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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Teknologi Pangan dan Gizi ANNALES BOGORIENSES Makara Journal of Science Jurnal Kefarmasian Indonesia
Andini Sundowo
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang, Banten
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Immunology & microbiology Medicine & Pharmacology

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Isolation and Identification of Antiplasmodial Compound from Methanol Extract of Calophyllum bicolor P. F. Steven Abbas, Jamilah; Hanafi, Muhammad; Artanti, Nina; Sundowo, Andini; Minarti, Minarti; Asih, Puji Budi Setia; Syafrudin, Din
ANNALES BOGORIENSES Vol 19, No 2 (2015): Annales Bogorienses
Publisher : Research Center for Biotechnology - Indonesian Institute of Sciences (LIPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/ab.v19i2.253

Abstract

Calophyllum bicolor (Clusiacea) is a big tree from Indonesian rain forest in Palangkaraya, Central Kalimantan. Calophyllum or bintagor is one of many sources of natural bioactive compounds that can be used in the fields of health and pharmaceuticals. The aim of this research was to explore the antiplasmodial activity of methanol extract of Calophyllum bicolor P.F. Steven against Plasmodium falciparum. The methanol extract was purified by colomn chromatography system, hexane – ethyl acetate was used as solvent with increasing polarity. One pure compound was obtained and was elucidated based on the 1H-&13C-NMR and 2D-NMR, [COSY, HMBC and HMQC] data and the isolated compound was identified as xanthone. Methanol extract showed antiplasmodial activity growth inhibition against P. falciparum with IC50 5.2 ppm and the new 5-methoxy trapezifolixanthone compound have maximum inhibition at concentration 0.11 nMol.
PENGARUH PENAMBAHAN STARTER DAN WAKTU INKUBASI: DARK COKLAT (Theobromo cacao L.) TERHADAP AKTIVITAS ANTIOKSIDAN DAN KUALITAS MINUMAN PROBIOTIK Mulyani, Hani; Sundowo, Andini; Filailla, Euis; Ernawati, Teni
Jurnal Teknologi Pangan dan Gizi Vol 18, No 1 (2019)
Publisher : Widya Mandala Surabaya Catholic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.33508/jtpg.v18i1.1984

Abstract

Pada pembuatan yogurt terjadi konversi gula susu (laktosa) menjadi asam laktat melalui proses fermentasi oleh bakteri asam laktat (BAL). Konsentrasi stater dan waktu fermentasi yang digunakan akan mempengaruhi kecepatan perombakan laktosa menjadi asam laktat. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan stater dengan variasi sebesar : 1, 5, 10, 15 dan 20% dan waktu fermentasi pada 24 jam dan 48 jam terhadap asam laktat. Parameter yang diuji diantaranya adalah pH, kadar laktosa, kadar protein, kadar asam lakat, dan aktivitas antioksidan. Parameter yang diuji dari hasil proses fermentasi adalah pH, laktosa, asam laktat, protein terlarut. Pengujian laktosa dan asam laktat dilakukan dengan menggunakan HPLC, pengujian konsentrasi protein terlarut dengan menggunakan metode Lowry. Asam laktosa dan asam laktat tertinggi diperoleh dari fermentasi dengan variasi konsentrasi BAL starter 15% dalam waktu fermentasi selama 24 jam. Hasil analisis % inhibisi pada yogurt konsentrasi stater 10% dan waktu fermentasi 48 jam tanpa penambahan dark coklat dan penambahan dark coklat menunjukkan % inhibisi antioksidan paling tinggi dibandingkan dengan yang lainnya sebesar 20,84 % dan 95,58%. Hasil penelitian Variasi starter konsentrasi BAL dan lamanya proses fermentasi tidak mempengaruhi pH dan kadar protein terlarut.
PREPARATION OF 2-AMINOETHYLSULFONIC ACID Widiyarti, Galuh; Hanafi, Muhammad; Isnijah, Siti; Kardono, Broto Sugeng; Ermawan, Ermawan; Ngadiman, Ngadiman; Sundowo, Andini
Makara Journal of Science Vol. 13, No. 1
Publisher : UI Scholars Hub

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Abstract

Preparation process of 2-aminoethylsulfonic acid (taurine) from ethanolamine, sulfuric acid and sodium sulfite has been studied. The process involves two steps of reactions, the first was esterification of ethanolamine (H2N-CH2-CH2-OH) with sulfuric acid to produce the intermediate product of 2-aminoethyl ester (H2N-CH2-CH2-OSO3H) which then was extended to the second step by sulfonation with sodium sulfite to produce 2-aminoethylsulfonic acid (H2N-CH2-CH2- SO3H). These two process conditions were observed by varying mole ratio of reactants, temperature and time period of reactions. Taurine product was qualitatively analyzed using 1 H-NMR and LC-MS. Physical-chemical analysis were done by observing its melting point and determining its water, chloride and sulfate contents. Its melting point, water content, and sulfate content were 290o C, 0.303%, and 3 ppm, respectively, while its chloride content was undetected. After purification, the yield of process was 25.57%.
THE FREE RADICAL SCAVENGING AND ANTI-HYPERGLYCEMIC ACTIVITIES OF VARIOUS GAMBIERS AVAILABLE IN INDONESIAN MARKET Widiyarti, Galuh; Sundowo, Andini; Hanafi, Muhammad
Makara Journal of Science Vol. 15, No. 2
Publisher : UI Scholars Hub

