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ANALYSIS OF PHYTOCHEMICAL SUBSTANCE AND THE EFFECT OF CANG SALAK TEA (CST) DIET TO LIPID PROFILE ON HYPERLIPIDEMIC RAT Karta, I Wayan; Burhannuddin, Burhannuddin; Kartawidjajaputra, Felicia
JST (Jurnal Sains dan Teknologi) Vol 10, No 2 (2021)
Publisher : Universitas Pendidikan Ganesha

The bark of Sibetan snakefruit (Salacca zalacca) and sappan wood (Caesalpinia sappan L.) are combined into the product of Cang Salak Tea (CST). This tea is expected to be useful for diseases associated with dyslipidemia. The purpose of this study was to examine the secondary metabolites in CST and to determine the effect of CST treatment on the lipid profile of total cholesterol (TC), triglyceride (TG), HDL, and LDL level. Wistar rats were divided into three groups: control group (K), hyperlipidemic rats group given CST (P1), and hyperlipidemic rat group without CST treatment. Group P1 was given CST as much as 1.2 mL per day for 4 weeks. CST contains alkaloid, flavanoid, tannin, phenol, and saponine. Flavonoid level about 81.026 ppm; tannin 525.706 ppm, IC50 177.689 ppm, and phenol 622.7844 ppm. There were significant differences in the lipid profile of K and P1 with P2. CST treatment to hyperlipidemic rats can reduce total cholesterol and normalize level of TG, HDL, and LDL. The active substance in CST has role in lipid metabolism, so it can improve the lipid profile of hyperlipidemic rats.

Cholesterol-lowering Effect of Soy Nuts and Tempeh on Hypercholesterolemic Subjects Zulaikha, Hermawati Nur; Dijaya Muliadi, Rendy; Kartawidjajaputra, Felicia; Antono, Lina
Journal Akademik Universitas Swiss German Vol. 4 No. 2 (Feb 2023)
Publisher : Swiss German University & Perhimpunan Penggiat Pangan Fungsional dan Nutrasetikal Indonesia (P3FNI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33555/jffn.v4i2.100

Exploration towards food with cholesterol-lowering property would be beneficial to reduce the incidents of cardiovascular caused by increasing number of people with hypercholesterolaemia. As much as 42 participants with total cholesterol (TC) levels ≥4.92 mmol/L were studied in a three-arms parallel intervention trial. As much as 72g soy nuts and 66g tempeh were consumed daily (25g soy protein/day) for six weeks, while control group was not given any sample. TC level and body composition were measured before and after the treatment for all groups. In soy nuts group, lower TC level was observed (-0.85±0.82 mmol/L, p<0.05) compared to the control group. Meanwhile in tempeh group, non-significant lower TC level was also observed (-0.40±1.19 mmol/L). Differences in body composition parameters were also measured and resulted in significant lower body weight, fat, and visceral fat in soy nuts group (p<0.05) while in tempeh group, only body weight and waist circumference were significantly decreased (p<0.05). This study suggested that daily consumption of soy nuts and tempeh containing 25g soy protein for six weeks showed a tendency to lower TC levels in hypercholesterolaemic-Indonesian participants. A more significant effect might be observed in subject with higher TC levels; and thus, further study is encouraged.

ANALYSIS OF PHYTOCHEMICAL SUBSTANCE AND THE EFFECT OF CANG SALAK TEA (CST) DIET TO LIPID PROFILE ON HYPERLIPIDEMIC RAT Karta, I Wayan; Burhannuddin, Burhannuddin; Kartawidjajaputra, Felicia
JST (Jurnal Sains dan Teknologi) Vol. 10 No. 2 (2021)
Publisher : Universitas Pendidikan Ganesha

The bark of Sibetan snakefruit (Salacca zalacca) and sappan wood (Caesalpinia sappan L.) are combined into the product of Cang Salak Tea (CST). This tea is expected to be useful for diseases associated with dyslipidemia. The purpose of this study was to examine the secondary metabolites in CST and to determine the effect of CST treatment on the lipid profile of total cholesterol (TC), triglyceride (TG), HDL, and LDL level. Wistar rats were divided into three groups: control group (K), hyperlipidemic rats group given CST (P1), and hyperlipidemic rat group without CST treatment. Group P1 was given CST as much as 1.2 mL per day for 4 weeks. CST contains alkaloid, flavanoid, tannin, phenol, and saponine. Flavonoid level about 81.026 ppm; tannin 525.706 ppm, IC50 177.689 ppm, and phenol 622.7844 ppm. There were significant differences in the lipid profile of K and P1 with P2. CST treatment to hyperlipidemic rats can reduce total cholesterol and normalize level of TG, HDL, and LDL. The active substance in CST has role in lipid metabolism, so it can improve the lipid profile of hyperlipidemic rats.

