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All Journal Jurnal Media Gizi Indonesia (MGI) Journal of Health and Nutrition Research
Dijaya, Rendy
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Health Professions Medicine & Pharmacology Nursing Public Health

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Metabolic Diseases Predictor Analysis Based on Single Nucleotide Polymorphisms and Lifestyle Factors: Preliminary Study in Indonesia Subali, Dionysius; Setiawan, James; Kimberly, Patricia; Dijaya, Rendy; Kartawidjajaputra, Felicia; Antono, Lina; Christos, Revelo Eved; Wibisana, Lenny Mulianie; Shih, Yang-Chia
Journal of Health and Nutrition Research Vol. 4 No. 3 (2025)
Publisher : Media Publikasi Cendekia Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56303/jhnresearch.v4i3.527

Abstract

Type 2 Diabetes Mellitus (T2DM) and cardiovascular disease (CVD) emerged as a cause of high mortality rates in low-middle-income countries, including Indonesia. Understanding predictor variables to the commonly used biomarkers, including lipid profiles and blood glucose levels, can thus be beneficial in disease prevention strategies. To support that, this study aims to analyze the genetic, lifestyle, and disease history variables as predictors towards lipid and blood glucose profiles. The respondent’s data were collected from clinical data, food recall, health history, and genetic profiling. From the results, APOA5 rs662799 is positively correlated with triglyceride (TG) levels. Sugar, fat, fiber, and calorie intake also significantly affect lipid and blood glucose profiles. Exercise conditions such as aerobic and flexibility exercise duration significantly correlated with low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) profiles. Disease history in individuals and families emerged as additional variables associated with the response variables. These findings can serve as a preliminary study for understanding health predictors that can be used to predict incident of metabolic diseases in the Indonesian population.
Effects of Tele-Exercise on Body Composition, Lipid Profile, Mental Health, and SIRT1 Gene Expression in Obese Office Employees in Indonesia Kuswari, Mury; Rimbawan, Rimbawan; Hardinsyah, Hardinsyah; Dewi, Mira; Gifari, Nazhif; Pamungkas, Rian Adi; Seprianto, Seprianto; Himarwan, Aditya; Putra, Felicia Kartawidjaja; Dijaya, Rendy; Subali, Dionysius
Media Gizi Indonesia Vol. 21 No. 1 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i1.75-89

Abstract

Tele-exercise delivers remote physical activity programs via digital platforms, enhancing accessibility and adherence, making it a promising strategy to address obesity among workers. This study aimed to evaluate the effects of tele-exercise programs on body fat percentage, lipid profile, mental health measures and Sirtuin 1 (SIRT1) gene expression measured via venipuncture & RT-PCR in obese office employees. A total of 33 overweight or obese employees (male/female, 18-45 years old, Body Mass Index (BMI) 23-30 kg/m2) were randomly assigned to the strength (SE) group, strength-cardio (SC) group, and control (CT) group. The strength exercise protocol included core training, circuit training, High Intensity Interval Training (HIIT) and Tabata training; cardio exercise includes low-high impact aerobic exercises. Each group was given nutrition education, whereas the two intervention groups participated in tele-exercise three times/week for twelve weeks. Tele-exercise was delivered via ZOOM application. Mental health indicators were measured using the Depression Anxiety Stress Scale (DASS-42) questionnaire. Compliance levels between intervention groups did not differ significantly (p>0.05). There was a significant reduction in bodyweight in the SC group (p=0.046). Blood High Density Lipoprotein (HDL) levels increased only in the SC group (0.50 mg/dL), but decreased in the SE group and CT group. SIRT1 gene expression increased in SE and CT groups (2.39- and 5.33-fold, respectively), whereas a significant decrease was observed in the SC group (p=0.043). Only the SE group showed a significant reduction in stress level (p=0.03), with a decrease of 30.9%. Strength exercise intervention improves total cholesterol level by -19.09 mg/dL. 
Co-Authors Antono, Lina Christos, Revelo Eved Dionysius Subali Gifari, Nazhif Hardinsyah Himarwan, Aditya Kartawidjajaputra, Felicia Kimberly, Patricia Mury Kuswari Putra, Felicia Kartawidjaja Rian Adi Pamungkas Rimbawan , Seprianto, Seprianto Setiawan, James Shih, Yang-Chia Wibisana, Lenny Mulianie