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All Journal Imajiner: Jurnal Matematika dan Pendidikan Matematika Sciences of Pharmacy
Haidar, Hilal
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Public Health Other

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Efektivitas Model Pembelajaran Time Token terhadap Kemampuan Pemecahan Masalah ditinjau dari Motivasi Belajar Siswa Kelas VIII SMP Negeri 1 Gembong Haidar, Hilal; Purnomo, Djoko; Nugroho, Aryo Andri
Imajiner: Jurnal Matematika dan Pendidikan Matematika Vol 2, No 5 (2020): Imajiner: Jurnal Matematika dan Pendidikan Matematika
Publisher : Universitas PGRI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26877/imajiner.v2i5.6669

Abstract

Penelitian ini bertujuan untuk mengetahui hasil belajar pada pembelajaran dengan pengaruh positif model Time Tokenmencapai KKM, untuk mengetahui apakah terdapat korelasi positif motivasi belajar terhadap kemampuan pemecahan masalah siswa, untuk mengetahui perbedaan kemampuan pemecahan masalah antara motivasi belajar kelas eksperimen dan motivasi belajar kelas kontrol. Penelitian ini menggunakan metode anava dua jalur. Hasil penelitian ini terdapat hasil belajar pada pembelajaran dengan menggunakan model Time Token yang mencapai di atas KKM, hal ini ditunjukkan melalui hasil  uji ketuntasan yang diperoleh 70% untuk kelas control sedangkan 93% untuk kelas eksperimen. Kedua terdapat korelasi positif motivasi belajar terhadap kemampuan pemecahan masalah siswa. Hal ini ditunjukkan melalui hasil uji korelasi yang diperoleh dengan nilai signifikansi 0.006<0.05 (5%). Ketiga terdapat perbedaan kemampuan pemecahan masalah antara motivasi belajar kelas eksperimen dan motivasi belajar kelas kontrol.
Liposomal Gel of Centella asiatica: Antioxidant Activity and Release Profile Indriaty, Sulistiorini; Firmansyah, Deni; Utami, Mima Eliestya; Karlina, Nina; Suharyani, Ine; Haidar, Hilal; Safitri, Amanda; Setiawati, Elis
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404437

Abstract

Centella asiatica (L.) Urban contains flavonoids and triterpenoids with strong antioxidant activity; however, its topical bioavailability is limited by poor solubility. This study aimed to formulate and evaluate liposomal gel systems containing a 70% ethanol extract of C. asiatica to enhance dermal penetration while preserving antioxidant activity. The extract was incorporated into liposomes using a lecithin–cholesterol ratio of 9:1 and formulated into gels at concentrations of 0.3% (FG1) and 0.5% (FG2). Physicochemical characterization showed mean particle sizes of 119.8 ± 7.21 nm (FG1) and 101.3 ± 6.55 nm (FG2), with polydispersity index values of 0.410 and 0.306, respectively, indicating acceptable vesicle homogeneity across three independent replicates (n = 3). The formulations were physically stable for two weeks at 4 °C but exhibited instability at elevated temperatures. Antioxidant activity evaluated using the DPPH assay yielded IC₅₀ values of 13.87 ± 0.02 µg/mL for FG1 and 13.97 ± 0.06 µg/mL for FG2, which were not significantly different (p > 0.05) from vitamin C (9.16 ± 0.06 µg/mL), indicating preservation of radical-scavenging capacity. In vitro permeation studies using Franz diffusion cells demonstrated cumulative quercetin penetration of 280.86 ± 1.12 µg/cm² for FG1 and 314.40 ± 0.93 µg/cm² for FG2 over 4 h, with FG2 showing significantly higher flux (p < 0.05). Release kinetics followed a zero-order model (R² = 0.9881–0.9914), suggesting controlled release behavior. Overall, liposomal gel formulations show potential for improving topical delivery of C. asiatica without overstating long-term stability or therapeutic superiority.
Co-Authors Aryo Andri Nugroho Deni Firmansyah Djoko Purnomo Elis Setiawati, Elis Nina Karlina Safitri, Amanda Suharyani, Ine Sulistiorini Indriaty Utami, Mima Eliestya