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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Berkala Epidemiologi INDONESIAN JOURNAL OF PHARMACY Jurnal Respirasi (JR) Biomolecular and Health Science Journal Indian Journal of Forensic Medicine & Toxicology

Prastuti Asta Wulaningrum

Department Of Pulmonology And Respiratory Medicine, Universitas Airlangga Teaching Hospital, Surabaya

Author-ID : 2762411

Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Articles

Seorang Penderita Tuberkulosis Testis Prastuti Asta Wulaningrum
Jurnal Kedokteran Syiah Kuala Vol 6, No 2 (2006): Volume 6 Nomor 2 Agustus 2006
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstrak. Seorang laki - laki, berusia 40 tahun, dengan diagnosis, TB testis kiri, limfadenopati kelenjar inguinal kanan maupun kiri, kecurigaan adanya HIV karena riwayat seks bebas, anemia dan hipoalbuminemia. Hal ini dapat disebabkan oleh antara lain penyebaran hematogen, limfogen, aliran batik urin, dan jarang melalui kontak seksual. Pasien ini mendapatkan terapi obat anti tuberkulosis danmengalarni perbaikan secara klinis. (JKS2006; 2:69-74) Kata Kunci : Tuberkulosis, testis Abstract. A 40 years old man had the diagnosis: left testis TB, right and left inguinal lymphadenopathy gland. It is suspected that this man has HIV since he has a free sex history ,anemia and hypoalbuminemia. This may be caused by the spreading of hematogenous, limfogen, backflow of urine, and rarely through the sexual contacts. The patient is getting anti-tuberculosis drug therapy and as a result his condition shows a clinical improvement. (JKS 2006; 2:69-74) Keywords : Tuberculosis, testis

Effects of Probiotics and Vitamin B Supplementation on IFN-γ and IL-12 Levels During Intensive Phase Treatment of Tuberculosis Budi Suprapti; Suharjono Suharjono; Rahmawati Raising; Yulistiani Yulistiani; Zamrotul Izzah; Wenny Putri Nilamsari; Prastuti Asta Wulaningrum; Arief Bachtiar
Indonesian Journal of Pharmacy Vol 29 No 2, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Tuberculosis is an acute infectious disease that primarily affects the lungs. Probiotics supplementation can increase the number and activity of NK cell in peripheral blood by modulation of IL-12, thus increasing IFN-γ production by Th1 response. Vitamin B1 acts on macrophages and affects neutrophil motility. Vitamin B6 is associated with the release of cytokines and the responsiveness of NK cells, while vitamin B12 affects to lymphocytes, Tcell proliferation, CD4+ ratios, and NK cell activity. To analyze the effects of probiotics and vitamin B1, B6, B12 supplementation on IFN-γ and IL-12 levels during intensive phase of antituberculosis treatment. The study was pre-post test randomised control by time series. The control group was TB patients with standard therapy of antituberculosis and vitamin B6, while the intervention group was TB patients receiving therapy plus once daily probiotics and vitamin B1, B6, B12supplementation during the intensive phase. Blood samples were withdrawn at baseline, one month, and two months after therapy to measure plasma IFN-γ and IL-12 levels using the ELISA method. Twenty two patients were divided equally into two groups. There was a tendency to greater increase of IFN-γ in the first month of the intervention group, followed by a significant decline after two-month therapy (p < 0.05). In both groups there was a rise in IL-12 levels after one month followed by a decrease in the second month (p > 0.05). However, the percentage was higher in the supplementation group. Adding probiotics and vitamins B1, B6, B12 could improve immune response through IL-12 and IFN-γ modulation during intensive phase therapy.

Factors Cause of Switching Shorter Regimen to Longer Regimen in Multidrug-Resistant/ Rifampicin-Resistant Tuberculosis Treated Patients in Dr. Soetomo Hospital Surabaya, Indonesia Soedarsono Soedarsono1,2, Tutik Kusmiati1,2, Prastuti Asta Wulaningrum1 , Ariani Permatasari1 , Dwi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i1.13636

Background: Indonesia started to implement the Shorter Regimen (STR) since 2017, but not all of MDR/RR-TB patients were treated with STR until the end of treatment. The presence of side effects of one orseveral drugs in the STR and the resistance to fluoroquinolone and or 2nd line injection drug after startingtreatment caused a switch in regimen from STR to a longer regimen. This study was conducted to evaluatethe factors that caused switch STR to the longer regimen.Methods: This was a descriptive study in MDR/RR-TB patients who received STR from October 2017to December 2019. Patients who switch their regimen were analyzed and determine the factors cause ofswitching STR to a longer regimen.Conclusion: The major cause of switching was due to the presence of resistance to fluoroquinolone and 2ndline injection drugs and incidence of prolonged QT. A diagnostic rapid test such as the line probe assay 2ndline TB drugs is absolutely a screening tool to determine MDR-TB patients, pre-XDR-TB or XDR TB assoon as the regimen is given. Monitoring and efforts to overcome prolonged QT side effects are also neededto prevent switch regimens that can affect the patient’s psychological condition.

