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All Journal Berkala Kedokteran Jurnal Kesehatan Manarang MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Healthy Tadulako Journal (Jurnal Kesehatan Tadulako)
Djunet, Nur Aini
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PENGARUH DIET PUASA (INTERMITTENT FASTING) TERHADAP PENURUNAN BERAT BADAN, PERUBAHAN METABOLIK, DAN MASSA OTOT Fairuz, Ratna Amalia; Absari, Nurmala Widya; Utami, Rizki Fajar; Djunet, Nur Aini
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 1 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i1.975

Abstract

Obesitas didefinisikan sebagai akumulasi lemak yang tidak normal atau berlebihan yang dapat mengganggu kesehatan. Cara mengurangi makanan adalah dengan cara diet. Ada berbagai metode diet yang bisa dilakukan untuk menurunkan berat badan. Cara yang sering dilakukan adalah puasa intermiten dengan cara dan aturan tertentu. Puasa intermiten melibatkan makan harian yang dibatasi waktu (seperti puasa 16-24 jam) atau puasa sehari penuh pada 2 hingga 4 hari (atau lebih) per minggu. Cara diet ini berpengaruh pada perubahan berat badan, dan perubahan metabolisme dalam tubuh baik jangka panjang maupun jangka pendek. Tujuan penelitian ini adalah memberikan informasi tentang pengaruh puasa intermiten terhadap perubahan berat badan, perubahan metabolisme, dan massa otot. Metode yang digunakan adalah scooping review dengan meninjau 7 dari 1875 jurnal yang dipilih dengan menghilangkan kriteria duplikasi dan eksklusi. Hasil penelitian menunjukkan puasa intermiten dapat menurunkan berat badan dan menurunkan kadar insulin dan lipid dalam tubuh, namun tidak terjadi perubahan massa otot. Beberapa efek samping diet puasa masih dalam batas aman. Kesimpulan dalam penelitian ini adalah puasa intermiten bermanfaat dalam penurunan berat badan dan perubahan metabolisme, terutama dalam menurunkan kadar insulin dan lipid dalam tubuh.
Raphanus Sativus Leaves Ethanol Extract’s Effect on Heart Muscle’s Nuclear Factor Kappa B in Diabetic Rats Hendrawati, Asri; Djunet, Nur Aini
Berkala Kedokteran Vol 20, No 2 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i2.20583

Abstract

Type 2 diabetes mellitus is characterized by hyperglycemia. Hyperglycemia increases oxidative stress that damage cells including in heart muscle. Oral hypoglycemic drugs cant reduce the expression of nuclear factor kappa B (NFkB) which plays an important role in inflammation and cell damage. Radish leaves (Raphanus sativus) are known to have compounds that can reduce the expression of NFkB.This study aimed to determine the effect of radish leaves on the expression of NFkB in heart muscle. The study design was an experimental laboratory post-test control group design. The subjects were DM male Wistar rats (Rattus norvegicus), weight 150-300 grams, 3-4 months old. Rats were divided into four groups and took the treatment orally for 28 days. The 1st group got plain water. The 2nd group got glibenclamide 5 mg/kg BW/day. The 3rd and 4th groups got 50% and 100% ethanol extract of radish leaves. After the end of treatment, the heart's tissue was taken for immunohistochemical (IHC) staining to measure the proportion of NFkB. The intervention of ethanol extract of radish leaves 50% and 100% for 28 days reduced the percentage of NFkB in the heart muscle cell of rats than placebo and glibenclamide 5 mg/kg BW ((p=0.000). There was no difference between radish leaf extract concentration of 50% and 100% for 28 days in reducing the expression level of NFkB in the heart muscle cell of rats (p=0.876).This research has not been done before and is important for the treatment of diabetes mellitus in the future.
Unveiling Research Gaps in Sarcopenic Obesity among Young Adults: Insight from Open Knowledge Map and VOS Viewer Djunet, Nur Aini; Rizkawati, Muflihah
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): December 2024
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1338

