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All Journal JMM (Jurnal Masyarakat Mandiri) Martabe : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Care : Jurnal Ilmiah Ilmu Kesehatan Journal of Telenursing (JOTING) Abdimasku : Jurnal Pengabdian Masyarakat Indian Journal of Forensic Medicine & Toxicology Caring : Jurnal Pengabdian Masyarakat Journal of Nursing Science Update DUNIA KEPERAWATAN: JURNAL KEPERAWATAN DAN KESEHATAN
Wisnasari, Shila
Program Studi Ilmu Keperawatan, Departemen Keperawatan, Fakultas Ilmu Kesehatan, Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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An An Assessment of the Efficacy of Chlorhexidine in Nebulizer Disinfectant to Prevent Contaminated Aerosol Administration Rustiana Tasya Ariningpraja; Shila Wisnasari; Ahsan Ahsan; Heri Kristianto; Luis Figo Febriano
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 3 (2025): J Sains Farm Klin 12(3), December 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.3.186-191.2025

Abstract

Nebulization therapy is an essential method of drug administration that enables effective delivery of medicationsto the respiratory tract in aerosol form; however, contaminated nebulizer components may serve as a source of pathogenicmicroorganisms associated with nosocomial pneumonia. This in vitro experimental study aimed to evaluate the effectiveness ofchlorhexidine as a nebulizer disinfectant in eliminating pathogenic bacteria. The study employed a post-test control group designusing six groups of nebulizer chambers, consisting of two control groups and four intervention groups. Two clinically relevantbacteria, Pseudomonas aeruginosa and Acinetobacter baumannii, were inoculated into the nebulizer chambers. The interventiongroups were disinfected using chlorhexidine gluconate at concentrations of 2.5%, 4%, and 5% diluted in 70% alcohol, and 2.5%chlorhexidine diluted in distilled water, while the control groups received sterile water and 70% alcohol, in accordance withexisting guidelines. After a standardized exposure period, bacterial growth was assessed using Colony Forming Unit (CFU) counts. Data were analyzed descriptively and comparatively to evaluate bacterial eradication across groups. The results demonstrated that 5% chlorhexidine diluted in 70% alcohol achieved complete bacterial elimination (0 CFU) for both bacterial strains, whereas lower concentrations showed residual growth. These findings indicate that chlorhexidine, particularly at higher concentrations, demonstrates strong disinfectant activity against common nosocomial pneumonia pathogens in nebulizer chambers. Nevertheless, the results are limited to in vitro conditions; therefore, further studies involving a wider range of microorganisms, standardized exposure times, and assessments of aerosol contamination during clinical nebulization are warranted to support its practical application.
Co-Authors Adi Santoso Ahsan Ahsan Ahsan Ahsan Ahsan Akhiyan Hadi Susanto Anindita Suwondo, Rifka Ariningpraja, Rustiana Tasya Dudella Desnani Firman Yasin, Dudella Desnani Firman Effendy, Nuraeni Hadi Susanto, Akhiyan Heri Kristianto Ike Nesdia Rahmawati, Ike Nesdia Kuswantoro Rusca Putra Luis Figo Febriano Nurona Azizah Pawestri, Frilian Niken Perkasa, Wendi Genta Rahma Micho Widyanto Retno Lestari Rismawan Adi Yunanto Rivaldi, Hengky Rustiana Tasya Ariningpraja Sahadewo Pintarto, Muhammad Septi Dewi Rachmawati Susanto, Akhiyan Hadi Suwondo, Rifka Anindita Titin Andri Wihastuti Yulian Wiji Utami Yulian Wiji Utami, Yulian