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All Journal Science and Technology Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Andalasian International Journal of Social and Entrepreneurial Development
Jessica, Adhitya
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health Social Sciences Other

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Improvement of Solubility Usnic Acid Loaded on Mesoporous Silica SBA-15 and Physicochemical Characterization Fitriani, Lili; Azzahra, Cindy Maynia; Jessica, Adhitya; Hasanah, Uswatul; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.251-259

Abstract

Usnic acid, a secondary metabolite of lichen Usnea sp., has several pharmacological activities, but it is poorly soluble in water. This study aimed to improve the solubility and dissolution rate of usnic acid loaded in mesoporous silica SBA-15 at a mass ratio of 1:1. and evaluate its physical stability. Physicochemical characterization was carried out via the nitrogen adsorption desorption isotherm, differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, and powder X-ray diffraction (PXRD). Usnic acid-loaded SBA-15 was stored at 40 °C with various relative humidities (RH) and then analyzed by PXRD for the physical stability. Usnic acid adsorbed well in the pores of SBA-15, as shown by a decrease in the volume pore and surface area of SBA-15 according to the nitrogen adsorption. Moreover, usnic acid-SBA-15 showed a decrease in the degree of crystallinity according to PXRD analysis and no melting point based on DSC analysis. The FTIR spectrum of usnic acid–SBA-15 corresponds to the spectra of each raw material. The solubility of usnic acid increased 5.15 times after adsorbed on SBA-15. The dissolution rate also showed a significant increase (p < 0.05) from 19.51% to 84.27%. Usnic acid–SBA-15 was relatively stable at RH 75%. Thus, the adsorption of usnic acid on SBA-15 can increase its solubility, dissolution rate, and physical stability.
Ketoprofen-Tromethamine: Binary Phase Diagram of Multicomponent Crystal, Dissolution Rate, and Analgesic Activity Evaluation Hasanah, Uswatul; Badriyya, Elsa; Safitri, Reza; Yuliza, Sukma; Ihsan, Ikhwanul; Saafrida; Rosaini, Henni; Jessica, Adhitya; Zaini, Erizal
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.726-734

Abstract

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) whose formulation options are limited due to its low dissolution rate in aqueous media. This research aimed to enhance the solubility of ketoprofen in distilled water and to compare the anti-inflammatory and analgesic effects of its resulting multicomponent crystal with tromethamine. The binary phase diagram of ketoprofen-tromethamine was created across molar ratios ranging from 1:9 to 9:1. The multicomponent crystal comprising ketoprofen and tromethamine in the selected ratio was synthesized using a solvent drop grinding method and subjected to further characterization for thermal properties, crystallinity, chemical groups, and morphology. The dissolution rate assessments were evaluated in CO2-free distilled water. Pharmacological analyses examined the anti-inflammatory and analgesic effects of the multicomponent crystal. The binary phase analysis identified the 5:5 (1:1) molar ratio as optimal in forming a multicomponent crystal. Thermograms and diffractograms revealed crystalline alterations attributed to a new crystalline phase. The new multicomponent crystal exhibited approximately 2.7 times higher dissolution rate after 30 minutes, outperforming pure ketoprofen. Pharmacological assessments demonstrated superior analgesic effects of the multicomponent crystal. In summary, the ketoprofen-tromethamine cocrystal in 1:1 molar ratio offers enhanced dissolution rate and provides better analgesic activity than ketoprofen alone.
Pembentukan dan Karakterisasi Multikomponen Kristal Aseklofenak – Asam Suksinat Dengan Metode Solvent Drop Grinding. Jessica, Adhitya; Agustina, Annisa; Fitriani, Lili; Zaini, Erizal
JSFK (Jurnal Sains Farmasi & Klinis) Vol 9 (2022): J Sains Farm Klin 9(suplemen), Desember 2022
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.9.sup.138-145.2022

Abstract

Aseklofenak merupakan obat golongan antiinflamasi nonsteroid (OAINS) yang mempunyai efek farmakologi utama sebagai antiinflamasi dan analgesik, turunan asam fenil asetat. Namun, aseklofenak memiliki kelarutan yang rendah sehingga mempengaruhi bioavaibilitasnya. Penelitian ini bertujuan untuk memperbaiki laju disolusi aseklofenak melalui pembentukan multikomponen kristal dengan metode pembuatan solvent drop grinding dan asam suksinat sebagai koformer. Multikomponen kristal yang terbentuk dikarakterisasi menggunakan instrumen Powder X-ray Diffractor (PXRD), Differential Scanning Calorimeter (DSC), Fourier Transform Infrared (FT-IR) spectrometer, dan Scanning Electron Microscope (SEM). Aseklofenak yang terlarut dan terdisolusi ditentukan dengan spektrofotometer UV-Vis. Hasil karakterisasi dari multikomponen kristal: penurunan intensitas puncak pada difraktogram, penurunan titik lebur dan nilai entalpi peleburan pada  termogram, pergeseran yang tidak signifikan pada bilangan gelombang spektrum spektroskopi FT-IR, dan habit kristal baru pada hasil SEM. Hasil uji disolusi aseklofenak murni, campuran fisik dan multikomponen kristal aseklofenak-asam suksinat dalam medium dapar fosfat pH 6,8 dengan sodium lauril sulfat 0,1 % pada menit ke-60 secara berturut-turut adalah 8,43 %, 26,60 % dan 34,14 %. Dari hasil penelitian ini dapat disimpulkan bahwa multikomponen kristal aseklofenak - asam suksinat yang terbentuk merupakan tipe campuran eutektik dan dapat meningkatkan laju disolusi aseklofenak 4,09 kali dibandingkan aseklofenak murni.
Pembentukan dan Karakterisasi Dispersi Padat Kandesartan Sileksetil-HPMC dengan Teknik Solvent Co-Evaporation Jessica, Adhitya; Sari, Elvita; Yenti, Revi; Zaini, Erizal
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.71-77.2023

