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CORRELATION BETWEEN NUCLEUS FACTOR KAPPA B AND MICROVESSEL DENSITY IN NASOPHARYNGEAL CARCINOMA Farrel; Tobing, Izry Naomi; Fahat; Asnir, Rizalina A; Adnan, Adlin
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i02.3924

Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-ÎºB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-ÎºB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-ÎºB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-ÎºB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-ÎºB expression and MVD. Results: Positive NF-ÎºB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-ÎºB and MVD. Conclusion: This study has not confirmed any correlation between NF-ÎºB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.

Factors Affecting Presbycusis on Audiogram Overview at H. Adam Malik General Hospital Medan Manullang, Frenky Sorimuda; Adnan, Adlin; Munir, Delfitri
Journal of Epidemiology and Public Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Background: Presbycusis incidence is thought to have a relationship with hereditary factors, metabolism, atherosclerosis, noise and lifestyle. The presbycusis classification consists of Sensory (outer hair-cell), neural (ganglion-cell), metabolic (strial atrophy), and conductive cochlea (stiffness of the basilar membrane). Factors that influence presbycusis include age, gender, genetics, hypertension, gout, diabetes mellitus, hypercholesterolemia, noise exposure, and smoking. This study aims to determine the factors that influence presbycusis on the audiogram image at H. Adam Malik Hospital Medan. Subjects and Method: This study was an analytical study with a cross sectional design in elderly patients at the polyclinic. The study was conducted in November to December 2019. The dependent variable was the incidence of presbycusis. The independent variables were uric acid levels, blood sugar levels, smoking habits, hypercholesterolemia, and hypertension. Data were analyzed by using chi square test. Results: The prevalence of presbycusis in the 45-59 years age group was 39 people (54.2%) and the 60-74 years age group was 33 people (45.8%). In this study, it shows that male respondents are more than female respondents, where the number of men is 58 people (80.6%) and women are 14 people (19.4%). Based on presbycusis type, there were 33 (45.9%) people (normal), 18 (25%) people (strrial type), 7 (7.9%) people (neural type), 7 (7.9%) people (sensory type), 7 (7.9%) people (cochlear type). High sugar content (OR= 3.33; 95% CI= 1.81 to 6.13; p <0.001), uric acid levels (OR= 2.36; 95% CI= 1.19 to 4.70; p= 0.005), total cholesterol levels (OR= 3.33; 95% CI= 1.81 to 6.13; p <0.001), and smoking (OR= 1.90; 95% CI = 1.21 to 2.97; p= 0.016) increased the risk of presbycusis. Conclusion: High sugar levels, uric acid levels, total cholesterol levels, and smoking habits increase the risk of presbycusis.

