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All Journal Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Mitra Masyarakat (JMM) Medical and Health Journal Jurnal Forensik dan Medikolegal Indonesia Linggamas: Jurnal Pengabdian Masyarakat
Rani Afifah Nur Histiyani
Universitas Jenderal Soedirman, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) of Ethanol Extract of God's Crown (Phaleria macrocarpa) Leaves, Peel, and Fruit Flesh Hestiyani, Rani Afifah Nur; Handini, Tri Okmawati
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.2

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that becomes the main concern since it is a multidrug-resistant organism and causes high morbidity and mortality. This study aimed to investigate the antibacterial activity of ethanolic extract of Phaleria macrocarpa leaves, peel, and fruit flesh on MRSA. This study was an experimental laboratory study with a post-test only control group design to assess the antibacterial activity of ethanolic extract from leaves, peel, and fruit flesh of Phaleria macrocarpa against MRSA ATCC 43300 and MRSA clinical isolates using a disk diffusion method. Extracts from the leaves, peel, and flesh of Phaleria macrocarpa had potential as an antibacterial agent against MRSA ATCC 43300 at a concentration of 40%, although not yet equivalent to antibiotic control. The ethanol extract of Phaleria macrocarpa peel at a concentration of 30-40% had potential as an antibacterial agent against MRSA clinical isolates, although not yet equivalent to antibiotic control. Further research needs to be performed so that Phaleria macrocarpa extract can be a potential source of subsequent antibacterial development against MRSA.
Antibiotic resistance of biofilm-producing bacteria from sepsis patients in Prof. Dr. Margono Soekarjo Hospital, Purwokerto, Central Java Rani Afifah Nur Hestiyani; Wahyu Siswandari; Vitasari Indriani; I Dewa Sang Ayu Putu Peramiarti; Dwi Utami Anjarwati; Hermin Prihartini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 2 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005402202207

Abstract

Sepsis is a life-threatening organ dysfunction induced by the body's response to infection and is a significant cause of critical illness and death in hospitals. Bacteria are the most common pathogens that cause sepsis, and their ability to form biofilms increases their resistance to antibiotics. As a result of the failure of antibiotic administration therapy, the severity and pain of sepsis worsen. The study used a descriptive research design to determine the antibiotic resistance pattern of biofilm-producing bacteria from clinical isolates of sepsis patients. Using the BacT/Blood Culture System Alert, all patients suspected of sepsis in the intensive care unit of Prof. Dr. Margono Soekarjo General Hospital Purwokerto were examined for blood cultures between March and July 2018. These were then identified and tested for antibiotic resistance with the Vitek 2 Compact. Biofilm formation was detected utilizing the microtiter plate assay method, and the data were analyzed using a frequency distribution table. The results obtained 12 bacterial isolates, with Escherichia coli (41.67%), Staphylococcus haemolyticus (33.33%), Klebsiella pneumoniae ssp pneumoniae, Enterobacter cloacae complex, and Acinetobacter baumannii complex (8.33%) as the most common bacteria. All gram-negative bacteria (more than 80%) were resistant to ampicillin, cefoxitin, ceftazidime, ceftriaxone, aztreonam, and trimethoprim but were sensitive to meropenem (100%). Gram-positive bacteria were resistant to cefoxitin, benzylpenicillin, oxacillin, ciprofloxacin, erythromycin, and clindamycin (100% each). However, they were sensitive to tigecycline, nitrofuran, quinupristin, linezolid, vancomycin, and tetracycline (100% each). Gram-negative bacteria formed 50% biofilms, and 50% did not, whereas gram-positive bacteria produced 100% biofilms. In conclusion, bacteria clinical isolates of septic patients from Prof. Dr. Margono Soekarjo General Hospital Purwokerto are multiresistant to more than six types of antibiotics and produce weak to moderate biofilms, which can promote antibiotic resistance.
UPAYA PENINGKATAN PENGETAHUAN DAN KETERAMPILAN WALI SISWA TAMAN KANAK-KANAK (TK) DI BANYUMAS DALAM PENANGANAN PENYAKIT INFEKSI SALURAN PERNAPASAN AKUT (ISPA) : UPAYA PENINGKATAN PENGETAHUAN DAN KETERAMPILAN WALI SISWA TAMAN KANAK-KANAK (TK) DI BANYUMAS DALAM PENANGANAN PENYAKIT INFEKSI SALURAN PERNAPASAN AKUT (ISPA) Rani Afifah Nur Histiyani; Tri Okmawati Handini; afifah
Jurnal Mitra Masyarakat Vol. 3 No. 1 (2022): Jurnal Mitra Masyarakat
Publisher : STIKes Mitra Keluarga

