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All Journal Pharmaceutical Sciences and Research (PSR) Media Penelitian dan Pengembangan Kesehatan Holistik Jurnal Kesehatan
Puspitasari, Atika Wahyu
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Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Analisis Potensi Interaksi Obat Golongan Antidepresan pada Pasien Skizofrenia di Rumah Sakit Jiwa Dr. Soeharto Heerdjan Tahun 2016 Puspitasari, Atika Wahyu; Angeline, Loranda
Pharmaceutical Sciences and Research Vol. 6, No. 1
Publisher : UI Scholars Hub

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Abstract

Schizophrenic patients who used antidepressant combination drug therapy in their treatment can cause drug interaction. This study aimed to determine the potential drug interactions of antidepressant in schizophrenic patients. The study designed was cross-sectional by random sampling. The samples were secondary data from outpatient prescriptions and medical record of schizophrenic patients in Psychiatric Hospital Dr. Soeharto Heerdjan during 2016. From 743 drug prescriptions, it was found that 694 (91.41%) drug prescriptions having 1286 (61.24%) cases of drug interaction. The most common interaction were fluoxetine and risperidone in 376 cases (29.24%). The proportion based on interaction level was 1246 cases (96.89%) for severe, 34 cases (2.64%) for moderate, and 6 cases (0.47%) for minor. The study concluded that antidepressant prescribing needs to be closely monitored because of high incidence in drug interactions or modified when the negative impact was greater than the positive impact.
Evaluation of Potential Drug Interaction of Analgesic in Cancer Patient Receiving Palliative Care in Dharmais Cancer Hospital Sitepu, Eme Stepani; Puspitasari, Atika Wahyu; Azmi, Nuriza Ulul; Sari, Lila Nilam
Pharmaceutical Sciences and Research Vol. 7, No. 1
Publisher : UI Scholars Hub

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Analgesics are mostly used in cancer patients receiving palliative care to improve the quality of life of patients. Besides analgesics, cancer patients receiving palliative care were also given other drugs in combination to overcome other symptoms of cancer, and this combination could potentially cause drug interactions. This study was aimed to analyze the potential of drug interactions with analgesics in cancer patients. The study design was cross-sectional with a retrospective method and descriptive study. The sample of this study was cancer palliative care patient’s prescription at Dharmais Cancer Hospital in the period of January – December 2017. The sample analyzed in this study consisted of 273 prescriptions. This study found that there were 191 prescriptions (69.9%) of analgesics which potential- ly interacted with 316 interaction cases. Fentanyl and morphine with 61 cases (19.3%), morphine and gabapentin with 60 cases (18.9%) and morphine and amitriptyline with 33 cases (10.4%) were observed as the three most analgesics-other drugs interaction. Based on severity levels, there were 73.5% of major interaction, 26.3% of moderate interaction, and 0.2% of minor interaction. This study concluded that high occurrence of drug interactions was observed in analgesic drugs, therefore close monitoring is needed in cancer patient receiving palliative care.
Analisis obat yang berpotensi tidak tepat terhadap reaksi obat yang tidak diinginkan (ROTD) pada pasien lansia Fauziah, Nur; Andrajati, Retnosari; Puspitasari, Atika Wahyu
Holistik Jurnal Kesehatan Vol. 19 No. 7 (2025): Volume 19 Nomor 7
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i7.1103

