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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Ilmiah Kesehatan Sandi Husada
Reymon, Reymon
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Computer Science & IT Health Professions Medicine & Pharmacology Nursing Public Health

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Analysis of blood calcium levels in calcium water consumers Rubak, Bonni; Umar, Ani; Reymon, Reymon; Jannah, Nanda Reski
Jurnal Ilmiah Kesehatan Sandi Husada Vol 13 No 2 (2024): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v13i2.1216

Abstract

Introduction: Water is a primary and basic human need. One of the chemical parameters that must be met for drinking water needs is mineral content, such as calcium and magnesium. Water hardness is a condition in which there is excessive calcium and magnesium content, which is commonly known as calcareous water. If consumed long-term, high-water hardness that exceeds normal limits can interfere with body health. Specifically, excess calcium in the body can cause hypercalcemia, hyperparathyroidism, kidney stones, and muscle tissue damage (muscle weakness). Objective: This study aims to determine blood calcium levels in individuals who consume calcareous healthy water. Methods: The type of research used is descriptive-analytical, with blood calcium level analysis carried out using the Ion Selective Electrode (ISE) method through the Electrolyte Analyzer (CBS400). Result: Based on the results of the study, it was obtained that blood calcium levels in 30 community respondents in Ranomeeto District (100%) were above the reference value, indicating high blood calcium levels. Conclusion: blood calcium levels in people who consume lime juice indicate high blood calcium levels. Consuming water with a high lime content can hurt health. Therefore, people need to consider the quality of the drinking water they drink, especially those that have a high lime content, to maintain heart and kidney health in the long term.
Rimpang Etlingera rubroloba A.D. Poulsen sebagai Kandidat Imunostimulator terhadap Fagositosis Makrofag dan Sel CD8 Ilyas Y., Muhammad; Reymon, Reymon; Rasak, Adriatman; Rubak, Bonni; Pascayantri, Asniar; Malik, Fadhliyah; Jabbar, Asriullah; Wahyuni, Wahyuni; Setiawan, La Ode Roni; Halik, Halik; Sahidin, Idin
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.52621

Abstract

Etlingera rubroloba A.D. Poulsen merupakan tumbuhan yang digunakan secara tradisional oleh masyarakat Sulawesi Tenggara untuk menjaga kebugaran tubuh dan telah terbukti secara ilmiah mampu meningkatkan sistem imun bawaan melalui peningkatan ekspresi reseptor sel makrofag (CD14). Namun, pengaruhnya terhadap aktivitas fagositosis makrofag dan kadar sel limfosit T sitotoksik (CD8+) belum pernah dilaporkan. Penelitian ini bermaksud mengevaluasi ekstrak etanol rimpang E. rubroloba terhadap efek peningkatan fagositosis makrofag dan kadar CD8+ pada tikus putih (Rattus norvegicus) galur Wistar. Sebanyak 24 ekor tikus dibagi enam kelompok, yaitu kontrol normal, kontrol negatif, kontrol positif, serta kelompok ekstrak dosis 200, 300, dan 400 mg/kg BB. Ekstrak diberikan secara oral selama tujuh hari, kemudian pada hari kedelapan hewan uji diinfeksi Staphylococcus aureus secara intraperitoneal. Aktivitas fagositosis diamati secara mikroskopik, sedangkan kadar CD8+ diukur menggunakan metode ELISA. Dosis 300 mg/kg BB menghasilkan peningkatan aktivitas fagositosis tertinggi sebesar 77,25% dan kadar CD8+ tertinggi sebesar 650,71 ng/mL, dengan perbedaan bermakna dibandingkan kontrol negatif (p<0,05). Temuan ini mengindikasikan bahwa rimpang E. rubroloba berpotensi dikembangkan sebagai kandidat imunostimulator alami.
Co-Authors Ani Umar Bonni Rubak Fadhliyah Malik Halik, Halik Ilyas Y., Muhammad Jabbar, Asriullah Jannah, Nanda Reski Pascayantri, Asniar Rasak, Adriatman Rubak, Bonni Sahidin, Idin Setiawan, La Ode Roni wahyuni wahyuni