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All Journal Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research MEDICINUS
Endra Yustin Ellistasari
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Veterinary

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Nevus Comedonicus, a Rare Case : Dermoscopic and Histopathological Findings Nugrohoaji Dharmawan; Endra Yustin Ellistasari; Oyong Oyong; Adniana Nareswari
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15 No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2168

Abstract

Nevus comedonicus is an extremely rare adnexal hamartoma of pilosebaceous apparatus, with approximately 200 cases reported in the literature so far. It appears as cluster of adjacent honeycomb-like dillated follicular openings with firm pigmented keratin plugs resembling comedones.The comedones oftentimes arranged in linear pattern paralled to Blaschko’s lines. We report a case of a 5-year-old boy with open brown to black comedones in a linear pattern localized on the back of the left thigh that appearing since birth. Pain, itch and discharge were not obtain. There were some episodes of infection, due to manual removal done by his mother which left some hypertrophic scars. Dermoscopic examination revealed the distinctive pattern consisting of pigmented, sharply demarcated keratin plugs of 1-3 mm in diameter, some open pores, multiple structurless, various shades of brown homogenous circular areas surrounding the plugs. Histopathological examination showed an aggregation of dilated follicular infundibulum with laminated keratinous material plugging. This case report prove that dermoscopy examination, a simple non-invasive diagnostic tool is very helpful in diagnosing nevus comedonicus. We recommend this tool to differentiate the diagnosis of other rare epidermal nevi while histopathological examination should be performed only in uncertain cases.
GAMBARAN DEPOSISI KOLAGEN TIPE I TERHADAP USIA TIKUS GALUR WISTAR: PENELITIAN IN VIVO Frieda Yanuar; Indah Julianto; Nugrohoaji Dharmawan; Arie Kusumawardani; Novan Adi; Endra Yustin Ellistasari
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 5 No 2 (2022): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (379.183 KB)

Abstract

Penuaan kulit merupakan akumulasi berbagai perubahan progresif yang terjadi pada sel dan jaringan kulit. Kulit manusia terdiri matriks ekstraseluler (MES) dermal dengan protein penyusunnya adalah kolagen. Selama penuaan, kolagen tipe I mengalami perubahan organisasi dan struktural, penurunan sintesis protein MES, dan terjadi peningkatan degradasi metaloproteinase mengakibatkan hilangnya kekuatan mekanik. Studi menunjukkan peran penurunan fungsi penghalang kulit terkait usia dalam penuaan pada tikus. Tujuan penelitian ini untuk mengetahui deposisi kolagen tipe I berdasarkan usia pada jaringan kulit tikus Wistar. Desain penelitian merupakan observasional analitik cross-sectional. Penelitian menggunakan tikus Wistar yang telah memenuhi kriteria inklusi dan eksklusi. Tikus dikelompokkan menjadi kelompok usia 3 bulan, 6 bulan, 12 bulan, dan 18 bulan. Pengambilan jaringan kulit dengan biopsi plong dilanjutkan pembuatan preparat dengan pewarnaan Trichome masson. Perhitungan deposisi kolagen dilakukan pada area berwarna biru dan diinterpretasikan (%) menggunakan software ImageJ. Rerata persentase deposisi kolagen terbesar pada kelompok usia 3 bulan dengan nilai 57,6±0,17% dan 57,5±0,43% pada pembesaran 40x dan 100x. Persentase deposisi kolagen terendah terdapat pada kelompok usia 18 bulan dengan nilai 12,1±1,6% dan 6,9±0,52% pada pembesaran 40x dan 100x. Pada penelitian ini dapat disimpulkan bahwa terdapat penurunan deposisi kolagen jaringan kulit tikus Wistar seiring dengan pertambahan usia akibat proses penuaan, dengan deposisi kolagen jaringan kulit tikus Wistar kelompok usia muda lebih besar dibandingkan kelompok usia yang lebih tua. DOI : 10.35990/mk.v5n2.p183-194
INFERTILITAS PADA WANITA AKIBAT INFEKSI GONORE Fatimah Fitriani; Putri Oktriana; Budi Eko Prasetyorini; Nathania Amelinda; Achmad Satya Negara; Endra Yustin Ellistasari
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 1 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Gonore (GO) merupakan infeksi menular seksual (IMS) akibat Neisseria gonorrhoeae, bakteri gram negatif yang bersifat patogen obligat intraseluler penyebab infeksi permukaan mukosa organ reproduksi pria dan wanita, faring, rektum, dan konjungtiva. Infeksi GO ascending pada tuba falopii berdampak jangka panjang dan serius pada organ reproduksi wanita. Kerusakan organ reproduksi pada infeksi GO dan respon inflamasi dapat menyebabkan penyakit radang panggul, jaringan parut tuba falopi, risiko kehamilan ektopik, dan infertilitas tuba wanita. Tujuan penulisan tinjauan pustaka ini untuk memahami dampak infeksi N. gonorrhoeae terhadap infertilitas wanita sehingga dapat meningkatkan kesadaran untuk melakukan deteksi dini serta memberikan penanganan yang tepat dalam upaya pencegahan terjadinya infertilitas. Kata Kunci : gonore, infertilitas, infeksi menular seksual, wanita DOI : 10.35990/mk.v6n1.p91-102
Analisis In Silico pada VCO untuk Terapi Dermatitis Atopik Mardiana; Primadhanty B; Adniana N; Halim PK; Didik H. Utomo; Endra Yustin Ellistasari; Suci Widhiati
MEDICINUS Vol. 33 No. 3 (2020): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.324 KB) | DOI: 10.56951/medicinus.v33i3.74

