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All Journal Journal of Health Sciences and Medical Development Pharmacology And Pharmacy Scientific Journals (PAPS Journals) Journal of Pharmaceutical Science and Herbal Technology Jurnal Medika: Medika
Sadsyam, Sriyanty
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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FORMULATION OF ANTI-ACNE MASK OF PAPAYA LEAF EXTRACT (Carica papaya L.) AND HONEY AGAINST Propionibacterium acn Wali, Putri; Asri SR, Muhammad; Sadsyam, Sriyanty
Journal of Pharmaceutical Science and Herbal Technology Vol. 9 No. 1 (2024): Journal of Pharmaceutical Science and Herbal Technology
Publisher : STIKES Nani Hasanuddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Papaya leaves (Carica papaya L.) are ornamental plants that are very useful because they contain alkaloids, flavonoids, saponins, tannins and terpenoids. The alkaloids here have antibacterial properties. Honey is usually used as an antibacterial. Apart from being an antibacterial, honey is also an antioxidant because honey contains vitamin C. Acne (Acne vulgaris) is a skin disease caused by chronic inflammation with a complex pathogenesis, involving the sebaceous glands caused by the bacteria Propiobacerium acne. This research aims to determine whether the anti-acne mask formulation of papaya leaf extract and honey is physically and chemically stable and that the anti-acne mask formulation of papaya leaf extract and honey has anti-acne activity against Propionibacterium acne. This research is an experimental laboratory using the diffusion technique so that the well method is used to determine the diameter of the inhibition zone and for data analysis using the one-way ANOVA test. The results of research on the formulation of an anti-acne mask from papaya leaf extract and honey are physically and chemically stable. The anti-acne mask formulation of papaya leaf and honey extract has antibacterial activity against Propionibacterium acne with an inhibition zone of 17.2 mm (strong) in formulation 1, 19.6 mm (strong) in formulation 2, 19.8 (strong) in formulation 3 and 21.9 mm (very strong) on ​​the positive cotrol, namely benzolac (Benzolic peroxide).
Exploring the Potent Anti-Hyperglycemic Properties of Red Betel Leaf Ethanol Extract Fraction on Male Wistar Rats Upi, Andi Ulfiana Utari; Aliah, Ahmad Irsyad; Hasniah; Basir, Nasrawati; Sadsyam, Sriyanty
Journal of Health Sciences and Medical Development Vol. 2 No. 03 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i03.267

Abstract

Hyperglycemia is characterized by an increase in blood glucose levels exceeding 200 mg/dL, an initial symptom of diabetes mellitus. Hyperglycemia can be addressed through traditional treatment with Red Betel Leaf. Red betel leaf contains phytochemical compounds, including flavonoids. Flavonoid compounds in red betel leaves possess antioxidant properties. These antioxidants can scavenge hydroxyl radicals that damage the β cells of the pancreas, thereby maximizing insulin production. Empirically, the flavonoid content in red betel leaves has been shown to lower blood glucose levels and cure diabetes mellitus. An effectiveness test of the anti-hyperglycemic properties of the ethanol extract fraction of red betel leaf was conducted. This research aimed to determine the effectiveness of the ethanol extract fraction of red betel leaf on male white rats. The method employed in this study was laboratory experimentation. Fifteen rats were divided into five treatment groups: Group I, healthy control without treatment; Group II, negative control with Na.CMC administration; Group III, positive control with glibenclamide administration; Group IV, the polar group with polar extract suspension of red betel leaf administration; Group V, the nonpolar group with nonpolar extract suspension of red betel leaf administration. In conclusion, administering the polar fraction was more effective in reducing blood glucose levels than the nonpolar fraction.
POTENSI EKSTRAK ETANOL BUAH KELOR (Moringa oleifera L.) SEBAGAI BAHAN AKTIF SEDIAAN GEL TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS PUTIH JANTAN Sadsyam, Sriyanty; Awaluddin, Nurhikma; Suharniayanti, Suharniayanti
Pharmacology And Pharmacy Scientific Journals Vol. 4 No. 1: Juni, 2025, PAPS
Publisher : Unit Publikasi Ilmiah Perkumpulan Intelektual Madani Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51577/papsjournals.v4i1.692

