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All Journal TAZKIR: Jurnal Penelitian Ilmu-ilmu Sosial dan Keislaman Journal SAGO Gizi dan Kesehatan Jurnal Natural Jurnal Kedokteran Hewan Jurnal Medika Veterinaria
Frengki Frengki, Frengki
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Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Energy Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Multi-drug resistance-1 (MDR-1) gene expression in MCF-7 cells after treated with doxorubicin-deoxyelephantopin combination and prediction of inhibitory activity against Pgp receptors with in silico DANIEL, DANIEL; FRENGKI, FRENGKI; JALALUDDIN, MUHAMMAD; SARI, WAHYU EKA; ROSMAIDAR, ROSMAIDAR; HASRIATI, HASRIATI; ZAKIAH, NONI
Jurnal Natural Volume 24 Number 3, October 2024
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jn.v24i3.33237

Abstract

Doxorubicin chemotherapy has been a strong focus in breast cancer research. Side effects, toxicity and resistance have been extensively studied. One proposed solution to these issues that its combination with deoxyelephantopin. Deoxyelephantopin is known to be toxic in many cancer cells but safe in normal cells. IC50 of each compound were determined by using a MTT assay, and the MDR-1 gene mRNA expression were determined by using qPCR method, while the interaction of doxorubicin in combination with deoxyelephantonin on Pgp receptor were predicted by using an in silico approach. The IC50 of deoxyelephantopin was found to be 11.2 g/mL, while IC50 of doxorubicin was 448 nM IC50 values showed a deoxyelephantopin-doxorubicin combination was able to reduce MDR-1 expression by 19% compared to doxorubicin and IC50 values indicated that the combination formula reduced the expression by 15% over doxorubicin alone. The affinity of doxorubicin and deoxyelephantopin is -12.16 kcal/mol and -9.51 kcal/mol, respectively, while the affinity of doxorubicin after combine with deoxyelephantopin decreases from -12,16 kcal/mol to -11,25 kcal/mol due to the release of one Leu 221 hydrogen bond. The combination of doxorubicin with deoxyelephantopin is able to reduce expression and suppress the function of the Pgp protein.
Screening of Bioactive Compounds of Gambir leaf (Uncaria gambir Roxb) as Antibiofilm Againts the Glucosyltransferase of Streptococus mutans Enzyme Khalid, Idham; Sari, Dea Kurnia; Bakri, Muttaqien; Daniel, Daniel; Frengki, Frengki; Makmur, Ali; Riandi, Lian Varis; Ferdian, Riyan; Amiruddin, Amiruddin
Jurnal Medika Veterinaria Vol 18, No 2 (2024): J. Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i2.43265

Abstract

The use of natural ingredients in dental care, such as manginang which has become part of the Minang community culture, is considered an alternative dental care that must be created to overcome the negative impacts of dental care made from artificial materials. The core of this study is to change the manginang tradition towards logical verification through screening of bioactive compounds of gambir leaves (Uncaria gambir Roxb.) as antibiofilms against Streptococcus mutans. This study was conducted using an in silico strategy approach with the help of computer programs such as MOE v.09 and Chimera 1.13.1, as well as the Way2Drug site, protein information bank, and protox_ii. This study began with the collection of ligand information from the writing, followed by transformation into 2D and 3D designs. Other antibiofilm actions were decided using the QSAR procedure through the website (http://www.way2drug.com/PASSOnline/predict.php). The selected antibiofilm compounds were then followed by observing their affinity for the receptor (pdb id. 3AIB) using an atomic docking strategy. Finally, the ligand damage profile was observed to anticipate. The results of this study indicate that of the 41 identified gambir leaf compounds, there are 20 compounds that have the potential to have antibiofilm effects with quinnic acid having the highest score (Pa 0.703), while the compound with the strongest affinity for the receptor is chlorogenic acid with an affinity score (Gbinding) of -16.03 kcal/mol and an average of low toxicity (level IV-VI). However, of the 20 bioactive compounds of gambir leaves, only 5 compounds are predicted to have the same potential as the -maltose control.
Variasi tipe pelarut dan pengaruhnya terhadap kadar flavonoid total daun kirinyuh (Chromolaena odorata) yang tumbuh di kawasan geotermal Ie Seum Aceh Besar menggunakan spektrofotometri uv-vis Munira, Munira; Zakiah, Noni; Handayani, Rini; Nasir, Muhammad; Frengki, Frengki
Jurnal SAGO Gizi dan Kesehatan Vol 6, No 2 (2025): Agustus
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v6i2.2575

