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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Kedokteran Brawijaya Public Health of Indonesia Jurnal Respirologi Indonesia Jurnal Ilmu Kefarmasian Indonesia Sumatera Medical Journal Narra J Jurnal Impresi Indonesia Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) International Journal of Health and Pharmaceutical (IJHP) The Journal of Society Medicine (JSOCMED) JUKEJ: Jurnal Kesehatan Jompa Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Parluhutan Siagian

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Author-ID : 379241

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Diagnostic Accuracy of Gene X-pert MTB/RIF for Tuberculous Pleural Effusion Compared to Adenosine Deaminase (ADA) at Haji Adam Malik General Hospital Medan Muhammad Zainul A; Fajrinur Syahrani; Siagian, Parluhutan; Eyanoer, Putri Chairani
Sumatera Medical Journal Vol. 2 No. 2 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Indonesia is one of the few countries in the world with very high burden of tuberculosis (TB). Tubercular pleural effusion (Pleural TB) is the most common form of extra-pulmonary TB, however the remains a common clinical challenge. This research from May 2017 through September 2017 a total of 42 patients with exudative lymphocytic pleural effusions suspected to pleural tuberculosis were enrolled in this study. Adenosine deaminase (ADA) and Gene X-pert were examined from pleural fluid. Diagnosis was made clinically or based from sputum/pleural fluid culture. The result of this research showed out of all participants, 64,3% (27/42) had ADA in positive level (>40 IU/L) and 31% (13/24) had Gene X-pert positive Mycobacterium Tb. The Gene X-pert sensitivity was 40.7% with specificity 86.6%, PPV and NPV were 44.8% and 57.1% respectively. Kappa Compatibility study show that Gene X-pert point was 0.227 (p 0.066). The usefulness of Gene X-pert to diagnose pleural TB is limited by its poor sensitivity. Gene X-pert cannot be used as single diagnostic tool for tuberculous pleural effusion

Dukungan Keluarga meningkatkan Kepatuhan Minum Obat pada Penderita Tuberkulosis Paru di Kabupaten Tapanuli Utara Siregar, Idawaty; Siagian, Parluhutan; Effendy, Elmeida
Jurnal Kedokteran Brawijaya Vol 30, No 4 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2019.030.04.14

Salah satu penyakit yang masih menjadi permasalahan kesehatan di dunia termasuk Indonesia adalah tuberkulosis (TB) yang disebabkan oleh kuman Mycobacterium tuberculosis (M. tuberculosis). Keberhasilan pengobatan TB memerlukan kepatuhan penderita dalam minum obat anti tuberkulosis (OAT). Dukungan keluarga seperti pengawasan dan memberi motivasi kepada penderita TB merupakan faktor yang berperan dalam kepatuhan penderita. Penelitian ini dilakukan untuk mengetahui hubungan dukungan keluarga dengan kepatuhan minum obat pada penderita TB paru di Kabupaten Tapanuli Utara. Desain penelitian ini adalah cross sectional dengan responden 60 penderita TB paru kategori 1 dan 2 yang mendapat pengobatan minimal 1 bulan serta tinggal bersama keluarga. Penelitian dilaksanakan di Puskesmas Pangaribuan, Puskesmas Situmeang Habinsaran, dan Puskesmas Hutabaginda di Kabupaten Tapanuli Utara pada bulan Juni-September 2017. Responden diwawancarai dengan menggunakan pertanyaan kuesioner untuk mengumpulkan data. Hasil penelitian ini menunjukkan terdapat hubungan antara dukungan keluarga dengan kepatuhan minum obat pada penderita TB paru di Puskesmas Tapanuli Utara (p=0,002). Pada penelitian ini, dukungan keluarga yang baik meningkatkan kepatuhan penderita TB untuk minum obat anti tuberkulosis (OAT).

