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Clinical Profile of Scabies in Children in the Outpatient Installation of Dr. Moewardi General Hospital Surakarta, the Period of January 2015- December 2019 Eka Devinta Novi Diana; Alfina Rahma; Frieda; Indah Julianto; Moerbono Mochtar; Suci Widhiati
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16841

Background: Scabies is caused by parasite, called Sarcoptes scabiei, infestation into the skin. Scabies isgenerally found in children who live in crowded environments and poor hygiene.Methods: This is a retrospective descriptive study with secondary data collection from medical record datain the Outpatient Installation of RSDM for the period January 2015-December 2019. The subjects wereinfants to children aged 14 years with a diagnosis of scabies. Data variables used included age, gender,family history of scabies, diagnosis, comorbidities, supporting examinations and, therapy in scabies patients.Results: There were 88 pediatric patients with scabies. The most age group that experienced child scabieswas 11-14 years (33%) with the most sex being male (55%). The largest source of scabies transmission wasfrom the family (39%). The most common lesion morphology was papules and excoriations (49%). Thelesion location was found mostly between the fingers (24%). Examination of skin scrapings using NaCl0.9% was positive only in 5 patients (6%) with the most diagnosis was scabies (77%)Conclusion: This study shows that most of pediatric patients with scabies in the 11-14 years range aredominated by males. The most common sources of infection were families with papule morphology andexcoriation, whereas the most lesions were found between the fingers. Skin scrapings are only positive 6%of cases. The most commonly used topical therapies are 5% permethrin and 2% ointment mupirocin whilethe systemic therapies are cetirizine and cefadroxil.

The Relationship between Healthy Life Behavior (Knowledge, Attitude, and Practice) with the Occurrence of Scabies in Daarul Quran Islamic Boarding School Surakarta Astrid Astari Aulia; Nurrachmat Mulianto; Suci Widhiati
Nexus Kedokteran Komunitas Vol 6, No 1 (2017): Nexus Kedokteran Komunitas
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (154.608 KB)

Introduction: Healthy life behavior is knowledge, attitudes, and practice to maintain healthy condition and prevent disease, as well as an active role in public health movement. The high prevalence of scabies in boarding school in Indonesia is influenced by lack of knowledge about scabies. Data from Daarul Quran Islamic Boarding Schools health center during the period of February-August 2015 show that there were 40 students from total of 162 (24.6%) students who at least once been infected by scabies. Based on the explanation above, researchers interested in conducting a study to determine the relationship between healthy behavior which consist of knowledge, attitudes, and practices with the occurance of scabies in Daarul Quran Islamic Boarding School Surakarta. Methods: This study was an observational analytic with cross-sectional approach. A total of 155 students of Daarul Quran Islamic Boarding School Surakarta involved as research subjects. The dependent variable in this study was the occurance of scabies while the independent variables consist of knowledge, attitudes, personal hygiene and habits. Independent variables were measured using a questionnaire. The variables were analyzed by bivariate analysis using chi-square test. Result: There were 59 (38,1%) from 155 students of Daarul Qur'an Surakarta Islamic Boarding School infected by scabies. A number of 31 (52.5%) of the total 59 infected students aged 13 years. Most of the students exposed to scabies still in 7th grade (55.9%). Bivariate analysis showed that there was a significant relationship between knowledge (p = 0.021), attitude (p = 0.029), action (personal hygiene (p = 0.024) and habits (p = 0.024)) with occurence of scabies in Pondok Pesantren Daarul Qur 'an Surakarta. Conclusions: There is a relationship between healthy life behavior (knowledge, attitudes, and practices) and scabies occurrence in Daarul Qur'an Islamic Boarding School Surakarta, therefore more effective promotion and health education is needed to lower scabies incidence. Keywords: Scabies, Healthy Life Behavior, Knowledge, Attitude, Practices

MUKORMIKOSIS KUTAN PADA ANAK: TINJAUAN PUSTAKA Dina Febriani; Suci Widhiati
Media Dermato-Venereologica Indonesiana Vol 49 No 3 (2022): Media Dermato-Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v49i3.308