Abstract

Background: One plant that can be a source of natural healing for various ailments is the kirinyuh (Chromolaena odorata). This plant can grow in geothermal areas. Plants grown in geothermal areas have the potential to produce higher levels of active substances. The kirinyuh plant is rich in flavonoid compounds. Flavonoids have antioxidant, anti-inflammatory, antibacterial, antiviral properties, and have potential as anticancer agents. The level and quality of flavonoid compounds are influenced by the type of solvent.Objectives: This study was conducted to determine the total flavonoid content of kirinyuh leaf extract from the Ie Seum geothermal area of Aceh Besar based on different types of solvents.Methods: Determination of total flavonoid content using UV-Vis spectrophotometry and quercetin was used as a standard in the measurement. Each measurement was repeated three times. The results were analyzed using an independent t-test.Results: The results of the determination of total flavonoid levels obtained in kirinyuh leaves using ethanol solvent were 10,65 mg QE/g and ethyl acetate was 8,97 mg QE/g. Based on the results of the Independent T-test, a significance result of 0,000 (P<0,05) was obtained. These results indicate that there is a difference in total flavonoid levels between ethanol and ethyl acetate solvents.Conclusion: The total flavonoid content using ethanol solvent types were higher than ethyl acetate.
Antidiabetic Test of Ethanolic Extract of Ant Nest Plants (Myrmecodia sp.) Against the -Glucosidase Enzyme In Vitro Daniel, Daniel; Isa, Muhammad; Hasan, Muhammad; Sari, Wahyu Eka; Rosmaidar, Rosmaidar; Aisyah, Siti; Athaillah, Farida; Frengki, Frengki
Jurnal Medika Veterinaria Vol 18, No 1 (2024): J.Med.Vet.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v18i1.37431

Abstract

The use of plants, one of the biological sources, as an alternative medicine for degenerative diseases is increasingly being studied. Usually, the biological effects of these plants come from the secondary metabolite components contained therein. Ant nest is one of them which is reported to contain compounds belonging to the class of flavonoids, tannins, and polyphenols. This research was conducted in vitro by observing the antidiabetic potential of the ethanolic extract of ant nests against the -glucosidase enzyme following the modified "Wako Pure Chemical Industries Ltd., Japan" protocol. The results showed that the inhibitory power of -glucosidase of the extract was stronger than that of the quercetin control with IC50 values of 10.59 g/mL and 38.09 g/mL, respectively. These results proved that the ethanolic extract of ant nest had very strong -glucosidase inhibitory property. Predictive analysis of the pharmacokinetics and toxicity of the bioactive compounds contained in the ant nest extract showed that rutin has similar characteristics to acarbose as a first-line anti-diabetic drug of choice through an -glucosidase inhibitor mechanism, so rutin is worthy of consideration for development as an anti-diabetic candidate.
Antibacterial Activity of Tamarind Leaf-Based Shampoo Against Staphylococcus aureus and Pseudomonas aeruginosa, Candida albicans, and Malesezia globose Sari, Wahyu Eka; Sadri, Hidayatus; Hasanah, Lailatul; Yona, Safetri; Triyuliani, Ririn; Maghfirah, Aura; Frengki, Frengki; Riandi, Lian Varis; Riady, Ginta
Jurnal Medika Veterinaria Vol 17, No 2 (2023): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v17i2.35271