Association between Smoking Habit and Pulmonary Tuberculosis at Dr. Soetomo General Academic Hospita Balivia Andi Permata Hapsari; Prastuti Asta Wulaningrum; Rimbun Rimbun
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.30641

Introduction: Smoking has been reported as one of tuberculosis (TB) risk factor. The association between smoking and TB has been proven in multiple studies, but little known about the association between smoking degree and sputum smear positive. Methods: An analytic observational study using cross-sectional design. Data of patients with pulmonary TB conducted at DOTS (Directly Observed Treatment Short course)/MDR (Multi Drug Resistance) outpatient and inpatient ward in Dr Soetomo General Hospital Surabaya from January to October 2018. The degree of smoking was measured using Brinkman Index (BI). The odds ratio (OR) and 95% confidence intervals (CI) were also estimated.Results: There were 94 patients with pulmonary TB, 56 non-smoker and 38 smoker. Light smoking (P = 0,120, OR = 0.200, 95% CI: 0.022-1.823), moderate smoking (P=0.377, OR = 1.667, 95% CI: 0.533-5.209), heavy smoking (P=0.076, OR= 0.333, 95% CI: 0.96-1.160). Moderate smoking compared to heavy smoking as a control (P=0.33, OR = 5.000, 95% CI=1.096-22.820). Conclusion: There’s no significant correlation between smoking habits and sputum smear positive, but the present study evidenced the patients with smoking habits had greater chance to get sputum smear positive than non-smokers. Patient with moderate smoking compared to heavy smoking had greater chance to get sputum smear positive.

Appendicular Tuberculosis as Manifestation of Gastrointestinal Tuberculosis: A Case Report Yuliza Yuliza; Alfian Nur Rosyid; Wiwin Is Effendi; Prastuti Asta Wulaningrum; Herley Windo Setiawan
Jurnal Respirasi Vol. 7 No. 3 (2021): September 2021
Publisher : Faculty of Medicine Universitas Airlangga

Introduction: Gastrointestinal tuberculosis (GI TB) is quite rare with 3% incidence of all extrapulmonary involvement. Appendicular TB may occur in 0.1 - 3% of cases. Diagnosis is often difficult because the patient usually complains about chronic abdominal pain and fever. A definite diagnosis is based on histopathological examination of resected specimens from the appendectomy procedure.Case: We present a 37-year-old male patient admitted to the hospital with chronic abdominal pain, fever, nausea, and loss of body weight. The patient never had a persistent cough, hemoptysis, or night sweating. Physical examination showed pain and muscular rigidity in the right iliac area during palpation with Blumberg's sign and Rovsing's sign positive. Abdomen ultrasound imaging showed an appendicular abscess. The patient underwent appendectomy afterwards with histopathology result showing TB. The patient was treated with first category anti-tuberculosis drugs (ATD).Discussion: Diagnosis of appendicular TB is difficult due to unspecific clinical presentations. Appendicular TB patients often complain of signs and symptoms which are similar to acute appendicitis. These conditions can delay ATD treatment because the definitive diagnosis could be made after histopathological examination.Summary: Appendicular TB is a rare case of extrapulmonary TB. It can present as acute appendicitis. The definitive diagnosis is based on the histopathological examination. It is recommended to check the appendicectomy specimens histopathologically to exclude TB or other diseases.

ANALYSIS OF RISK FACTORS FOR DEATH IN PATIENTS WITH COVID-19 IN 2021 AT UNIVERSITAS AIRLANGGA HOSPITAL: Analisis Faktor Risiko Kematian Pada Penderita COVID-19 Tahun 2021 di Rumah Sakit Universitas Airlangga Ayunda Solehan, Zahra; Atikasari, Fitri; Dwi Artanti, Kurnia; Asta Wulaningrum, Prastuti; Is Effendi, Wiwin; Yi Li, Chung
Jurnal Berkala Epidemiologi Vol. 12 No. 3 (2024): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V12I32024.230-237

Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV2, first detected in China in 2019. This disease causes respiratory infections and significantly impacts global health. Purpose: This study aims to analyze the risk factors for mortality in COVID-19 patients at Universitas Airlangga Hospital in 2021. Methods: This observational analytical study uses a case-control design, including 168 samples with 64 cases and 64 controls. Secondary data from patient medical records at Universitas Airlangga Hospital, including age, gender, education, comorbidities, oxygen saturation, and length of stay. Chi-square tests analyzed the data with a 95% confidence level (α=5%). Results: The analysis revealed significant associations between COVID-19 mortality and several factors. Age (p=0.01; OR=3.24; 95%CI=1.57-6.65), gender (p=0.01; OR=2.2; 95%CI=1.17-4.02), education (p=0.00; OR=2.40; 95%CI=1.11-5.40), comorbidities (p=0.08; OR=2.50; 95%CI=1.26-4.91), and oxygen saturation (p=0.00; OR=5.40; 95%CI=117.10-2490.06) were significantly associated with COVID-19 mortality. Oxygen saturation was the most influential factor (p=0.00; OR=901.73; 95%CI=120.75-6733.48) associated with mortality. Conclusion: Age, gender, education, comorbidities, and oxygen saturation significantly affect Covid-19 mortality rates. This study highlights the importance of monitoring and managing these risk factors in managing COVID-19 at Universitas Airlangga Hospital.

Co-Authors Arief Bachtiar Atikasari, Fitri Ayunda Solehan, Zahra Balivia Andi Permata Hapsari Budi Suprapti Dwi Artanti, Kurnia Effendi, Wiwin Is Herley Windo Setiawan Is Effendi, Wiwin Rahmawati Raising Rimbun Rimbun Rosyid, Alfian Nur Suharjono, Suharjono WENNY PUTRI NILAMSARI Yi Li, Chung Yulistiani Yulistiani Yuliza Yuliza Zamrotul Izzah

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