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Potensi Daun Pacar Air (Impatiens balsamina L.) dalam Menghambat Pertumbuhan Jamur Rhizopus oryzae L. Adfa, Morina; Ekasari, Munifilia; Avidlyandi, Avidlyandi; Supriati, Rochmah; Yudha S., Salprima
Jurnal Riset Kimia Vol 12, No 2 (2021): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.404

Pacar air (Impatiens balsamina L.) plant belongs to the Balsaminaceae family and is used as an indigenous medicine in Asia for fingernail inflammation, fractures, and rheumatism treatments. Moreover, the antipruritic, antianaphylactic, antifungal, antibacterial, and antitumor activities of some compounds, especially phenolics and quinones from this plant have been studied extensively. Therefore, this study aims to determine the antifungal activity of Pacar air leaves (Impatiens balsamina L.) methanol extract against Rhizopus oryzae L. and the IC50 value. The results showed that an increase in the concentrations of I. balsamina L. leaves methanol extract significantly raised the fungal growth. Furthermore, the extract inhibition against R. oryzae L. at various concentrations of 0.5; 0.7; 0.9; 1.1; and 1.3% w/v were 10, 21.9, 58.06, 68.06, and 79.72%, respectively, while the IC50 value was 0.896%. Hence, the presence of naphthoquinones and other secondary metabolites are responsible for its antifungal activity. Based on these results, the antifungal potential of I. balsamina L. leaves against soft-rot fungi is useful in the future.

Termiticidal Activity of Methanol Extract of Pegagan (Centella asiatica L. Urban) Toward Coptotermes curvignathus Holmgren Dina Erliana; Charles Banon; Avidlyandi Avidlyandi; Rahmaga Febriansyah; Morina Adfa
Mangifera Edu Vol 6 No 2 (2022): Jurnal Mangifera Edu
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/mangiferaedu.v6i2.125

Termiticide activity of methanol extract of Centella asiatica L. Urban against Coptotermes curvignathus Holmgren was investigated using the no choice test. The chemical components of methanol extract of C. asiatica were identified by GC-MS. The antitermite activity showed that the percentage of termite mortality increased when the concentrations of extract increased. The concentrations of 25% indicated the highest termite mortality which reached 100% on the sixth day. Profiling GC-MS methanol extract of C. asiatica revealed 85 chemical components. Based on MS spectral data, 56 chemical components were identified which were grouped into fatty acids (27.09%), esters (23.73%), hydrocarbons (16.56%), ethers (8.28%), sesquiterpenes (1.61 %), alcohol (1.55 %), aldehydes (3.50%), monoterpenes (1.08%), diterpenes (0.67%), steroids (0.43%), and ketones (0.31 %). Among these, the presence of palmitic acid, patchouli alcohol, and β-caryophyllene may be responsible for its termiticide activity. Other compounds such as triterpenoids, saponins, flavonoids, tannins, steroids, and glycosides that were reported previously not detected by GC-MS in this study, possibly contributing to its activity.

Potensi Daun Pacar Air (Impatiens balsamina L.) dalam Menghambat Pertumbuhan Jamur Rhizopus oryzae L. Morina Adfa; Munifilia Ekasari; Avidlyandi Avidlyandi; Rochmah Supriati; Salprima Yudha S.
Jurnal Riset Kimia Vol. 12 No. 2 (2021): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.404

Pacar air (Impatiens balsamina L.) plant belongs to the Balsaminaceae family and is used as an indigenous medicine in Asia for fingernail inflammation, fractures, and rheumatism treatments. Moreover, the antipruritic, antianaphylactic, antifungal, antibacterial, and antitumor activities of some compounds, especially phenolics and quinones from this plant have been studied extensively. Therefore, this study aims to determine the antifungal activity of Pacar air leaves (Impatiens balsamina L.) methanol extract against Rhizopus oryzae L. and the IC50 value. The results showed that an increase in the concentrations of I. balsamina L. leaves methanol extract significantly raised the fungal growth. Furthermore, the extract inhibition against R. oryzae L. at various concentrations of 0.5; 0.7; 0.9; 1.1; and 1.3% w/v were 10, 21.9, 58.06, 68.06, and 79.72%, respectively, while the IC50 value was 0.896%. Hence, the presence of naphthoquinones and other secondary metabolites are responsible for its antifungal activity. Based on these results, the antifungal potential of I. balsamina L. leaves against soft-rot fungi is useful in the future.

