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Retnani, Diah
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Gambaran Klinikopatologi Parapsoriasis Puspitasari, Galuh; Yuniaswan, Anggun; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1311.24 KB) | DOI: 10.11594/jk-risk.01.1.6

Abstract

Parapsoriasis merupakan penyakit kulit yang mencerminkan tumpang tindih klinis termasuk kronisitas, penyebab yang idiopatik, recalcitrans terhadap terapi, dan lesi nonpruritik, yang menyerupai psoriasis. Terdapat 2 bentuk parapsoriasis yaitu Small Plaque Parapsoriasis (SPP) dan Large Plaque Parapsoriasis (LPP). Banyak penyakit kulit yang memiliki gejala menyerupai parapsoriasis, sehingga diagnosisnya sulit ditegakkan. Oleh karena itu pemeriksaan histopatologi dan imunohistokimia perlu dilakukan. Parapsoriasis dikarakteristikkan dengan infiltrat limfoid kutaneus superfisial yang terdiri dari sel T pada pemeriksaan histopatologi baik pada LPP maupun SPP. Namun infiltrat LPP sering mengandung limfosit dengan inti cerebriform (sel Lutzner) yang mirip dengan sel Sezary pada Mycosis fungoides (MF). Pemeriksaan imunohistokimia CD3 dapat menunjukkan gambaran sel T tersebut normal atau atipikal jika mengarah suatu keganasan. Oleh karena itu, evaluasi densitas sel T pada gambaran histopatologi dan pemeriksaan imunohistokimia CD3 dapat membantu menegakkan diagnosis parapsoriasis, serta untuk mengenali tanda-tanda keganasan mengarah pada MF.
Pemeriksaan Histopatologi dan Imunofluoresen pada Pemfigus Vulgaris Devitasari, Rizky; Yuniaswan, Anggun; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1217.843 KB) | DOI: 10.11594/jk-risk.01.1.5

Abstract

Pemphigus vulgaris (PV) adalah suatu penyakit autoimun yang ditandai lepuhan pada kulit dan membran mukosa. Lesi primer PV adalah terdapat lepuhan kendur dengan predileksi pada seluruh permukaan kulit dan mukosa. Tes diagnostik untuk menegakkan diagnosis PV terhadap penyakit vesikobulosa yang lain, meliputi biopsi kulit ataupun mukosa untuk pemeriksaan histopatologi dan immunoflouresence (IF). Gambaran histopatologi yang ditemukan berupa adanya intraepithelial blister dan achantolysis suprabasilar dengan ciri khas row of tombstone yang merupakan hasil dari IgG autoantibodi terhadap glikoprotein desmoglein 3 (dsg3) dan sebagian terhadap desmoglein 1 (dsg1). Pemeriksaan direct immunoflourescence menunjukkan deposit IgG, IgM dan C3 di ruang antar sel dalam epitel.
Evaluasi Klinikopatologis Karsinoma Sel Skuamosa yang Berkembang dari Ulkus Marjolin Kharisma, Anggie; Retnani, Diah; Susilo, Hery
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1482.714 KB) | DOI: 10.11594/jk-risk.01.1.7

Abstract

Pendahuluan: Ulkus Marjolin adalah suatu proses keganasan pada kulit yang diakibatkan oleh proses trauma atau inflamasi kronis. Keganasan ini bersifat jarang dan agresif. Karsinoma sel skuamosa (KSS) adalah manifestasi tersering akibat luka bakar. Ilustrasi Kasus: Seorang wanita berusia 51 tahun datang ke Ruma Sakit Saiful Anwar Malang dengan keluhan benjolan seperti kembang kol pada lengan atas tangan kanan sejak 8 bulan yang lalu. Benjolan awalnya kecil sebesar ujung jari (1cm), lalu semakin membesar. Pasien mengalami luka bakar di badan setelah terkena siraman bensin 33 tahun yang lalu. Pasien juga mengeluhkan sensasi nyeri dan bau busuk pada area benjolan. Kesimpulan: Proses inflamasi memiliki peran penting dalam perkembangan ulkus Marjolin.
Gambaran Klinis dan Histopatologi Keratosis Seboroik Mayati Suwoko, Wika Umayatul Choiroh; Yuniaswan, Anggun; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.4

