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All Journal Jurnal Ilmiah Manusia dan Kesehatan Altifani Journal: International Journal of Community Engagement Golden Ratio of Data in Summary Jurnal Medika Veterinaria
Fitria, Dinda
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : Jurnal Medika Veterinaria

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The Effectivity of Muntingia calabura L. Leaf Extract Cream on Skin Incision Wound Healing Day 7 on White Rat (Rattus Norvegicus) with Diabetes Mellitus Salim, M Nur; Masyitha, Dian; Hennivanda, Hennivanda; Aisyah, Siti; Daud, Razali; Sabri, Mustafa; Fitria, Dinda
Jurnal Medika Veterinaria Vol 17, No 2 (2023): J.Med.Vet
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.med.vet..v17i2.36274

Abstract

Wounds are damage to tissue integrity and function that occurs in the body. High blood glucose levels in diabetes mellitus can inhibit wound healing. This study aimed to determine the effectiveness of kersen leaf extract cream (Muntingia calabura L.) on the healing process of incision wounds on the skin of white rats (Rattus norvegicus) with diabetes mellitus on day 7. The experimental animal used were 12 male white rats weighing 150-200 g, aged 2-3 months old which were induced by streptozotocin 45 mg/kg BW intraperitonially. This research method used a completely randomized design (CRD) consisting of K1 as a negative control given a cream base and distilled water, K2 as a positive control given 0,1% silver sulfadiazine cream and metformin 4.5 mg/kg BW, K3 and K4 given 5% and 15% kersen leaf extract cream and 450 mg/kg BW kersen leaf extract orally. Incision wounds were made in the paravetebral area along 2 cm with a depth of 2 mm. Wound care was performed twice a day for 7 days. ANOVA test result showed that the administration of cream and kersen leaf extract significantly affected the number of fibroblast cells, collagen, and angiogenesis. The results showed that K1 was significantly different (P0,05) from K2, K3 and K4. K3 and K4 groups had higher average numbers of fibroblast cells, collagen, and angiogenesis. The application of kersen leaf extract cream was able to increase the number of fibroblast cells, collagen, and angiogenesis so that it could accelerate the healing of incision wound on day 7 in white rats with diabetes mellitus.
Co-Authors D., Sukaria Delimawati Delimawati, Delimawati Dian Masyitha Faisal Mustafa Fatri, Tri Hennivanda, Hennivanda Ilham, M. M Nur Salim, M Nur Pratama, Akram Puput, Puput Putri Mellaratna, Wizar Razali Daud Sentot Imam Wahjono Siti Aisyah Sofia, Rizka Vadilla, Anatasya Eka Zubaidah R, Zubaidah