Abstract

Sarcopenic obesity (SO) refers to the coexistence of elevated body fat mass and sarcopenia. Sarcopenia is characterized by a reduction in muscle mass, leading to diminished skeletal muscle mass and impaired functional status. While research on SO is predominantly focused on the elderly, it is conceivable that younger adults also experience SO, especially considering the high incidence of sedentary lifestyles within this demographic. This study wants to identify the distribution of research topics and the existing gaps in the literature. The research utilized a bibliometric analysis, integrating the Open Knowledge Map (OKM) and VOSviewer (VV) applications. The analysis revealed that the key clusters are associated with “insulin resistance,” “body composition,” and “muscle strength.” Data from developing nations is scarce. There is insufficient research into the effects of genetic, epigenetic, and psychosocial factors on SO. Combined interventions involving nutrition and resistance training show significant promise in enhancing muscle mass and functionality, yet long-term assessments and synergistic mechanisms require additional investigation. While exercise and nutrition-based interventions yield encouraging outcomes, multidisciplinary research incorporating social, economic, and cultural factors is essential for a comprehensive understanding of SO. The development of universal diagnostic criteria is crucial to address methodological discrepancies that impede the comparability of studies.
Raphanus Sativus Leaves Ethanol Extract's Effect on Heart Muscle's Nuclear Factor Kappa B (NFkB) in Diabetic Rats Hendrawati, Asri; Djunet, Nur Aini
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.198-204

Abstract

Background:  Type 2 diabetes mellitus is characterized by hyperglycemia. Hyperglycemia increases free radicals and oxidative stress that damage heart muscle cells. Nuclear factor kappa B (NFkB) plays an important role in inflammation and cell damage. Radish leaves (Raphanus sativus) are known to have compounds that can control NFkB expression.Objective: To measure the effect of radish leaves on the expression of NFkB in heart muscle.Methods: The study design was experimental laboratory post test control group design. The subjects were diabetic male Wistar rats, weight 150-300 grams, 3-4 months old. Rats were divided into four groups and given treatment orally for 28 days. The 1st group received placebo. The 2nd group received glibenclamide 5 mg/kg BW/day. The 3rd and 4th groups received 50% and 100% ethanol extract of radish leaves. Heart NFkB was measured using immunohistochemistry.  Results: Radish leaves ethanol extract 50% and 100% reduced NFkB  in the heart muscle better than placebo and glibenclamide 5 mg/kg BW ((p=0.000). There was no difference between radish leaf extract 50% and 100% in reducing heart NFkB expression (p=0.876).Conclusion: Radish leaf extract 50% and 100% reduce NFkB expression better than placebo and glibenclamide 5 mg/kg BW.
Unveiling Research Gaps in Sarcopenic Obesity among Young Adults: Insight from Open Knowledge Map and VOS Viewer Djunet, Nur Aini; Rizkawati, Muflihah
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): Bahasa Inggris
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1338

Abstract

Sarcopenic obesity (SO) refers to the coexistence of elevated body fat mass and sarcopenia. Sarcopenia is characterized by a reduction in muscle mass, leading to diminished skeletal muscle mass and impaired functional status. While research on SO is predominantly focused on the elderly, it is conceivable that younger adults also experience SO, especially considering the high incidence of sedentary lifestyles within this demographic. This study wants to identify the distribution of research topics and the existing gaps in the literature. The research utilized a bibliometric analysis, integrating the Open Knowledge Map (OKM) and VOSviewer (VV) applications. The analysis revealed that the key clusters are associated with “insulin resistance,” “body composition,” and “muscle strength.” Data from developing nations is scarce. There is insufficient research into the effects of genetic, epigenetic, and psychosocial factors on SO. Combined interventions involving nutrition and resistance training show significant promise in enhancing muscle mass and functionality, yet long-term assessments and synergistic mechanisms require additional investigation. While exercise and nutrition-based interventions yield encouraging outcomes, multidisciplinary research incorporating social, economic, and cultural factors is essential for a comprehensive understanding of SO. The development of universal diagnostic criteria is crucial to address methodological discrepancies that impede the comparability of studies.
Co-Authors Absari, Nurmala Widya Asri Hendrawati Fairuz, Ratna Amalia Rizkawati, Muflihah RIZKI FAJAR UTAMI