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Growth Profile in Pediatric Patients with Diabetes Mellitus at Dr. M. Djamil General Hospital, Padang Michael Mettafortuna Sephberlian; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.549

Background: Diabetes mellitus (DM) is a glucose metabolism disorder characterized by chronic hyperglycemia that often occurs and is a major health problem. During puberty, increased Growth Hormone (GH) secretion results in increased insulin resistance. This study aimed to describe the growth profile of pediatric patients with diabetes mellitus at Dr. M. Djamil General Hospital. Methods: A descriptive retrospective study with conducted by collecting data on body height, HbA1C level, and status of puberty from medical records at the pediatric ward of Dr. M. Djamil General Hospital from January 2019 - December 2020. Results: The sample was 67 (63 T1DM, 2 T2DM, and 2 double DM). Ten of them with short stature (8 with poor metabolic control). Conclusion: Children with DM may experience growth disturbance.

GANGGUAN ENDOKRIN PADA PASIEN THALASSEMIA Β MAYOR DI RSUP M DJAMIL PADANG Shinta Ayudhia; Eka Agustia Rini
HUMAN CARE JOURNAL Vol 5, No 2 (2020): Human Care Journal Special Edition
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i2.708

Latar belakang. Gangguan endokrin merupakan komplikasi yang sering terjadi pada pasien thalassemia β mayor yang berefek pada kualitas hidupnya. Komplikasi ini terjadi karena penumpukan besi di dalam tubuh dan melibatkan organ seperti kelenjar endokrin sehingga pasien dapat mengalami hipotiroid, pubertas terlambat, perawakan pendek, gangguan insulin, usia tulang terlambat dan osteoporosis. Tujuan dari penelitian ini adalah untuk mengetahui kejadian endokrinopati pada pasien thalassemia β mayor di RSUP M Djamil Padang. Metode. Penelitian prospektif observasional terhadap pasien thalassemia β mayor yang di RSUP DR M Djamil pada bulan Januari – April 2018. Dilakukan pengumpulan data kadar feritin serum, tinggi badan, gula darah sewaktu, fungsi tiroid, status pubertas dan bone age. Data dianalisis secara univariat dan bivariat dengan menggunakan uji Chi square untuk mencari hubungan antara kadar feritin dengan perawakan pendek, status pubertas, usia tulang dan osteoporosis, dikatakan berhubungan apabila p value < 0,05. Data dianalisis dengan menggunakan program SPSS. Hasil. Didapatkan 39 pasien thalassemia β Mayor, 3 orang menolak pemeriksaan, usia rata-rata 9,7 ± 3,9 tahun, 14 laki–laki (38,9%), 22 perempuan (61,1%), lama menderita thalasemia 5,6 ± 4,0 tahun. Perawakan pendek ditemukan pada 28 pasien (77,8%), tidak ada pasien yang menderita hiperglikemia. Dua orang (5,6%) mengalami hipotiroid, 4 dari 6 orang usia pubertas (66,67%) mengalami pubertas terlambat. Usia tulang retarded ditemukan pada 16 orang (44,4%) dan 3 orang (8,3%) mengalami osteoporosis. Tidak terdapat hubungan antara kadar feritin dengan perawakan pendek,status pubertas, usia tulang dan osteoporosis (p= 0,434 , p= 0,601 , p = 0,839 , p= 1.000). Kesimpulan. Gangguan endokrin terbanyak pada penelitian ini adalah perawakan pendek yaitu 28 pasien (77,8%). Tidak terdapat hubungan antara kadar feritin dengan perawakan pendek, status pubertas, usia tulang dan osteoporosis

HYPERTHYROIDISM IN ADOLESCENT WITH TYPE 1 DIABETES MELLITUS Luthfi Suhaimi; Eka Agustia Rini
HUMAN CARE JOURNAL Vol 5, No 2 (2020): Human Care Journal Special Edition
Publisher : Universitas Fort De Kock

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32883/hcj.v5i2.682

hyroid disorders and diabetes mellitus are the two most common endocrine cases in clinical practice. Autoimmune thyroid disease (AITD) being more prevalent in people with type 1 diabetes mellitus (T1DM), and the occurrence of both in the same patient is defined as autoimmune polyglandular syndrome type 3 variant (APS3v). We are presenting a 12-years-old girl with hyperthyroid and T1DM occured as diabetic ketoacidosis (DKA). Diagnosed by symptoms, physical examinations, and confirmed by laboratory results. Patient was treated with insulin injection and oral anti-thyroid drug, and had clinical improvement.

