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All Journal Malacca Pharmaceutics Depik Jurnal Ilmu-Ilmu Perairan, Pesisir, dan Perikanan
SALMA, ITSNATANI
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Education Engineering Immunology & microbiology Medicine & Pharmacology

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Antioxidant and Cytotoxic Activities of Postpartum Herbal Remedies Use in Aceh, Indonesia Saudah, Saudah; Rubiah, Rubiah; Zumaidar, Zumaidar; Salma, Itsnatani; Rahmawati, Rahmawati
Malacca Pharmaceutics Vol. 4 No. 1 (2026): March 2026
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v4i1.358

Abstract

Traditional medicinal plants continue to play an important role in postpartum care in Aceh, Indonesia, yet their pharmacological properties remain insufficiently documented. This study examined the phytochemical composition, antioxidant capacity, and cytotoxic profile of five commonly used postpartum plants: Glochidion zeylanicum var. zeylanicum, Glochidion obscurum, Mesua ferrea, Vitex pinnata, and Salix babylonica. Ethanolic leaf extracts were prepared by macerating the leaves and analyzed for major secondary metabolites. Antioxidant activity was evaluated using the DPPH radical scavenging assay, while cytotoxicity was assessed through the brine shrimp lethality test (BSLT). All extracts contained flavonoids, phenolics, tannins, and terpenoids, with alkaloids detected in most species. G. obscurum showed the strongest antioxidant activity (IC50 = 2.30 µg/mL), followed by M. ferrea, V. pinnata, and G. zeylanicum, whereas S. babylonica exhibited moderate activity. BSLT results indicated high cytotoxicity in M. ferrea, V. pinnata, and S. babylonica (LC50 < 10 µg/mL), while G. obscurum and G. zeylanicum demonstrated moderate toxicity. These findings provide scientific support for the traditional postpartum use of these plants, particularly regarding antioxidant and restorative functions. However, the strong cytotoxicity observed in several species highlights the need for cautious dosage and further toxicological validation. Additional studies are recommended to isolate active constituents and clarify their safety and therapeutic relevance.
The effect of cryoprotectant on the viability and motility of goldfish Carassius aurtus sperm after 48 hours refrigerated Nurlaili, Nurlaili; Salma, Itsnatani; Eriani, Kartini; Maulida, Siti; Muchlisin, Zainal Abidin
Depik Vol 11, No 3 (2022): DECEMBER 2022
Publisher : Faculty of Marine and Fisheries, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13170/depik.11.3.28480

Abstract

The principle of sperm preservation is to prolong the viability of spermatozoa by reducing the degree of metabolism during storage at low temperatures, and one method involved was a cryoprotectant as a sperm protector. This study aimed to determine the best type of cryoprotectant for refrigeration storage of goldfish Carrasius auratus sperm. A completely randomized design was used, and five types of cryoprotectant were tested, namely Methanol, Ethanol, Ethylene Glycol, Glycerol, and DMSO at a 10% concentration combined with 15% egg yolks. The sperm was diluted with Ringers solution and stored at 4C for 48 hours. The ANOVA test revealed that cryoprotectant significantly affected the motility and viability of sperm after 48 hours of refrigeration (P0.05). The results showed that 10% DMSO combined with 15% egg yolk could maintain sperm motility and viability better than other treatments, with values of 85.80% and 86.50%, respectively, which were significantly different from the other treatments. Glycerol produced the second-best sperm quality with motility and viability values of 71.13% and 74.13%, respectively. Therefore, DMSO is the most effective cryoprotectant for refrigeration storage of goldfish sperm.
Co-Authors KARTINI ERIANI Maulida, Siti Nurlaili Nurlaili Rahmawati, Rahmawati Rubiah, Rubiah SAUDAH SAUDAH ZAINAL ABIDIN MUCHLISIN Zumaidar Zumaidar