Mukormikosiskutanpadaanakadalahinfeksijamur Mucor sp. yangdapatmenyebabkanbeberapa komplikasi dan kematian dengan angka morbiditas dan mortalitas yang cukup tinggi.Tinjauan pustaka ini bertujuanuntukmengenaldanmemahamigambaranklinisbeberapakelainankulitakibatmukormikosis kutanpadaanak,melakukanpenegakandiagnosissertamemberikantatalaksanayangtepat.Pencarian literaturmenggunakanpedoman Preferred reporting items for systemic reviews and meta analyses (PRISMA)melaluibasisdata PubMed dan Science Direct padabulanApril2020.Sejumlah15artikel termasukdalamtinjauanpustakaini.Mukormikosiskutanpadaanakadalahsuatuinfeksijamur oportunistikyangdisebabkanolehjamurMucor sp.,penyakitinidapatmenjadiinfeksiprimeratau sebuahmanifestasiklinissebagaico-infection pada underlying disease lainnya. Ujud kelainankulit pada mukormikosis kutan memiliki kesamaan padainfeksi jamurlainnya, sehinggaperlu dilakukan pemeriksaan kultur danhistopatologi sebagaibaku emas untukmenegakkandiagnosis.Manifestasi klinis kelainankulitdapatsalingtumpangtindihdenganbeberapainfeksikulityangdisebabkanolehjamur, namunpadamukormikosiskutanmemilikigejalayangkhas.Padapasienanak-anak,perludilakukan pemeriksaansecaraintensifdanmenyeluruh,anamnesisgejalapenyakitdanriwayatpenyakityangdapat menjadi underlying disease yang dapat menyebabkan terjadinya mukormikosis kutan. Kata Kunci: manifestasi kulit, mukormikosis kutan.

Analisis In Silico pada VCO untuk Terapi Dermatitis Atopik Mardiana; Primadhanty B; Adniana N; Halim PK; Didik H. Utomo; Endra Yustin Ellistasari; Suci Widhiati
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Introduction: In silico analysis is used in the early stages of drug discovery to speed the rate of discovery that is considered cost and time-efficient. Virgin Coconut Oil (VCO) is a treatment option for atopic dermatitis because it has function to repair skin barrier and as anti-inflammation. Objective: To evaluate the VCO content using computational in silico analysis for the treatment of atopic dermatitis. Methods: The active compounds of Cocos nucifera extracted from KNApSAcK database were predicted experimentally and analyzed computationally using Simple Molecular-Input Line-Entry System (SMILES), Prediction of Activity Spectra for biologically active Substances (PASS) server, and Search Tool for Interactions of Chemicals (STITCH). Results: There are 19 active compounds found in VCO. The analysis shows that VCO has free fatty acid (FFA) protein which acts as a receptor for long and medium chain saturated and unsaturated fatty acids. The highest potential bioactivity of active VCO compounds was as antieczema, with the most important component was linoleic acid, with an average value of probable to be active (Pa) = 0.872, predicted to be highly potential in computational and laboratory tests. Conclusion: Based on this study, we recommend the use of VCO as treatment for atopic dermatitis because VCO has anti-inflammatory potential bioactivity, histamine inhibitor, improves skin barrier function and antieczema which could improve the outcome of atopic dermatitis.

Sindrom Kindler Budi Eko Prasetyorini; Suci Widhiati
MEDICINUS Vol. 36 No. 1 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v36i1.117

Kindler syndrome (KS) is a very rare form of epidermolysis bullosa (EB) and is a disease with defective FERMT1 gene. The FERMT1 gene provides the information needed to produce a protein called kindlin-1 where this protein plays an important role in attaching cells to the extracellular matrix which functions to hold, organize and connect cells in the body. Abnormalities in KS cause cells in the extracellular matrix to weaken so that the skin becomes brittle, prone to blisters and sores. Symptoms of SK are characterized by blisters that most often form on the backs of the hands and the tops of the feet, and thin, fragile skin. Mucosa of the eyes, intestines, esophagus, mouth, urinary tract and genitals may be affected. SK sufferers have a high sensitivity to light. Other symptoms can include discolored skin, thickened skin on the palms and soles and skin thatis atrophied or thin, dry and wrinkled. These symptoms appear in infancy and continue into adulthood, the risk of gingivitis (inflammation of the gums) which can lead to periodontitis or gum disease, throat, eye problems, higher risk of developing skin cancer and intestinal bleeding. Kindler syndrome management is basically preventive and symptomatic. Good wound care including the use of topical and systemic antibiotics for infected and ulcerated bullous lesions can reduce morbidity. Educating the patient to avoid trauma can help prevent blister formation.