Uji Diagnostik Genexpert Mtb/Rif Di Rumah Sakit Umum Pusat Haji Adam Malik Medan Elva Susanty; Zainuddin Amir; Parluhutan Siagian; Rina Yunita; Putri Chairani Eyanoer
JBIO: jurnal biosains (the journal of biosciences) Vol 1, No 2 (2015): Jurnal Biosains
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v1i2.2783

Background: Cases of multidrug resistant tuberculosis (MDR TB) is increasing in number in the world and requires early detection to prevent further transmission. GeneXpert MTB/RIF is a tool that can be used for detection of rifampicin resistance, as a surrogate marker for MDR TB. This study aims to assess the sensitivity and specificity of the GeneXpert MTB/RIF in diagnosis of MDR TB. Methods: diagnostic test study was conducted at a poly MDR TB General Hospital Haji Adam Malik Medan. The subjects were all suspected MDR TB who had results positive GeneXpert MTB/ RIF with sensitive rifampin or resistant rifampin and had a drug sensitivity test results with the proportion method Lowenstein Jensen medium. Data retrieved from the medical records, between January until December 2013. Results: founded 64 samples that had results of GeneXpert MTB/RIF test positive and had the results of drug sensitivity, 87.5% of rifampin-resistant samples were also resistant to isoniazid. The GeneXpert MTB/RIF examination showed the sensitivity of 92.86% and the specificitu of 59.09%. Conclusion: GeneXpert MTB/ RIF has a high sensitivity for diagnosing MDR TB compared the gold standard drug sensitivity testing proportion method on Lowenstein Jensen medium. This study recommends the GeneXpert MTB/RIF be used for MDR TB screening tool. Keywords: GeneXpert MTB/RIF, multidrug resistant tuberculosis, drug susceptibility test, Lowenstein Jensen medium

Pengaruh Suplementasi Vitamin A pada Pengobatan Pasien TB Paru terhadap Percepatan Konversi Dahak pada Fase Intensif Di Wilayah Kerja Puskesmas Kecamatan Medan Kota Alexander Marpaung; Parluhutan Siagian; Dina Keumala Sari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Indonesia is the second rank for the most TB (Tuberculosis) cases in the world after India. It’s estimated there are a million cases per year in Indonesia. The objective of the research was to find out the influence of Vitamin A supplementation in the medication of pulmonary TB on the acceleration of sputum conversion time at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. This research applied clinical testing design with experimental approach and Experimental Quasi method. The samples were 30 newly diagnosed pulmonary TB patients consisting of 15 patients in the treatment group and 15 patients in the control group. They were ≥ 18 years old, regularly consumed category I OAT with BMI ≥ 18.5. The statistical data were analyzed by Mann-Whitney statistical testing at reliability rate 95% (p < 0.05). The results of the research on the treatment group discovered that they were mostly 18-27 years old 40.0%, male 73.3%, mostly university students 26.7%, had BTA conversion in the second week 80.0%; and the sputumconversion time was 2.4 weeks in average. The results of the research on the control group demonstrated that they were mostly 18-27 years old 33.3%, male 80.0%, mostly university students and entrepreneurs 20.0%, had BTA conversion in the second week 80%; and the sputum conversion time was 4.1 weeks in average. Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase (p = <0.001) < (alpha = 0.05). Vitamin A supplementation in the medication of pulmonary TB patients had some influence on the acceleration of sputum conversion at intensive phase in the Working Area of Puskesmas in Medan Kota Subdistrict. speed up wound healing on second degree burns. White egg gel had significantly difference compared to negative control of NaCl 0.9% and no signifi cantly difference compared to Bioplacenton as positive control.

Profile and risk factors of pre-XDR-TB and XDR-TB patients in a national reference hospital for Sumatra region of Indonesia Sinulingga, Herison E.; Sinaga, Bintang YM.; Siagian, Parluhutan; Ashar, Taufik
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.407

