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All Journal BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Jurnal Biosilampari: Jurnal Biologi Jurnal Ilmu Kefarmasian Indonesia
Nurhasana, Devi
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Aktivitas Antibakteri Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Terhadap 2 Jenis Bakteri Penyebab Jerawat dengan KLT-Bioautografi Erliana, Dina; Nurhasana, Devi; Wiradimafan, Khafit; Avidlyandi, Avidlyandi; Yudha, Salprima; Adfa, Morina
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol 7 No 2 (2024): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/bioedusains.v7i2.10373

Abstract

This research aims to examine the antibacterial activity of an ethanol extract of old sungkai leaves (DST) (Peronema canescens Jack) against the test bacteria Staphylococcus aureus and Staphylococcus epidermidis using the TLC-bioautography method. The concentration of the test extract was 15%, with the amount of extract spotting being 25 μL, and the eluent used was chloroform p.a. The results showed that the TLC chromatogram of DST ethanol extract showed 10 dense spots/spots, 6 spots of which could inhibit the growth of S. aureus (spots no. 2-7), and 7 of them (spots no. 1-7) could inhibit the growth of S. epidermidis. Spots with Rf = 0.06; 0.12; 0.27; 0.35 (spots no. 2-5) showed a larger clear zone than spots with Rf = 0.47 and 0.64 (spots no. 6-7) in inhibiting S. aureus. Meanwhile, spot number 1 (Rf = 0) showed the clearest zone among the other 6 spots in inhibiting S. epidermidis. In conclusion, the ethanol extract of old sungkai leaves (DST) has strong antibacterial properties against S. aureus and S. epidermidis. The results of this research have the potential to be developed to obtain potential candidate compounds as antibacterials from sungkai leaves. Keywords: Antibacterial, TLC-bioautography, Peronema canescens Jack, Staphylococcus aureus, Staphylococcus epidermidis
AKTIVITAS ANTIJAMUR PELAPUK KAYU NANOPARTIKEL KITOSAN-EKSTRAK N-HEKSAN DAGING BUAH KAYU GADIS (Cinnamomum parthenoxylon) Ekasari, Munifilia; Nurhasana, Devi; Mudyanto, Andre; Avidlyandi, Avidlyandi; Banon, Charles; Adfa, Morina
Jurnal Biosilampari : Jurnal Biologi Vol 5 No 2 (2023): Biosilampari
Publisher : LP4MK STKIP PGRI Lubuklinggau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31540/biosilampari.v5i2.2401

Abstract

This study aims to synthesize chitosan nanoparticles - n-hexane extract of Cinnamomum parthenoxylon (CP) fruit using the ionic gelation method, to characterize them, and to determine their antifungal activity against the wood-rotting fungi Trametes versicolor and Fomitopsis palustris. Chitosan-CP extract nanoparticles were formulated with chitosan:Na-TPP:CP extract ratio of 1:1:0.5. Particle size and polydispersity index were determined using a particle size analyzer (PSA), and particles morphology was observed using a scanning electron microscope (SEM), and antifungal activity was measured using agar media. The results revealed that the average size of chitosan nanoparticles (base) was 276.9 nm, while the average size of chitosan-CP extract nanoparticles was 807.6 nm. The polydispersity index (PI) of both nanoparticles was greater than 0.7. Observations of the nanoparticles' morphology revealed that aggregation/agglomeration formed in the resulting particles. Both nanoparticles chitosan (base) and chitosan-CP extract inhibited the growth of white rot fungi (T. versicolor) more than brown rot fungi (F. palustris), as measured by the inhibitory zone.
Aktivitas Antibakteri Secara In-Vitro Ekstrak Metanol Excoecaria cochinchinensis Lour dan Kombinasinya dengan Obat Komersial Nurhasana, Devi; Febriansyah, Rahmaga; Avidlyandi, Avidlyandi; S., Salprima Yudha; Banon, Charles; Oktiarni, Dwita; Adfa, Morina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1383

Abstract

The purpose of this study was to look into the antibacterial activity of methanolic extract of Excoecaria cochinchinensis as well as the effect of its combination with antibiotics on the growth of Klebsiella pneumoniae, Enterobacter aerogenes, and Staphylococcus epidermidis. The antibacterial activity test was carried out using the well diffusion method, and the combined effect of the extract and antibiotics was observed using the paper strip diffusion method. At various concentrations (25, 50, 75, 100, 150, 200, and 250 mg/mL), the extract significantly inhibited the growth of K. pneumoniae, E. aerogenes, and S. epidermidis. The inhibitory zone's diameter increased proportionally with the extract concentration. The growth of K. pneumoniae and S. epidermidis was then classified as extremely sensitive (+++) to the addition of the extract at 200 and 250 mg/mL concentrations, meanwhile, E. aerogenes’s with 250 mg/mL of the extract. Secondary metabolites such as oleanolic acid, arjunolic acid, scopoletin, kaempferol, quercetin, diterpenoid compounds, tannins, and other phenolics have been reported from E. cochinchinensis leaves and are thought to be responsible for its antimicrobial activity. The effect of the extract’s combination with antibiotics was insignificant compared to their individual activity, thereby classifying them as indifferent.
Co-Authors Avidlyandi, Avidlyandi Charles Banon Dwita Oktiarni Febriansyah, Rahmaga Khafit Wiradimafan Morina Adfa Mudyanto, Andre Munifilia Ekasari SALPRIMA YUDHA S