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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin MEDISAINS Universa Medicina Syntax Literate: Jurnal Ilmiah Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Cahaya Mandalika Open Access Indonesian Journal of Medical Reviews Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Journal of Social Research MEDICINUS Proceeding ISETH (International Summit on Science, Technology, and Humanity) Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Plexus Medical Journal Indonesian Basic and Experimental Health Sciences

Ellistasari, Endra Yustin

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Author-ID : 1803353

Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Kombinasi Krioterapi dan KOH 5% untuk Terapi Kondiloma Akuminata Raksasa dengan Infeksi HIV Hastuti, Rini; Farida Mustifah, Etty; Ellistasari, Endra Yustin
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Pendahuluan. Kondiloma akuminata raksasa (KAR) atau disebut juga tumor Buschke-Lowenstein adalah tumor akibat infeksi human papillomavirus (HPV) di daerah anorektal dan genitalia eksterna dengan diameter lebih dari 2,5 cm. Kasus. Seorang laki-laki homoseksual, 32 tahun dengan benjolan yang bertambah banyak dan membesar sejak 2 bulan. Pasien terinfeksi HIV sejak 2 tahun. Kombinasi krioterapi dan larutan KOH 5% memberikan perbaikan klinis. Diskusi. Terapi kombinasi dapat dijadikan pilihan terapi KAR disertai penyulit atau jika terapi tunggal tidak memberikan perbaikan klinis.Background. Giant condyloma acuminata also known as Buschke-Lowenstein tumor is a tumor caused by human papillomavirus (HPV) infection in anorectal area and external genitalia with diameter more than 2,5 cm. Case. A 32 year-old homosexual male, with multiplying and growing lumps since two months. Patient was diagnosed with HIV since 2 years. A combination therapy with cryotherapy and KOH 5% solution resulted in clinical improvement. Discussion. Combination therapy may be an option for giant condyloma acuminata if single therapy does not provide clinical improvement.

Pemeriksaan Serologi untuk Diagnosis Sifilis Aliwardani, Ambar; Fatiharani, Putti; Rosita, Fiska; Ellistasari, Endra Yustin
Cermin Dunia Kedokteran Vol 48, No 11 (2021): Kardio-SerebroVaskular
Publisher : PT. Kalbe Farma Tbk.

Sifilis merupakan infeksi kronis bakteri T. pallidum subspesies pallidum dengan manifestasi klinis dapat menyerupai penyakit kulit lain. Diagnosis sifilis dari anamnesis dan pemeriksaan fisik harus selalu didukung oleh temuan laboratorium. Pemeriksaan serologi untuk deteksi antibodi terdiri dari pemeriksaan non-treponema untuk skrining dan evaluasi pengobatan serta pemeriksaan treponema untuk konfirmasi diagnosis. Klinisi hendaknya memahami pemeriksaan serologi agar dapat memilih pemeriksaan yang tepat sesuai klinis dan menentukan terapi.Â Syphilis is a chronic infectious disease caused by the bacteria T. pallidum subspecies pallidum with clinical manifestations resembling other skin diseases. Diagnosis should always be supported by appropriate laboratory findings. Serological examination to detect antibodies consists of non-treponema examination for treatment screening and evaluation and treponema examination for diagnosis confirmation. Clinicians should be able to choose the appropriate examinations for diagnosis and therapy.

Physical Stability Test of Ethanol Extract Cream of Bajakah Wood as Topical Antiaging Cream Prasetyorini, Budi Eko; Kusumawardani, Arie; Ellistasari, Endra Yustin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

The barakah ethanolic extract (Spatholobus littoralis Hassk) contains antioxidants that function as antiaging. The use of barakah wood ethanolic extract cream as a cosmetic preparation requires a long preparation time, so it is necessary to formulate a preparation that is practical and durable in storage. Cream components affect the physical stability of the preparation. Physical stability tests need to be carried out to ensure the quality, safety, and benefits of the cream meet the expected specifications and are stable during storage. This study aims to make the physical stability of the formulation of the cream preparations of barakah wood ethanol extract at concentrations of 7.5%, 15%, and 30%. The design of this study was an experimental laboratory. The stability test was carried out using the cycling test method for 6 cycles by re-testing its physical properties. Physical evaluation includes organoleptic tests, homogeneity, pH, dispersion, and adhesion. Preparation of cream formula 7.5%, 15%, and 30% of the results of testing physical properties (cycle 0) namely organoleptic test (smell: typical of wood; color: dark brown; texture: semi-solid), homogenity (homogeneous arrangement), pH F1, 2 and 3 p = 0.524; 0.350 and 0.745 adhesion F1, 2 and 3 p = 0.209; 0.207 and 0.377 spreadability F1, 2 and 3: p = 0.690; 0.207 and 0.395 the results of statistical values in formula 1, 2 and 3 which show the value of Sig(2-tailed) where this value is p > 0.05 which means there is no significant difference before and after the cycling test. In the cream stability during the cycling test (cycles 1-6) there was no significant difference. There was no statistically significant difference in any physical evaluation of the cream stem ethanolic extract barakah 7.5%, 15%, and 30% so the three concentrations of cream were stable creams.