The low treatment rate, low treatment success rate and high mortality rate of patients with pre-extensively drug-resistant tuberculosis (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB) need serious attention. The aim of this study was to describe the profiles of patients with pre-XDR-TB and XDR-TB cases and to determine associated risk factors of their incidence in Indonesia. A retrospective case-control study was conducted at H. Adam Malik General Hospital in Medan, North Sumatra of which all sensitive-drug TB (SD-TB), pre-XDR-TB, and XDR-TB patients aged 18 years or older treated between October 2019 to June 2022 were included. Chi-squared test or Kruskal Wallis test and multiple logistic regression were used to determine the risk factors associated with pre-XDR-TB and XDR-TB incidence. A total 16 patients of case group (15 pre-XDR-TB and one XDR-TB) and 116 SD-TB patients (control group) were included in the final analysis. Out of total patients within case group, 62.5% were male, 43.8% aged between 56–65 years, 62.5% graduated from high school or equivalent, and 25% were unemployed. The majority of patients had no comorbid (62.5%), had history of anti-TB treatment (93.8%), and had secondary resistance (93.8%). Multivariate analysis indicated that age (OR: 10.01; 95%CI: 1.49–66.91, p=0.018) and previous history of anti-TB treatment (OR: 216.25; 95%CI: 18.62–2511.60, p<0.001) were significantly associated with incidence of pre-XDR-TB and XDR-TB. This study highlights that having previous history of anti-TB treatment and older age are the predictors of the incidence of pre-XDR-TB and XDR-TB.

Factors associated with the quality of life and persistent dyspnea severity in COVID-19 survivors: A cross-sectional study among healthcare workers Sinaga, Joshua P.; Sinaga, Bintang YM.; Siagian, Parluhutan; Eyanoer, Putri C.; Unata , Iduh M.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.419

The coronavirus disease 2019 (COVID-19) pandemic has a significant impact on global health. The alterations in quality of life (QoL) and the persistent symptom of dyspnea have been the healthcare workers’ challenges during and after the pandemic. The aim of this study was to assess factors associated with the QoL and persistent dyspnea experienced by COVID-19 survivors, particularly among healthcare workers. A cross-sectional study was conducted among healthcare workers at H. Adam Malik Hospital, Medan, Indonesia, using direct interviews to collect the data. The EuroQol 5-dimensional 5-level (EQ-5D-5L) and the self-assessment EuroQol-visual analog scale (EQ-VAS) were used to assess the QoL of the healthcare workers; and persistent dyspnea was evaluated using the modified Medical Research Council (mMRC) scale. Possible risk factors such as demographic characteristics, clinical characteristics (comorbidities, history of hospitalization, oxygen usage, history of COVID-19 vaccination, the severity of previous COVID-19, existence of post-COVID syndrome) and the symptoms of the post-COVID syndrome were collected. Chi-squared test or Fisher’s exact test were used to identify the risk factors associated with the QoL and persistent dyspnea. A total of 100 healthcare workers were included in the study and 2% of healthcare workers experienced pain/discomfortand 4% experienced anxiety/depression. The average healthcare worker’s EQ-VAS score was 87.6±8.1. There was no significant association between studied demographics and clinical characteristics with QoL dimensions. However, post-COVID symptoms of activity limitation (p=0.004), sore throat (p=0.026), headache (p=0.012), myalgia (p=0.006), and arthralgia (p=0.001) were associated with pain/discomfort dimension of QoL. In addition, there was a significant association between activity limitation (p=0.012), headache (p=0.020), myalgia (p=0.015) and arthralgia (p=0.032) with anxiety/depression dimension of QoL. Our data suggested that the presence of post-COVID syndrome (p=0.006) and the presence of post-COVID syndrome symptoms of cough (p=0.021) and fatigue (p=0.015) were associated with the persistent dyspnea. In conclusion, this study suggests that the presence of post-COVID syndrome and its symptoms are associated with low quality of health-related QoL and persistent dyspnea. Therefore, cautions are needed for such patients to prevent low QoL in the future.

Fatigue in healthcare workers with mild COVID-19 survivors in Indonesia Sinaga, Bintang YM.; Siagian, Parluhutan; Sinaga, Joshua P.; Samodra, Yoseph L.
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.656

