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All Journal Folia Medica Indonesiana Majalah Kedokteran Andalas JURNAL MUTIARA KESEHATAN MASYARAKAT INFOKUM Jurnal Scientia Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences Jurnal EduHealth Jurnal Ekonomi INTERNATIONAL JOURNAL OF CULTURAL AND SOCIAL SCIENCE
Sri Lestari Ramadhani Nasution
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Religion Arts Humanities Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : INFOKUM

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Vitamin C Administration Method On Osteoblast Healing In Rats Femur Bone Sri Lestari Ramadhani Nasution; Muhammad Ari Pratama; Muhammad Faridz Syahrian
INFOKUM Vol. 13 No. 02 (2025): Infokum
Publisher : Sean Institute

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Abstract

Bone, as an important organ in the body, has a fundamental role in supporting biomechanical functions, carrying out the hematopoiesis process, and maintaining calcium homeostasis. The cellular components of bone involve various types of cells, including osteogenic precursor cells, osteoblasts, osteoclasts, osteocytes, and hematopoietic elements from the bone marrow. Vitamin C, or ascorbic acid, is a water-soluble vitamin that plays an important role in the formation of collagen, skin, tendons, ligaments, blood vessels, as well as in wound healing and maintenance of cartilage, bones, and teeth. This study aims to analysed mean value and difference in the number of osteoblast cells in the femur of rats exposed to alcohol between groups receiving vitamin C. Based on the results of the One Way ANOVA test, the p value = 0.018 <0.05 was obtained, which indicated a significant difference in the average osteoblasts between groups. Furthermore, in the Post Hoc test, a difference in the mean osteoblasts was found between groups T3 and T5 with a p value = 0.029 < 0.05 and between groups T4 and T5 with a p value = 0.044 < 0.05. Conclusion: Administration of vitamin C can affect the increase in the number of osteoblast cells in the bone healing process in mice exposed to alcohol.
Co-Authors Anita Merry Cisca Arie - Vonikartika Christine Wijaya Clinton Antony Clinton Antony Disti Amanda Putri Dzul Akbar Insani Erisman Hondro Ermi Girsang Gusbakti Gusbakti Ibnu Rushd Liani Br Ginting M. Ridho Fitra Alamsya Maria Seri Arihta Muhammad Ari Pratama Muhammad Faridz Syahrian Muhammad Insan Andika Nadia Zenni Andari Nasution, Ali Napiah Primanita Novi Andriati Putri Satriani Dachi Rapael Ginting Ria Hartaty S. Shelly Hazlina Hararap Sindy Zelvia Suci Erawati Suhartina Suhartina Tommy Adhi Wijaya Waoziduhu Ndruru Winda Tri Mutia Yuliani Yuliani