Proporsi karakteristik penderita rinosinusitis kronis dengan kultur jamur positif Siska Indriany; Delfitri Munir; Andrina Yunita Murni Rambe; Adlin Adnan; Rina Yunita; Sorimuda Sarumpaet
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Latar belakang: Rinosinusitis dengan infeksi jamur atau disebut juga rinosinusitis jamur adalahinflamasi mukosa sinus paranasal yang disebabkan oleh infeksi jamur. Gejala klinik rinosinusitis jamurmirip dengan rinosinusitis kronis. Apabila rinosinusitis tidak mengalami perbaikan sesudah terapimedikamentosa maksimal, perlu dipikirkan kemungkinan infeksi jamur.Tujuan: Mengetahui proporsikarakteristik penderita rinosinusitis kronis dengan kultur jamur positif.Metode: Penelitian observasionaldeskriptif terhadap 74 kasus rinosinusitis kronis tahun 2013-2015.Hasil: Dari 74 kasus rinosinusitis kronisyang dilakukan tindakan bedah sinus endoskopi fungsional, terdapat 30 positif jamur (40,5%). Dari 30kasus rinosinusitis dengan kultur jamur positif, 60% pada umur 20-40 tahun, 53,3% laki-laki, keluhanutama hidung tersumbat (66,6%). Hasil kultur 50% Aspergillus fumigatus. Uji statistik Fisher Exact Testp>0,05 tidak terdapat perbedaan hasil kultur jamur berdasarkan umur dan jenis kelamin pada penderitarinosinusitis kronis.Kesimpulan: Pada laporan ini penderita rinosinusitis kronis dengan kultur jamurpositif tahun 2013-2015 sebanyak 30 kasus. Rinosinusitis kronis dengan kultur jamur positif terjadi lebihbanyak pada laki-laki dengan rentang usia 20-40 tahun dan keluhan yang ditemukan hampir sama denganrinosinusitis kronis. Beberapa jenis jamur ditemukan pada hasil kultur, tetapi yang terbanyak Aspergilusfumigatus. Secara statistik tidak didapat perbedaan hasil kultur jamur berdasarkan umur dan jenis kelaminpada penderita rinosinusitis kronis. Pemberian antijamur tidak dapat diberikan pada rinosinusitis kronisdengan kultur jamur positif, karena antijamur hanya diindikasikan pada rinosinusitis jamur invasif. Kata kunci: Rinosinusitis kronis, kultur jamur positif, rinosinusitis jamur invasif ABSTRACTBackground: Fungal infection in paranasal sinuses were mostly undetected. The clinical symptomsof fungal rhinosinusitis were very similar to bacterial chronic rhinosinusitis. When maximal medicaltherapy remained unsuccessful, we must consider the possibility of fungal infection. Objective: To findout the characteristic proportion of positive fungal cultures in chronic rhinosinusitis patients. Methods:Descriptive observational study in 74 cases of chronic rhinosinusitis between 2013-2015. Results: From 74cases of chronic rhinosinusitis who underwent FESS, there were 30 positive fungal cultures (40,5%). Fromthese 30 cases, 60% were between 20-40 years old, 53,3% males, with nasal blockage (66,6%) and facialpain (16,7%) as the main complaints. Result of the cultures were 50% Aspergillus fumigatus. StatisticalFisher Exact Test p>0.05 showed that there were no differences in the results of fungal culture based onthe age and sex of patients with chronic rhinosinusitis. Conclusion: In our study, positive fungal culturein chronic rhinosinusitis cases occurred more frequently in 20-40 years of age males, and the clinicalcomplaints were similar to chronic rhinosinusitis. Several types of fungus were found on culture results,mostly were Aspergillus fumigatus. Statistically there were no differences of fungal culture based on ageand sex in chronic rhinosinusitis patients. Antifungal could not be prescribed in chronic rhinosinusitiswith positive fungal culture only. It is indicated only for invasive fungal rhinosinusitis. Keywords: Chronic rhinosinusitis, positive fungal culture, invasive fungal rhinosinusitis

Hubungan merokok dengan gangguan pendengaran akibat bising pada pekerja pabrik kelapa sawit X Maesyara Adinda Sari; Adlin Adnan; Delfitri Munir; Putri Chairani Eyanoer
Oto Rhino Laryngologica Indonesiana Vol 47, No 2 (2017): Volume 47, No. 2 July - December 2017
Publisher : PERHATI-KL

Latar belakang: Paparan bising dapat mengakibatkan kerusakan pada organ korti, dan menurunkan aliran darah koklea yang mengakibatkan hipoksia koklea. Merokok diketahui sebagai ototoksik langsung dan pemicu iskemia koklea. Kebiasaan merokok dan paparan bising secara sendiri ataupun secara bersama-sama dapat menyebabkan gangguan pendengaran. Tujuan: Mengetahui hubungan merokok terhadap kejadian gangguan pendengaran akibat bising (GPAB). Metode: Penelitian analitik dengan pendekatan potong lintang. Hasil: Dari 122 pekerja, didapati sebanyak 89,3% pekerja mengalami GPAB. Tuli ringan paling banyak ditemukan (68,8%). Didapatkan adanya hubungan yang signifikan antara tipe perokok dengan derajat beratnya GPAB (p=0,000). Kemungkinan pekerja yg merokok untuk mengalami GPAB 1,224 kali lebih besar dibandingkan dengan pekerja yang tidak merokok (PR=1,224, p=0,002, CI 95%=1,077–1,392). Kesimpulan: Terdapat hubungan yang signifikan antara kebiasaan merokok dengan kejadian GPAB.Kata kunci: Merokok, gangguan pendengaran, gangguan pendengaran akibat bising, bising lingkungan kerja ABSTRACT Introduction: Noise exposure can lead to the organ of corti damage, and decrease the blood flow to the cochlea resulting in cochlear hypoxia. Cigarette smoking could be ototoxic to cochlea, and could evoke cochlear ischemia. Cigarette smoking habit and noise exposure, each or together can cause hearing loss. Objective: To identify the correlation between cigarette smoking and noise induced hearing loss (NIHL). Method: Analytic with a cross-sectional study. Results: From the 122 workers, we found that the proportion of NIHL was 89.3%. Mild deafness was most common (68.8%). We found that there was a significant correlation between type of smokers and grade of hearing loss (p=0.000). Workers who smoked likely to undergo NIHL 1.224 times greater than nonsmokers (PR=1.224, p=0.002, CI 95%=1.077–1.392). Conclusion: There was a significant correlation between cigarette smoking habit and noise induced hearing loss.Keywords : Cigarette smoking, hearing loss, noise induced hearing loss, occupational noise exposure