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Abstract

Acute respiratory tract infection (ARI) is one of the infectious disease that is the main cause of morbidity and mortality in the world. ARI is the main cause of infant and under-five mortality. Parents knowledge and skills play an important role in handling ARI in toddlers. The purpose of this community service is to increase the knowledge and skills of parents about acute respiratory infections (ARI) in children and how to handle them. Community service is carried out in August-September 2020 with the target of guardians of the Aisyiyah Bustanul Atfal Kindegarten students in Banyumas. The methods used is interactive lectures and discussions to increase knowledge, while to improve skills by simulating cases in small groups. The knowledge of Kindegarten parents in dealing with ARI has increased, as evidenced by the increased in the questionnaire scores, from 77.5 to 90.8. Guardian skills improve after case simulation
PERCEPTIONS OF SOCIAL SUPPORT WITH STRESS LEVELS OF HOSPITAL INPATIENT PATIENTS Rafika Zamri; Wahyudin Wahyudin; Arfi Nurul Hidayah; Diyah Woro Dwi Lestari; Rani Afifah Nur Hestiyani
Medical and Health Journal Vol 2 No 2 (2023): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.099 KB) | DOI: 10.20884/1.mhj.2023.2.2.8247

Abstract

Latar Belakang: Hospitalisasi mengharuskan pasien melakukan perawatan di Rumah Sakit. Hal tersebut dapat menjadi stressor bagi beberapa pasien. Interaksi dengan tenaga kesehatan dan keluarga dapat mengurangi stres pada pasien. Selain itu, dukungan sosial dari teman juga dapat meningkatkan status kesehatan. Penelitian ini bertujuan untuk mengetahui hubungan antara persepsi dukungan sosial dengan tingkat stres pasien rawat inap di Rumah Sakit. Metode: Penelitian ini menggunakan metode observasional deskriptif analitik dengan pendekatan cross-sectional. Pengambilan sampel menggunakan teknik purposive sampling yaitu sebanyak 30 orang pasien rawat inap ruang perawatan interna Rumah Sakit Margono Soekarjo Purwokerto. Hasil: Pada penelitian ini 86,7% pasien memiliki tingkat stres normal. Persepsi dukungan sosial yang tinggi banyak diberikan oleh keluarga. Nilai signifikasi pada uji korelasi antara tingkat stres pasien rawat inap dengan persepsi dukungan keluarga 0,703, teman 0,815 dan significant others 0,249 (p<0,005). Hal ini berarti tidak ada hubungan yang signifikan antarvariabel. Kesimpulan: Tidak terdapat hubungan antara persepsi dukungan keluarga, teman dan significant others dengan tingkat stres pasien rawat inap rumah sakit.
Examining the Relationship between Infection Control Practices and ESBL Bacterial Carriage in Healthcare Workers Ayunisih, Lintang Sekar; Krisniawati, Nia; Wicaksono, Madya Ardi; Hestiyani, Rani Afifah Nur; Widhi, Anriani Puspita Karunia Ning
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.9

Abstract

The Enterobacteriaceae family widely produces Extended Spectrum Beta-Lactamase (ESBL), and infection by ESBL-producing bacteria can significantly increase morbidity, complicate therapeutic difficulties, escalating healthcare costs, and increase mortality rates. Transmission of these bacteria within the hospital environment may lead to the prevalence of ESBL-producing bacterial carriers among healthcare workers. Health workers' infection prevention and control (IPC) behavior plays a role in transmitting these pathogenic bacteria. This study aimed to determine the relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital. This research used an observational analytic approach with a cross-sectional method. The sampling technique involved purposive sampling, resulting in a total sample of 61 people. Data were obtained by completing an IPC behavior questionnaire and collecting rectal swab samples cultured on CHROM ESBL Agar media. Statistical analysis was done using the Mann-Whitney test. The research identified a prevalence of 13.1% (8/61) ESBL-producing bacterial carriers among health workers at Banjarnegara Islamic Hospital. However, based on statistical analysis, the p-value was 0.664, leading to the rejection of the hypothesis (accepted if p-value <0.05). In conclusion, there is no significant relationship between IPC behavior and the incidence of ESBL-producing bacterial carriers in health workers at Banjarnegara Islamic Hospital.
PREVALENSI Candida albicans PADA PASIEN OTOMIKOSIS DI RSUD MARGONO SOEKARJO Wijaya, Helmi Aditya; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah; Krisniawati, Nia; Rujito, Lantip
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8643

