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All Journal NUSANTARA : Jurnal Ilmu Pengetahuan Sosial JURNAL KESEHATAN PERINTIS Jurnal Ilmiah Profesi Pendidikan Muhammadiyah Medical Journal Cermin Dunia Kedokteran Media Publikasi Promosi Kesehatan Indonesia (MPPKI) e-Jurnal Inovasi Pembelajaran Sekolah Dasar Journal of Innovative and Creativity Georeference: Jurnal Kajian Ilmu dan Pembelajaran Geografi e-Jurnal Inovasi Pembelajaran Sekolah Dasar Varians Jurnal Kesehatan Masyarakat
Safitri, Yolanda
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Comparing Vaginal Misoprostol and Vaginal Dinoprostone on the Rate of Vaginal Delivery within 24 Hours Syaharani, Nabilla; Safitri, Yolanda; Saputri, Vivi Saharani; Salsabilla, Azira Isnaini; Yahya, Nur Khalisha; Yudistira, Dimas
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8900

Abstract

Background: Labor induction with misoprostol and vaginal dinoprostone remains controversial regarding its effectiveness in achieving vaginal delivery within 24 hours. Objective: To compare the efficacy and safety of misoprostol versus dinoprostone in term pregnancies. Methods: An Evidence-Based Clinical Review (EBCR) synthesized RCTs and meta-analyses using the PICO framework (Population: term pregnant women; Intervention: dinoprostone; Comparison: misoprostol; Outcome: vaginal delivery <24 hours). PubMed, Cochrane, and EBSCO were searched October 2025. The CEBM tool identified 3 studies (1 RCT, 2 meta-analyses). PRISMA 2020 guided the narrative synthesis. Population/Sample: Term singleton pregnancies; 3 included studies (Gaudineau et al., 2021; Lakho et al., 2024; Ramadan et al., 2024). Analysis: A critical appraisal assessed validity, effect size (RR, NNT), and heterogeneity (I²). Results: Misoprostol resulted in higher vaginal delivery rates (Gaudineau: RR 1.30, NNT 7; Ramadan: RR 1.15, 95% CI 1.08-1.22; Lakho: RR 1.08). Conclusion: Vaginal misoprostol was superior or equivalent, providing cost-effective advantages for limited facilities.
Co-Authors Ahyar Ahyar Alatas, M. Syahdi Arief Bowo Prayoga Kasmo Ashabulkahvi, Vikri Claudia, Regita Almira Diah Trismi Harjanti Egar, Eugenius Frima Elda Hamda, Fadhilah Habibul Harni, Harni Lucky Nugroho Masniladevi, Masniladevi Melva Louisa Novita, Rachma Nurul Yakin Romi Marnelly, T. Salsabilla, Azira Isnaini Saputri, Vivi Saharani Sari, Shinta Dewi Permata Sukarmi Sukarmi, Sukarmi Syaharani, Nabilla Tri Krianto Yahya, Nur Khalisha Yudistira, Dimas