Aktivitas Antibakteri Ekstrak Etanol Daun Tapak Kuda (Ipomoea pes-caprae (L.) R. Br.) terhadap Bakteri Staphylococcus epidermidis Sri Wahyu Kurnia Putri; Devi Nurhasana; Avidlyandi Avidlyandi; Irfan Gustian; Sipriyadi Sipriyadi; Morina Adfa
BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Vol 4 No 2 (2021): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

This study aimed to determine the antibacterial activity of the ethanol extract of the leaves of Tapak Kuda (Ipomoea pes-caprae) against Staphylococcus epidermidis. The method used was Kirby-Bauer for the antibacterial test with various concentrations of ethanolic extract of I. pes-caprae leaf extract: 5 mg/mL, 20 mg/mL, 35 mg/mL, and 50 mg/mL, with five replications. The antibiotic clindamycin was used as a positive control, while DMSO was a negative control. The results showed that after 24 hours of incubation, the zone of inhibition of bacterial growth was demonstrated by the experimental and the positive control groups, while the negative control did not show the zone of inhibition. The diameter of the largest inhibition zone (11.40 mm) was at a 50 mg/mL test concentration, which was indicated as a strong category. In conclusion, the ethanolic extract of the leaves of I. pes-caprae can inhibit the growth of S. epidermidis at all test concentrations. Keywords: Antibacterial, Ipomoea pes-caprae, Staphylococcus epidermidis

Kombinasi Ekstrak Metanol Daun Ketepeng Cina (Cassia alata Linn.) dengan Enam Ekstrak Tumbuhan Terpilih dalam Menghambat Pertumbuhan Bakteri Staphylococcus aureus Lisna Hamni; Avidlyandi Avidlyandi; Charles Banon; Khafit Wiradimafan; Deni Agus Triawan; Risky Hadi Wibowo; Morina Adfa
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol 5 No 2 (2022): BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/bioedusains.v5i2.3996

This study aimed to determine the antibacterial activity and the effect of the combination of methanol extract of the leaves of Chinese ketepeng (Cassia alata Linn.) with six selected plant extracts against Staphylococcus aureus bacteria. The method used is well diffusion and paper tape method. The concentration of the test extract was 100 mg/mL (1:1), DMSO 50% v/v was used as a negative control and the antibiotic clindamycin as a positive control. The results showed that most of the combinations of the methanol extract of the Chinese ketepeng leaf (C. alata) with the six selected plant extracts produced an average diameter of the inhibition zone, which was greater than the average diameter of the inhibition zone of every single extract. However, the average diameter of the combined inhibition zones was not more significant than the sum of the average diameters of the inhibition zones of every single extract. In conclusion, the combination of the methanol extract of the Chinese ketepeng leaf (C. alata) with six selected plant extracts had additive/indifferent effects in inhibiting the growth of S. aureus. Keywords: Antibacterial, Cassia alata Linn, Combination, Staphylococcus aureus

EFEKTIVITAS EKSTRAK METANOL DAUN KETEPENG CINA (Cassia alata L.) DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Staphylococcus epidermidis SECARA TUNGGAL DAN KOMBINASI Annisa Putri Hanifa; Dina Erliana; Avidlyandi Avidlyandi; Meika Rizka; Deni Agus Triawan; Sal Prima Yudha S; Morina Adfa
Jurnal Biosilampari : Jurnal Biologi Vol 5 No 1 (2022): Biosilampari
Publisher : LP4MK STKIP PGRI Lubuklinggau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31540/biosilampari.v5i1.1787