Persistent symptoms after the coronavirus disease 2019 (COVID-19, known as post-COVID syndrome (PCS), presented an ongoing health burden among COVID-19 survivors, including health workers. The existence of fatigue in mild COVID-19 survivors has not been widely reported. The aim of this study was to present the symptoms of fatigue in healthcare workers who experienced mild COVID-19 and the factors associated with fatigue. A cross-sectional study was conducted at H. Adam Malik General Hospital in Medan, Indonesia, from September to December 2022, included doctors, nurses, ancillary workers, and medical support workers who experienced mild COVID-19. Fatigue was measured by a fatigue assessment scale (FAS). The assessed possible risk factors were gender, age, vaccination history, comorbid, presence of PCS, duration of PCS symptoms, and number of PCS symptoms. The chi-squared or Fisher’s exact test was used to assess the association between the incidence of fatigue and risk factors. A total of 100 healthcare workers of mild COVID-19 survivors were included. Most of them were nurses (58%), women (81%), and aged 19−30 years old (36%). The majority had incomplete vaccination history (64%), experienced PCS (71%), no comorbidities (61%), and experienced <3 months of PCS symptoms (55%). Mild to moderate fatigue was found in 23% of healthcare workers and only 1% experienced severe fatigue. No significant association was found between gender, vaccination history, and comorbidities with the incidence of fatigue. However, a significant association was observed between age (p=0.021), the presence of PCS (p=0.041), and the number of PCS symptoms (p=0.047) with fatigue incidence. Furthermore, there were significant associations between symptoms of PCS (confusion (p=0.004), insomnia (p=0.001), myalgia (p=0.035), arthralgia (p=0.028), throat pain (p=0.042), headache (p=0.042), and chest pain (p=0.011)) with fatigue. These findings can contribute to providing the necessary support for mild COVID-19 survivors and persistent fatigue.

Factors Associated with the Severity of COVID-19 at H. Adam Malik Hospital, Medan, Indonesia Destylya, Dyana; Bintang Yinke Magdalena Sinaga; Siagian, Parluhutan; Eyanoer, Putri Chairani
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 5 No. 4 (2023): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v5i4.14389

Background: Several studies have shown an association among laboratory values, comorbidities, and the severity of COVID-19. This study aimed to find the factors associated with the severity of COVID-19 patients in Adam Malik Hospital. Method: This is a descriptive study with a cross-sectional design. The subjects were COVID-19 patients from December 2020 to April 2021 whose data were in the form of secondary data obtained from their medical records. The inclusion criteria were patients diagnosed with COVID-19 based on RT-PCR while the exclusion criteria were incomplete medical record data. Statistical analysis was conducted via the following tests Kruskal Wallis Test, Kolmogorov Test, and Chi-Square based on the data category. Results: A total of 110 subjects were enrolled in this study. Most subjects were male (55.45%) with age >40 years old (66.36%). The laboratory values of lymphocyte count, NLR, D-dimer, procalcitonin, ferritin, fibrinogen, and CRP were significantly associated with the severity of COVID-19. Also, there were several comorbidities statistically associated with the severity of COVID-19, including hypertension, diabetes mellitus, coronary artery disease, renal disease, and HIV (p <0.05). Conclusion: Lymphocyte count, NLR, CRP, procalcitonin, D-dimer, fibrinogen, ferritin, and comorbidities including diabetes mellitus, hypertension, HIV, coronary disease, and renal disease, were associated with the severity of COVID-19.

Perianal Fistula Due to Tuberculosis Infection: A Case Report Sinaga, Bintang Yinke Magdalena; Siagian, Novi Andriani; Siagian, Parluhutan; Muhar, Adi Muradi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 6 No. 3 (2024): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v6i3.15613

Introduction: Approximately 5% of all cases of tuberculosis are extrapulmonary. A rare extrapulmonary variant of the disease is known as perianal tuberculosis, which accounts for 0.001% of all extrapulmonary tuberculosis cases. Case Report: A 28-year-old male presented with intermittent chronic anal pain and purulent discharge from the anal for 6 months, without respiratory complaints. Chest X-Ray examination shows minimal infiltrate on the right lung apex and broncho vascular pattern partially covered with infiltrate. Fistulotomy has been done three times in this patient within 6 months. Colonoscopy examination shows recti polyp, and the histopathology result from biopsy specimen taken from the last fistulotomy is tuberculosis-specific chronic inflammatory process. The Human Immunodeficiency Virus test is negative. This patient has been treated with anti-tuberculosis treatment for 7 months and 2 months after consuming it the wound on the perianal is healing and the patientâ€™s weight is gaining 10 kgs within 7 months. Conclusion: The diagnosis of perianal tuberculosis is challenging, especially in the absence of pulmonary focus. Tuberculosis should be considered in the differential diagnosis of perianal ulcers and fistulas, mainly in non-healing and recurrent anal lesions, especially in regions where tuberculosis is endemic. Management with anti-tuberculosis treatment can provide complete recovery.

