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Putra, Dominikus Evano
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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POLA PEMBERIAN ANTIBIOTIK DI ERA PANDEMI COVID-19 (STUDI KASUS DI RUMAH SAKIT NASIONAL DIPONEGORO) Putra, Dominikus Evano; Pramudo, Setyo Gundi; Arkhaesi, Nahwa; Retnoningrum, Dwi
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (283.94 KB) | DOI: 10.36408/mhjcm.v8i2.578

Abstract

Background: Inappropriate use of antibiotics could increase the incidence of antibiotic resistance, hence increasing morbidity, mortality, and health cost. WHO has recommended to conduct a study of rational use of antibiotics in order to overcome this problem. Aim: To analyze the quality and quantity of antibiotic use in inpatient care facility at Diponegoro National Hospital (RSND). Methods: Quality and quantity assessment conducted by the use of DDD/100 patient–days and the Gyssens criteria. The study was conducted retrospectively at 86 patients’ medical records that were obtained by consecutive sampling method. Results: There were 141 antibiotics prescriptions from 86 medical records. Azithromycin, levofloxacin, and ceftriaxone were the most commonly used and had 48,12; 44,01; and 21,13 DDD/100 patient–days. By Gyssens crieteria, 35,4% of antibiotic usage was appropriate, 51,1% of antibiotic usage was inappropriate, and 13,5% no indication of the use of antibiotic. Based on the type of therapy, ADE 89,4% and ADET 10,6%. Conclusion: In terms of quantity, the most commonly used antibiotic was azithromycin. In terms of quality, 35,4% antibiotic were used appropriately according to Gyssens criteria. Keywords: Antibiotic usage; internal medicine; DDD/100 patient–days; Gyssens criteria
Effects of α-Mangostin-Loaded Self-Nanoemulsion (MG-SNE) and Physical Exercise on The Reduction of Waist Circumference in Wistar Rats Setiawan, Andreas Arie; Sugiri, Sugiri; Prasetyo, Awal; Kurniawan, Eirin Yovita; Putra, Dominikus Evano
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 3 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i3.1103

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BACKGROUND : Waist circumference (WC) is a marker of intra-abdominal adipose tissue and a risk factor for cardiometabolic disease. A higher risk of coronary heart disease was associated with an increased WC. Garcinia mangostana Linn's anti-inflammatory activity would reduce abdominal fat deposition and WC. Additionally, Garcinia mangostana Linn's potential would increase in nanotechnology. AIMS :  To demonstrate that WC in Wistar rats induced by an atherogenic diet can be decreased by α-Mangostin-loaded self-nanoemulsion (MG-SNE) treatment combined with physical activity. METHOD : Experimental research with Randomized Control Trial design using a total sample of 15 male white rats (Rattus novergicus strain Wistar) weighing 300 grams and aged between 6 and 8 weeks, split into 3 groups given physical exercise for 8 weeks along with 3 different doses of medication (group K received Atorvastatin 1.44 mg once; group P1 received Garcinia mangostana Linn pericarp extract, at a dose of 800 mg/kg, divided into 3 administrations; and group P2 received MG-SNE 50 mg/kg once). Waist circumference was measured using a metline, before and after treatment. RESULT :  WC decreased in Groups K, P1, and P2, with deltas of -5.00±21.21 mm, -12.50±24.75 mm, and -17.50±12.58 mm. The greatest decrease in WC was P2. There was no significant difference, according to the paired test between the pre-test and posttest in all groups. The p value >0.05 was determined to indicate that there were no significant differences between the groups. CONCLUSION : WC in Wistar rats induced by an atherogenic diet can be decreased by MG-SNE treatment combined with physical exercise.
Co-Authors Andreas Arie Setiawan, Andreas Arie Awal Prasetyo Kurniawan, Eirin Yovita Nahwa Arkhaesi Pramudo, Setyo Gundi Retnoningrum, Dwi Sugiri, Sugiri