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All Journal Indian Journal of Forensic Medicine & Toxicology MEDICINUS
Eka Devinta Novi Diana
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : MEDICINUS

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Tinjauan Histopatologi pada Pyoderma Gangrenosum dengan Infeksi Sekunder Wibisono Nugraha; Danu Yuliarto; Eka Devinta Novi Diana; Alfina Rahma; Prasetyadi Mawardi; Frieda; Ambar Mudigdo
MEDICINUS Vol. 36 No. 2 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i2.123

Abstract

Background: Pyoderma gangrenosum (PG) is a complex neutrophilic dermatosis, characterized by sterile, painful, necrotic ulcer, and is associated with systemic conditions. PG manifests as papules and vesicles that evolve into painful ulcers. Incidence of PG is relatively rare in Dr. Moewardi Hospital, so it is important to identify and correctly diagnose PG based on its’ histopathological features. Case A 54-year-old man complained of painful scab on several body parts. Hematoxylin and eosin staining in the epidermal layer showed a basket-weave orthokeratosis with necrotic tissue, acanthosis, and basal cell hypermelanosis. In the dermis layer there is a lymphocyte and neutrophil cell infiltrate with slight appearance of leukocytoclastic. Discussion: Pyoderma gangrenosum is a reactive, non-infectious inflammatory dermatosis (neutrophilic dermatoses). In this case, PG occurs in 54-year-old man as painful scab on back and legs. Classical PG characterized by papules, pustules, crusted or necrotic plaque, which typically have undermined, overhanging, dusky purple edges with surrounding induration and erythema. In this patient, the epidermal layer showed ulceration and slight appearance of leukocytoclastic vasculitis in the dermis area and lymphocyte infiltrate with slight neutrophil in the perivascular accompanied by erythrocyte extravasation, which support the diagnosis of PG.
Terapi Zink Oral pada Vitiligo Eka Devinta Novi Diana; Muhammad Eko Irawanto
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/g52hfk35

Abstract

Background: World Health Organization (WHO) estimates that 2 billion people in the world have zinc deficiency. Clinical manifestation of zinc deficiency includes immune system dysfunction, increase of oxidative stress, and release of proinflammatory cytokines. Oxidative stress is one of main factors that plays important role in various autoimmune diseases such as vitiligo. Discussion: Vitiligo is the most common depigmentation disease caused by melanocyte damages which characterized by depigmentation macule or patch on the skin or mucous membranes. Treatment of vitiligo is still considered a challenge, and various treatment modalities show varying results. Zinc is a micronutrient and antioxidant that posseses antiapoptotic activity by influencing melanogenesis and eliminating free radicals. Conclusion: Zinc inhibits oxidative stress and prevent melanocyte damage so it can bd considered as an adjuvant treatment for vitiligo.
Co-Authors Alfina Rahma Ambar Mudigdo Danu Yuliarto Frieda Indah Julianto Moerbono Mochtar Muhammad Eko Irawanto Prasetyadi Mawardi Suci Widhiati Wibisono Nugraha