Abstract

Keratosis seboroik merupakan tumor jinak epidermal yang paling banyak ditemukan dan sering ditemukan pada orangtua yakni sekitar 20% dari populasi keseluruhan. Faktor penyebab pasti kelainan ini masih belum jelas diketahui. Paparan sinar matahari dikatakan sebagai salah satu penyebab dari keratosis seboroik. Lesi dapat berupa bercak kecokelatan yang datar, sirkumskrip dan tampak kusam, dengan permukaan halus seperti beludru dapat pula berbentuk papul atau plak hiperpimentasi, bulat atau lonjong, sirkumskrip, seperti dilapisi lilin (waxy) dengan permukaan verukosa, atau gambaran menempel “stuck on” pada kulit. Keratosis seboroik dapat berupa lesi yang multipel, soliter, disseminata pada usia lanjut, dermatosis papulosa nigra dan juga berupa tanda Leser-Trelat. Penegakkan diagnosis keratosis seboroik melalui anamnesis, pemeriksaan fisik dan dapat dilanjutkan pemeriksaan histopatologi. Terdapat bermacam-macam gambaran histopatologi dari keratosis seboroik sehingga berdasarkan uraian di atas, tinjauan pustaka ini bertujuan untuk menjelaskan berbagai gambaran klinis dari keratosis seboroik beserta gambaran histopatologinya dan dapat membantu pembaca dalam menentukan jenis keratosis seboroik apabila menemukan kasus tersebut.
Plasma cell myeloma: Pendekatan diagnosis dari aspek kliniko-morfologik dan imunofenotipe Angelina, Aina; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.5

Abstract

Plasma cell myeloma (PCM)/Mutiple myeloma (MM) merupakan keganasan hematologi ditandai proliferasi sel plasma neoplastik pada sumsum tulang. Manifestasinya berupa lesi litik multifokal tulang, peningkatan M protein serum atau urin, kerusakan organ target, dan bisa didapatkan pembentukan massa di ekstrameduler. Biopsi massa tumor ekstrameduler dapat menujukkan morfologi mikroskopik yang tumpang tindih dengan neoplasma sel plasma lainnya maupun limfoma maligna, hal ini merupakan tantangan diagnosis tersendiri terutama jika keterangan klinis maupun radiologis tidak lengkap. Kerusakan organ target akibat proliferasi sel plasma abnormal dikenal dengan istilah CRAB terdiri atas hiperkalsemia, insufisiensi renal, anemia dan lesi tulang. Spektrum klinis seringkali bervariasi sehingga diagnosis PCM memerlukan integrasi data klinis, laboratorium, radiologi, morfologi, dan imunofenotipe. Pemeriksaan histopatologi dari bahan biopsi sumsum tulang maupun biopsi massa tumor perlu dikonfirmasi dengan pemeriksaan imunohistokimia serta tes klonalitas untuk penegakan diagnosis yang akurat. Tinjauan ini bermaksud menjelaskan aspek klinis, morfologi dan immunofenotipe serta merangkai suatu pendekatan diagnosis PCM.
Penelitian Retrospektif Profil Klinikopatologi Tumor Kelenjar Liur di Instalasi Patologi Anatomi RSUD Dr. Saiful Anwar Malang Periode Tahun 2017-2021 Lukman Firmansyah, Muhammad; Fadli, Muhammad; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 3 No 1 (2023): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.03.1.3

Abstract

Abstract Background: Cases of salivary gland tumors are relatively rare. There are not many data that explain the prevalence of salivary gland tumor incidence in Indonesia. Objective: This study aims to determine the clinicopathological profile of salivary gland tumors based on case incidence, age, gender, location and histopathological subtype at the Anatomical Pathology Installation of Dr. Saiful Anwar Hospital Malang in 2017-2021. Methods: This research is a quantitative descriptive study. Data was collected from medical records from 2017 to 2021 at the Anatomical Pathology Installation of Saiful Anwar Hospital, Malang. All subjects in this study were all clinical data of patients with tumor located salivary gland (parotid, submandibular, sublingual/cavum oris). Results and Discussion: There were 162 cases of salivary gland tumors from 2017-2021, malignant neoplasm 57 (35%), benign neoplasm 60 (37%) and non neoplasm 45 (28%). The distribution of the incidence of cases per year is not the same and does not always increase. There was a relationship between the increase in cases of malignancy with increasing age. There is no relationship between increasing cases of salivary gland tumors and malignancy with gender. The most common locations for salivary gland tumors and malignant neoplasm in parotid gland. The most malignant neoplasm is mucoepidermoid carcinoma 11 (19.2%), the most benign neoplasm is pleomorphic adenoma 38 (63.3%), the most non-neoplastic cases is inflammation and abscess 34 (75.5%). Conclusion: Salivary gland tumors are rare cases. Cases of malignancy increase in adults and the elderly. The most common location in the parotid gland with the most cases of malignant neoplasm is mucoepidermoid carcinoma and the most benign neoplasms is pleomorphic adenoma. Keywords: Salivary gland tumor, histopathology.
Gambaran Klinikopatologi Parapsoriasis Puspitasari, Galuh; Yuniaswan, Anggun; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.1.6

