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All Journal Jurnal Akuntansi Indonesia Chemistry Indonesian Journal of Chemical Research
Shofia, Shofia
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Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Engineering Environmental Science

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Exploring the Relationship between Financial and Macroeconomic Factors with Manufacturing Stock Prices Mubarok, Faizul; Indasaputry, Erliana; Shofia, Shofia; Sepviani, Aulia
Jurnal Akuntansi Indonesia Vol 13, No 2 (2024): Jurnal Akuntansi Indonesia
Publisher : Universitas Islam Sultan Agung (UNISSULA), Faculty of Economics, Department of Accounting

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/jai.13.2.160 - 173

Abstract

ABSTRACTStock is a promising investment option for investors, encouraging the need for an in-depth understanding of the impact of internal and external factors on share price movements. This research aims to analyze the influence of liquidity, profitability, inflation, and exchange rates on stock prices in the manufacturing sector. With a quantitative approach, the research uses secondary data. It applies a purposive sampling method to select a sample of manufacturing companies that meet the criteria for being listed companies on the Indonesia Stock Exchange during the 2018-2023 period by applying the Fixed Effect Model. The analysis was carried out using the Fixed Effect Model (FEM) in selecting the best model where FEM takes into account time-invariant heterogeneity across companies, effectively controlling for unobserved variables that differ between companies but remain constant over time. The research results show that profitability and inflation have a significant influence on stock price movements, while liquidity and exchange rates do not have a significant influence. The implications of these findings provide a deeper look into the factors influencing share prices in the manufacturing sector, contributing to a better understanding of investment decision-making.
Formulation and Characterization of Uncaria gambir (U. gambir) Extract Cream as an Anti-Psoriasis Candidate: In Silico and In Vitro Studies Abidin, Khoirul Rista; Nurhidayattulloh, Ariffialdi; Siregar, Febrina; Dermawan, Abdurrafi Maududi; Dwisari, Fath; Oktaviria, Oktaviria; Suchi, Suchi; Indriani, Melly; Putri, Firda Aulia; Prasetyaningsi, Hernyati; Shofia, Shofia
Indonesian Journal of Chemical Research Vol 13 No 3 (2026): Edition for January 2026
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2026.13-kho

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder in which oxidative stress and COX-2–mediated pathways contribute to disease progression. Conventional topical therapies, particularly corticosteroids, are effective but associated with adverse effects and limited mechanistic targeting. Objective: This study investigated Uncaria gambir (U. gambir) extract as a natural anti-psoriasis candidate in a topical cream formulation through phytochemical, antioxidant, in silico, and physicochemical evaluations. Methods: The extract was screened for phenolic and flavonoid content and evaluated for DPPH radical scavenging activity (IC₅₀). Molecular docking of catechin against the COX-2 receptor was performed using quercetin as a reference. Cream formulations containing varying extract concentrations were assessed for pH, spreadability, and adhesiveness. Results: U. gambir extract exhibited very strong antioxidant activity (IC₅₀ = 6.84 ppm), falling within the range of highly active antioxidants, although less potent than vitamin C. Catechin showed stable COX-2 binding (−4.76 kcal/mol). The 4.5% cream formulation (F2) demonstrated optimal properties, with a skin-compatible pH (~7.5) and good spreadability (~5.5 cm). Conclusion: U. gambir extract shows promising potential as a natural topical agent targeting oxidative stress and inflammation in psoriasis, supporting further in vivo and clinical validation.
Co-Authors Abidin, Khoirul Rista Dermawan, Abdurrafi Maududi Faizul Mubarok Indasaputry, Erliana Indriani, Melly Nurhidayattulloh, Ariffialdi Oktaviria, Oktaviria Prasetyaningsi, Hernyati Putri, Firda Aulia Sepviani, Aulia Siregar, Febrina Suchi, Suchi