare workers. This research was conducted as observational analytical research using the quantitative and cross-sectional approaches. The research used purposive sampling, involving 61 healthcare workers at Banjarnegara Islamic Hospital. Research instruments included a 24-item questionnaire assessing IPC knowledge and rectal swabs intended to detect the incidence of ESBL carriers using the CHROMagar™ ESBL medium. Most respondents have a relatively good understanding of IPC, with a median score of 16 (25%). Of the 61 rectal swab samples, eight incidences of ESBL carriers were identified (13%). The isolates of the recognized carriers consist of five Escherichia coli (63%), two Klebsiella pneumoniae (25%), and one Acinetobacter baumannii (12%). Statistical analysis using the Mann-Whitney hypothesis test with the SPSS software showed a significant value of 0.493. Therefore, there is no correlation between IPC knowledge level and the incidence of extended-spectrum beta-lactamase-producing bacteria carriers in hospital healthcare workers.
Peningkatan Kompetensi Pengasuh Pondok Pesantren Dalam Pencegahan Penyebaran Tuberkulosis (TB) Di Kabupaten Banyumas Krisniawati, Nia; Puspita Karunia Ning Widhi, Anriani; Afifah Nur Hestiyani, Rani; Rahmawati, Indah
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.13658

Abstract

Program peningkatan kompetensi pengasuh pondok pesantren dalam pencegahan Tuberkulosis (TB) di Kabupaten Banyumas bertujuan untuk meningkatkan pengetahuan dan keterampilan pengasuh dalam mengidentifikasi gejala dan mencegah penyebaran TB. Melalui pendekatan penyuluhan, pelatihan identifikasi gejala, dan penguatan sistem rujukan, program ini membekali pengasuh dengan kemampuan dasar untuk mendeteksi dan merujuk kasus TB secara cepat. Hasil evaluasi menunjukkan adanya peningkatan signifikan dalam pengetahuan peserta, dengan skor post-test lebih tinggi dibandingkan pre-test. Program ini berhasil memperkuat sistem pencegahan dan pengendalian TB di lingkungan pesantren, dan diharapkan dapat menjadi model bagi institusi serupa di wilayah lain untuk mendukung kesehatan santri dan mencegah penularan TB secara berkelanjutan.
GAMBARAN KLINIS OTOMIKOSIS DI RS MARGONO SOEKARJO Kinanthi, Rusy; Kusdaryanto, Wahyu Dwi; Darmawan, Anton Budhi; Krisniawati, Nia; Nur Hestiyanti, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.11498

Abstract

Otomycosis is a disease of the outer ear canal caused by fungal microorganisms. Signs found in patients with otomycosis may also vary, such as edema, redness of the outer ear canal, tragus pain, discharge, or fungal mass through the clinical examination. This study aimed to determine the clinical features of patients diagnosed with otomycosis at Margono Soekarjo Hospital. This research was a descriptive study with a cross-sectional approach using primary data from July-November 2022 at the ENT clinic, Margono Soekarjo Hospital. An ENT specialist took data through the stages of anamnesis and physical examination. After otomycosis is clinically diagnosed, further documentation is carried out on the patient’s examination sheet regarding the characteristics of the subject and the clinical features in the form of symptoms and signs experienced by the subject. The data analysis performed was a univariate analysis to demonstrate the frequency distribution of clinical features in the study subjects. The total samples obtained are 46 samples from 42 subjects diagnosed with otomycosis with an age range of 17-73 years, and the susceptible age to undergo otomycosis is 26-35 years. The most common symptom is itching (80,43%). Other commonly found symptoms are hearing loss (78,26%) and a sensation of blockage in the ears (73,91%). At the same time, the sign commonly found in the physical examination is a fungal mass (100%). The most typical form of fungal group is white mass. In addition, signs are frequently found in discharge (64,04%) and perforation (60,87%). Otomycosis is a common disease in young adults. Symptoms and signs of otomycosis vary, but the common symptoms are itching, hearing loss, and the sensation of blockage in the ears. At the same time, the common signs are fungal mass in the ear, discharge, and perforation of the ear.
TINGKAT POSITIVITAS PEMERIKSAAN KALIUM HIDROKSIDA PADA PASIEN OTOMIKOSIS Widhi, Anriani Puspita Karunia Ning; Krisniawati, Nia; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah
Mandala Of Health Vol 17 No 2 (2024): Mandala of Health: a Scientific Journal
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2024.17.2.12096