Abstract

Parapsoriasis is a dermatoses which reflect clinical overlap includes chronicity, recalcitrans, idiopathic causes against the therapy, and the lesions often nonpruritic, which resembles to psoriasis. There are two common forms of parapsoriasis i.e. small plaque parapsoriasis (SPP) and a large plaque parapsoriasis (LPP). Many skin diseases have symptoms that resemble parapsoriasis, so the diagnosis is difficult to establish. Therefore histopathological and immunohistochemical examination needs to be done. Parapsoriasis is characterized by superficial cutaneous lymphoid infiltrates consisting of T cells in histopathological examination both on LPP and SPP. But, LPP infiltrates often contain lymphocytes with cerebriform nuclei (Lutzner cells) that are similar to Sezary cells in Mycosis fungoides (MF). Immunohistochemical examination of CD3 can show that T cells are normal or atypical if they lead to a malignancy. Therefore, evaluation of T cell density on histopathological features and CD3 immunohistochemical examination can help establish the diagnosis of parapsoriasis, as well as to recognize signs of malignancy leading to MF.
Pemeriksaan Histopatologi dan Imunofluoresen pada Pemfigus Vulgaris Devitasari, Rizky; Yuniaswan, Anggun; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.1.5

Abstract

Pemphigus vulgaris (PV) is an autoimmune disease characterized by blisters on the skin and mucous membranes. The primary lesion of PV are loose blisters, which can occur anywhere on the surface of the skin and mucosal surface. Diagnostic test aims to confirm the diagnosis of PV to other vesiculobullous disease, including skin or mucosal biopsies for histopathological examination and immunofluorescence (IF). Histopathological features intraepithelial blisters and suprabasilar achantolysis with characteristic row of tombstones which were the result of IgG autoantibodies to glycoprotein desmoglein 3 (dsg3) and partly to desmoglein 1 (dsg1). Direct immunofluorescence examination showed deposits of IgG, IgM and C3 in the intercellular spaces in the epithelium. Blood tests with the ELISA test can only be used to check the levels of autoantibodies to Dsg3 and Dsg1.
Evaluasi Klinikopatologis Karsinoma Sel Skuamosa yang Berkembang dari Ulkus Marjolin Kharisma, Anggie; Retnani, Diah; Susilo, Hery
Jurnal Klinik dan Riset Kesehatan Vol 1 No 1 (2021): Edisi Oktober
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.01.1.7

Abstract

Introduction: Marjolin's ulcer is a malignant process in the skin caused by trauma or chronic inflammation. This malignancy is rare and aggressive. Squamous cell carcinoma (SCC) is the most common manifestation of burns. Case Illustration: A 51-year-old woman came to Saiful Anwar Hospital Malang with a complaint of a cauliflower-like lump on the upper arm of her right hand since 8 months ago. The lump was initially as small as a fingertip (1cm), then it got bigger. The patient suffered burns on his body after being hit by gasoline spray 33 years ago. The patient also complains of a painful sensation and a foul odor in the area of ​​the lump. Conclusion: The inflammatory process has an essential role in the development of Marjolin's ulcer.
Gambaran Klinis dan Histopatologi Keratosis Seboroik : Clinical and Histopathological Features of Seborrheic Keratosis Mayati Suwoko, Wika Umayatul Choiroh; Yuniaswan, Anggun; Retnani, Diah
Jurnal Klinik dan Riset Kesehatan Vol 2 No 2 (2023): Februari 2023
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.02.2.4

Abstract

Seborrheic keratosis is the most common benign epidermal tumor and is often found in the elderly, which is about 20% of the total population. The exact cause of this disorder is still not clearly known. Sun exposure is said to be one of the causes of seborrheic keratosis. Lesions can be flat, circumscript and dull-looking brown spots, with a smooth, velvety surface, can also take the form of hyperpimented papules or plaques, round or oval, circumscript, such as coated wax (waxy) with a verrucosa surface, or a picture of sticking "stuck on" to the surface of the skin. skin. Seborrheic keratosis can be in the form of multiple, solitary, disseminated lesions in old age, dermatosis papulosa nigra and also in the form of Leser-Trelat signs. The diagnosis of seborrheic keratosis is made through anamnesis, physical examination and by histopathological examination. There are various histopathological features of seborrheic keratosis, this literature review aims to explain the various clinical features of seborrheic keratosis along with their histopathological features and can assist readers in determining the type of seborrheic keratosis when they come across such cases.
Co-Authors Aina Angelina Devitasari, Rizky Kharisma, Anggie Lukman Firmansyah, Muhammad Mayati Suwoko, Wika Umayatul Choiroh Muhammad Fadli Puspitasari, Galuh Susilo, Hery Yuniaswan, Anggun