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All Journal BALI MEDICAL JOURNAL (BMJ) Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran
Nurmiati Amir
Department of Psychiatry, Universitas Indonesia, Jakarta, DKI Jakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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SNP8NRG433E1006 NEUREGULIN-1 GENETIC VARIATION IN BATAKS ETHNIC WITH SCHIZOPHRENIA PARANOID AND HEALTHY CONTROL Effendy, Elmeida; Loebis, Bahagia; Amir, Nurmiati; Siregar, Yahwardiah
BALI MEDICAL JOURNAL Vol 3 No 2 (2014)
Publisher : BALI MEDICAL JOURNAL

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Abstract

The neuregulin 1 (NRG1) gene which influences the development of white matterconnectivity has been associated with schizophrenia. It influences neuronal migration, synaptogenesis,gliogenesis, neuron-glia communication, myelination, and neurotransmission in the brain and others.NRG1 is located in 8p13, and it is frequently replicated in schizphrenia. SNP8NRG433E1006 geneNRG1 is one of core at risk haplotype of schizphrenia. This study looked forward differencesSNP8NRG433E1006 neuregulin 1 between Bataks ethnic with schizophrenia paranoid and Bataksethnic healthy control. Methods: Batak ethnic with schizophrenia paranoid were recruited andinterviewed with semi-structured MINI ICD-X to establish the diagnosis. All the eligible subjectswere requested their permission for blood sampling. Healthy Batak ethnic were also recruited bymathcing the age and gender. The blood samples went through DNA isolation, Nested PCR, and DNAsequencing. Results: Ninety three subjects were recruited, but only 74 blood samples weresuccesfully sequenced. We found three types of polymorphisms, i.e. G/A allele at base pair (bp) 76,G/T allele at bp 112, and deletion at bp 110 in Batak ethnic with schizophrenia. There were two kindsequences at bp 113-116 in Batak ethnics, and Batak ethnics with ATCG were at higher risk forhaving schizophrenia. This study support that NRG1 is a schizophrenia-susceptibility gene.
KOMORBIDITAS FISIK PADA GANGGUAN BIPOLAR DI RS. DR. H. MARZOEKI MAHDI BOGOR Tinambunan, Iriawan Rembak; Amir, Nurmiati; Budiman, Richard; Kusumaningrum, Profitasari
Majalah Kedokteran Indonesia Vol 68 No 8 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Pendahuluan: Gangguan bipolar dikenal memiliki kaitan dengan berbagai komorbiditas klinis yang memengaruhi pekerjaan, kehidupan berkeluarga, dan fungsi interpersonal. Duapertiga pasien dengan gangguan bipolar memiliki komorbid yang akan memperburuk luaran gangguan bipolar dan dapat menganggu penatalaksanaan terhadap penyakitnya. Belum ada penelitian yang menggambarkan frekuensi komorbiditas fisik yang terjadi pada penderita bipolar di Indonesia. Rumah Sakit Dr. H. Marzoeki Mahdi sebagai rumah sakit jiwa tertua di Indonesia juga belum memiliki data mengenai jenis dan frekuensi komorbid fisik, mengingat bahwa rumah sakit ini juga menangani rawat inap umum di samping rawat inap psikiatri. Metode: Penelitian menggunakan rancangan potong lintang pada 100 orang dengan Gangguan Bipolar di Poliklinik Jiwa Dewasa dan Bangsal Psikiatri R.S. Dr. H. Marzoeki Mahdi Bogor. Penelitian ini menggunakan instrument Structured Clinical Interview For the DSM-IV Axis I Disorders untuk menentukan Gangguan Bipolar, dan kriteria diagnostik sepuluh komorbid fisik yang mengacu pada kriteria diagnostik masing-masing komorbid fisik. Hasil: Pada penelitian ini didapatkan adanya hubungan bermakna antara umur dengan terjadinya komorbid fisik yaitu p= 0.001(p di bawah 0.005). Pada analisis tambahan didapatkan adanya hubungan bermakna antara pemberian obat polifarmasi/monoterapi dengan terjadinya komobid fisik terbanyak yakni hipertensi (nilai p= 0,0001). Pada sepuluh komorbid fisik yang dinilai, migrain, hipertensi dan dermatitis merupakan yang paling banyak. Kesimpulan: Hipertensi, migrain dan dermatitis merupakan tiga besar komorbid fisik di R.S. Dr. Marzoeki Mahdi Bogor. Terdapat hubungan bermakna antara umur dengan terjadinya komorbid fisik. Pemberian obat polifarmasi/monoterapi juga bermakna dalam terjadinya hipertensi. Diperlukan kewaspadaan psikiater dalam mengawasi terjadinya komorbid fisik pada gangguan bipolar di layanan psikiatri. 
HUBUNGAN ANTARA SIKAP HIGIENE TIDUR DAN FAKTOR LAIN DENGAN ANGKA KEJADIAN INSOMNIA PADA SATUAN PENGAMANAN (SATPAM) DENGAN KERJA GILIR DI PT. X H, Intan Vindalia Dian Sari; Roestam, Ambar W.; Amir, Nurmiati
Majalah Kedokteran Indonesia Vol 68 No 1 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Abstract