Abstract

Otomycosis is an opportunistic fungal infection of the external ear canal and is widespread worldwide. The clinical manifestations of otomycosis are non-specific symptoms such as earache, discharge, itching, hearing loss, feeling of fullness in the ear, and tinnitus. The most common etiology found is Aspergillus sp. and Candida sp. The purpose of this study was to assess the positivity level of KOH examination in patients with a clinical diagnosis of otomycosis. The method used in this research uses a descriptive quantitative approach. The research subjects were otomycosis patients at the ENT-KL clinic at Margono Soekarjo Hospital from April to August 2022. Samples were taken using Flexible minitip flocked sterile swabs (Copan, Italy) on white to black ear secretions. Swabs were isolated on Saboraud Dextrose Agar (SDA) mushroom culture media (Himedia, India) and for KOH examination. The results obtained in this study were 48(85.7%) positive KOH, positive culture and 8(14.3%) negative KOH, positive culture. In a sample of 56 patients with a clinical diagnosis of otomycosis the most common isolates were Aspergillus sp 32 (57.1%) and Candida sp (42.9%). KOH sensitivity and specificity test results for Aspergillus sp were 37.7% and 100%, while for Candida sp were 97.7% and 50%. The conclusion of this study is that the KOH examination has a positivity rate of 85.7%. This examination needs to be routinely carried out as an initial screening to support the clinical diagnosis of otomycosis.
Association Between Prematurity and Neonatal Sepsis: A Case–Control Study at a Tertiary Referral Hospital in Indonesia Hapsari, Ariadne Tiara; Krisniawati, Nia; Syiraz, Thauriq Azfa; Pratidina, Rr. Wening Gelar
Medical and Health Journal Vol 5 No 1 (2025): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2025.5.1.17292

Abstract

Background: Neonatal sepsis remains a leading cause of morbidity and mortality in newborns, particularly among preterm infants whose immature organ systems and immune defenses increase their vulnerability to infection. Evidence on the association between prematurity and neonatal sepsis remains variable across settings, highlighting the need for context-specific research. Objective: To examine the association between prematurity and the occurrence of neonatal sepsis at a tertiary referral hospital in Indonesia. Methods: A hospital-based analytic observational study with an unmatched case–control design was conducted at Margono Soekarjo Regional Hospital, Central Java, Indonesia, from June to November 2024. Medical records of neonates admitted in 2023 were reviewed. Cases were neonates diagnosed with sepsis, while controls had no sepsis diagnosis. A total of 136 neonates were selected using simple random sampling, with 68 cases and 68 controls. Data were analyzed using Chi-square tests and odds ratios (OR) with 95% confidence intervals (CI). Results: Preterm birth was more frequent among cases (64.7%) compared to controls (32.4%). The majority of sepsis cases were moderate-to-late preterm (41.2%) and predominantly late-onset (86.8%). Bivariable analysis demonstrated a significant association between prematurity and neonatal sepsis (χ² = 14.248, p < 0.001), with an OR of 3.833 (95% CI: 1.883–7.805), indicating that preterm neonates had nearly four times higher risk of developing sepsis than term neonates. Conclusion: Prematurity is a significant risk factor for neonatal sepsis, particularly late-onset cases, in this tertiary care setting. These findings highlight the urgent need for targeted infection prevention strategies and enhanced clinical monitoring for preterm infants in neonatal intensive care units.
Co-Authors Afifah Nur Hestiyani, Rani Ariadne Tiara Hapsari Ayunisih, Lintang Sekar Darmawan, Anton Budhi Darmayan, Bella Jovita Dhadhang Wahyu Kurniawan Eman Sutrisna Fanani, Navalia Azkarifda Handayani, Mira Syafira Hidayah, Arfi Nurul Indah Rahmawati Karunia Ning Widhi, Anriani Puspita Kinanthi, Rusy Kusdaryanto, Wahyu Dwi Lantip Rujito Madya Ardi Wicaksono, Madya Ardi Nur Hestiyanti, Rani Afifah Nuranisa, Aulia Pratidina, Rr. Wening Gelar Puspita Karunia Ning Widhi, Anriani Rani Afifah Nur Histiyani Reki, Winarto Setiawati Setiawati Syiraz, Thauriq Azfa V. Rizke Ciptaningtyas Widhi, Anriani Puspita Karunia Ning Wijaya, Helmi Aditya