The Difference In Transepidermal Water Loss (TEWL) Values Between Sun-exposed and Non-sun-exposed Skin Among Male Medical Students Prihadi, Ihsany Arafiasetyanto; Ellistasari, Endra Yustin; Kusumawardani, Arie
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Background: Transepidermal Water Loss (TEWL) is the amount of water released from the human body into the atmosphere through a diffusion process per unit of time. Changes in TEWL indicate impaired skin barrier function. Exposure to ultraviolet light for an extended period can cause photoaging, characterized by rough and dry skin (xerosis cutis). TEWL will increase significantly in the skin exposed to ultraviolet radiation. This study aims to determine the difference in the TEWL values among male medical students in the sun-exposed and non-sun-exposed skin areas. Methods: An analytical observational cross-sectional study was conducted at the Dermatology and Venereology Department of RSUD Dr. Moewardi Surakarta in January-March 2021. Sampling was carried out through consecutive sampling and 25 samples were obtained. TEWL examination was performed on the dorsal area of the forearm and the medial area of the upper arm using the Tewameter TM300. The mean value of TEWL was analyzed using the non-parametric Wilcoxon signed rank test and Spearman's correlation test. Results: Based on the Wilcoxon signed rank test, there was a significant difference in the value of TEWL (p = 0.000). Spearman correlation analysis shows the coefficient value of r = 0.599, with p = 0.002. Conclusion: There is a significant difference in TEWL values in the sun-exposed skin area compared to the non-sun-exposed skin area, with a moderate positive correlation.

The comparison of skin irritation level between topical cajeput oil and telon oil: A pilot study Ilona, Sri Esa; Cahyono, Aris; Ellistasari, Endra Yustin; Irawanto, Muh. Eko; Kariosentono, Harijono
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 3
Publisher : UI Scholars Hub

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Background: Cajuputi/Cajeput/Melalueca leucadendron oil is a type of essential oil, widely known and used by Indonesian for infants, children, and elderly. It is also included in telon oil compositions (±42%). Excessive application of cajeput oil and telon oil may lead to skin irritation. Methods: This randomized single-blind control trial was conducted with 10 subjects who met the inclusion criteria. Four areas with diameter of 10 mm each were made on the flexor surface of the upper arm. Area 1 was designated as negative control. Area 2 to 4 were pre-irritated with tape stripping for 40 ± 10 times using Nachitape®, followed by repeated open application test (ROAT) with cajeput oil, telon oil and alcohol (positive control). The skin irritation was examined in 15 minutes after each cycle by measuring transepidermal water loss (TEWL) using Tewameter® TM300 (Courage-Khazaka, Germany) and erythema using Mexameter® MDD4. Data were analyzed using One-way ANOVA with p<0.05 considered significance. Results: The average TEWL and erythema of cajeput oil (15.59; 345.42) were the highest compared to telon oil (12.63; 316.60), alcohol (13.87; 319.06) and negative control (7,48; 296.68). All treatment groups had significant differences in TEWL (p<0.000) and erythema (p<0.002) when compared to the negative control. However, cajeput oil showed the largest difference. Conclusion: Cajeput oil caused the most irritation compared to alcohol and telon oil. Therefore, it should be used with caution.

Prevalence and risk factors of bacterial vaginosis among female sex workers in Surakarta Hastuti, Rini; Yuliarto, Danu; Triana, Agung; Damayanti, Willa; Irfanti, Rakhma Tri; Mardiana, Mardiana; Dewi, Putti Fatiharani; Aliwardani, Ambar; Abas, Ervianti; Sulistyo, Sulistyo; Mawardi, Prasetyadi; Ellistasari, Endra Yustin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Background: Bacterial vaginosis (BV) is the most common vaginal infection in women of reproductive age and increases the risk of acquiring human immunodeficiency virus (HIV) and other sexually transmitted diseases (STDs). Data regarding the association between sexual activity and BV acquisition is contradictory. Thus, tracking the prevalence and associated risk factors of BV among female sex workers (FSWs) is necessary to improve our understanding and control of STDs and the HIV epidemic. Methods: The subjects of this study were FSWs in Surakarta. This study adopted a cross-sectional design, and diagnosis was established using Amsel criteria. Interviews were conducted using questionnaires to collect data of risk factors, including demographic factors (age, education level, daily income, marital status, location of sex), sociologic factors (age of first intercourse; age of first FSW encounter; duration of work as an FSW; number of clients/day; condom, contraceptive, and vaginal douching use; violence experienced as an FSW; smoking habits; alcohol consumption; and drug use), and knowledge factors (knowledge of STDs and HIV). Statistical analysis was performed by using bivariate analysis. Results: We interviewed 175 FSWs with an average age of 40.66 years. BV was detected in 28 subjects (16%). Risk factors associated with BV include alcohol (p = 0.022) and drug use (p = 0.022). Conclusion: Other than routine screening for STDs and HIV, FSWs should be encouraged to participate in prevention programs aiming to regulate alcohol and drug use to decrease the incidence of BV infection.