Type 1 Diabetes Mellitus Comorbid with Malnutrition in Siblings Freidlander Pangestu; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.593

Background: Diabetes mellitus is a disorder of the metabolic homeostasis controlled by insulin, resulting in abnormalities of carbohydrate and lipid metabolism. Type 1 diabetes mellitus is one of the most common chronic conditions in children. This study aims to describe two cases of type 1 diabetes mellitus accompanied by malnutrition in children at Dr. M. Djamil General Hospital Padang. Case presentation: The case series describes two cases of diabetes mellitus type one with comorbid undernutrition. Both patients had a family history of diabetes mellitus. And their sibling died because of diabetes type 1. Grandmother and grandfather from the father's side had diabetes. The management of this disease consists of the management of type 1 diabetes mellitus and its complications and accompanying malnutrition. Conclusion: The management of type 1 diabetes mellitus includes the administration of insulin according to the monitoring of blood sugar levels and the management of comorbid diseases that accompany it. Education about the use of insulin and diabetes diet patterns is very important for parents and children with type 1 diabetes mellitus.

Type 1 Diabetes Mellitus Comorbid with Malnutrition in Siblings Freidlander Pangestu; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.593

Background: Diabetes mellitus is a disorder of the metabolic homeostasis controlled by insulin, resulting in abnormalities of carbohydrate and lipid metabolism. Type 1 diabetes mellitus is one of the most common chronic conditions in children. This study aims to describe two cases of type 1 diabetes mellitus accompanied by malnutrition in children at Dr. M. Djamil General Hospital Padang. Case presentation: The case series describes two cases of diabetes mellitus type one with comorbid undernutrition. Both patients had a family history of diabetes mellitus. And their sibling died because of diabetes type 1. Grandmother and grandfather from the father's side had diabetes. The management of this disease consists of the management of type 1 diabetes mellitus and its complications and accompanying malnutrition. Conclusion: The management of type 1 diabetes mellitus includes the administration of insulin according to the monitoring of blood sugar levels and the management of comorbid diseases that accompany it. Education about the use of insulin and diabetes diet patterns is very important for parents and children with type 1 diabetes mellitus.

The Relationship between Metabolic Control Status and Microalbuminuria in Pediatric Diabetes Mellitus Patients at Dr. M. Djamil General Hospital, Padang, Indonesia Fatmah Sindi; Aumas Pabuti; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.757

Background: Diabetes mellitus (DM) is a complex metabolic disorder that can cause many complications. HbA1c measurement can help monitor long-term serum glucose regulation. Microalbuminuria in DM patients is a risk factor for these complications, so evaluation of risk factors for prevention is necessary. This study aimed to determine the relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study is an analytic observational study with a cross-sectional approach. A total of 34 children with DM aged 1-18 years participated in this study. Sampling was carried out using the consecutive sampling method at the pediatric polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from November 2021-April 2022. Metabolic control status was assessed by measuring HbA1C levels and microalbuminuria by measuring the urine albumin-creatinine ratio. Data analysis used the Chi-square test, with a p-value <0.05. Results: The average respondent was 13.2 ± 3.3 years old with a duration of suffering from DM 2.5 ± 2 years. Most of the respondents were male (52.9%), suffered from type 1 DM (94.1%), had uncontrolled metabolic control status (82.3%), had a normal creatine albumin ratio (82.4%), never had diabetic ketoacidosis (79.4%), had no family history of DM (85.3%) and had normal blood pressure (94.1%). It is known that the average urea and creatinine are within normal limits. The average HbA1c value is 11.9 ± 3.39%. The median urine creatine albumin ratio was 7.98 (0-255.74) ug/mg. Microalbuminuria in uncontrolled metabolic control status was found in as much as 17.6%, whereas in controlled metabolic control status, no microalbuminuria was found. Statistically, there is no significant relationship (p>0.05). Conclusion: There is no relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

The Relationship between Metabolic Control Status and Microalbuminuria in Pediatric Diabetes Mellitus Patients at Dr. M. Djamil General Hospital, Padang, Indonesia Fatmah Sindi; Aumas Pabuti; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 1 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i1.757

Background: Diabetes mellitus (DM) is a complex metabolic disorder that can cause many complications. HbA1c measurement can help monitor long-term serum glucose regulation. Microalbuminuria in DM patients is a risk factor for these complications, so evaluation of risk factors for prevention is necessary. This study aimed to determine the relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This study is an analytic observational study with a cross-sectional approach. A total of 34 children with DM aged 1-18 years participated in this study. Sampling was carried out using the consecutive sampling method at the pediatric polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from November 2021-April 2022. Metabolic control status was assessed by measuring HbA1C levels and microalbuminuria by measuring the urine albumin-creatinine ratio. Data analysis used the Chi-square test, with a p-value <0.05. Results: The average respondent was 13.2 ± 3.3 years old with a duration of suffering from DM 2.5 ± 2 years. Most of the respondents were male (52.9%), suffered from type 1 DM (94.1%), had uncontrolled metabolic control status (82.3%), had a normal creatine albumin ratio (82.4%), never had diabetic ketoacidosis (79.4%), had no family history of DM (85.3%) and had normal blood pressure (94.1%). It is known that the average urea and creatinine are within normal limits. The average HbA1c value is 11.9 ± 3.39%. The median urine creatine albumin ratio was 7.98 (0-255.74) ug/mg. Microalbuminuria in uncontrolled metabolic control status was found in as much as 17.6%, whereas in controlled metabolic control status, no microalbuminuria was found. Statistically, there is no significant relationship (p>0.05). Conclusion: There is no relationship between metabolic control status and microalbuminuria in pediatric diabetes mellitus patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