Abstract

Background: The elderly population is a vulnerable group due to physiological changes, including decreased organ function. In Depok City, the number of elderly people is expected to increase to 202,194 by 2023. Potentially inappropriate medication use (PDR) in the elderly is associated with an increased risk of adverse drug reactions (ADRs). STOPP_INA is a tool for identifying PDRs and can help reduce the incidence of PDRs. Purpose: To analyze potentially inappropriate medication use associated with adverse drug reactions (ADRs) in elderly patients. Method: This was a descriptive observational study with a cross-sectional design. Data were collected retrospectively from electronic prescriptions and electronic medical records of elderly inpatients at RSUI. The minimum sample size was 52. Results: Of 528 medications prescribed to 52 patients, 90 PDRs (17.04%) were identified. The most common medications included in the STOPP_INA criteria were aspirin, ramipril, clopidogrel, spironolactone, clonidine, and amlodipine. Twenty-two patients (42.3%) experienced ADRs, with the most common adverse effects being hypotension (12 cases), followed by cognitive impairment, gastric ulcer recurrence, bleeding, and decreased renal function (3 cases each). Conclusion: There was a very strong correlation between the number of PIMs and ADRs (r = 0.758; p < 0.01) in patients with polypharmacy.   Keywords: Adverse Drug Reactions (ADRs); Elderly; Potentially Inappropriate Medications.   Pendahuluan: Populasi lanjut usia merupakan kelompok rentan karena mengalami perubahan fisiologis, termasuk penurunan fungsi organ. Di Kota Depok, jumlah lansia meningkat mencapai 202,194 jiwa pada tahun 2023. Penggunaan obat yang berpotensi tidak tepat atau potentially inappropriate medications (PIMs) pada lansia dikaitkan dengan peningkatan risiko reaksi obat yang tidak diinginkan (ROTD). STOPP_INA merupakan salah satu instrumen untuk mengidentifikasi PIMs dan dapat membantu mengurangi kejadian ROTD. Tujuan: Untuk menganalisis obat yang berpotensi tidak tepat terhadap reaksi obat yang tidak diinginkan (ROTD) pada pasien lansia. Metode: Studi observasional deskriptif dengan desain cross-sectional. Data dikumpulkan secara retrospektif dari resep elektronik dan catatan rekam medis elektronik pasien lansia rawat inap di RSUI. Jumlah sampel minimal berdasarkan perhitungan adalah 52 sampel. Hasil: Dari total 528 obat yang diresepkan kepada 52 pasien, ditemukan 90 PIMs (17.04%). Obat yang paling sering termasuk dalam kriteria STOPP_INA adalah aspirin, ramipril, klopidogrel, spironolakton, klonidin, dan amlodipin. Sebanyak 22 pasien (42.3%) mengalami kejadian ROTD, dengan efek samping terbanyak berupa hipotensi (12 kasus), diikuti gangguan kognitif, kekambuhan tukak peptik, perdarahan, dan penurunan fungsi ginjal (masing-masing 3 kasus). Simpulan: Terdapat korelasi yang sangat kuat antara jumlah PIMs dan ROTD (r = 0.758; p < 0.01) pada pasien dengan polifarmasi.   Kata Kunci: Lansia; Obat yang Berpotensi Tidak Tepat; Reaksi Obat yang tidak Diinginkan (ROTD).
ERYTHROPOIESIS-STIMULATING AGENT THERAPY IN HEMODIALYSIS FOR KIDNEY DISEASE RELATED ANEMIA: A SYSTEMATIC REVIEW Sinabutar, Reniati; Andrajati, Retnosari; Puspitasari, Atika Wahyu
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 4 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i4.3323

Abstract

Anemia merupakan komplikasi umum pada pasien penyakit ginjal kronik (PGK) yang menjalani hemodialisis dan berdampak pada kualitas hidup serta prognosis. Tinjauan sistematis ini dilakukan berdasarkan kerangka Arksey dan O’Malley serta panduan PRISMA untuk mengevaluasi efektivitas dan keamanan erythropoiesis-stimulating agents (ESA) konvensional. Dari 539 artikel yang teridentifikasi pada periode 2015–2025, sebanyak 9 studi memenuhi kriteria inklusi. Sebagian besar ESA terbukti efektif meningkatkan hemoglobin (Hb) ke kisaran target 10–12 g/dL, meskipun terdapat variasi antar agen. Epoetin alfa menunjukkan peningkatan Hb yang lebih besar (2,3 g/dL) dibanding epoetin beta (1,2 g/dL), dengan efek samping ringan seperti pusing dan pruritus. Darbepoetin alfa mencapai proporsi pasien tertinggi yang berada dalam target Hb (88–90%), meskipun pada sebagian kasus ditemukan hipertensi dan komplikasi akses vaskular. C.E.R.A. menawarkan keuntungan interval dosis bulanan dan stabilitas Hb, namun hanya 55,9% pasien yang mencapai target Hb. Kejadian efek samping serius dengan C.E.R.A. relatif rendah (12%) dan sebagian besar terkait komorbiditas pasien. Kesimpulannya, terapi ESA efektif dalam mengoreksi anemia pada pasien PGK dengan hemodialisis, tetapi perbedaan efektivitas dan keamanan antar agen menekankan pentingnya pemilihan yang terindividualisasi. Epoetin alfa lebih sesuai untuk koreksi Hb yang cepat, darbepoetin alfa unggul dalam pencapaian target Hb, sementara C.E.R.A. bermanfaat pada pasien yang memerlukan regimen sederhana dengan penyesuaian dosis minimal. Pemilihan terapi ESA perlu mempertimbangkan kondisi klinis, komorbiditas, kepatuhan pasien, serta kapasitas sistem pelayanan kesehatan untuk mengoptimalkan luaran.
Co-Authors Angeline, Loranda Azmi, Nuriza Ulul Nur Fauziah Retnosari Andrajati Sari, Lila Nilam Sinabutar, Reniati Sitepu, Eme Stepani