Abstract

Background: Otomycosis is an infection of the ear caused by various fungi. One of the most common fungi that cause Otomycosis is Candida albicans. Otomycosis is a challenge for the medical world and patients because it requires long-term treatment and has a high recurrence rate. It causes the importance of an overview of the prevalence in a place as planning health services, description of cases, and eradication programs. Banyumas Regency has a climate that supports the growth of mushrooms. One of the major hospitals in Banyumas is RSUD Margono Soekarjo. Objective: Knew the prevalence of Candida albicans on Otomycosis at Margono Soekarjo Hospital. Method: This research is a descriptive observational study on the target population of patients at the ENT clinic at RSUD Margono Soekarjo—sampling technique using a total sampling of as many as 42 subjects with 46 samples. Data analysis techniques use univariate analysis to describe the characteristics of each variable. Results: The results of otomycosis sufferers at Margono Soekarjo Hospital were male compared to female by 50:50, namely 21 of 42 subjects (50.00%), respectively. The age group that suffered the most from Otomycosis was the 26-35 age group, with 12 out of 42 subjects (28.57%). The prevalence of Candida albicans in Otomycosis of 2.17% or 1 of 46 patient samples with a clinical diagnosis of Otomycosis at Margono Soekarjo Hospital was caused by a fungus Candida albicans. Conclusion: Prevalence Candida albicans as a cause of Otomycosis in patients at the ENT polyclinic at Margono Soekarjo Hospital in the Januari-February 2023 period of 2.17%, namely 1 out of 46 samples, with 26 years of age included in the 26-35 years age group and female.
The DESCRIPTION OF DIATOMES EXAMINATION IN HEPARIAL ORGANS IN DROWNING CASE IN THE PELUS RIVER SOKARAJA BANYUMAS USING THE WHITE RATS (Rattus novergicus) Imaniah, Ira; Hestiyani, Rani Afifah Nur; Hidayat, Muhammad Zaenuri Syamsu; Peramiarti, IDSAP
Jurnal Forensik dan Medikolegal Indonesia Vol 4 No 1 (2023): Jurnal Forensik dan Medikolegal Indonesia
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jfmi.2023.4.1.7438

Abstract

Diatoms can be used to identificate and diagnose drowning cases because it can enter the body during inhaling in the water. Previous studies have shown that diatoms can be found in the liver of drowning cases, but this cannot be used as evidence of drowning cases. This study aimsto determine diatoms in the liver organs of white rats that drowned in Pelus River. This studyuses an experimental method, with 15 white rats (Rattus norvegicus) which were submerged in water from the Pelus River. Identification of diatoms in the liver was carried out using the acid destruction method. The results of the research are 9 genus of diatoms that can be identified; Amphora, Eunotia, Amphorotia, Simonsenia, Epithemia, Synedra, Ulnaria, Fragilaria, Asterionella. Meanwhile, there were only 5 genus of diatoms identified in the river water samples; Amphora, Eunotia, Craticula, Diadesmis, and Fragilaria. From this research it can be concluded that there are 9 genus of diatoms that can be identified in the livers of white rats that drowned in the fresh waters of the Pelus River
STUDI DIATOM DI DI PARU DAN LAMBUNG TIKUS PUTIH (Rattus norvegicus) PADA BERBAGAI KEADAAN TENGGELAM DI PERAIRAN TAWAR Hestiyani, Rani Afifah Nur
Jurnal Forensik dan Medikolegal Indonesia Vol 5 No 2 (2024): Jurnal Forensik dan Medikolegal Indonesia
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jfmi.2024.5.2.12476

Abstract

Kasus tenggelam menempati urutan ketiga sebagai penyebab kematian karena cedera yang tidak sengaja di seluruh dunia, dengan Indonesia memiliki kejadian tiga kali lipat lebih banyak dibandingkan dengan negara-negara berpendapatan tinggi. Pemeriksaan diatom pada organ tubuh korban tenggelam merupakan metode penting dalam identifikasi lokasi dan penyebab kematian, dalam kondisi tenggelam yang berbeda. Tujuan penelitian ini untuk mengetahui gambaran diatom pada organ paru dan lambung tikus putih Rattus norvegicus dalam berbagai keadaan tenggelam di perairan tawar Sungai Pelus, Banyumas. Metode penelitian dengan eksperimental menggunakan 20 ekor tikus putih (Rattus norvegicus) yang ditenggelamkan ke dalam Sungai Pelus dalam berbagai keadaan tenggelam yaitu hidup (H), pingsan (P), dan mati (M). Sebelum ditenggelamkan kelompok tikus P diinjeksi ketamin 0,2 cc pada setiap tikus, hingga pingsan dan kelompok tikus M diberi perlakuan inhalasi kloroform hingga mati. Organ paru dan lambung diambil dari 3 kelompok tikus tersebut untuk diamati jumlah dan jenis diatom yang ditemukan. Sampel air sungai diambil untuk membandingkan jumlah dan jenis diatom di lokasi tenggelam dan organ tikus perlakuan. Hasil pemeriksaan diatom didapatkan 12 genus diatom yang teridentifikasi. Gambaran diatom yang ditemukan pada organ paru dan lambung dalam berbagai keadaan tenggelam lebih banyak ditemukan pada organ paru tikus hidup (H) dibandingkan kelompok tikus pingsan (P), bahkan mati (M). Jumlah diatom pada organ paru lebih banyak ditemukan (70%) dibandingkan jumlah diatom di organ lambung (30%). Kesimpulan penelitian ini, yaitu gambaran diatom lebih banyak ditemukan pada organ paru Rattus norvegicus yang mati akibat tenggelam dalam kondisi hidup dibandingkan pingsan bahkan mati.
Pelatihan Pengukuran Antropometri pada Balita sebagai Skrining Awal Stunting Anriani Puspita Karunia Ning Widhi; Nenden Nursyamsi Agustina; Nia Krisniawati; Rani Afifah Nur Hestiyani; Sulastri Sulastri
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 1 (2023): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2023.1.1.9363