Abstract

Ekstrak Buah Kelor (Moringa oleifera L.) memiliki senyawa alkaloid, flavonoid, tannin, fenol, yang dapat menyembuhkan luka diabetes pada tikus putih Jantan. Penelitian ini bertujuan untuk mengetahui bahwa ekstrak etanol buah kelor (Moringa oleifera L.) dapat dijadikan sediaan gel yang stabil secara fisika dan kimia dan untuk mengetahui pada konsentrasi efektif ektrak etanol buah kelor (Moringa oleifera L.) dapat menyembuhkan luka diabetes pada tikus putih Jantan. Metode penelitian ini dilakukan secara eksperimental laboratorium. Ekstrak buah kelor dimaserasi dengan pelarut etanol 96%, lalu hasil diekstraksi diambil 5%,10% dan 15% untuk dibuat menjadi sediaan gel penyembuh luka diabetes dengan variasi konsentrasi F1 (5%), F2 (10%), dan F3 (15%). Selanjutnya dilakukan pengujian pada luka diabetes pada tikus putih jantan. Hasil formulasi sediaan gel ekstrak buah kelor (Moringa oleifera L.) menunjukkan stabil pada pengujian organoleptik, homogenitas, pH, viskositas, daya lekat dan daya sebar. Hasil uji terhadap luka diabetes menunjukkan bahwa F1 memiliki persentase penurunan diameter luka 100% pada hari ke-19, sedangkan untuk F2 dan F3 memiliki persentase penurunan diameter luka 100% pada hari ke-18 dan hari ke-17. Hasil analisis statistik One Way ANOVA, menunjukkan perbedaan yang signifikan (p<0,05) persentase penurunan diameter luka diabetes pada tikus putih jantan dan konsentrasi efektif F3 (15%). Moringa fruit extract (Moringa oleifera L.) has alkaloid, flavonoid, tannin, and phenol compounds that can heal diabetic wounds in male white rats. This study aims to determine that moringa fruit ethanol extract (Moringa oleifera L.) can be used as a physically and chemically stable gel preparation and to determine the concentration of moringa fruit ethanol extract (Moringa oleifera L.) that is effective in healing diabetic wounds in male white rats. This research method was conducted experimentally in the laboratory. Moringa fruit extract was macerated using 96% ethanol solvent, then the extraction results were taken 5%, 10%, 15% to be used as a gel preparation as a diabetic wound healing gel with variations in concentration, namely F1 (5%). F2 (10%), and F3 (15%). Furthermore, testing was carried out on diabetic wounds in male white rats. The results of the formulation of moringa fruit extract gel preparation (Moringa oleifera L.) showed stable in organoleptical testing, homogeneity, pH, viscosity, adhesion and spreadability. The test results on diabetic wounds showed that F1 had a percentage decrease in wound diameter of 100% on day 19, while for F2 and F3 had a percentage decrease in wound diameter of 100% on day 18 and day 17. The results of One Way ANOVA statistical analysis, showed a significant difference (p<0.05) in the percentage of diabetic wound diameter reduction in male white rats and the effective concentration of F3 (15%).
Peran Apoteker Dalam Edukasi Obat Untuk Lansia di Desa Belabori Kab. Gowa Awaluddin, Nurhikma; Basir, Nasrawati; Sadsyam, Sriyanty; Awaluddin, Akbar
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/c3qm7k08

Abstract

Di Indonesia, populasi usia lanjut terus meningkat seiring dengan tingginya angka harapan hidup. Menurut Badan Pusat Statistik, jumlah penduduk lansia di Indonesia pada tahun 2024 diperkirakan mencapai lebih dari 26 juta orang. Lansia sering kali menghadapi berbagai tantangan kesehatan yang kompleks, termasuk penyakit kronis seperti diabetes, hipertensi, dan gangguan jantung. Selain itu, mereka juga cenderung menggunakan beberapa jenis obat secara bersamaan, yang dikenal sebagai polifarmasi. Polifarmasi dapat meningkatkan risiko terjadinya efek samping, interaksi antar obat, serta kesalahan penggunaan obat, yang semuanya dapat berdampak negatif pada kesehatan lansia. Dalam konteks ini, peran apoteker menjadi sangat vital. Apoteker memiliki pengetahuan mendalam tentang farmakologi, termasuk mekanisme kerja obat, interaksi obat, dan efek samping yang mungkin terjadi. Dengan pengetahuan ini, apoteker dapat memberikan edukasi yang tepat kepada lansia mengenai cara penggunaan obat yang aman dan efektif. Edukasi ini meliputi informasi mengenai dosis yang benar, waktu yang tepat untuk mengonsumsi obat, serta tanda-tanda efek samping yang perlu diwaspadai. Selain itu, apoteker juga dapat membantu lansia dalam memahami pentingnya mematuhi regimen pengobatan yang telah ditentukan oleh dokter, sehingga dapat mencegah komplikasi yang lebih serius. Pemeriksaan kesehatan secara berkala juga merupakan aspek penting dalam pengelolaan kesehatan lansia. Melalui pemeriksaan rutin, masalah kesehatan dapat terdeteksi lebih awal, sehingga penanganan yang tepat dapat dilakukan. Apoteker dapat berkontribusi dalam hal ini dengan mengedukasi masyarakat tentang pentingnya pemeriksaan kesehatan dan bagaimana cara mengakses layanan kesehatan yang ada. Dengan memberikan informasi yang akurat dan mudah dipahami, apoteker dapat memberdayakan lansia untuk mengambil keputusan yang lebih baik terkait kesehatan mereka.
Co-Authors Aliah, Ahmad Irsyad Asri SR, Muhammad Awaluddin, Akbar Nasrawati Basir Nurhikma Awaluddin RR. Ella Evrita Hestiandari Suharniayanti, Suharniayanti Upi, Andi Ulfiana Utari Wali, Putri