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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Bali Medika Jurnal
Wirawati, Ida Ayu Putri
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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GAMBARAN SKRINING HASIL PEMERIKSAAN HBsAg PADA PASIEN PRE-HEMODIALISIS DI RSUD WANGAYA TAHUN 2021 Antika, Novia Putri; Prasetya, Didik; Wirawati, Ida Ayu Putri
Bali Medika Jurnal Vol 10 No 1 (2023): Bali Medika Jurnal Vol 10 No 1 Juli 2023
Publisher : Stikes Wira Medika Bali

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36376/bmj.v10i1.330

Abstract

Perhimpunan Nefrologi Indonesia telah mensyaratkan tentang keharusan pemeriksaan yang dilakukan sebelum melakukan hemodialisis salah satunya yaitu pemeriksaan HBsAg. Pasien hemodialisis berisiko tinggi untuk terinfeksi virus hepatitis B karena memiliki daya tahan tubuh yang turun dan infeksi virus yang ditularkan melalui darah. Hemodialisis menjadi tindakan yang sangat membantu pasien PGK untuk memperpanjang usia pasien. Tes HBsAg diperlukan untuk memastikan keberadaan virus hepatitis B di dalam tubuh. Tujuan dari penelitian ini yaitu untuk mengetahui gambaran hasil skrining pemeriksaan HBsAg pada pasien pre-hemodialisis di RSUD Wangaya tahun 2021. Penelitian ini merupakan penelitian deskriptif observasional menggunakan data sekunder. Jumlah sampel pada penelitian ini adalah 63 pasien yang diambil dengan teknik total sampling. Hasil penelitian berdasarkan usia menunjukkan proporsi terbanyak pada pasien dengan usia 20-60 tahun sebanyak 39 (61,9%) dan pasien >60 tahun sebanyak 24 (38,1%). Berdasarkan jenis kelamin menunjukan proporsi laki-laki lebih banyak yaitu sebanyak 38 (60,3%) dan perempuan sebanyak 25 (39,7%). Hasil dari pemeriksaan skrining HBsAg didapatkan pasien negatif HBsAg sebanyak 62 pasien (98,4%) dan positif sebanyak 1 pasien (1,6%). Hasil dari pengelompokan berdasarkan diagnosa yaitu diagnosa terbanyak adalah hipertensi sebanyak 14 pasien (22,2%) dan diagnosa Diabetes melitus sebanyak 13 pasien (20,6%). Skrining hepatitis B perlu dilakukan saat pertama kali hemodialisis agar dapat menjaga keselamatan kerja petugas kesehatan dan mencegah penularan terhadap pasien lainnya. Kata Kunci: Hepatitis B, Hemodialisis, Gagal ginjal kronik
The Correlation between HbA1c and MCP-1 Levels in Diabetic Retinopathy Patients Lestari, Anak Agung Wiradewi; Nabu, Ekarini Katharina Yunarti; Triningrat, Anak Agung Mas Putrawati; Wande, I Nyoman; Wirawati, Ida Ayu Putri; Mahartini, Ni Nyoman; Cong, Tzeto Han; Prabawa, I Putu Yuda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2678

Abstract

Diabetic Retinopathy (DR) is a common microvascular complication of diabetes mellitus and a leading cause of vision loss. Persistent hyperglycemia plays a central role in the pathogenesis of DR by promoting chronic inflammation. Monocyte Chemoattractant Protein-1 (MCP-1), a key pro-inflammatory chemokine, is believed to mediate this process. This study aimed to investigate the correlation between glycemic control, as reflected by glycated hemoglobin (HbA1c) levels, and serum MCP-1 concentrations in patients with DR. A cross-sectional analysis was conducted involving 45 DR patients at Prof. dr. I. G. N. G. Ngoerah General Hospital. HbA1c levels were assessed enzymatically and reported in NGSP units, while serum MCP-1 concentrations were measured through ELISA and expressed in pg/mL. The correlation between the two parameters was evaluated using Spearman's rank correlation test, with significance determined at p <0.05.The participants consisted of 64.4% males and 35.6% females, with a mean age of 55.0±6.6 years. The median HbA1c was 9.5% (range: 5.9–12.3%), and the median MCP-1 level was 320.57 pg/mL (range: 32.34–605.41 pg/mL). A moderate positive correlation was identified between HbA1c and MCP-1 levels r = 0.45; p = 0.007). These findings indicate that increased blood glucose levels may coincide with elevated MCP-1, suggesting an ongoing inflammatory response contributing to DR progression. This study demonstrates a significant moderate positive correlation between HbA1c and serum MCP-1 in DR patients, suggesting that elevated blood glucose levels may contribute to increased MCP-1 expression. These findings support the potential role of MCP-1 as a biomarker of both poor glycemic regulation and inflammation in the progression of diabetic retinopathy.
Co-Authors Anak Agung Wiradewi Lestari Antika, Novia Putri Cong, Tzeto Han I Nyoman Wande Mahartini, Ni Nyoman Nabu, Ekarini Katharina Yunarti Prabawa, I Putu Yuda Prasetya, Didik Triningrat, Anak Agung Mas Putrawati