Pengaruh bising lingkungan sekolah terhadap kelelahan bersuara pada guru sekolah dasar Hellena Miranda; Abdul Rachman Saragih; Adlin Adnan; Tengku Siti Hajar Haryuna
Oto Rhino Laryngologica Indonesiana Vol 41, No 1 (2011): Volume 41, No. 1 January - June 2011
Publisher : PERHATI-KL

Background: The effect of noisy school environment is not only affecting student’s consentration level, but also causing problem to teachers’s voice. Purpose: To know the influence of noisy school environment techers voice intensity of the lecturer toward the lecturer’s speaking exhaustion at a number of elementary school located in Medan. Method: The research used case control method upon 90 elementary school teachers as the subject. The teachers came from schools influenced by noisy environment and schools with quite environment located in the city of Medan. The exhaustion level of speaking is identified by score of voice handicap index (VHI). The statistical tests used were “t-test”, Chi-square test and the multinomial logistic regression test. Result: Average level of noise in case group was 80.8 dB, in control group was 54.6 dB, with voice intensity of 79.6 dB and 61 dB. The voice disturbance in both group identified as medium level with the score of VHI ranges from 20-40 (p=0.03). By statistical analysis using “Xtest”, we found significant corelations between the VHI score with school noise (p=0.03), the lecturer’s voice (p=0.03) and sex (p=0.01). The result of multinomial logistic regression test shows that voice exhaustion disruption were influenced by school noise intensity (OR=3.4, IK95%=1.05-10.94) and the lecturer’s voice intensity (OR=3.2, IK95%=1.04-10.07).Conclusion: Teachers at schools with noisy environment had 3.4 times higher risk than teachers from schools with quite environment, and teachers who used high intensity voice had 3.2 times higher risk than teachers with low intensity for voice disturbance. Key words: voice exhaustion, noise intensity, voice intensity Abstrak : Latar belakang: Lingkungan sekolah yang bising selain mempengaruhi konsentrasi belajar-mengajar, dapat juga menyebabkan masalah bersuara pada guru. Tujuan: Untuk mengetahui pengaruh bising lingkungan sekolah dan intensitas suara mengajar terhadap kelelahan bersuara pada guru di beberapa sekolah dasar negeri di kota Medan. Metode: Desain penelitian ini adalah studi kasus kontrol dengan subjek penelitian 90 guru yang mengajar di sekolah yang terpajan bising dan sekolah yang tidak terpajan bising di kota Medan. Tingkat kelelahan bersuara diidentifikasi melalui skor voice handicap index (VHI). Uji statistik yang digunakan uji t, uji X dan uji regresilogistic multinomial. Hasil: Rerata intensitas bising pada kelompok kasus sebesar 80,8 dB, sedangkan pada kelompok kontrol sebesar 54,6 dB. Intensitas suara guru saat mengajar, masing-masing sebesar 79,6 dB dan 61 dB. Gangguan kelelahan bersuara pada kedua kelompok tergolong ringan, dengan skor VHI sebesar 20-40 untuk kedua kelompok (p=0,03). Setelah dilakukan analisis statistik terhadap variabel yang diduga mempengaruhi skor VHI dengan menggunakan uji X2didapatkan hubungan yang bermakna antara intensitas bising sekolah (p=0,03) intensitas suara guru (p=0,03) dan jenis kelamin (p=0,01) dengan skor VHI. Hasil uji regresi logistik multinomial menunjukkan bahwa hanya intensitas bising sekolah (OR=3,4, IK95%= 1,05-10,94) dan intensitas suara guru (OR=3,2, IK95%=1,04-10,07) berpengaruh terhadap gangguan kelelahan bersuara.Kesimpulan: Guru yang mengajar di sekolah yang terpapar bising memiliki risiko kelelahan bersuara 3,4 kali lebih tinggi dibandingkan dengan guru di sekolah yang tidak terpapar bising, dan guru dengan intensitas suara yang tinggi saat mengajar akan mengalami kelelahan bersuara 3,2 kali lebih sering dibandingkan guru dengan intensitas suara rendah. Kata kunci: kelelahan bersuara, intensitas bising, intensitas suara

