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All Journal Jurnal Kedokteran Syiah Kuala Jurnal Kesehatan Andalas Sari Pediatri Paediatrica Indonesiana Majalah Kedokteran Andalas Human Care Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Eduvest - Journal of Universal Studies
Eka Agustia Rini
Universitas Andalas
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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The Relationship between Metabolic Control Status and Microalbuminuria in Pediatric Diabetes Mellitus Patients at Dr. M. Djamil General Hospital, Padang, Indonesia Fatmah Sindi; Aumas Pabuti; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.757

Abstract

Background: Diabetes mellitus (DM) is a complex metabolic disorder that can cause many complications. HbA1c measurement can help monitor long-term serum glucose regulation. Microalbuminuria in DM patients is a risk factor for these complications, so evaluation of risk factors for prevention is necessary. This study aimed to determine the relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study is an analytic observational study with a cross-sectional approach. A total of 34 children with DM aged 1-18 years participated in this study. Sampling was carried out using the consecutive sampling method at the pediatric polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from November 2021-April 2022. Metabolic control status was assessed by measuring HbA1C levels and microalbuminuria by measuring the urine albumin-creatinine ratio. Data analysis used the Chi-square test, with a p-value <0.05. Results: The average respondent was 13.2 ± 3.3 years old with a duration of suffering from DM 2.5 ± 2 years. Most of the respondents were male (52.9%), suffered from type 1 DM (94.1%), had uncontrolled metabolic control status (82.3%), had a normal creatine albumin ratio (82.4%), never had diabetic ketoacidosis (79.4%), had no family history of DM (85.3%) and had normal blood pressure (94.1%). It is known that the average urea and creatinine are within normal limits. The average HbA1c value is 11.9 ± 3.39%. The median urine creatine albumin ratio was 7.98 (0-255.74) ug/mg. Microalbuminuria in uncontrolled metabolic control status was found in as much as 17.6%, whereas in controlled metabolic control status, no microalbuminuria was found. Statistically, there is no significant relationship (p>0.05). Conclusion: There is no relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia.
Central Diabetes Insipidus in Langerhans Cell Histiocytosis: A Case Report Dya Mulya Lestari; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.776

Abstract

Background: Diabetes insipidus (DI) is part of a group of hereditary or acquired polyuria and polydipsia diseases. Diabetes insipidus can be caused by central and nephrogenic disorders. This study aimed to describe the etiologies, clinical symptoms, and management of central diabetes insipidus in Langerhans cell histiocytosis. Case presentation: A 4 years 4 months old boy came with excessive and frequent micturition since 9 months ago. The patient drinks 4-5 L per day and still feels thirsty. The patient had a history of Langerhans cell histiocytosis (LCH). During laboratory work-up, urine osmolarity decreased, and serum osmolarity and electrolyte were normal. The patient was diagnosed with central diabetes insipidus with Langerhans cell histiocytosis. The treatment given to the patient is desmopressin. Conclusion: Langerhans cell histiocytosis may affect any organs of the body. The long-term management of diabetes insipidus in Langerhans cell histiocytosis requires measurement to prevent dehydration and, at the same time to prevent water intoxication. The focus of management is based on the education of the patient about the importance of regulating their fluid intake according to the patient’s hydration status.
Hubungan Kadar Ferritin Serum dengan Fungsi Tiroid pada Anak dengan Thalassemia beta Mayor Melisha Lisman Gaya; Eka Agustia Rini; Amirah Zatil Izzah
Sari Pediatri Vol 25, No 1 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.1.2023.27-31