The aim of this study was to determine the antibacterial activity and the ccombined effect of methanol extract of the ketepeng cina leaves (Cassia alata L.) with six selected plant extracts against Staphylococcus epidermidis using the diffusion and the paper strip methods at a concentration of 10% w/v. The results showed the average antibacterial activity of each extract showed the inhibitory growth of Staphylococcus epidermidis. The average value of the inhibition zones of the single extract samples of ketepeng cina, sambang darah, ruku-ruku, avocado seed, bungli, pacar air, and sungkai resulted in inhibition zones of 6.28±0.20 mm, 7.90±0.31 mm, 2.30±0.37 mm, 3,53±0.50 mm, 4.35±0.52 mm, and 4.69±0.17 mm, respectively. Furthermore, the combination of methanol extract of ketepeng cina leaves (C. alata) with the six selected plants extract in an average diameter of inhibition zone greater than the average diameter of the inhibition zone of each extract. However, the average diameter of the inhibition zone of the combined extract was not more significant than the sum of the diameter of the inhibition zone of each extract. The conclusion of this study is the combination of the methanol extract of ketepeng cina leaves (C. alata) with six selected plant extracts has an additive/indifferent effect in inhibiting the growth of S. epidermidis.

Liquid Soap with Active Ingredients of Methanol Extract of Sambang Darah Leaves (Excoecaria cochinchinensis L.): Formulation, Characterization, and Antibacterial Activity Fatkhurrachman Fatkhurrachman; Avidlyandi Avidlyandi; Devi Nurhasana; Dina Erliana; Munifilia Eka Sari; Charles Banon; Risky Hadi Wibowo; Morina Adfa
Stannum : Jurnal Sains dan Terapan Kimia Vol 5 No 1 (2023): April 2023
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v5i1.3845

The methanol extract of sambang darah leaves (Excoecaria cochinchinensis L.) contains flavonoids, saponins, tannins and triterpenoids which have the potential as antibacterial compounds. The goal of this research is to produce liquid soap that preparations with four formulas by varying the methanol extract of sambang darah leaves as the active ingredient, characterizing, and understanding its antibacterial activity. Organoleptic tests, foam stability, pH, specific gravity, and viscosity were all used to characterize liquid soap. The best results were obtained with liquid soap formulation 3 (3 g extract), which had foam stability of 84.10%, a pH of 9.62, specific gravity of 1.03 g/mL, and viscosity of 492.933 cP. The organoleptic test revealed that the liquid soap was a homogeneous viscous liquid with a blackish-brown color and a characteristic extract odor. The inhibition zone for antibacterial activity against Staphylococcus aureus and Escherichia coli was 9.15 mm and 13.72 mm, respectively. In antiseptic tests, all soap formulas reduced bacteria on the thumb.

Aktivitas Sitotoksik Ekstrak Metanol Daun Dan Batang Kayu Gadis (Cinnamomum porrectum (Roxb.) Kosterm) Dengan Brine Shrimp Lethality Test (BSLT) Avidlyandi; Suryadi Jaya; Khafit Wirdimafan; Arif Juliari Kusnanda; Charles Banon; Morina Adfa
RAFFLESIA JOURNAL OF NATURAL AND APPLIED SCIENCES Vol. 4 No. 1 (2024): April
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/rjna.v4i1.34980

Penelitian ini bertujuan untuk mengetahui aktivitas sitotoksik ekstrak metanol daun dan batang kayu gadis terhadap Artemia salina Leach dengan metode Brine Shrimp Lethality Test (BSLT). Uji sitotoksik menggunakan 10 ekor larva Artemia salina yang berumur 48 jam pada setiap konsentrasi uji dengan tiga kali ulangan. Ekstrak metanol daun kayu gadis dibuat 3 variasi konsentrasi, yaitu 10 ppm, 100 ppm, dan 1000 ppm, sedangkan ekstrak metanol batang kayu gadis dibuat 4 variasi konsentrasi, yaitu 1 ppm, 2 ppm, 4 ppm dan 6 ppm. Sebagai kontrol digunakan pelarut untuk melarutkan ekstrak. Setelah 24 jam diamati kematian Artemia salina, ditentukan persentase mortality, dan dihitung nilai LC50 menggunakan analisis probit. Hasil penelitian menunjukkan aktivitas sitotoksik ekstrak metanol batang kayu gadis lebih tinggi dari pada ekstrak metanol daunnya, dapat dilihat dari LC50 ekstrak metanol batang lebih kecil (0,79 ppm) daripada ekstrak metanol daunnya (544,81 ppm). Ke-dua ekstrak memperlihatkan kematian 50% hewan uji pada konsentrasi lebih kecil dari 1000 ppm, yang artinya aktivitas sitotoksik yang diberikan berkorelasi positif dengan aktivitas anti kanker. Berdasarkan tinjauan literatur senyawa-senyawa yang berhasil diisolasi dari daun dan batang kayu gadis adalah flavonoid, fenil propanoid, lignan, kumarin, fenolik, asam lemak, dan alkohol. Diharapkan beberapa senyawa tersebut dapat berpotensi sebagai antikanker dimasa mendatang.