Optimizing Sunburn Prevention in Children: A Meta-Analysis of the Efficacy of Sunscreen Application, Protective Apparel, and Shade-Seeking Behaviors Ellistasari, Endra Yustin; Suci Widhiati; Sesia Pradestine
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1355

Background: Childhood sunburn significantly elevates lifelong skin cancer risk, underscoring the need for effective prevention. While sunscreen, protective apparel, and shade-seeking are advocated, a quantitative synthesis of their efficacy in children is crucial. This meta-analysis aimed to consolidate and quantify the evidence on the effectiveness of these core sun protection strategies in preventing pediatric sunburn. Methods: A systematic search of PubMed/MEDLINE, Scopus, Cochrane CENTRAL, and Web of Science (January 2014 - December 2024) identified randomized controlled trials and cohort studies evaluating sunscreen, protective apparel, or shade-seeking behaviors for sunburn prevention in individuals aged 0-18 years. Data on sunburn incidence were extracted, study quality assessed, and pooled Risk Ratios (RR) with 95% confidence intervals (CI) calculated using a random-effects model. Results: Six studies (two RCTs, four cohort studies) involving 8,500 children were included. Regular sunscreen use (SPF ≥30) significantly reduced sunburn incidence (RR 0.65, 95% CI 0.55-0.77). Protective apparel use also demonstrated substantial protection (RR 0.70, 95% CI 0.60-0.82). Enhanced shade provision and shade-seeking behaviors effectively lowered sunburn risk (RR 0.75, 95% CI 0.62-0.90). Multi-component strategies combining these approaches showed consistent protective benefits. Conclusion: This meta-analysis provides robust quantitative evidence that diligent sunscreen application, consistent use of protective apparel, and active shade-seeking are all significantly effective in reducing sunburn incidence in children. These findings strongly support multifaceted public health initiatives emphasizing comprehensive sun protection to safeguard pediatric skin health.

Optimizing Sunburn Prevention in Children: A Meta-Analysis of the Efficacy of Sunscreen Application, Protective Apparel, and Shade-Seeking Behaviors Ellistasari, Endra Yustin; Suci Widhiati; Sesia Pradestine
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1355

Background: Childhood sunburn significantly elevates lifelong skin cancer risk, underscoring the need for effective prevention. While sunscreen, protective apparel, and shade-seeking are advocated, a quantitative synthesis of their efficacy in children is crucial. This meta-analysis aimed to consolidate and quantify the evidence on the effectiveness of these core sun protection strategies in preventing pediatric sunburn. Methods: A systematic search of PubMed/MEDLINE, Scopus, Cochrane CENTRAL, and Web of Science (January 2014 - December 2024) identified randomized controlled trials and cohort studies evaluating sunscreen, protective apparel, or shade-seeking behaviors for sunburn prevention in individuals aged 0-18 years. Data on sunburn incidence were extracted, study quality assessed, and pooled Risk Ratios (RR) with 95% confidence intervals (CI) calculated using a random-effects model. Results: Six studies (two RCTs, four cohort studies) involving 8,500 children were included. Regular sunscreen use (SPF ≥30) significantly reduced sunburn incidence (RR 0.65, 95% CI 0.55-0.77). Protective apparel use also demonstrated substantial protection (RR 0.70, 95% CI 0.60-0.82). Enhanced shade provision and shade-seeking behaviors effectively lowered sunburn risk (RR 0.75, 95% CI 0.62-0.90). Multi-component strategies combining these approaches showed consistent protective benefits. Conclusion: This meta-analysis provides robust quantitative evidence that diligent sunscreen application, consistent use of protective apparel, and active shade-seeking are all significantly effective in reducing sunburn incidence in children. These findings strongly support multifaceted public health initiatives emphasizing comprehensive sun protection to safeguard pediatric skin health.

Platelet-Rich Plasma-Derived Exosomes Modulate Follicular Regeneration: A Comparative Mechanistic Analysis with Minoxidil in a Preclinical Model of Androgenetic Alopecia Trya Oktaviani; Arie Kusumawardani; Suci Widhiati; Nugrohoaji Dharmawan; Endra Yustin Ellistasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 11 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i11.1437