Abstract

Latar belakang. Thalassemia beta mayor merupakan penyakit yang ditandai dengan anemia kronik, hipoksia kronik jaringan, dan pemberian transfusi darah seumur hidup. Penumpukan besi akibat pemberian transfusi berulang berefek toksik pada berbagai organ, termasuk kelenjar tiroid.Tujuan. Mengetahui hubungan antara kelebihan beban besi dengan kejadian hipotiroid pada anak yang menderita thalassemia beta mayor.Metode. Penelitian cross-sectional terhadap 43 subjek dengan thalassemia beta mayor dan mendapat transfusi darah rutin pada periode April 2018-Februari 2019. Subjek dipilih secara total sampling dan dikelompokkan berdasarkan kadar ferritin serum <2500 µg/L dan >2500 µg/L. Hasil kadar tiroksin dan thyroid stimulating hormone dikelompokkan menjadi eutiroid dan hipotiroid. Hasil analisis statistik bermakna bila p<0,05.Hasil. Kadar ferritin serum <2500 µg/L dan >2500 µg/L terdapat pada masing-masing 19 (44,2%) dan 24 (55,8%) subjek. Hipotiroid terjadi pada 13 (38,1%) subjek dengan kadar ferritin >2500 ?g/L dan delapan (38,1%) subjek dengan kadar ferritin <2500 µg/L. Tidak ditemukan hubungan bermakna antara ferritin serum dengan fungsi tiroid pada subjek (p=0,432).Kesimpulan. Persentase hipotiroid meningkat seiring peningkatan kadar ferritin serum, tetapi tidak terdapat hubungan bermakna antara kadar ferritin serum dengan fungsi tiroid pada anak dengan thalassemia beta mayor. 
Pengamatan Jangka Panjang dan Intervensi Anak dengan Rakhitis dan Hipovitaminosis D Toni Kurniawan; Eka Agustia Rini; Asrawati Asrawati
Majalah Kedokteran Andalas Vol 46, No 8 (2024): Online Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i8.p1331-1340.2024

Abstract

Rickets is associated with impaired calcium and phosphate homeostasis, which can lead to short stature and joint deformities. Nutritional rickets results from deficiencies of vitamin D, calcium and phosphate. Vitamin D regulates calcium and phosphorus in the blood, if there is a deficiency of vitamin D it results in inadequate mineralization of osteoid produced by osteoblasts. It is important to ensure adequate vitamin D supplementation in nutritional rickets and rule out vitamin D deficiency in other forms of rickets, which may hinder healing of rickets. Medical rehabilitation can improve functional independence by reducing pain and improving joint mobility, muscle strength, endurance, and gait in rickets patients.
Impact Of The Covid-19 Pandemic On Glycemic Control In Childhood Type 1 DM Patients Toni Kurniawan; Eka Agustia Rini; Asrawati Asrawati
Eduvest - Journal of Universal Studies Vol. 4 No. 3 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i3.1117

Abstract

There has been an increase in cases of diabetic ketoacidosis in children aged 1-14 years from 73% in 2019 to 83% in 2020 during the COVID-19 pandemic. An increase in acute complications of type-1 DM can occur due to lack of compliance with glycemic control and activity restrictions which have the impact of reducing the level of glycemic control in children with type-1 DM. Based on these findings, researchers wanted to know the impact of restrictions on community activities during pandemic on the glycemic control of children with type 1 DM. The aims of this study is to determine the impact of the COVID-19 pandemic on glycemic control through HbA1c parameters in children with type 1 DM. Methods of this research is a cross sectional study with a sample size of 26 patients. Results are The average age of respondents was 15.58 years. More than half of respondents were female (73.1%). The average duration of suffering from type 1 DM was 4.77 years. More than half of the respondents had a history of diabetic ketoacidosis, 53.8%, and all respondents were Health Insurance (BPJS) participants (100%). There was a decrease in HbA1c levels during the pandemic compared to before the pandemic, namely 12.17 ± 2.60 to 10.32 ± 2.21. Statistically, this decrease means that there is an impact of the COVID-19 pandemic on glycemic control through the HbA1c parameter in children with type 1 DM (p<0.05). There was a decrease in HbA1c levels during the pandemic compared to before the pandemic.
Co-Authors Abdiana Abdiana Afdal Afdal Alania Rosari Amirah Zatil Izzah Asrawati Nurdin Aumas Pabuti Dini Anggini Dini Anggini Dini Noviarti Dya Mulya Lestari Elza Desdamona Eti Yerizel Fadil Oenzil Fatmah Sindi Finny Fitry Yani Freidlander Pangestu Hafni Bachtiar IGM Afridoni A Indra Ihsan Ivanny Khosasih Khairunnisa Khairunnisa Lestry Fibriani Luthfi Suhaimi Masrul Djalal Melisha Lisman Gaya Michael Mettafortuna Sephberlian R. Trin Suciati Rismawati Yaswir Shinta Ayudhia Silvy Dioni Tiara Ella Sari Toni Kurniawan Toni Kurniawan Wilson Wilson Yessi Arsurya