Central Diabetes Insipidus in Langerhans Cell Histiocytosis: A Case Report Dya Mulya Lestari; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.776

Background: Diabetes insipidus (DI) is part of a group of hereditary or acquired polyuria and polydipsia diseases. Diabetes insipidus can be caused by central and nephrogenic disorders. This study aimed to describe the etiologies, clinical symptoms, and management of central diabetes insipidus in Langerhans cell histiocytosis. Case presentation: A 4 years 4 months old boy came with excessive and frequent micturition since 9 months ago. The patient drinks 4-5 L per day and still feels thirsty. The patient had a history of Langerhans cell histiocytosis (LCH). During laboratory work-up, urine osmolarity decreased, and serum osmolarity and electrolyte were normal. The patient was diagnosed with central diabetes insipidus with Langerhans cell histiocytosis. The treatment given to the patient is desmopressin. Conclusion: Langerhans cell histiocytosis may affect any organs of the body. The long-term management of diabetes insipidus in Langerhans cell histiocytosis requires measurement to prevent dehydration and, at the same time to prevent water intoxication. The focus of management is based on the education of the patient about the importance of regulating their fluid intake according to the patient’s hydration status.

Central Diabetes Insipidus in Langerhans Cell Histiocytosis: A Case Report Dya Mulya Lestari; Eka Agustia Rini
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 7 No. 2 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v7i2.776

Background: Diabetes insipidus (DI) is part of a group of hereditary or acquired polyuria and polydipsia diseases. Diabetes insipidus can be caused by central and nephrogenic disorders. This study aimed to describe the etiologies, clinical symptoms, and management of central diabetes insipidus in Langerhans cell histiocytosis. Case presentation: A 4 years 4 months old boy came with excessive and frequent micturition since 9 months ago. The patient drinks 4-5 L per day and still feels thirsty. The patient had a history of Langerhans cell histiocytosis (LCH). During laboratory work-up, urine osmolarity decreased, and serum osmolarity and electrolyte were normal. The patient was diagnosed with central diabetes insipidus with Langerhans cell histiocytosis. The treatment given to the patient is desmopressin. Conclusion: Langerhans cell histiocytosis may affect any organs of the body. The long-term management of diabetes insipidus in Langerhans cell histiocytosis requires measurement to prevent dehydration and, at the same time to prevent water intoxication. The focus of management is based on the education of the patient about the importance of regulating their fluid intake according to the patient’s hydration status.

Hubungan Kadar Ferritin Serum dengan Fungsi Tiroid pada Anak dengan Thalassemia beta Mayor Melisha Lisman Gaya; Eka Agustia Rini; Amirah Zatil Izzah
Sari Pediatri Vol 25, No 1 (2023)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.1.2023.27-31

Latar belakang. Thalassemia beta mayor merupakan penyakit yang ditandai dengan anemia kronik, hipoksia kronik jaringan, dan pemberian transfusi darah seumur hidup. Penumpukan besi akibat pemberian transfusi berulang berefek toksik pada berbagai organ, termasuk kelenjar tiroid.Tujuan. Mengetahui hubungan antara kelebihan beban besi dengan kejadian hipotiroid pada anak yang menderita thalassemia beta mayor.Metode. Penelitian cross-sectional terhadap 43 subjek dengan thalassemia beta mayor dan mendapat transfusi darah rutin pada periode April 2018-Februari 2019. Subjek dipilih secara total sampling dan dikelompokkan berdasarkan kadar ferritin serum <2500 µg/L dan >2500 µg/L. Hasil kadar tiroksin dan thyroid stimulating hormone dikelompokkan menjadi eutiroid dan hipotiroid. Hasil analisis statistik bermakna bila p<0,05.Hasil. Kadar ferritin serum <2500 µg/L dan >2500 µg/L terdapat pada masing-masing 19 (44,2%) dan 24 (55,8%) subjek. Hipotiroid terjadi pada 13 (38,1%) subjek dengan kadar ferritin >2500 ?g/L dan delapan (38,1%) subjek dengan kadar ferritin <2500 µg/L. Tidak ditemukan hubungan bermakna antara ferritin serum dengan fungsi tiroid pada subjek (p=0,432).Kesimpulan. Persentase hipotiroid meningkat seiring peningkatan kadar ferritin serum, tetapi tidak terdapat hubungan bermakna antara kadar ferritin serum dengan fungsi tiroid pada anak dengan thalassemia beta mayor.

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