Abstract

Candesartan cilexetil (CC) merupakan agen antihipertensi yang sangat efektif tetapi memiliki kelarutan yang buruk sehingga bioavailabilitasnya terbatas. Penelitian ini bertujuan untuk meningkatkan CC terdisolusi melalui pembuatan dispersi padat dengan hidroxypropylmethylcellulose (HPMC). Dispersi padat CC-HPMC dibuat menjadi 3 formula, yaitu 2:1, 1:1 dan 1:2 (b/b) menggunakan metode solvent co-evaporation. CC tunggal, campuran fisik dan dispersi padat yang terbentuk kemudian dikarakterisasi secara fisikokimia dan pengaruh variasi konsentrasi HPMC diselidiki terhadap laju disolusi. Hasil PXRD menunjukkan penurunan intensitas puncak pada dispersi padat. Analisis termal dengan DSC memperlihatkan titik leleh yang lebih rendah pada dispersi padat. Morfologi dispersi padat menggambarkan bentuk yang berbeda dibandingkan dengan CC tunggal dan campuran fisik. Spektrum inframerah menunjukkan sedikit pergeseran pada bilangan gelombang gugus fungsi tetapi tidak terbentuk gugus fungsi baru. Disolusi dispersi padat meningkat secara signifikan, hasil uji disolusi setelah 60 menit masing-masing untuk CC tunggal, campuran fisik, dispersi padat F1, F2, dan F3 adalah 32,46 ± 0,26; 67,76 ± 0,07; 61,22 ± 0,20; 71,74 ± 0,20; dan 78,58 ± 020 (μg/ml). Kesimpulannya, sistem dispersi padat CC-HPMC mampu memodifikasi sifat fisikokimia dan meningkatkan disolusi hingga 2,42 kali CC tunggal. Selain itu, peningkatan konsentrasi HPMC berdampak positif pada peningkatan CC yang terdisolusi.
Technical Assistance in Determining the Heat Adequacy Number (F0) in the Sterilization Process of Packaged Rendang for Rendang Business Actors IKABOGA in Padang City Syukri, Daimon; Bahar, Rini; Jessica, Adhitya; Novelina, Novelina; Dini Hari, Purnama; Meuthia Fiana, Risa; Anggraini, Tuty; Mislaini, Mislaini; Amaliyah Tarumiyo, Aurelia; Azzahra, Yasmin; Aidila Fitria, Eddwina
Andalasian International Journal of Social and Entrepreneurial Development Vol. 4 No. 02 (2024): Andalasian International Journal of Social and Entrepreneurial Development
Publisher : Institute of Research And Community Service, Andalas University / LPPM Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aijsed.4.02.14-19.2024

Abstract

This community service activity aims to assist rendang business actors who are members of IKABOGA in Padang City in determining the heat adequacy number (F0) in the sterilization process of packaged rendang. Determining the correct F0 number is very important to ensure food safety, extend product shelf life, and maintain rendang quality. Assistance methods include theoretical training, F0 calculation simulations, sterilization practices, and preparation of Standard Operating Procedures (SOPs). The results of the activity showed an increase in business actors' understanding of the F0 concept, as well as the implementation of a more measurable and safe sterilization process. Laboratory tests showed that rendang products sterilized with the appropriate F0 value were proven to be free from pathogenic microorganisms, while the quality of taste, texture, and aroma were maintained. This activity is expected to help business actors improve product quality and competitiveness, and comply with applicable food safety standards.
Co-Authors Agustina, Annisa Aidila Fitria, Eddwina Amaliyah Tarumiyo, Aurelia Azzahra, Cindy Maynia Azzahra, Yasmin Bahar, Rini Daimon Syukri Dini Hari, Purnama Elsa Badriyya Erizal Zaini Ihsan, Ikhwanul Lili Fitriani Meuthia Fiana, Risa Mislaini Mislaini Novelina Reza Safitri Rosaini, Henni Saafrida Sari, Elvita Tuty Anggraini Uswatul Hasanah, Uswatul Yuliza, Sukma