Abstract

Introduction: In silico analysis is used in the early stages of drug discovery to speed the rate of discovery that is considered cost and time-efficient. Virgin Coconut Oil (VCO) is a treatment option for atopic dermatitis because it has function to repair skin barrier and as anti-inflammation. Objective: To evaluate the VCO content using computational in silico analysis for the treatment of atopic dermatitis. Methods: The active compounds of Cocos nucifera extracted from KNApSAcK database were predicted experimentally and analyzed computationally using Simple Molecular-Input Line-Entry System (SMILES), Prediction of Activity Spectra for biologically active Substances (PASS) server, and Search Tool for Interactions of Chemicals (STITCH). Results: There are 19 active compounds found in VCO. The analysis shows that VCO has free fatty acid (FFA) protein which acts as a receptor for long and medium chain saturated and unsaturated fatty acids. The highest potential bioactivity of active VCO compounds was as antieczema, with the most important component was linoleic acid, with an average value of probable to be active (Pa) = 0.872, predicted to be highly potential in computational and laboratory tests. Conclusion: Based on this study, we recommend the use of VCO as treatment for atopic dermatitis because VCO has anti-inflammatory potential bioactivity, histamine inhibitor, improves skin barrier function and antieczema which could improve the outcome of atopic dermatitis.
Laporan Kasus Pyoderma Gangrenosum disertai Kandidiasis Kutis pada Wanita dengan Sindrom Metabolik Ambar Aliwardani; Fiska Rosita; Putti Fatiharani; Endra Yustin Ellistasari
MEDICINUS Vol. 35 No. 1 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (319.591 KB) | DOI: 10.56951/medicinus.v35i1.85

Abstract

Introduction: Pyoderma gangrenosum (PG) is a rare inflammatory disease characterized by sterile, predominantly neutrophilic infiltration of the skin and other organs. PG is found particularly in women aged between 40-60 years. Metabolic syndrome is reported to have a potential role to induce PG. Case: A 45-year-old woman came to Dr. Moewardi Hospital with chief complaints of ulcer in the chest and legs that was preceded by reddish fluid filled bump which then broke into painful wound. History of trauma, gastrointestinal, and joint pain was denied. Dermatological examination of anterior trunk region and inferior extremity showed erythematous patches with multiple ulcers with irregular border covered with hemorrhagic crusts and necrotic tissue. Pathergy test was negative. In the right and left axillary, inframammary and inguinal, there were hyperpigmented patches with scales and satellite lesions, KOH 10% examination obtained pseudohyphae and cell budding. The patient also has metabolic syndrome. Diagnosis of PG was made based on the presence of 2 major and 2 minor criteria. Patient was given intravenous methylprednisolone 93.75 mg/24 hours, analgesics, antibiotics, topical antifungals, debridement and breast reconstructive surgery after response to steroid therapy was seen. The patient was discharges from hospital with improvement. Discussion: Metabolic syndrome is considered to be a risk factor contributing to the development of systemic chronic inflammatory processes and has been described as one of the precipitating factors for PG and skin candidiasis. Management of metabolic syndrome as the known risk factor aims to minimize the recurrence of PG in the future.
Modalitas Terapi Vitiligo pada Anak Nathania Amelinda; Endra Yustin Ellistasari; Indah Julianto
MEDICINUS Vol. 35 No. 3 (2022): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/medicinus.v35i3.106