A comparison of single-dose versus divided-dose of metronidazole on bacterial vaginosis among female sex workers in Surakarta Damayanti, Willa; Hastuti, Rini; Triana, Agung; Yuliarto, Danu; Ayu, Ardelia Dyah; Ellistasari, Endra Yustin
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 2
Publisher : UI Scholars Hub

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Background: Bacterial vaginosis (BV) is the most common vaginal infection in sexually active women. Metronidazole (MTZ) is still one of the recommended regimens for BV either as a single-dose or divided-dose. In addition to its affordability and availability, oral metronidazole also produces fewer adverse effects. This study aimedto determine the efficacy of single-dose versus divided-dose metronidazole for BV among female sex workers (FSWs) in Surakarta. Methods: A single-blind randomized clinical trial was conducted in Surakarta. FSWswith BV (⩾3 Amsel criteria) were enrolled. The subjects were grouped into two, and treated with MTZ either as a single-dose of 2 gr (single-dose group) or 500 mg twice daily for one week (divided-dose group). After two weeks, we performed second vaginal swabs and reassessed the Amsel criteria, complaints and adverse events. Results: Out of 75 FSWs, 30 (42%) were diagnosed with BV. The efficacy between two groups was not significantly different. However, patients in the single-dose group were 2 times more likely to develop recurrent BV (OR = 2.000; 95% CI 0.146 – 27.447), and 1.5 times more likely to have vaginal discharge complaints (OR = 1,500; 95% CI 0,181-12,459) than divided-dose group. Conclusion: Single-dose and divided-dose metronidazole produce similar efficacy for treating BV in sexually active women. Single-dose metronidazole has a higher risk of BV recurrence and vaginal discharge complaint. Divided-dose metronidazole is recommended for treating BV.

Hand Eczema in Nurses in COVID-19 Treatment Room: Frequency of Handwashing, Hand Sanitizer, Moisturizer, and Duration of Latex Gloves Use Rosmarwati, Ervina; Widhiati, Suci; Novriana, Dita Eka; Rahma, Alfina; Kariosentono, Harijono; Irawanto, Muhammad Eko; Kusumawardani, Arie; Ellistasari, Endra Yustin; Oktavriana, Triasari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 34 No. 2 (2022): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V34.2.2022.92-98

Background: The COVID-19 pandemic causes health workers to use level 2 and level 3 personal protective equipment. Hand washing and the use of latex gloves are important in limiting the spread of COVID-19, but they can potentially induce hand eczema and skin pH disturbance if used too frequently. Purpose: Determine the correlation between the frequency of handwashing and duration of using hand sanitizer and moisturizer as well as skin pH level on the incidence of hand eczema in nurses in the COVID-19 treatment room at RSUD Dr. Moewardi Surakarta. Methods: This cross-sectional study was conducted in the COVID-19 treatment room at RSUD Dr. Moewardi Surakarta with 90 nurses as subjects. A validated questionnaire carried out the frequency of handwashing, hand sanitizer, moisturizer, duration of using latex gloves, and hand eczema complaints. The subject's pH assessment was conducted after 4-5 hours in the COVID-19 treatment room. Data were analyzed bivariately with a Spearman rank correlation test. Result: There was a significant correlation with the incidence of hand eczema with the frequency of handwashing with soap (r=0.305 and p=0.003) and the duration of using latex gloves (r=0.328 and p=0.002) with a weak category correlation (r=0.200-0.399). The frequency of using hand sanitizer, moisturizer, and skin pH did not correlate with the incidence of hand eczema. Conclusion: Frequency of handwashing and the duration of using latex gloves correlated with the incidence of hand eczema, meanwhile frequency of using hand sanitizer, using moisturizer, and skin pH didn't correlate with the incidence of hand eczema.