Abstract

Fase penting tumbuh kembang anak terjadi pada lima tahun pertama, atau saat anak mencapai usia batita dan balita. Pada usia ini anak membutuhkan nutrisi yang cukup untuk mendukung pertumbuhan dan perkembangannya. Jika gizi tidak tercukupi maka akan sangat rentan terhadap gangguan kesehatan berupa malnutrisi. Pengukuran antropometri berperan penting dalam menentukan status gizi anak. Kesalaham yang terjadi pada pengukuran akan menyebabkan perbedaan interpretasi data. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan keterampilan kader Posyandu dalam melakukan pengukuran antropometri serta menginterpretasi hasil pengukuran. Metode kegiatan ini dilaksanakan melalui pelatihan, diskusi dan berbagi pengalaman seputar kegiatan posyandu yang telah dilaksakan oleh para kader. Khalayak sasaran kegiatan ini yaitu kader Posyandu Mugi Lestari 13 Desa Kedung Bunder Kecamatan Kalibagor Banyumas. Metode evaluasi untuk mengetahui dampak positif kegiatan ini yaitu dengan melakukan monitoring kegiatan Posyandu terkait keterampilan kader dalam melakukan pengukuran antropometri pada balita.
Pelatihan Manajemen ASI Perah dan Pembuatan MP-ASI Sebagai Pemenuhan Gizi di 1000 Hari Pertama Kehidupan Anak Anriani Puspita Karunia Ning Widhi; Nia Krisniawati; Rani Afifah Nur Hestiyani; Nenden Nursyamsi Agustina; Lily Kusumasita Burkon; Sulastri Sulastri
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 2 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.1.2.10180

Abstract

Gerakan 1000 Hari Pertama Kehidupan (HPK) merupakan inisiatif pemerintah untuk meningkatkan gizi anak-anak pada periode emas ini. ASI eksklusif dan pemberian MP-ASI yang tepat berperan penting dalam memenuhi kebutuhan gizi bayi selama 1000 HPK. Namun, kurangnya pengetahuan ibu tentang manajemen ASI perah dan MP-ASI serta faktor eksternal memengaruhi keberhasilan pelaksanaan. Data RISKESDAS menunjukkan rendahnya cakupan ASI eksklusif di Indonesia. Pelatihan di Posyandu Mugi Lestari berhasil meningkatkan pengetahuan dan keterampilan ibu tentang manajemen ASI perah dan pembuatan MP-ASI. Hal ini dapat meningkatkan asupan gizi bayi selama 1000 HPK, mencegah stunting, dan mendukung pertumbuhan anak. Inisiatif semacam ini perlu dilakukan secara rutin untuk edukasi ibu dan pencegahan stunting di periode emas 1000 HPK anak.
Co-Authors Afifah Afifah Anriani Puspita Karunia Ning Widhi Arfi Nurul Hidayah Ayunisih, Lintang Sekar Darmawan, Anton Budhi Diyah Woro Dwi Lestari Dwi Utami Anjarwati Handini, Tri Okmawati Hermin Prihartini Hidayat, Muhammad Zaenuri Syamsu I Dewa Sang Ayu Putu Peramiarti Imaniah, Ira Krisniawati, Nia Lantip Rujito Lily Kusumasita Burkon Madya Ardi Wicaksono, Madya Ardi Nenden Nursyamsi Agustina Nia Krisniawati Peramiarti, IDSAP Rafika Zamri Sulastri Sulastri Sulastri Sulastri Tri Okmawati Handini Vitasari Indriani Wahyu Siswandari Wahyudin Wahyudin Widhi, Anriani Puspita Karunia Ning Wijaya, Helmi Aditya