Hubungan paparan bising dan profil lipid dengan gangguan pendengaran pada pekerja pabrik minyak goreng Adlin Adnan; Renold Yurensa
Oto Rhino Laryngologica Indonesiana Vol 46, No 1 (2016): Volume 46, No. 1 January - June 2016
Publisher : PERHATI-KL

Latar belakang: Gangguan pendengaran akibat bising (GPAB) adalah komplikasi yang palingumum disebabkan oleh paparan terhadap bising, meskipun ada beberapa komplikasi lain yang bisadisebabkan oleh paparan bising. Komplikasi metabolik dari paparan terhadap bising telah dievaluasi olehberbagai penelitian.Tujuan: Meneliti hubungan antara GPAB dengan kadar profil lipid pada pekerja yangterpapar bising di lingkungan kerja.Metode: Penelitian ini bersifat deskriptif analitik dengan desain crosssectional study. Data diperoleh melalui proses wawancara, pemeriksaan audiometri, dan pemeriksaankadar profil lipid.Hasil: Rerata intensitas kebisingan bagian proses 98 dB, dan non-proses berkisar 46-98 dB. Berdasarkan hasil pemeriksaan audiometri terhadap 50 pekerja yang memenuhi kriteria inklusidan eksklusi, didapatkan 26 orang (52%) dengan GPAB tuli sensorineural dan 24 orang (48%) tidakmengalami GPAB. Kami menemukan hubungan signifikan antara paparan bising pada pekerja denganpeningkatan kadar trigliserida (TG), total kolesterol (TC), low-density lipoprotein (LDL), dan penurunankadar high-density lipoprotein (HDL) (p<0,05). Terdapat hubungan antara kadar TG yang tinggi terhadapterjadinya GPAB pada pekerja yang terpapar bising dengan intensitas >85 dB (p<0,05) dan tidak dijumpaihubungan peningkatan kadar TC, LDL, dan penurunan kadar HDL terhadap terjadinya GPAB (p>0,05).Kesimpulan: Pada penelitian ini, ada hubungan antara hiperlipidemia dengan GPAB. Pekerja denganhipertrigliseridemia yang tepapar bising >85 dB berisiko lebih besar menderita GPAB. Kata kunci: Kebisingan, GPAB, profil lipid ABSTRACTBackground: Noise induced hearing loss (NIHL) is the most common complication that causedby noise exposure, although there are other complications as a result of noise exposure. Metaboliccomplications from noise exposure have been evaluated in various studies. Purpose: To examine therelationship between NIHL with lipid profile in workers who are exposed to noise in workplace. Methods:The study design was analytic descriptive with cross-sectional study. Data collection was done throughinterviews, audiometry screening, and lipid profile examinations. Results: The average intensity in processsection was 98 dB, and in non-process section ranged between 46-98 dB. The results of audiometricexamination of the 50 workers who met the inclusion criteria, were 26 persons (52%) with sensorineuralNIHL and 24 persons (48%) did not experience NIHL. We found a significant association between noiseexposure among workers with elevated levels of triglyceride (TG), total cholesterol (TC), low-densitylipoprotein (LDL), and decreased high-density lipoprotein (HDL) levels (p<0,05). There was highcorrelation beween TG levels with the NIHL among workers who are exposed to noise >85 dB (p<0,05),and no correlation between elevated levels of TC, LDL and decreased HDL levels with NIHL (p>0,05).Conclusion: We found a significant relationship between hyperlipidemia and NIHL. Workers withhypertriglyceridemia had greater risk of suffering NIHL when exposed to noise >85 dB in the workplace. Keywords: Noise, NIHL, lipid profile