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Abstract

Chemical Profiles and Biological Activities of Microalga Chlorella sp. from Southeast Sulawesi Haslianti, Haslianti; Asnani, Asnani; Fristiohady, Adryan; Sadarun, Baru; Sutariati, Gusti Ayu Kade; Sundowo, Andini; Yodha, Agung Wibawa Mahatva; Baharum, Syarul Nataqain; Idin, Sahidin
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 29, No 2 (2024): Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/ik.ijms.29.2.233-240

Abstract

Microalgae Chlorella sp. grows in the seas of South-East Sulawesi, Indonesia. However, information on the chemical and pharmaceutical aspects of this species from this region is still limited. Therefore, this research aims to explore the chemical contents and biological activities of Chlorella sp. The sample was collected from the Kali Biru and Nambo waters, Kendari. The microalgae were isolated by the agar plating technique and extracted by ethanol. Chemical content was analyzed by phytochemical screening, Liquid Chromatography-tandem Mass Spectroscopy (LC-MS/MS), Total Phenolics Content (TPC) and Total Flavonoids Contents (TFC). Biological activities evaluation includes antioxidant, toxicity, cytotoxicity and antimicrobial. Antioxidant potency was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals and ABTS (2,2’-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid). Toxicity and cytotoxicity properties were analyzed by BSLT (Brine Shrimp Lethality Test) and MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assays against Breast cancer (MCF-7) cell lines. Antimicrobial potency was tested towards E. coli, S. aureus and C. albicans. The result showed that ethanol extract of Chlorella sp. (EEC) contained phenolics, flavonoids, alkaloids and terpenoids/steroids which were supported by LC-MS/MS data, TPC and TFC with value 150.33 and 33.18 mgGAE.g-1 extract. Seven of ten identified major compounds caused this extract to have antioxidant and anticancer including xanthin, 1,1-Diethyl-3-oxo-2- triazanolate, Azelaic acid, ruspolinone, 6-keto prostaglandin F1a and glycol stearate. In general, the biological activity of EEC is less active than the positive controls for each assay. However, the EEC is more potential to be developed as antioxidant such as sunscreen and anticancer especially breast cancer with IC50 value 151-200 ppm and 100-500 ppm, respectively. 
Sintesis dan Evaluasi Antimalaria In Vitro Turunan Kinin Terhadap Plasmodium falciparum Salahuddin, Salahuddin; K, Rahmana Emran; Hanafi, Muhammad; Sundowo, Andini; NL, Puspa Dewi; Adipratiwi, Nadia; Ariyani, Titin; Prabandari, Erwahyuni Endang; Waluyo, Danang
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 2, AGUSTUS 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i2.3923

Abstract

Nowadays kinin is the most effective antimalarial drug and its used as an alternative in malaria treatment. However, toxicity of quinine restrict its use as an antimalarial drug. Lipophilicity and long half-life (t½) of quinine that reach 10-20 hours are responsible for its toxicity. The aim of this research is to obtain more polar quinine derivatives by means of hydrogen peroxide reactions to reduce the toxicity. The reactions using hydrogen peroxyde is performed analogously to the procedures reported in the literature. Extract of pure anhydrous kinin is purified in coloumn chromatography followed by structure elucidation. Synthetic product is tested in vitro against Plasmodium falciparum. The characterization of reaction products is performed with proton (1H) and carbon 13 (13C) nuclear magnetic resonance (NMR) spectroscopy. It showed that the reaction using reagents led to epoxidation of vinyl substituents of chinuclidine ring with 61,08% yields. Antimalarial test against Plasmodium falciparum obtained 1.250-2.500 μg/mL of IC50 value. The IC50 values indicated that the synthesis products were not potential for malaria treatment.
Co-Authors A.A. Ketut Agung Cahyawan W Adipratiwi, Nadia Ariyani, Titin Asnani Asnani Baharum, Syarul Nataqain Baru Sadarun Ermawan Ermawan ERWAHYUNI ENDANG PRABANDARI Filailla, Euis Fristiohady, Adryan Galuh Widiyarti Gusti Ayu Kade Sutariati Hani Mulyani, Hani Haslianti Haslianti, Haslianti Idin, Sahidin Jamilah Abbas K, Rahmana Emran Kardono, Broto Sugeng Minarti Minarti Muhammad Hanafi Ngadiman Ngadiman Nina Artanti NL, Puspa Dewi Puji Budi Setia Asih, Puji Budi Salahuddin Salahuddin Siti Isnijah Syafrudin, Din Teni Ernawati Waluyo, Danang Yodha, Agung Wibawa Mahatva