Abstract

Skin and feather diseases are common in cats. The main causative agents of these diseases are bacteria and fungi, including Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Malassezia globosa fungi which are one of the fungi that play a role in the formation of dandruff. Preventive measures that can be carried out are grooming or bathing cats using special shampoos. The use of natural-based shampoos is an alternative to reduce the side effects of using chemical-based shampoos. Like herbal shampoo from tamarind leaf extract. The samples used in the study were tamarind leaves and isolates of S. aureus and P. aeruginosa, C. albicans and M. globosa. This research used completely randomized design (CRD) model with three treatment groups (2% and 20% for extract, tamarind leaf extract shampoo) for antibacterial test. Positive controls consisted of vancomycin 30 mg for S. aureus, and gentamicin 10 mg for P. aeruginosa, and distilled water as negative control. For antifungal test, there were three different concentrations (16%, 8%, and 4%), tamarind leaf extract shampoo, one positive control (zinc pyrithione 1%) and one negative control (distilled water) with two replications. Data was analyzed by measuring the inhibition zone formed. The results of the inhibition zone on S. aureus were 6.03 mm (2%) and 13.48 mm (20%), and for tamarind leaf extract shampoo was 9.54 mm, categorized as weak. For P. aeruginosa, the inhibition zone was 6.61 for 2%, and 19.78 for 20% (categorized as strong), tamarind leaf extract shampoo was 10.23 mm (weak category. For C. albicans, inhibition zone formed at a concentration of 4% was 6 mm, 8% was 6 mm, 16% was 6 mm, and tamarind leaf extract shampoo was 6 mm, (weak category). For M. globosa at a concentration of 4% was 0 mm, 8% was 6 mm, 16% was 6 mm, and tamarind leaf extract shampoo was 12.32 mm (strong category). It can be concluded that the ethanolic extract of tamarind leaf had inhibition activity on the growth of S. aureus, P. aeruginosa, C. albicans, and M. globosa.
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
PENYALAHGUNAAN IDENTITAS NAHDATUL ULAMA PEMILIHAN KEPALA DAERAH DI LAMPUNG TIMUR Muhammad, Hasanuddin; Frengki, Frengki; Gumiri, Erik Rahman
Tazkir: Jurnal Penelitian Ilmu-ilmu Sosial dan Keislaman Vol 10, No 1 (2024)
Publisher : Universitas Islam Negeri Syekh Ali Hasan Ahmad Addary Padangsidimpuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24952/tazkir.v10i1.10952

Abstract

Penyalahgunaan politik identitas yang digunakan untuk berkompetensi merebut kekuasaan adalah sebuah kejahatan dan bertentangan dengan semangat demokrasi. Pada dua kontestasi Pemilihan Kepala Daerah (Pilkada) di Lampung Timur tersebut, ada kecenderungan menggunakan identitas keagamaan dengan memanfaatkan identitas warga NU sebagai modal social sekaligus modal politik untuk meraih kemenangan Kapitalisasi isu identitas Nahdaltul Ulama di Lampung Timur merupakan ancaman terjadinya sekat dan konflik antara masyarakat lampung timur. Adanya kecemburuan terhadap para suku pendatang akan menambah runcing persoalan memainkan politik identitas di Lampung Timur. Tulisan ini bertujuan untuk melihat sejuahmana bentuk penyalahgunaan identitas Nahdlatul Ulama dalam kontestasi Pemilihan Kepala Daerah di Lampung Timur. Sumber data penelitian diperoleh dari media sosial. Hasil ada tiga pasangan calon yang mengikuti kontestasi pemilihan bupati lampung timur. Pasangan Dawam-Azwar Hadi yang dominan menggunakan identitas Nahdlatul Ulama. Kedua pasangan zaiful-sudibyo. Pasangan Yusron-Kisworo tidak menggunakan identitas Nahdlatul Ulama.
Co-Authors Amiruddin Amiruddin Athaillah, Farida Daan Khambri Daniel Daniel Deddi Prima Putra Erik Rahman Gumiri Fatma Sri Wahyuni Ferdian, Riyan Ginta Riady Hasanah, Lailatul Hasriati Hasriati, Hasriati Henni Vanda Idham Khalid Maghfirah, Aura Makmur, Ali Muhammad Hasan Muhammad Isa Muhammad Jalaluddin, Muhammad Muhammad Nasir Munira Munira, Munira Muttaqien Bakri, Muttaqien Noni Zakiah Riandi, Lian Varis Rini Handayani Rosmaidar Rosmaidar, Rosmaidar Sadri, Hidayatus Sari, Dea Kurnia Sari, Wahyu Eka Siti Aisyah Triyuliani, Ririn Vivi Sofia Yona, Safetri