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All Journal ACTA VETERINARIA INDONESIANA Indian Journal of Forensic Medicine & Toxicology
Viol Dhea Kharisma
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Public Health Veterinary

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Concept of SARS-CoV-2 Vaccine Design to Fight COVID-19 Pandemic: A Review Insight Viol Dhea Kharisma; Arif Nur Muhammad Ansori; Rasyadan Taufiq Probojati; Dora Dayu Rahma Turista; Yulanda Antonius
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17127

Abstract

Cluster of pneumonia infection emerged in Wuhan, China due to severe acute respiratory syndromecoronavirus 2 (SARS-CoV-2). Additionally, more than 190 countries have confirmed 82 million casesof SARS-CoV-2 infection. Currently, there is a SARS-CoV-2 epidemic, and no effective prophylacticmethods are available. A vaccine is considered as an effective method to restrict an epidemic. Severalvaccine designing techniques have been established, which is enabling researchers from various institutesfor developing vaccine towards SARS-CoV-2 infections. In this review, we condense the development ofvaccine research against SARS-CoV-2.
Edible Bird’s Nest as Potential Food with Anti-Viral and Anti-Inflammatory Properties Against Covid-19: an in Silico Study Siti Gusti Ningrum; Rochiman Sasmita; Viol Dhea Kharisma
Acta VETERINARIA Indonesiana Vol. 11 No. 1 (2023): Maret 2023
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.11.1.43-50

Abstract

The Chinese believe consuming edible bird’s nests (EBN) can increase immunity to various diseases, including Covid-19. This study attempts to identify SARS COV-2-specific anti-viral and anti-inflammatory agents of EBN. We gathered samples from PubChem and Protein Data Bank (PDB). Afterwards, drug likeness was examined using the Lipinski model from the SCFBIO online service. The PASS web server analyzed the bioactive likelihood of chemicals found in EBN. Using PyRx 0.8 software with the blind docking technique. The PoseView web server and PyMol v2.4.1 software were utilized to ascertain molecular interactions. The in silico results show the potential of EBN as food therapy for Covid-19 sufferers, which is indicated by the presence of bioactive compounds from edible bird’s nest consisting of 9-O-acetylated GD3, glycopeptide, N-acetyl neuraminic acid, N-glycolyl-neuraminic acid, sialic acid, and tetra acetyl-thymol-beta-D-glucoside. These bio compounds are predicted to work as anti-viral and anti-inflammatory candidates against SARS-COV-2.
Co-Authors Arif Nur Muhammad Ansori Rasyadan Taufiq Probojati Rochiman Sasmita Siti Gusti Ningrum Turista, Dora Dayu Rahma Yulanda Antonius