CORRELATION BETWEEN NUCLEUS FACTOR KAPPA B AND MICROVESSEL DENSITY IN NASOPHARYNGEAL CARCINOMA Farrel; Izry Naomi Tobing; Fahat; Rizalina A Asnir; Adlin Adnan
INTERNATIONAL JOURNAL OF NASOPHARYNGEAL CARCINOMA Vol. 2 No. 02 (2020): International Journal of Nasopharyngeal Carcinoma
Publisher : TALENTA PUBLISHER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijnpc.v2i02.3924

Abstract Introduction: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer, mostly associated with EBV infection. Nuclear factor kappa B (NF-κB) is transcription factors that act as a tumor promoter, especially in inflammation-associated cancer. It also attracts angiogenesis. Microvessel Density (MVD) is widely used as an index for tumor angiogenesis. There have been no studies found about the correlation of NF-κB and MVD expression in NPC. Objective: The aim of this study is to investigate the correlation of NF-κB and MVD expression that may affect targeted therapies in NPC patients Methods: A total of 30 paraffin blocks of NPC patients biopsies were assessed immunohistochemically for NF-κB expression and MVD. Data were analyzed using the Spearman's nonparametric test to assess the correlation between NF-κB expression and MVD. Results: Positive NF-κB expression was found in 22 (73.33%) patients and negative in 8 (26.67%) patients. High MVD expression in 17 (56.67%) patients and low MVD expression in 13 (43.33%) patients. There was no significant correlation found between NF-κB and MVD. Conclusion: This study has not confirmed any correlation between NF-κB and MVD. Further research needs to be done to get a better assessment on nuclear proliferation rates and tumor-related angiogenesis in NPC.

Prevalence and Profile of Patients with Otitis Externa at the Universitas Sumatera Utara Hospital in Medan in 2020-2021 Qatrunnada Medina Salim; Adlin Adnan; Indri Adriztina; Iman Dwi Winanto
Buletin Farmatera Vol 8, No 1 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i1.13101

Otitis externa is an acute or chronic inflammation of the ear canal which also involves the tympanic membrane and pinna. This disease has a prevalence rate of about 10% of all ENT diseases. Aim. This research aims to determine the prevalence and profile of the disease based on demographic characteristics (age, sex, and occupation), chief complaint, type, location, and comorbidities in patients with otitis externa. Methods. This research is a hospital-based retrospective study of patients diagnosed with otitis externa in Universitas Sumatera Utara Hospital Medan for the period January 2020 to December 2021. Data were obtained from medical records then processed using the SPSS program and analyzed using descriptive statistics. Results. The total number of patients in Universitas Sumatera Utara Hospital for the 2020-2021 period who met the study inclusion and exclusion criteria was 291 patients. Found 47.4% male and 52.6% female with a ratio of 1:1.1. The peak age group at 26-45 years was 36.8%. In employment status, 23.0% are self-employed and patients who do not work 22.7% are the majority while 0.3% POLRI of and laborers are a minority. The majority 72.5% come with a chief complaint of pain or tenderness in the ear followed by 10% of the ear that felt full. The most common type of otitis externa was acute diffuse as much as 91.8% with the location of the right ear that was most often complained of as much as 44.7%. Otitis externa disease is commonly found in patients who do not have other comorbidities as much as 87.3%. Conclusion. Otitis externa is a common ear disease that affects all age groups and genders. Most of the patients come with complaints of pain in the right ear and were diagnosed with acute diffuse otitis externa.

