Nursing care for infectious diseases should only be carried out by trained nurses. This is because nurses need experience and precision, especially skills in using Personal Protective Equipment (PPE). Length of work and workload are possible factors that cause problems in the use of PPE. The purpose of this study was to explain the relationship between length of work and workload with the completeness of PPE use during infectious disease care. This study used a correlation research design with a cross-sectional approach. The sample of this study was 72 respondents. Respondents in this study were nurses who treated patients with TB and Pneumonia infections. Sampling was carried out using a purposive sampling technique. Data were collected in 2 months using recording of the results of direct observation and interviews. Data were analyzed using the Spearman rho test with a significance level of <0.05. The results showed a p-value between length of work and completeness of PPE use> 0.05, while the p-value between workload and completeness of PPE use <0.05. This means that there is no relationship between length of work and completeness of PPE use, while workload has a relationship with completeness of PPE use. Length of work does not make a nurse able to use PPE properly. This is because nurses have less opportunity to care for infectious patients. Infectious cases with complete PPE are quite rare. While the workload is related to the completeness of the use of PPE. The higher the workload will require nurses to install PPE quickly. Therefore, in order for nurses to use complete PPE, the nurse's workload should not be too high.