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All Journal Jurnal Ilmu Pangan dan Hasil Pertanian Jurnal Medika Veterinaria
Sari, Dea Kurnia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Immunology & microbiology Medicine & Pharmacology Public Health Veterinary Other

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Screening of Bioactive Compounds of Gambir leaf (Uncaria gambir Roxb) as Antibiofilm Againts the Glucosyltransferase of Streptococus mutans Enzyme Khalid, Idham; Sari, Dea Kurnia; Bakri, Muttaqien; Daniel, Daniel; Frengki, Frengki; Makmur, Ali; Riandi, Lian Varis; Ferdian, Riyan; Amiruddin, Amiruddin
Jurnal Medika Veterinaria Vol 18, No 2 (2024): J. Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i2.43265

Abstract

The use of natural ingredients in dental care, such as manginang which has become part of the Minang community culture, is considered an alternative dental care that must be created to overcome the negative impacts of dental care made from artificial materials. The core of this study is to change the manginang tradition towards logical verification through screening of bioactive compounds of gambir leaves (Uncaria gambir Roxb.) as antibiofilms against Streptococcus mutans. This study was conducted using an in silico strategy approach with the help of computer programs such as MOE v.09 and Chimera 1.13.1, as well as the Way2Drug site, protein information bank, and protox_ii. This study began with the collection of ligand information from the writing, followed by transformation into 2D and 3D designs. Other antibiofilm actions were decided using the QSAR procedure through the website (http://www.way2drug.com/PASSOnline/predict.php). The selected antibiofilm compounds were then followed by observing their affinity for the receptor (pdb id. 3AIB) using an atomic docking strategy. Finally, the ligand damage profile was observed to anticipate. The results of this study indicate that of the 41 identified gambir leaf compounds, there are 20 compounds that have the potential to have antibiofilm effects with quinnic acid having the highest score (Pa 0.703), while the compound with the strongest affinity for the receptor is chlorogenic acid with an affinity score (Gbinding) of -16.03 kcal/mol and an average of low toxicity (level IV-VI). However, of the 20 bioactive compounds of gambir leaves, only 5 compounds are predicted to have the same potential as the -maltose control.
Pemanfaatan Limbah Hasil Perikanan: Lem Ikan Berbahan Baku Sisik Ikan yang Berbeda Sari, Dea Kurnia
Jurnal Ilmu Pangan dan Hasil Pertanian Vol 1, No 2 (2017)
Publisher : Program Studi Teknologi Pangan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/jiphp.v1i2.1913

Abstract

Fishery processing industry such as fillet fish and boneless milkfish which are increasing rapidly raises new problem, that is industrial waste which one of them is fish scales. Fish scales in the know contain collagen which can be used as adhesive or glue and can be one of the innovations for waste processing of scales. The purpose of this study was to determine the effect of different fish scales on quality of fish glue from three different types of fish scales. The material used in this study is the scales of fish Seabass (Lates calcarifer), nile tilapia (Oreochromis niloticus), and milkfish (Chanos chanos Forks), acetic acid, NaOH, and aquadest. The research method used is experimental laboratories using Completely Randomized Design with treatment of three different types of fish scales with three repetitions each. The results obtained were analyzed using the analysis of variance, stickiness value, wood surface damage, viscosity, pH and water content of fish glue. To know the difference between treatments, the data were analyzed with real honest difference analysis. The results of this study showed that fish scales differed significantly (P 0.05) on all analysis, but not pH of fish glue. Based on the results of this study that meets the Indonesian National Standard no. 06-6049-1999 on Quality Requirements of Polyvinyl Acetate Emulsion For Wood Working Adhesives, Seabass fish scales is the best fish glue with quality: stickiness value 8.64 N/mm2, 40.47 % wood surface damage, viscosity 7.68 poise, pH 4.80, and water content of 59.92 %. Keywords: Fish glue; Milkfish Scale; Nile Tilapia Scale; Seabass Scale
Co-Authors Amiruddin Amiruddin Daniel Daniel Ferdian, Riyan Frengki Frengki, Frengki Idham Khalid Makmur, Ali Muttaqien Bakri, Muttaqien Riandi, Lian Varis