Abstract

itiligo is a pigmentation disorder characterized by depigmented patches on skin and hair due to functional loss of melanocytes. Vitiligo in children is generally associated with other autoimmune diseases and has serious cosmetic and psychosocial impact. Treatment modalities for vitiligo in children consist of topical therapy, phototherapy, systemic therapy, and surgery. Vitiligo in children has a relatively good prognosis compared to adult cases. Repigmentation in childhood vitiligo usually happen spontaneously and relapses are rare.
Fototerapi pada Dermatologi Anak Wibisono Nugraha; Endra Yustin Ellistasari
MEDICINUS Vol. 36 No. 3 (2023): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/b5jqva33

Abstract

Phototherapy is a non-ionizing ultraviolet (UV) radiation therapy used as a treatment for several medical conditions. The mechanism of action of phototherapy is to act as antiproliferative, induce apoptotic, and provide immunosuppressive effect. Several therapeutic modalities that can be used as alternative therapy in children include NB-UVB, BB-UVB, ultraviolet A, PUVA, and excimer laser. Phototherapy in children is indicated especially in diseases such as psoriasis, atopic dermatitis, vitiligo, pityriasis lichenoides, and mycoses fungoides. The use of phototherapy has indications, contraindications, dose, and side effects that should be considered when choosing appropriate phototherapy in children. Common side effects are erythema, xerosis, burning sensation, and itching. Several groups of patients with refractory complaints are advised to use additional phototherapy modalities, either as monotherapy or in combination with topical and systemic therapy.
Platelet-Rich Plasma-Derived Exosomes Modulate Follicular Regeneration: A Comparative Mechanistic Analysis with Minoxidil in a Preclinical Model of Androgenetic Alopecia Trya Oktaviani; Arie Kusumawardani; Suci Widhiati; Nugrohoaji Dharmawan; Endra Yustin Ellistasari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 11 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i11.1437

Abstract

Background: The therapeutic armamentarium for androgenetic alopecia (AGA) is limited, with variable efficacy and potential side effects associated with standard treatments like minoxidil. Platelet-rich plasma-derived exosomes (PRP-Exo) represent a novel acellular strategy, offering a concentrated payload of regenerative biomolecules. This study aimed to rigorously evaluate the therapeutic efficacy and underlying mechanisms of PRP-Exo, as a monotherapy and in combination with minoxidil, in a validated murine model of AGA. Methods: A parallel-group, randomized, double-blind, controlled experimental study was conducted. Thirty-two male C57BL/6 mice with testosterone-induced AGA were randomized (n=8/group) to one of four groups: Negative Control (NC), Positive Control (PC; 5% topical minoxidil), Treatment 1 (T1; intradermal PRP-Exo), or Treatment 2 (T2; combination of PRP-Exo and minoxidil). PRP-Exo were characterized by Transmission Electron Microscopy, Nanoparticle Tracking Analysis, and ELISA for marker proteins. After a 14-day treatment period, efficacy was assessed via hair follicle density (HFD), anagen-to-telogen (A/T) ratio, and hair shaft thickness. Mechanistic insight was obtained by quantifying tissue protein levels of Ki-67 and β-catenin by ELISA. Results: All active treatments significantly improved hair regeneration compared to the NC group. The combination therapy (T2) demonstrated the most profound effects across all metrics, showing statistically superior outcomes compared to both minoxidil (PC) and PRP-Exo (T1) monotherapies in HFD (65.8 ± 12.1 vs. 36.2 ± 8.5 and 47.3 ± 10.4 follicles/mm², respectively; p<0.01). Furthermore, T2 treatment led to the highest A/T ratio and hair shaft thickness. ELISA revealed that T2 treatment also resulted in the highest tissue concentrations of the proliferation marker Ki-67 and the Wnt pathway protein β-catenin, suggesting enhanced mitogenic activity and modulation of key developmental pathways. Conclusion: PRP-Exo is a potent hair regenerative agent, significantly outperforming minoxidil in this preclinical model. The combination of PRP-Exo and minoxidil exhibits a synergistic effect, promoting superior follicular regeneration by concurrently stimulating tissue proliferation and upregulating key components of the anagen-promoting Wnt signaling pathway. These findings underscore the significant clinical potential of PRP-Exo as a next-generation therapy for AGA.
UVB-Induced Oxidative Collapse and Melanogenic Activation in a Rat Model of Cutaneous Hyperpigmentation: A Multi-Parametric Analysis Sesia Pradestine; Endra Yustin Ellistasari; Nurrachmat Mulianto; Indah Julianto; Muhammad Eko Irawanto; Nugrohoaji Dharmawan
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 11 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i11.1442

