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All Journal Chemistry Indonesian Journal of Chemical Research Jurnal Laboratorium Khatulistiwa
Nurhidayattulloh, Ariffialdi
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Biochemistry, Genetics & Molecular Biology Chemistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Potensi Air Perasan Kunyit Putih, Kunyit Kuning Dan Kunyit Hitam Terhadap Bakteri Escherichia coli Penyebab Diare Sari, Emilda; Suwandi, Edy; Triana, Linda; Nurhidayattulloh, Ariffialdi
Jurnal Laboratorium Khatulistiwa Vol 7, No 2 (2024): Mei 2024
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v7i2.1392

Abstract

Turmeric is a herbal plant that is widely used by the public (Curcuma domestica Val) which is proven to contain ingredients that can function as an antibacterial. The antibacterial properties of turmeric rhizomes are caused by its main chemical content, namely curcuminoids and essential oils. Other active substances in turmeric that can be used as antibacterials are flavonoids, alkaloids and tannins. This compound functions as an antibacterial.This research aims to explain the differences in the inhibitory power of White Turmeric, Yellow Turmeric and Black Turmeric juice against Escherichia coli bacteria. The research design used was quasi-experimental. The samples in this study were the juice of White Turmeric, Yellow Turmeric and Black Turmeric which was repeated 10 times for each treatment.Based on the research results, it is known that white turmeric rhizome juice has an average barrier potential of 33.7 mm against Escherichia coli bacteria. This is no different from the juice of Yellow Turmeric rhizomes which has an average barrier potential of 32.7 mm against Escherichia coli bacteria. Meanwhile, the juice from Black Turmeric has a smaller potential resistance compared to the juice from the rhizomes of White Turmeric and Yellow Turmeric, namely an average of 26.2 mm.
Formulation and Characterization of Uncaria gambir (U. gambir) Extract Cream as an Anti-Psoriasis Candidate: In Silico and In Vitro Studies Abidin, Khoirul Rista; Nurhidayattulloh, Ariffialdi; Siregar, Febrina; Dermawan, Abdurrafi Maududi; Dwisari, Fath; Oktaviria, Oktaviria; Suchi, Suchi; Indriani, Melly; Putri, Firda Aulia; Prasetyaningsi, Hernyati; Shofia, Shofia
Indonesian Journal of Chemical Research Vol 13 No 3 (2026): Edition for January 2026
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2026.13-kho

Abstract

Background: Psoriasis is a chronic inflammatory skin disorder in which oxidative stress and COX-2–mediated pathways contribute to disease progression. Conventional topical therapies, particularly corticosteroids, are effective but associated with adverse effects and limited mechanistic targeting. Objective: This study investigated Uncaria gambir (U. gambir) extract as a natural anti-psoriasis candidate in a topical cream formulation through phytochemical, antioxidant, in silico, and physicochemical evaluations. Methods: The extract was screened for phenolic and flavonoid content and evaluated for DPPH radical scavenging activity (IC₅₀). Molecular docking of catechin against the COX-2 receptor was performed using quercetin as a reference. Cream formulations containing varying extract concentrations were assessed for pH, spreadability, and adhesiveness. Results: U. gambir extract exhibited very strong antioxidant activity (IC₅₀ = 6.84 ppm), falling within the range of highly active antioxidants, although less potent than vitamin C. Catechin showed stable COX-2 binding (−4.76 kcal/mol). The 4.5% cream formulation (F2) demonstrated optimal properties, with a skin-compatible pH (~7.5) and good spreadability (~5.5 cm). Conclusion: U. gambir extract shows promising potential as a natural topical agent targeting oxidative stress and inflammation in psoriasis, supporting further in vivo and clinical validation.
Co-Authors Abidin, Khoirul Rista Dermawan, Abdurrafi Maududi Indriani, Melly Linda Triana Oktaviria, Oktaviria Prasetyaningsi, Hernyati Putri, Firda Aulia Sari, Emilda Shofia, Shofia Siregar, Febrina Suchi, Suchi Suwandi, Edy