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All Journal Jurnal Kesehatan Manarang Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat
Rizkawati, Muflihah
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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POTENSI TANAMAN HERBAL BUNGA TELANG (CLITORIA TERNATEA) SEBAGAI ALTERNATIF ANTIHIPERTENSI rizkawati, Muflihah; Fairuz, Ratna Amalia; Absari, Nurmala Widya
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 9 No. 1 (2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v9i1.637

Abstract

ABSTRAK Hipertensi merupakan penyebab utama penyakit kardiovaskular dengan angka kematian tertinggi di dunia. Berbagai upaya dapat dilakukan untuk menurunkan peningkatan tekanan darah dengan mengkonsumsi obat antihipertensi, melakukan olahraga dan aktivitas fisik, mengelola stres serta melakukan pembatasan terhadap asupan makanan tinggi garam dan lemak. Permasalahan utama dari sulitnya melakukan kontrol terhadap tingginya tekanan darah adalah lemahnya kepatuhan terhadap konsumsi obat antihipertensi dan sulitnya mengatur pola makan rendah garam dan kolesterol. Selain itu, penggunaan obat jangka panjang dapat memunculkan kecemasan terhadap efek samping. Alternatif pemanfaatan tanaman herbal Bunga Telang (Clitoria ternatea) dapat menjadi pilihan yang lebih baik dalam penanganan hipertensi. Metode yang digunakan dalam penelitian ini adalah literature review dengan melakukan penelusuran artikel dari Google Scholar, Sciencedirect, dan Pubmed yang terbit pada tahun 2012-2022. Berdasarkan hasil telaah jurnal didapatkan 4 artikel sesuai yang menunjukkan adanya efek positif dari bunga telang dalam menurunkan kadar tekanan darah pada studi yang dilakukan.
Unveiling Research Gaps in Sarcopenic Obesity among Young Adults: Insight from Open Knowledge Map and VOS Viewer Djunet, Nur Aini; Rizkawati, Muflihah
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): December 2024
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1338

Abstract

Sarcopenic obesity (SO) refers to the coexistence of elevated body fat mass and sarcopenia. Sarcopenia is characterized by a reduction in muscle mass, leading to diminished skeletal muscle mass and impaired functional status. While research on SO is predominantly focused on the elderly, it is conceivable that younger adults also experience SO, especially considering the high incidence of sedentary lifestyles within this demographic. This study wants to identify the distribution of research topics and the existing gaps in the literature. The research utilized a bibliometric analysis, integrating the Open Knowledge Map (OKM) and VOSviewer (VV) applications. The analysis revealed that the key clusters are associated with “insulin resistance,” “body composition,” and “muscle strength.” Data from developing nations is scarce. There is insufficient research into the effects of genetic, epigenetic, and psychosocial factors on SO. Combined interventions involving nutrition and resistance training show significant promise in enhancing muscle mass and functionality, yet long-term assessments and synergistic mechanisms require additional investigation. While exercise and nutrition-based interventions yield encouraging outcomes, multidisciplinary research incorporating social, economic, and cultural factors is essential for a comprehensive understanding of SO. The development of universal diagnostic criteria is crucial to address methodological discrepancies that impede the comparability of studies.
EFEK NEFROPROTEKTOR EKSTRAK TEMULAWAK (Curcuma xanthorrhiza roxb) TERHADAP KADAR KREATININ TIKUS (Rattus Norvegicus) YANG DIINDUKSI PARACETAMOL Putri, Jilan Fandini; Rizkawati, Muflihah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.1799

Abstract

Paracetamol is commonly used as an analgesic and antipyretic. The toxic doses of paracetamol-induced toxic effects such as renal tubular necrosis. Creatinine (Cr) is a biochemical function to assess kidney function. In Indonesia, ginger is one of the leading plants which has health benefits, as a hepatoprotector and nephroprotector because it contains curcumin and xanthorrhizol. This research was conducted to determine the effect of ginger extract on the creatinine levels of Wistar rats induced by paracetamol. The method used an experimental pre-post-test control group design. The research subjects divided into five groups consisting of 5 rats, K1 (negative control), K2 ( paracetamol 2 g/kgBW), P1, P2, and P3 given curcuma 800 mg/kgBW, 1.600 mg/kgBW, 3.200 mg/kgBW and a toxic dose of paracetamol of 2 g/kgBW on the last three days. The data was analyzed with the Paired T-test followed by a one-way ANOVA test to see differences between groups. The results showed a significant difference between the creatinine levels of Wistar rats before and after treatment (p=0.029). Administration of graded doses of ginger to the Wistar Rat group which was induced by paracetamol, showed a significant difference compared to the control group, between groups K2 and P1 (dose 800 mg/kgBB) with a p-value=0.031. Based on the results, it can be concluded that graded doses of Temulawak can minimize damage to the kidneys of Wistar Rats due to paracetamol induction as shown by the difference in creatinine levels in the 800 mg/kgBB treatment group compared to the control group.
Unveiling Research Gaps in Sarcopenic Obesity among Young Adults: Insight from Open Knowledge Map and VOS Viewer Djunet, Nur Aini; Rizkawati, Muflihah
Jurnal Kesehatan Manarang Vol 10 No 3 (2024): Bahasa Inggris
Publisher : Politeknik Kesehatan Kemenkes Mamuju