Adaptasi Lintas Budaya Kuesioner STOP-Bang Versi Indonesia Putri Anggilina Manullang; Muhammad Arfiza Putra Saragih; Adlin Adnan; Ester Lantika Ronauli Silaen
eJournal Kedokteran Indonesia Vol. 11 No. 2 - Agustus 2023
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.11.335.126

Obstructive Sleep Apnea (OSA) merupakan obstruksi saluran napas atas saat tidur yang mengakibatkan penurunan saturasi oksigen. Di Indonesia, data prevalensi OSA masih sangat minim. Dari beberapa alat penapisan OSA, hanya BQ dan ESS yang memiliki versi Bahasa Indonesia, sementara STOP-Bang belum terdapat versi Bahasa Indonesia. Melakukan penapisan terhadap tanda dan gejala sangat penting dalam proses perencanaan dan evaluasi. Suatu alat ukur harus memenuhi unsur psikometrik dan mampu menyesuaikan dengan karakteristik sosial dan budaya setempat. Untuk menghasilkan alat ukur kuesioner STOP-Bang versi Indonesia dengan metode adaptasi lintas budaya yang reliabel dan tervalidasi. Penelitian ini merupakan penelitian observasional analitik menggunakan metode cross sectional. Setelah kuesioner STOP-Bang diadaptasikan ke Indonesia, kuesioner diberikan kepada 500 orang masyarakat Indonesia, kemudian setelah 14 hari akan dilakukan pengisian ulang terhadap 20 responden. Penelitian dilakukan pada bulan Juli sampai September 2023 di Kota Medan dan Binjai. Pengambilan sampel memakai metode purposive sampling. Dari 500 responden penelitian dan validitas diolah menggunakan Spearman correlation didapatkan (p<0.001 dan r=0.422±0.118) berarti ada korelasi bermakna dan cukup valid. Analisis reliabilitas menggunakan Cronbach’s-alpha (r=0,694) dan nilai Interclass Correlation Coefficient menggunakan Spearman correlation coefficient (r=0,886). Adaptasi lintas budaya kuesioner STOP-Bang versi Indonesia memiliki nilai validitas dan reliabilitas yang baik.

Factors Affecting Presbycusis on Audiogram Overview at H. Adam Malik General Hospital Medan Manullang, Frenky Sorimuda; Adnan, Adlin; Munir, Delfitri
Journal of Epidemiology and Public Health Vol. 6 No. 1 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/jepublichealth.2021.06.01.02

Background: Presbycusis incidence is thought to have a relationship with hereditary factors, metabolism, atherosclerosis, noise and lifestyle. The presbycusis classification consists of Sensory (outer hair-cell), neural (ganglion-cell), metabolic (strial atrophy), and conductive cochlea (stiffness of the basilar membrane). Factors that influence presbycusis include age, gender, genetics, hypertension, gout, diabetes mellitus, hypercholesterolemia, noise exposure, and smoking. This study aims to determine the factors that influence presbycusis on the audiogram image at H. Adam Malik Hospital Medan. Subjects and Method: This study was an analytical study with a cross sectional design in elderly patients at the polyclinic. The study was conducted in November to December 2019. The dependent variable was the incidence of presbycusis. The independent variables were uric acid levels, blood sugar levels, smoking habits, hypercholesterolemia, and hypertension. Data were analyzed by using chi square test. Results: The prevalence of presbycusis in the 45-59 years age group was 39 people (54.2%) and the 60-74 years age group was 33 people (45.8%). In this study, it shows that male respondents are more than female respondents, where the number of men is 58 people (80.6%) and women are 14 people (19.4%). Based on presbycusis type, there were 33 (45.9%) people (normal), 18 (25%) people (strrial type), 7 (7.9%) people (neural type), 7 (7.9%) people (sensory type), 7 (7.9%) people (cochlear type). High sugar content (OR= 3.33; 95% CI= 1.81 to 6.13; p <0.001), uric acid levels (OR= 2.36; 95% CI= 1.19 to 4.70; p= 0.005), total cholesterol levels (OR= 3.33; 95% CI= 1.81 to 6.13; p <0.001), and smoking (OR= 1.90; 95% CI = 1.21 to 2.97; p= 0.016) increased the risk of presbycusis. Conclusion: High sugar levels, uric acid levels, total cholesterol levels, and smoking habits increase the risk of presbycusis.

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