PENDAMPINGAN PRAKTIKUM KIMIA KELAS IPA XI DI MADRASAH ALIYAH AL-KARIM BENGKULU TENGAH Avidlyandi Avidlyandi; Adfa Morina; Wiradimafan Khafit; Yudha S Yudha S; Triawan Deni Agus; Wibowo Risky Hadi; Erliana Dina; Sari Munifilia Eka; Endarwati Wiwik Endarwati; Azizah Khusnul; Shari Winda
Indonesian Journal of Community Empowerment and Service (ICOMES) Vol. 4 No. 1: June 2024
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/icomes.v4i1.34461

Praktikum adalah salah satu metode pembelajaran yang dapat meningkatkan minat dan pemahaman siswa terhadap konsep dan teori suatu pelajaran terutama pada mata pelajaran sains seperti kimia. Kegiatan pengabdian kepada masyarakt (PKM) ini bertujuan untuk memberikan pendampingan praktikum kimia sederhana kepada siswa kelas XI IPA di Madrasah Aliyah Al-Karim Bengkulu Tengah. Pendampingan praktikum dilakukan dengan beberapa metode yaitu metode ceramah, project base learning (PBL), diskusi dan evaluasi pemahaman siswa terhadap objek praktikum secara kuantitatif melalui pre-test dan post-test. Berdasarkan hasil observasi dan evaluasi secara langsung, pendampingan praktikum oleh tim pengabdian telah meningkatkan minat dan pemahaman siswa terhadap objek praktikum. Serta melalui kegiatan pengabdian kepada masyarakat ini juga telah mampu mengoptimalkan fungsi laboratorium dengan mengusung prinsip Green Chemistry dengan memanfaatkan bahan-bahan dari sekitar/lingkungan untuk beberapa objek praktikum.

Application of FTIR Spectroscopy and Chemometric to Differentiate Azadirachta excelsa (Jack.) Jacobs Leaves Extracts Based on Solvent Polarity and Assessment of Antibacterial Activity Adfa, Morina; Erliana, Dina; Wiradimafan, Khafit; Triawan, Deni Agus; Yudha S., Salprima; Avidlyandi, Avidlyandi; Rafi, Mohamad
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.10790

ABSTRACT. Azadirachta excelsa is a plant belonging to the same genus as the Indian neem (Azadirachta indica) which is expected to have similar biological activities. However, its active components and pharmacological effects are limited. The composition and quantity of these metabolites in A. excelsa may differ due to different polarities of extracting solvents, so selecting an effective extractive solvent with a high level of biological activity is important. Therefore, in this study, we examined differences in the metabolite finger printing using FTIR-based metabolomics, as well as evaluated their antibacterial activity against Staphylococcus aureus (ATCC 6538) and Escherichia coli (ATCC 8739). A. excelsa was extracted using chloroform, ethyl acetate, ethanol p.a., 70% and 50% ethanol. Extracts obtained were analyzed using FTIR and the inhibition zones were then determined. The results showed that principal component analysis (PCA) could distinguish each sample based on the extraction solvent. In this study, we found 50% and 70% ethanol extracts had similar metabolite compositions and concentrations based on their respective FTIR spectrum. The inhibition zone of A. excelsa extracts ranged from 12.37-17.20 mm and 13.88-15.89 mm against S. aureus and E.coli, respectively. The chloroform extract was more effective against both bacteria. Duncan's further test showed that chloroform extract reduced E. coli similarly to ethyl acetate but not S. aureus. While 50%, 70%, and ethanol p.a. extracts inhibited S. aureus and E. coli equally. Based on these results, the polarity of the extracting solvent had an important influence on the metabolite profile and antibacterial activity of A. excelsa. Keywords: Azadirachta excelsa, antibacterial activity, metabolite fingerprinting, FTIR.

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