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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Laboratorium Khatulistiwa
Abidin, Khoirul Rista
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Identifikasi Bakteri Escherichia Coli Pada Ulkus Diabetikum Studi di Klink Kanazawa Pontianak Menggunakan PCR gen 16S rRNA Nurhidayatulloh, Ariffialdi; Ramadhani, Natasya Intan; Abidin, Khoirul Rista; Suwandi, Edy; Salsabila, Aisha; Widodo, Kaltri; Andriani, Lulu; Hamidah, Najwa; Wulandari, Tri
Jurnal Laboratorium Khatulistiwa Vol 9, No 1 (2025): November 2025
Publisher : poltekkes kemenkes pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30602/jlk.v9i1.1976

Abstract

Diabetes mellitus can lead to complications such as ulcers that are highly susceptible to bacterial infection. Escherichia coli is one of the pathogenic bacteria commonly found in diabetic foot ulcers. Accurate detection of E. coli species is essential to support appropriate infection management, and one of the reliable methods is Polymerase Chain Reaction (PCR) targeting the 16S rRNA gene. This study employed a descriptive design with an accidental sampling technique. Samples were obtained from swab specimens of diabetic foot ulcer patients. The procedures included culture on Eosin Methylene Blue (EMB) agar, Gram staining, bacterial DNA isolation, PCR amplification of the 16S rRNA gene, electrophoresis for visualization of PCR products, and sequencing for species confirmation. Based on the results of the study involving 30 diabetic foot ulcer patients at Kanazawa Clinic Pontianak, culture analysis showed that 4 isolates were positive for Escherichia coli. Gram staining further confirmed the presence of E. coli by demonstrating its characteristic morphology. The PCR results visualized through electrophoresis showed that 4 samples (13.3%) were positive for Escherichia coli based on the 16S rRNA gene, indicated by the presence of DNA bands at approximately 1500 bp. Sequencing analysis further confirmed the isolates as Escherichia coli with 99% similarity. 
Antibacterial Activity of Bajakah Tampala (Spatholobus littoralis Hassk.) Methanol Extract in Roll-On Deodorant against Staphylococcus epidermidis Dwisari, Fath; Dermawan, Abdurraafi' Maududi; Rahma, Nur Atika; Tjoadri, Tessa Nathalia; Abidin, Khoirul Rista
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.865

Abstract

Body malodor results from the bacterial breakdown of apocrine gland secretions, with Staphylococcus epidermidis identified as a key contributor. Conventional deodorants often rely on synthetic compounds that may cause skin irritation or pose long-term health risks. This study aimed to formulate and assess an antibacterial roll-on deodorant containing methanolic extract of Spatholobus littoralis Hassk., a Kalimantan-native medicinal plant known for its antibacterial properties. The extract, prepared via maceration, was incorporated into a multiphase emulsion base comprising zinc ricinoleate, aluminum potassium sulfate, Carbopol 940, triethanolamine, Lexemul CS20, BHT, and phenoxyethanol. The formulations were evaluated for their physicochemical characteristics—pH, spreadability, adhesiveness, and homogeneity—as well as antibacterial activity against S. epidermidis using the disc diffusion assay. The extract-containing formulations (F1–F3) exhibited a beige color, herbal aroma, and uniform texture. The pH values (4.12–4.35) were within the dermally acceptable range. The spreadability varied from 4.59 to 4.81?cm, while the adhesiveness ranged from 0.34?s to 5.25?min, indicating favorable application and retention properties. Antibacterial testing showed inhibition zones of 10.40–12.37?mm, comparable to a commercial control (p?>?0.05). These findings suggest that S. littoralis extract is a potential natural, skin-compatible antibacterial agent for topical deodorant applications
Co-Authors Andriani, Lulu Dermawan, Abdurraafi Maududi Fath Dwisari Hamidah, Najwa Nurhidayatulloh, Ariffialdi Rahma, Nur Atika Ramadhani, Natasya Intan Salsabila, Aisha Suwandi, Edy Tjoadri, Tessa Nathalia Tri Wulandari Widodo, Kaltri