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33490/jkm.v10i3.1338

Abstract

Sarcopenic obesity (SO) refers to the coexistence of elevated body fat mass and sarcopenia. Sarcopenia is characterized by a reduction in muscle mass, leading to diminished skeletal muscle mass and impaired functional status. While research on SO is predominantly focused on the elderly, it is conceivable that younger adults also experience SO, especially considering the high incidence of sedentary lifestyles within this demographic. This study wants to identify the distribution of research topics and the existing gaps in the literature. The research utilized a bibliometric analysis, integrating the Open Knowledge Map (OKM) and VOSviewer (VV) applications. The analysis revealed that the key clusters are associated with “insulin resistance,” “body composition,” and “muscle strength.” Data from developing nations is scarce. There is insufficient research into the effects of genetic, epigenetic, and psychosocial factors on SO. Combined interventions involving nutrition and resistance training show significant promise in enhancing muscle mass and functionality, yet long-term assessments and synergistic mechanisms require additional investigation. While exercise and nutrition-based interventions yield encouraging outcomes, multidisciplinary research incorporating social, economic, and cultural factors is essential for a comprehensive understanding of SO. The development of universal diagnostic criteria is crucial to address methodological discrepancies that impede the comparability of studies.
Efek Pemberian Ekstrak Temulawak (Curcuma xanthorrhiza) terhadap Fungsi Hati Tikus Wistar yang Diinduksi Parasetamol Rizkawati, Muflihah; Rizky Wijayanti, Arini; Djunet, Nur Aini; Astuti, Ernadita Budi; Anggraeni, Marlina
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 4 No. 1 (2026)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: Parasetamol merupakan obat analgesik-antipiretik yang paling umum digunakan karena memiliki profil efek samping yang relatif minim dibandingkan golongan analgesik lain. Namun, penggunaan jangka panjang atau dosis berlebih dapat memicu kerusakan hati (hepatotoksisitas). Mekanisme kerusakan ini terutama disebabkan oleh akumulasi metabolit toksik N-acetyl-p-benzoquinone imine (NAPQI) akibat saturasi jalur glukuronidasi, yang memicu stres oksidatif pada sel hepar. Tujuan: Penelitian ini bertujuan untuk mengevaluasi aktivitas hepatoprotektor ekstrak temulawak (Curcuma xanthorrhiza) dalam mencegah kerusakan fungsi hati yang diakibatkan oleh induksi parasetamol. Metode: Penelitian ini merupakan studi eksperimental laboratoris menggunakan 25 ekor tikus putih galur Wistar yang dibagi secara acak menjadi lima kelompok. Kelompok kontrol negatif hanya diberikan akuades; kontrol positif diinduksi parasetamol dosis 2 g/kgBB selama tiga hari terakhir; dan tiga kelompok perlakuan diberikan ekstrak C. xanthorrhiza dengan variasi dosis bertingkat (800 mg/kgBB, 1600 mg/kgBB, dan 3200 mg/kgBB) sebelum induksi. Parameter kerusakan hati dinilai melalui pengukuran kadar enzim Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Pyruvic Transaminase (SGPT) dari sampel darah sinus orbital. Hasil: Hasil pengukuran menunjukkan bahwa seluruh kelompok yang menerima perlakuan ekstrak memiliki kadar enzim transaminase yang lebih rendah dibandingkan kelompok kontrol positif. Penurunan kadar SGOT dan SGPT yang paling signifikan dan optimal terlihat pada kelompok perlakuan dengan dosis 800 mg/kgBB, yang mendekati nilai normal. Simpulan: Pemberian ekstrak Curcuma xanthorrhiza terbukti memiliki efek hepatoprotektif yang efektif terhadap kerusakan hati akibat induksi parasetamol, dengan dosis 800 mg/kgBB sebagai dosis yang memberikan proteksi paling optimal. Kata kunci: hepatoprotektor; Curcuma xanthorrhiza; parasetamol; fungsi hati; SGOT; SGPT.
Co-Authors Absari, Nurmala Widya Anggraeni, Marlina Astuti, Ernadita Budi Djunet, Nur Aini Fairuz, Ratna Amalia Putri, Jilan Fandini Rizky Wijayanti, Arini