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All Journal AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam The International Journal of Tropical Veterinary and Biomedical Research
Ichwan, M
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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GINGIVA CHANGES IN DIABETES MELLITUS PATIENTS: LITERATURE REVIEW Uswatul Husnaini; Nasution, Badai Buana; ichwan, M
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 15 No 2 (2025): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v15i2.1730

Abstract

Diabetes mellitus is a chronic metabolic disease that leads to oral complications generally, including changes and damage to the gingiva due to increased inflammation. The incidence of periodontal disease is two to three times higher compared to individuals without diabetes, which exacerbates gingival tissue damage and slows down healing. Hyperglycemia triggers the formation of advanced glycation end-products (AGEs), which increase the production of pro-inflammatory cytokines. This article aims to identify changes in the gingiva associated with diabetes mellitus. The method used is a literature review of articles published online through databases such as Google Scholar and PubMed. The analyzed articles are publications from 2019 to 2024, with a total of 21 articles meeting the inclusion criteria and relevant to the research objectives. The study results indicate that the interaction between hyperglycemia causes changes in the gingiva of diabetic patients, increased oxidative stress, and dysfunction in the immune system, which worsens inflammation and gingival tissue damage. Factors such as increased free radicals, impaired tissue healing due to vascular dysfunction, and decreased collagen production also contribute to the exacerbation of tissue damage, thereby increasing the risk of periodontal disease in patients with diabetes mellitus. Gingivitis and periodontitis are two common forms of periodontal disease caused by pathogenic biofilms around the teeth.
Potensi Pegagan (Centella asiatica) terhadap Fungsi Kognitif Lanjut Usia Siregar, Sarah Rahmayani; Widyawati, Tri; Ichwan, M
AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Averrous, Vol.9 No.1 Mei 2023
Publisher : Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/averrous.v9i1.10772

Abstract

Jumlah penduduk lanjut usia (lansia) yang semakin meningkat dapat menambah beban ekonomi negara jika lansia memiliki masalah gangguan kognitif akibat proses penuaan. Stres oksidatif menyebabkan kerusakan neuron pada lansia. Centella asiatica adalah salah satu tanaman herbal yang banyak dikaji efek neuroprotektifnya. Tujuan dari telaah singkat ini untuk menyajikan semua bukti mengenai manfaat C.asiatica terhadap fungsi kognitif lansia. Pencarian literatur dilakukan pada database PubMed, Scince Direct, Google Scholar dan Springer Link pada topik pengaruh C.asiatica terhadap fungsi kognitif. Bukti dan informasi yang diperoleh disajikan dalam bentuk narasi. Hasil telaah menunjukkan penelitian eksperimental mengenai efek C.asiatica terhadap fungsi kognitif telah dilaporkan.Berdasarkan bukti yang ada, C.asiatica berpotensi sebagai neuroprotektor, antioksidan dan antiinflamantori karena mengandung banyak senyawa bioaktif seperti triterpenoid dan flavonoid.  Kesimpulannya bahwa C.asiatica dapat meningkatkan fungsi kognitif.
Effectiveness of red palm oil supplementation on motor impairment in a Paraquat-induced Parkinsons disease rat mode Siregar, Ari Ramadhan; Ichwan, M; Siregar, Jelita; Anggraini, Dwi; Hasibuan, Hasrul
The International Journal of Tropical Veterinary and Biomedical Research Vol 9, No 1 (2024): Vol. 9 (1) May 2024
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v9i1.36536

Abstract

Parkinson's is a neurological disease that is rapidly increasing to surpass Alzheimer's disease. Parkinson's disease causes a decrease in the number of dopaminergic neurons, which can lead to disturbances in attention, memory, and motivation. Damage to dopaminergic nerve cells is caused by increased free radicals (ROS) levels in tissues and cells, thus inducing cell death signals. This study aims to determine whether red palm oil affects the acute level of Parkinson's syndrome in rats induced with paraquat. This study uses the BEAM and Cylinder tests to measure the effect of red palm oil because one of the alternative therapies for neurodegenerative illnesses like Parkinson's is red palm oil. The treatment was administered to paraquat-induced rats with injections given weekly for four weeks. Carotenoids are present in red palm oil at concentrations of 600 to 1000 ppm and are thought to have neuroprotective properties. As many as 30 rats were divided into three groups: K (control), PQT (paraquat 7 mg/kg body weight), and PQT+MSM (paraquat 7 mg/kg body weight + 2 ml of red palm oil). The data were then checked using the normality test Shapiro-Wilk and analyzed statistically using One-way ANOVA. The Cylinder and Beam tests were significant, with a P value of 0.00. Parkinsonian rats receiving red palm oil at a dose of 2 ml/kg body weight per week for four weeks showed improved motor function compared to those receiving only paraquat. The group with red palm oil had a lower beam test value. This indicates motor improvement in Parkinson's model rats. Similarly, the cylinder test showed higher performance in the group treated with red palm oil. Based on this, it can be concluded that red palm oil influences the motor movements of Parkinson's rats. The beam test and cylinder test methods prove this. Red palm oil could decrease the acute level of motor impairments in rats with Parkinson's induced by paraquat.
Co-Authors Dwi Anggraini Hasibuan, Hasrul Nasution, Badai Buana Sarah Rahmayani Siregar Siregar, Ari Ramadhan Siregar, Jelita Tri Widyawati, Tri Uswatul Husnaini