Characteristics of Loss to Follow-Up Patient in Drug-Sensitive Pulmonary TB in Medan Sari Mardia, Rina; Sinaga, Bintang YM; Siagian, Parluhutan; Taufik, Ashar
Journal of Society Medicine Vol. 3 No. 10 (2024): Oktober
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v3i10.166

Introduction: Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis. Adherence to TB treatment is a complex and dynamic phenomenon with various interacting factors. The characteristics of loss to follow-up patients include social, clinical, and economic characteristics. The Aim of study was to identify characteristics of loss to follow-up patients in drug-sensitive pulmonary TB in Medan. Method: This research is a descriptive study using a cross-sectional approach. All variables were measured and observed at a time during the study. The study was conducted at RSUP Adam Malik Medan and Prof. Dr. Chairuddin P. Lubis USU Hospital in loss to follow-up TB patients diagnosed bacteriologically that meet the criteria of inclusion and exclusion. This study used data from medical records and questionnaires. Independent variables include age, gender, educational level, employment, marital status, family history of lung tuberculosis, attitudes to TB treatment, social support, health services, and reasons for loss to follow-up. Results: Out of 40 patients with loss to follow-up pulmonary tuberculosis, the majority were patients in the age range of 45-65 years (n=26.65%), male (n=31.77,5%), equal level of high school education (n = 24.60%) had a fixed job (n=33.82.5%), marital status (n=33.90%), had no family history of lung tuberculosis (n=36.90%), poor attitude to TB treatment (n=36.90%), received low social support (n=51.52,5%), and received less supported health care services (n<33.82,5%). Reasons patients TB SO quit taking medication presented in this study vary, among others due to the side effects of TB drugs, patients choosing herbal drugs, already feeling healthy, laziness consuming TB medication, being embarrassed with pulmonary TB disease, not taking lung TB drugs because no one carries or has no transportation costs. Conclusion: The majority of patients with drug-sensitive pulmonary tuberculosis who quit their medication in the fields are between 46 and 65 years of age, male sex, high school graduates of equal degree, have a fixed job, marital status, have no family history of TB, have an inferior attitude to TB treatment, receive low social support, and receive less supportive health services. Reasons for loss to follow-up for SO TB patients vary, including TB drug effects, clinical, and economic.

Co-Authors Adhayanti, Ida Adlin Adnan Alexander Marpaung Ashar , Taufik Bintang Yinke Magdalena Sinaga Dalimunthe, Almira Destylya, Dyana Dina Keumala Sari Elmeida Effendy Elva Susanty Eyanoer, Putri C Eyanoer, Putri C. Fajrinur Syahrani Fotarisman Zaluchu, Fotarisman Indri Adriztina Magdalena Sinaga, Bintang Yinke Muhammad Zainul A Muhar, Adi Muradi Perangin-angin, Gwanita Nawariantina Permatasari, Ranti Putri Chairani Eyanoer, Putri Chairani Rina Amelia Rina Yunita Rizky, Handan Saing, Erna Debora Samodra, Yoseph L. Samodra, Yoseph Leonardo Samosir, Nelly Elfrida Santy, Diana Sari Mardia, Rina Siagian, Novi Andriani Simanjuntak, Christine Raphaela Tiarmauli Sinaga, Bintang Yinke Magdalena Sinaga, Bintang YM Sinaga, Bintang YM. Sinaga, Joshua P. Sinaga, Joshua Princeman Sinulingga, Herison E. Siregar, Idawaty Siti Hajar Haryuna Sorimuda Sarumpaet Taufik Ashar Taufik, Ashar Unata , Iduh M. Yinke Magdalena Sinaga, Bintang Youvella, Sylvia Zainuddin Amir

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