Background: The therapeutic armamentarium for androgenetic alopecia (AGA) is limited, with variable efficacy and potential side effects associated with standard treatments like minoxidil. Platelet-rich plasma-derived exosomes (PRP-Exo) represent a novel acellular strategy, offering a concentrated payload of regenerative biomolecules. This study aimed to rigorously evaluate the therapeutic efficacy and underlying mechanisms of PRP-Exo, as a monotherapy and in combination with minoxidil, in a validated murine model of AGA. Methods: A parallel-group, randomized, double-blind, controlled experimental study was conducted. Thirty-two male C57BL/6 mice with testosterone-induced AGA were randomized (n=8/group) to one of four groups: Negative Control (NC), Positive Control (PC; 5% topical minoxidil), Treatment 1 (T1; intradermal PRP-Exo), or Treatment 2 (T2; combination of PRP-Exo and minoxidil). PRP-Exo were characterized by Transmission Electron Microscopy, Nanoparticle Tracking Analysis, and ELISA for marker proteins. After a 14-day treatment period, efficacy was assessed via hair follicle density (HFD), anagen-to-telogen (A/T) ratio, and hair shaft thickness. Mechanistic insight was obtained by quantifying tissue protein levels of Ki-67 and β-catenin by ELISA. Results: All active treatments significantly improved hair regeneration compared to the NC group. The combination therapy (T2) demonstrated the most profound effects across all metrics, showing statistically superior outcomes compared to both minoxidil (PC) and PRP-Exo (T1) monotherapies in HFD (65.8 ± 12.1 vs. 36.2 ± 8.5 and 47.3 ± 10.4 follicles/mm², respectively; p<0.01). Furthermore, T2 treatment led to the highest A/T ratio and hair shaft thickness. ELISA revealed that T2 treatment also resulted in the highest tissue concentrations of the proliferation marker Ki-67 and the Wnt pathway protein β-catenin, suggesting enhanced mitogenic activity and modulation of key developmental pathways. Conclusion: PRP-Exo is a potent hair regenerative agent, significantly outperforming minoxidil in this preclinical model. The combination of PRP-Exo and minoxidil exhibits a synergistic effect, promoting superior follicular regeneration by concurrently stimulating tissue proliferation and upregulating key components of the anagen-promoting Wnt signaling pathway. These findings underscore the significant clinical potential of PRP-Exo as a next-generation therapy for AGA.

Platelet-Rich Plasma-Derived Exosomes Modulate Follicular Regeneration: A Comparative Mechanistic Analysis with Minoxidil in a Preclinical Model of Androgenetic Alopecia Trya Oktaviani; Arie Kusumawardani; Suci Widhiati; Nugrohoaji Dharmawan; Endra Yustin Ellistasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 11 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i11.1437

Background: The therapeutic armamentarium for androgenetic alopecia (AGA) is limited, with variable efficacy and potential side effects associated with standard treatments like minoxidil. Platelet-rich plasma-derived exosomes (PRP-Exo) represent a novel acellular strategy, offering a concentrated payload of regenerative biomolecules. This study aimed to rigorously evaluate the therapeutic efficacy and underlying mechanisms of PRP-Exo, as a monotherapy and in combination with minoxidil, in a validated murine model of AGA. Methods: A parallel-group, randomized, double-blind, controlled experimental study was conducted. Thirty-two male C57BL/6 mice with testosterone-induced AGA were randomized (n=8/group) to one of four groups: Negative Control (NC), Positive Control (PC; 5% topical minoxidil), Treatment 1 (T1; intradermal PRP-Exo), or Treatment 2 (T2; combination of PRP-Exo and minoxidil). PRP-Exo were characterized by Transmission Electron Microscopy, Nanoparticle Tracking Analysis, and ELISA for marker proteins. After a 14-day treatment period, efficacy was assessed via hair follicle density (HFD), anagen-to-telogen (A/T) ratio, and hair shaft thickness. Mechanistic insight was obtained by quantifying tissue protein levels of Ki-67 and β-catenin by ELISA. Results: All active treatments significantly improved hair regeneration compared to the NC group. The combination therapy (T2) demonstrated the most profound effects across all metrics, showing statistically superior outcomes compared to both minoxidil (PC) and PRP-Exo (T1) monotherapies in HFD (65.8 ± 12.1 vs. 36.2 ± 8.5 and 47.3 ± 10.4 follicles/mm², respectively; p<0.01). Furthermore, T2 treatment led to the highest A/T ratio and hair shaft thickness. ELISA revealed that T2 treatment also resulted in the highest tissue concentrations of the proliferation marker Ki-67 and the Wnt pathway protein β-catenin, suggesting enhanced mitogenic activity and modulation of key developmental pathways. Conclusion: PRP-Exo is a potent hair regenerative agent, significantly outperforming minoxidil in this preclinical model. The combination of PRP-Exo and minoxidil exhibits a synergistic effect, promoting superior follicular regeneration by concurrently stimulating tissue proliferation and upregulating key components of the anagen-promoting Wnt signaling pathway. These findings underscore the significant clinical potential of PRP-Exo as a next-generation therapy for AGA.

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