Laporan Kasus Acrodermatitis Enteropathica pada Anak 5 Tahun dengan Level Zink Serum Normal Nareswari, Adniana; Mochtar, Moerbono; Widhiati, Suci; Kusumawardani, Arie; Ellistasari, Endra Yustin; Julianto, Indah
MEDICINUS Vol. 34 No. 1 (2021): MEDICINUS
Publisher : PT Dexa Medica

Acrodermatitis enterophatica (AE) is an inherited or acquired condition associated with zinc malabsorption. Clinical symptoms of AE are periorificial and acral dermatitis, alopecia, and diarrhea. Serum zinc levels usually decrease in AE patients. A 5-year-old boy presented with crusted erosion on the face, trunks and extremities that have been appeared for one year and worsened last month. It also accompanied by hair and eyebrow loss, diarrhea, and eating disorder. Patient was also malnourished. Dermatovenereology examination showed papules, patches, multiple erythematous plaques with squama, erosions with brownish yellow crust above located on perioral, periorbital, posterior trunk, inguinal, perianal, cubital, popliteal and dorsum pedis region. The oral region showed stomatitis and cheilitis. The orbital region showed conjunctival injection and eye discharge. The scalp, eyebrows and lashes showed total alopecia. Laboratory test showed normal serum zinc levels and decreased levels of alkaline phosphatase. The patient was diagnosed with acquired form of AE. Clinical improvement was seen after zinc supplementation. The diagnosis of AE cannot be made only by low serum zinc levels. If a classical triad of AE was found, we must be able to recognize it immediately, thus prompt and appropriate therapy could be given.

Correlation of CD4+ levels and caspase-3 in condyloma acuminata with HIV reactive patients Nurfaiqoh, Elok; Mawardi, Prasetyadi; Dharmawan, Nugrohoaji; Julianto, Indah; Ellistasari, Endra Yustin
MEDISAINS Vol 22, No 1 (2024)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v22i1.21501

Background: Human papillomavirus is an infection that causes malignancy because of persistency and modulation of apoptotic pathways, especially caspase-3. Factors that can increase persistency, recurrency, and malignancy of HPV infection include HIV infection with low CD4 levels. There is disagreement or deep molecular understanding of the induction and modulation of apoptosis in HIV-mediated CD4+ T cell depletion, especially in CA. However, it is necessary to see how CD4+ levels can influence caspase-3, so it may open up new avenues for supporting investigation to consider the presence of malignancy or therapeutic strategies regarding CD4+ can induce apoptosis.Purpose: This study aimed to determine whether there is a correlation between CD4+ levels and caspase-3 expression in condyloma acuminata with HIV reactive patients.Methods: This is an analytic observational study with a cross-sectional design. The research was conducted at Dr. Moewardi General Hospital from August to December 2023. Nineteen patients with condyloma acuminata and HIV reactive were included in this study with a consecutive sampling technique. The expression of caspase-3 was assessed using immunohistochemical staining, looking at the percentage of stained cell nuclei and cytoplasm and CD4+ levels with flow cytometry examination—data analysis using Pearson correlation.Results: Respondents in this study were primarily men, self-employed with heterosexual orientation and genito-genital-oral sexual intercourse. The statistical analysis showed no significant relationship (p: 0.300, r: -0.251) between CD4+ levels and caspase-3 expression.Conclusions: While not statistically significant, CD4+ level is reduced in correlation with increased caspase-3 expressions.

Co-Authors Abas, Ervianti Aliwardani, Ambar Aulia Yasmin, Aulia Ayu, Ardelia Dyah Brian Wasita Cahyono, Aris Damayanti, Willa Dewi, Putti Fatiharani Dharmawan, Nugrohoaji Dita Eka Novriana Farida Mustifah, Etty Fatiharani, Putti Hidayatullah, Lalu Muh Syahrul Rio Ilona, Sri Esa Indah Julianto, Indah Irawanto, Muh. Eko Irawanto, Muhammad Eko Irfanti, Rakhma Tri Kamilah, Lian Kariosentono, Harijono Kariosentono, ⁠⁠Harijono Kasmitasari, Fitri Kusumawardani, Arie Mardiana Mardiana Mochtar, Moerbono Monica, Pristia Widya Mulianto, ⁠Nurrachmat Nareswari, Adniana Novan Adi Setyawan Nurfaiqoh, Elok Octarica , Stella Gracia Octarica, Stella Gracia Poncorini, Eti Prasetyadi Mawardi Prasetyorini, Budi Eko Prihadi, Ihsany Arafiasetyanto Primisawitri, Pratiwi Prasetya Rahma, Alfina Rini Hastuti Rosita, Fiska Rosmarwati, Ervina Sesia Pradestine Suci Widhiati Sulistyo Sulistyo Triana, Agung Triasari Oktavriana Widhiati, Suci Widyastuti, Zilpa Wuri P, Adelia Yudhistira, Muhammad Yurizar Yuliarto, Danu

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