Abstract

Background: Ultraviolet B (UVB) radiation is a primary driver of cutaneous hyperpigmentation disorders, with oxidative stress recognized as a key pathogenic mechanism. However, a comprehensive, multi-level characterization of the causal link between chronic UVB exposure and the resulting oxidative, histological, and melanogenic responses is needed. This study aimed to quantitatively validate a preclinical model of UVB-induced hyperpigmentation by characterizing the reciprocal regulation of key oxidative stress biomarkers and correlating these changes with objective histological evidence of hyperpigmentation. Methods: This controlled in vivo experimental study used 14 male Sprague Dawley rats, divided into a control group (KN; n=7) and a UVB-exposed group (KP; n=7). The KP group received chronic UVB radiation (300 mJ/cm² daily, 5 days/week for 4 weeks). Dorsal skin tissue was harvested for analysis. Oxidative stress was assessed by quantifying malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) levels via ELISA. Hyperpigmentation was objectively validated and quantified using Fontana-Masson staining for melanin deposition and immunohistochemistry for microphthalmia-associated transcription factor (MITF). Results: Chronic UVB exposure induced significant hyperpigmentation, confirmed by a 5.8-fold increase in epidermal melanin content (p < 0.001) and a 4.1-fold increase in the number of MITF-positive melanocytes (p < 0.001) in the KP group. This was accompanied by a profound oxidative imbalance: MDA levels increased by 7.5-fold (p < 0.001), while the activities of SOD, CAT, and GPx decreased by 80.5%, 65.2%, and 71.4%, respectively (all p < 0.001). A strong negative correlation was observed between MDA and all antioxidant enzymes, particularly SOD (r = -0.985, p < 0.001). Conclusion: Chronic UVB exposure directly triggers a collapse of the cutaneous antioxidant network, leading to severe lipid peroxidation. This state of profound oxidative stress is causally linked to melanocyte activation and excessive melanin synthesis, driving the hyperpigmentation phenotype. This robustly validated preclinical model provides a powerful platform for investigating the molecular pathophysiology of UVB-induced pigmentary disorders and for evaluating novel therapeutic interventions.
Intralesional Mumps, Measles, Rubella (MMR) Vaccine as Therapy for Recurrent Condyloma Acuminata: A Case Report Sambodo, Shelly Lavenia; Prasetyadi Mawardi; Endra Yustin Ellistasari; Ammarilis Murastami
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1092

Abstract

Background: Condyloma acuminata (CA), a prevalent sexually transmitted infection caused by the human papillomavirus (HPV), presents challenges in treatment due to its high recurrence rate. While various treatment modalities exist, intralesional immunotherapy with the mumps, measles, rubella (MMR) vaccine has shown promise in managing HPV-related conditions. This case report investigates intralesional MMR vaccine in treating recurrent CA. Case presentation: A 24-year-old female presented with recurrent CA lesions on the labia majora and perianal region. Despite prior treatment with trichloroacetic acid (TCA), the lesions had reappeared. Intralesional MMR vaccine injections were administered twice, one month apart, resulting in complete lesion resolution within six weeks of the second injection. No recurrence was observed during a six-month follow-up period, and the patient reported only mild, transient pain at the injection sites. Conclusion: This case report highlights the potential of intralesional MMR vaccine as an effective and well-tolerated treatment option for recurrent CA. Further research is warranted to validate these findings and establish optimal treatment protocols.
Co-Authors Achmad Satya Negara Adniana N Adniana Nareswari Ambar Aliwardani Ammarilis Murastami Arie Kusumawardani Azhar Arrosyid Benedikta Lauda Budi Eko Prasetyorini Dharmawan, Nugrohoaji Didik H. Utomo Fatimah Fitriani Fiska Rosita Frieda Yanuar Halim PK Indah Julianto Ivani Lidjaja, Lifesia Natali MARDIANA Muhammad Eko Irawanto Nathania Amelinda Novan Adi Nurrachmat Mulianto Oyong Oyong Prasetyadi Mawardi Primadhanty B Putri Oktriana Putti Fatiharani Sesia Pradestine Shelly Lavenia Sambodo Suci Widhiati Trya Oktaviani Vrenda Alia Wibisono Nugraha