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All Journal Indonesian Journal of Cancer Chemoprevention ANNALES BOGORIENSES Journal of Urban Planning Studies
Jamilah Abbas
Research Center for Chemistry, Indonesian Institute of Science, Serpong, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Engineering Environmental Science Immunology & microbiology Medicine & Pharmacology Transportation

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Isolation and Structure Elucidation of Soulatro Coumarin From Stem Bark of Calophyllum soulattri Burm F and In Vivo Antiplasmodial Activity by Using Mice Infected by Plasmodium berghei Abbas, Jamilah; Darmawan, Achmad; Syafruddin, .
Indonesian Journal of Cancer Chemoprevention Vol 2, No 2 (2011)
Publisher : Indonesian Research Gateway

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Abstract

The soulatro coumarin compound was isolated and elucidated from the stem bark of Calophyllum soulattri Burm F, the samples were collected from Jayapura Papua Irian Island in  Indonesia.  Isolation  process  was  done  by  maceration  at  room  temperature  in  methanol, than  partitioned  in  a  mixture  of  n  hexane-water  (1:1),  followed  by  dichloromethane-water (1:1)    and  ethyl  acetate-water  (1:1).  A  portion  of  ethyl  acetate  extract  was  subjected  to column chromatography over silica gel packed and eluted with n-hexane a gradient of ethyl acetate to 100% followed by CHCl3  in MeOH (20:1, 10 :1, 5:1, 1:1). Fraction  B (CHCl3 in MeOH 20:1) was subjected to column chromatography  over silica gel 300 mesh  and eluted with  EtOAc-MeOH  mixtures  of  increasing  polarity.  Faction  with  the  same  Rf  valeus  were combined  and  eluted  with  EtOAc-MeOH    (19:1)  showed  one  spot  on  TLC.  They  were combined  and  evaporated  to  yield  a  solid  than  was  recrystallized  in  mixture  of  CH2Cl2-methanol  to  give  soulatro  coumarin  compound.  The  structure  was  determinated  by spectroscopic analysis, in particular by 1D and 2D NMR techniques, from these spectra data conclution  that  compound  is  soulatro  coumarin.  Antimalarial  assay  was  tested  against Plasmodium berghei parasite as in vivo using 18 mices rodent wich was infected by  Plasmodium berghei  parasite.  The  soulatro  coumarin    showed  activity  against  P.  berghei  with  dosage 0.0005867  mM/1  kg  body  weight  ;  0.005867  mM/1  kg  bw;  0.05867  mM/1  kg  bw;  0.5867 mM/1  kg  bw  5.867  mM/1  kg  bw  and  58.67  mM/1  kg  bw  could  inhibite  growth  rate  of parasite = 57.32%; 63.37%; 43.02%; 53.49%; 47.67% respectively.   Keywords : Antiplasmodial activity, coumarin, Calophyllum soulattri Burm. F, in vivo,  Chloroquine, Plasmodium berghei.
Anticancer Evaluation of Plants from Indonesian Tropical Rain Forests Abbas, Jamilah
Indonesian Journal of Cancer Chemoprevention Vol 2, No 3 (2011)
Publisher : Indonesian Research Gateway

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The  anticancer  activities  of  medicinal  plants  from Indonesia’s tropical rainforests were investigated  against  Hela  cell  line.  Maytenfoliol  from  leaves  of  Calophyllumtetrapterum  3-epibetulinic  acid  from  stem  bark  of    C.  tomentosum Wight  and  D.A-friedo-oleanan-3-on  from stem bark of C. moonii showed anticancer activity. The compound 3-epibetulinic acid showed the more potent anticancer activity than maytenfoliol  and D.A-friedo-oleanan-3- with thean IC50  value were 3.17 μg/mL, 4.89 μg/mL and 5.63 μg/mL, respectively.Keywords: Anticancer  evaluation,  Hela  cell  line, Calophyllumtetrapterum.  C.  tomentosum Wight and  C. moonii
Isolation and Identification of Antiplasmodial Compound from Methanol Extract of Calophyllum bicolor P. F. Steven Abbas, Jamilah; Hanafi, Muhammad; Artanti, Nina; Sundowo, Andini; Minarti, Minarti; Asih, Puji Budi Setia; Syafrudin, Din
ANNALES BOGORIENSES Vol 19, No 2 (2015): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/ab.v19i2.253

Abstract

Calophyllum bicolor (Clusiacea) is a big tree from Indonesian rain forest in Palangkaraya, Central Kalimantan. Calophyllum or bintagor is one of many sources of natural bioactive compounds that can be used in the fields of health and pharmaceuticals. The aim of this research was to explore the antiplasmodial activity of methanol extract of Calophyllum bicolor P.F. Steven against Plasmodium falciparum. The methanol extract was purified by colomn chromatography system, hexane – ethyl acetate was used as solvent with increasing polarity. One pure compound was obtained and was elucidated based on the 1H-&13C-NMR and 2D-NMR, [COSY, HMBC and HMQC] data and the isolated compound was identified as xanthone. Methanol extract showed antiplasmodial activity growth inhibition against P. falciparum with IC50 5.2 ppm and the new 5-methoxy trapezifolixanthone compound have maximum inhibition at concentration 0.11 nMol.
Strategi Pemenuhan Ruang Terbuka Hijau (RTH) di Kecamatan Panakkukang Kota Makassar Nurhafifa; Ruslan, Rusneni; Abbas, Jamilah; AS, Kurniati
Journal of Urban Planning Studies Vol 4 No 1 (2023): Journal of Urban Planning Studies, November 2023
Publisher : Fakultas Teknik Universitas Bosowa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35965/jups.v4i1.473

Abstract

Abstract. The purpose of this study is to calculate the area of availability and need for Green Open Space (RTH) in Panakkukang District, Makassar City, and formulate a strategy for fulfilling Green Open Space in Panakkukang District, Makassar City. This research is qualitative research that is interpreted descriptively. The data obtained were then analyzed using qualitative analysis using the Indonesian Green-Blue Index (IHBI) method and descriptive analysis. (1) The results of the analysis obtained from calculating the area of green open space needs based on the area and population in Panakkukang District have been met to reach 30%, by looking at the results of calculating the area of availability of green open space using the Indonesian Green-Blue Index method, which is 668.10 Ha with a percentage of 39.2% of the area of Panakkukang District. (2) The strategy of fulfilling green open space in Panakkukang District is to maintain and maintain the preservation of existing green open space by meeting the criteria for the Green Open Space function consisting of ecological, water catchment, economic, socio-cultural, and disaster management functions.
Co-Authors . Frengki . Katrin . Rissyelly . Syafruddin A.A. Ketut Agung Cahyawan W Achmad Darmawan Andini Sundowo AS, Kurniati Berna Elya Minarti Minarti Nina Artanti Nurhafifa Puji Budi Setia Asih, Puji Budi Ruslan, Rusneni Syafrudin, Din