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All Journal Jurnal Rekayasa Proses Jurnal Ilmiah Farmasi Jurnal Teknosains Indonesian Journal of Biotechnology JURNAL PHARMASCIENCE INDONESIAN JOURNAL OF PHARMACY Pharmascience Majalah Farmaseutik Jurnal Rekayasa Proses Jurnal Rekayasa Proses
Hilda Ismail, Hilda
Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakartaa, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Education Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Social Sciences

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Kinetics study of paracetamol production from para-aminophenol and acetic anhydride Rifki Wahyu Kurnianto; Mohammad Fahrurrozi; Hilda Ismail; Raden Rara Endang Lukitaningsih; Indah Tri Nur'aini; Pudjono Lukitaningsih; Rochmadi Lukitaningsih; Ari Sudarmanto; Ratna Asmah Susidarti
Jurnal Rekayasa Proses Vol 15 No 1 (2021): Volume 15, Number 1, 2021
Publisher : Jurnal Rekayasa Proses

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jrekpros.64551

Abstract

In the last decade, Indonesia intensifies the efforts to reduce pharmaceutical imports. One of the initiatives is establishing a paracetamol production facility to start operating in 2024. Kinetics study is needed as a basis to design the paracetamol reactor. This study investigated the optimal temperature, reactant mole ratio, and agitation speed in the reactor for paracetamol production. In this study, aqueous solution of para-aminophenol was reacted with acetic anhydride. The mole ratio of para-aminophenol to acetic anhydride was varied to 1:1, 1:1.2, 1:1.5, and 1:2 while the temperature was varied to 80 °C, 90 °C, and 110 °C. However, due to uncontrolled heat of the reaction and limitation of the mixture’s boiling point, the actual reaction temperatures were 86 °C, 90 °C, and 108 °C. In addition, the agitation speed of 250 RPM and 350 RPM were also studied. Thin layer chromatography (TLC) and densitometry were used to determine the concentration of paracetamol in the reacting mixture. The optimum temperature, reactant mole ratio, and agitation speed in this study were 108 °C, 1:1.5, and 350 RPM, respectively. In addition, a reaction performed under those operating parameters gave the reaction rate constant of 1.95 L mol-1 min-1.
Co-Authors Adhyatmika Adhyatmika Anggun Feranisa Ari Sudarmanto Arimurni, Dewa Ayu B. S. Ari Sudarmanto Ciptasari, Ummi H. Dwi Titus Indriyawati Endang Lukitaningsih Evi Lande Setiyani Ikhsan, M Arief Nur Indah Tri Nugraha Indah Tri Nur'aini Kurnianto, Rifki Wahyu Lutfi Chabib, Lutfi Martien, Ronny Martien, Ronny Mohammad Fahrurrozi Muhammad Fahrurrozi Pudjono Lukitaningsih Pudjono Pudjono Ratna Asmah Susidarti Ratna Asmah Susidarti Rochmadi Lukitaningsih Rochmadi Rochmadi Ronny Martien Ronny Martien Ronny Martien Ronny Martien S. Sismindari Sismindari, Sismindari Suryani, Fidya Wintari Taurina Yuswanto, Ag