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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Pharmaceutical Sciences and Research (PSR)
Cong, Tzeto Han
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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L-citrulline as Alternative Pharmacological Substance in Protecting Against Cardiovascular Disease Laurentius, Andrea; Wikanendra, Gregorius Bhaskara; Cong, Tzeto Han; Arozal, Wawaimuli
Pharmaceutical Sciences and Research Vol. 5, No. 2
Publisher : UI Scholars Hub

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Abstract

Cardiovascular disease (CVD) has taken up to average 30% of death diagnoses in the world. Prevalent attempts of physicians to treat this disease came down to focus on using drugs with their specific mechanism of action. Since the method only cures the symptoms and need to be pharmacologically monitored, physicians and scientists have been struggling to find other treatment strategies. This problem led us to search for another substance dealing with CVD via preventive therapy, which does not require such close monitoring by physicians in its use. The answer relies on using L-citrulline as potential therapeutics in treating and preventing CVDs. This compound, found mostly in Citrus sp., contains chemical traits that could affect other bodily substances with its metabolic pathways. It has several functions, but boosting NO production is the dominant one in the cardiovascular system. By enhancing NO bioavailability, it suppresses the risk of having myocardial oxidative stress due to ischemia, cardiac pressure-overload, and post-infarct reperfusion. Thus, understanding of L-citrulline effects on endothelial NOS pathway in the generation of NO and its uncoupling mechanisms could be used as a foundation in developing alternative treatment and prevention of oxidative stress-induced CVD.
The Concordance of Platelet Counts on Hematology Analyzer with Thrombocytopenia Sample with Platelet Clump Prabawa, I Putu Yuda; Lestari, Anak Agung Wiradewi; Wande, I Nyoman; Mahartini, Ni Nyoman; Herawati, Sianny; Cong, Tzeto Han
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2437

Abstract

Pseudo-thrombocytopenia is a pre-analytical issue commonly observed in clinical laboratory settings due to platelet aggregation or clumps. In cases of thrombocytopenia, it is essential to conduct a platelet count via Peripheral Blood Smear (PBS) to identify clumping and subsequently re-evaluate the platelet count. The examination of platelets can now be carried out through different methodologies offered by Hematology Analyzers, such as PLT-I, PLT-O, and PLT-F. The primary objective of this research was to evaluate the correlation and agreement of platelet count findings (PLT-I, PLT-O, and PLT-F) in samples displaying flagged platelet clumps between a Hematology Analyzer and PBS at Prof. dr. I.G.N.G. Ngoerah General Hospital, Bali. An analytical cross-sectional observational study was conducted on 71 samples of thrombocytopenia with platelet clump flagging on the Sysmex® XN-1000 Series Hematology Analyzer at Prof. dr. I. G. N. G. Ngoerah Hospital. SPSS version 26.0 and MedCalc were used to conduct statistical analysis. There was a significant difference in the PLT clump Fluorescence index (p = 0.001) between the sample groups with and without the clump, and there was a strong positive correlation of the PLT count results between the Hematology Analyzer (p <0.001) and PBS in the sample groups with and without the clump. The Bland-Altman mean bias was lowest in the sample group without clumps against PLT-I (0.39x103/ml; 95% LOA: -57.05-57.83) and highest in the sample group with a clump to PLT-F (105.38x103/ml; 95% LOA: -14.7-225.46). There is a strong positive correlation and concordance of platelet count results between the Hematology Analyzer and PBS. However, there is no concordance between the platelet count results from the Hematology Analyzer and PBS in the clump group.
The Correlation between HbA1c and MCP-1 Levels in Diabetic Retinopathy Patients Lestari, Anak Agung Wiradewi; Nabu, Ekarini Katharina Yunarti; Triningrat, Anak Agung Mas Putrawati; Wande, I Nyoman; Wirawati, Ida Ayu Putri; Mahartini, Ni Nyoman; Cong, Tzeto Han; Prabawa, I Putu Yuda
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2678

Abstract

Diabetic Retinopathy (DR) is a common microvascular complication of diabetes mellitus and a leading cause of vision loss. Persistent hyperglycemia plays a central role in the pathogenesis of DR by promoting chronic inflammation. Monocyte Chemoattractant Protein-1 (MCP-1), a key pro-inflammatory chemokine, is believed to mediate this process. This study aimed to investigate the correlation between glycemic control, as reflected by glycated hemoglobin (HbA1c) levels, and serum MCP-1 concentrations in patients with DR. A cross-sectional analysis was conducted involving 45 DR patients at Prof. dr. I. G. N. G. Ngoerah General Hospital. HbA1c levels were assessed enzymatically and reported in NGSP units, while serum MCP-1 concentrations were measured through ELISA and expressed in pg/mL. The correlation between the two parameters was evaluated using Spearman's rank correlation test, with significance determined at p <0.05.The participants consisted of 64.4% males and 35.6% females, with a mean age of 55.0±6.6 years. The median HbA1c was 9.5% (range: 5.9–12.3%), and the median MCP-1 level was 320.57 pg/mL (range: 32.34–605.41 pg/mL). A moderate positive correlation was identified between HbA1c and MCP-1 levels r = 0.45; p = 0.007). These findings indicate that increased blood glucose levels may coincide with elevated MCP-1, suggesting an ongoing inflammatory response contributing to DR progression. This study demonstrates a significant moderate positive correlation between HbA1c and serum MCP-1 in DR patients, suggesting that elevated blood glucose levels may contribute to increased MCP-1 expression. These findings support the potential role of MCP-1 as a biomarker of both poor glycemic regulation and inflammation in the progression of diabetic retinopathy.
Co-Authors Anak Agung Wiradewi Lestari I Nyoman Wande Laurentius, Andrea Mahartini, Ni Nyoman Nabu, Ekarini Katharina Yunarti Prabawa, I Putu Yuda Sianny Herawati Triningrat, Anak Agung Mas Putrawati Wawaimuli Arozal Wikanendra, Gregorius Bhaskara Wirawati, Ida Ayu Putri