Metabolic Diseases Predictor Analysis Based on Single Nucleotide Polymorphisms and Lifestyle Factors: Preliminary Study in Indonesia Subali, Dionysius; Setiawan, James; Kimberly, Patricia; Dijaya, Rendy; Kartawidjajaputra, Felicia; Antono, Lina; Christos, Revelo Eved; Wibisana, Lenny Mulianie; Shih, Yang-Chia
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.527

Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease (CVD) emerged as a cause of high mortality rates in low-middle-income countries, including Indonesia. Understanding predictor variables to the commonly used biomarkers, including lipid profiles and blood glucose levels, can thus be beneficial in disease prevention strategies. To support that, this study aims to analyze the genetic, lifestyle, and disease history variables as predictors towards lipid and blood glucose profiles. The respondent’s data were collected from clinical data, food recall, health history, and genetic profiling. From the results, APOA5 rs662799 is positively correlated with triglyceride (TG) levels. Sugar, fat, fiber, and calorie intake also significantly affect lipid and blood glucose profiles. Exercise conditions such as aerobic and flexibility exercise duration significantly correlated with low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) profiles. Disease history in individuals and families emerged as additional variables associated with the response variables. These findings can serve as a preliminary study for understanding health predictors that can be used to predict incident of metabolic diseases in the Indonesian population.

The Effect of Energy Gel Administration in Preventing Declining Running Performance of Healthy Recreational Runners Sari, Salsabila Permata; Purba, Patricia Roulina; Oktaviani, Carissa Ramadhania; Muliadi, Rendy Dijaya; Antono, Lina; Kartawidjajaputra, Felicia
Sport and Nutrition Journal Vol. 7 No. 2 (2025)
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/spnj.v7i2.33652

A half-marathon is a type of endurance sport that is increasingly popular in Indonesia. During endurance activities, the body experiences a decrease in glycogen reserves and blood glucose levels, which can lead to reduced physical performance and increased fatigue. Energy gels are concentrated sources of carbohydrates to provide fast-absorbing energy during exercise. Consuming energy gels during running is considered beneficial for maintaining performance and preventing fatigue. Most research on energy gel consumption focused on trained athletes; the effect of energy gel consumption for recreational runners, however, is unclear. The objective of this study was to examine the impact of energy gel consumption on maintaining running performance in healthy, recreational Indonesian half-marathon runners. In this crossover study, sixteen recreational runners received energy gel (28 g/serving carbohydrate), konjac jelly (4 g/serving carbohydrate), and mineral water supplementation on three separate occasions during their running. Self-reported performance data (running duration, distance, elevation, rate of perceived exertion, and heart rate) were collected using a web-based questionnaire after each session, and assessed with the Friedman Test and the Wilcoxon Signed Ranks Test. In this study, energy gel consumption significantly reduced the rate of perceived exertion (RPE) compared to mineral water consumption (p < 0.05). However, no significant effect on running duration (p>0.05) nor heart rate (p>0.05) was observed.

Correlation of the cd36 rs1761667 Polymorphism and Lifestyle Factors with Fatty Acid Perception Threshold Subali, Dionysius; Soegiarto, Elena; Lizuardi, Ardy; Dijaya, Rendy; Kartawidjajaputra, Felicia; Antono, Lina; Delano, Richie
Journal of Health and Nutrition Research Vol. 5 No. 1 (2026)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v5i1.658

Genetic variations, such as in the CD36 gene (rs1761667), may influence fat perception and dietary patterns, contributing to obesity. This cross-sectional study involved 87 office workers who underwent genotyping for cd36 rs1761667, sensory testing for oleic acid perception threshold, and assessments of body composition, physical activity, and dietary intake. No direct association was found between the cd36 rs1761667 genotype and the fatty acid perception threshold (p > 0.05). However, stratified analyses revealed that men carrying the A allele (GA/AA, n=23) had a higher body fat percentage compared to those with the GG genotype (n=11). In women, GA/AA carriers consumed more protein, while GG carriers derived a higher proportion of energy from carbohydrates. Among overweight individuals, GG carriers reported higher carbohydrate intake than A allele carriers (p=0.026). These findings suggest that while cd36 rs1761667 may not be a primary determinant of fat taste sensitivity in this cohort, it may contribute modestly to body fat composition and dietary behaviors through interactions with gender and BMI status.

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