Pendahuluan: Satpam dengan kerja gilir berisiko mengalami insomnia. Berdasarkan studi oleh Didi Purwanto tahun 2005 pada pekerja pabrik semen Citeureup?Bogor, prevalensi insomnia mencakup 48,1% pada pekerja gilir dan mencapai hampir dua kali lebih tinggi dibandingkan pekerja non gilir. Tujuan penelitian ini adalah untuk mengetahui prevalensi insomnia dan faktor?faktor yang meningkatkan risiko kejadian insomnia pada satpam dengan kerja gilir di PT. X. Metode: Desain penelitian menggunakan potong lintang yang dianalisis secara analitik, melibatkan 107 satpam dengan kerja gilir. Pengambilan data menggunakan beberapa kuesioner, yaitu kuesioner Sleep Hygiene Index, kuesioner Stress Diagnostic Survey, kuesioner Insomnia Rating Scale-KSPBJ, serta wawancara menggunakan instrumen MINI. Hasil: Prevalensi insomnia pada satpam dengan kerja gilir di PT. X adalah 81,9%. Hasil analisis statistik menunjukkan sikap higiene tidur buruk meningkatkan risiko terjadinya insomnia hampir 10 kali lebih tinggi dibandingkan dengan sikap higiene tidur baik (OR=9,820, 95%IK=1,185?81,413). Usia lebih tua, masa kerja lebih lama, pola kerja gilir iregular dan stres kerja sedang-tinggi tidak terbukti meningkatkan risiko kejadian insomnia pada satpam dengan kerja gilir (p>0,05). Diskusi: Saran bagi satpam yang menjalani kerja gilir yaitu dapat menerapkan sikap higiene tidur dengan baik. Bagi manajemen PT. X, disarankan penyuluhan berkala setiap tiga bulan sekali mengenai gangguan kesehatan akibat kerja gilir terutama insomnia dan evaluasi kesehatan pada satpam yang mengalami insomnia setiap satu hingga tiga bulan sekali.
Tatalaksana Gangguan Afektif Bipolar pada Ibu Hamil Oktaria Safitri, Dian; Amir, Nurmiati
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (113.345 KB) | DOI: 10.55175/cdk.v46i1.535

Abstract

Sekitar 25%-30% pasien gangguan bipolar yang hamil gejalanya menjadi lebih berat. Gangguan jiwa pada periode perinatal dapat menyebabkan distres signifikan, dapat mengganggu perkembangan ibu dan anak, dan jangka panjang mempengaruhi kesejahteraan ibu, bayi, keluarganya, dan masyarakat luas. Dokter seyogyanya memiliki pengetahuan lebih mengenai tatalaksana komprehensif gangguan bipolar selama kehamilan.Around 25-30% bipolar disorder patients show worsening symptoms during pregnancy. Mental disorders in perinatal period can cause significant distress that will interfere maternal and child development, and the long-term implication can affect the mother, infant, family, and community. Doctors should have more knowledge on comprehensive management of bipolar disorder during pregnancy. 
Hubungan Antara Sikap Higiene Tidur dan Faktor Lain dengan Angka Kejadian Insomnia pada Satuan Pengamanan (Satpam) dengan Kerja Gilir di PT. X H, Intan Vindalia Dian Sari; Roestam, Ambar W.; Amir, Nurmiati
Majalah Kedokteran Indonesia Vol 68 No 1 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.1-2018-96

Abstract

Introduction : Securities who undergo work-shift, are at risk for insomnia. Based on study by Didi Purwanto at Citeureup-Bogor cement factory at 2005, prevalence of insomnia on shift workers is 48.1% and is almost twice higher than non-shift workers.The aim of this research is to know the prevalence of insomnia and to determine factors that increase the risk of insomnia on security with shift work at PT. X. Method : Design of this study is cross-sectional which involved 107 securities with shift. Data collection used several questionnaires, including Sleep Hygiene Index questionnaire, Stress Diagnostic Survey questionnaire, Insomnia Rating Scale-KSPBJ questionnaire, and interview using MINI instrument. The prevalence of insomnia on securities with shift work at PT.X is 81.9%. Result : The result showed that poor sleep hygiene behavior increased the risk of insomnia almost 10 times higher than good sleep hygiene behavior (OR=9.820, 95%CI=1.185-81.413). Olderage, longer working hours, irregular pattern of work shift, and medium-high stresses did not increase the risk of insomnia on securities with shift work (p > 0.05). Discussion : Suggestion to security who undergoes shift should implement good sleep hygiene. For PT.X management, counseling about the health problems caused by shift work, especially insomnia every three months and taking health evalu ation at security who have insomnia everyone to three months are recommended.
Emotional Impact of In Vitro Fertilization (IVF): Anxiety, Depression, and Their Relationship with Pregnancy Outcomes Agiananda, Feranindhya; Natadisastra, Raden Muharram; Amir, Nurmiati; Irwanto; Aninditha, Tiara; Wibisono, Sasanto; Wahmurti, Tuti; Kekalih, Aria; Karnasih, Artasya; Samjunanto, Achmad; Puspaseruni, Putri Air; Velyani, Dyani Pitra; Prayangga, Regina
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2626

Abstract

Objectives: Infertility can significantly impact women's physical and psychological health. Numerous treatment options are commonly pursued, with IVF often considered the last resort for infertile couples. However, IVF is associated with increased stress at every stage, potentially influencing women's perceptions and experiences throughout the procedure. This research examines anxiety and depression faced by women at different stages of IVF and analyzes their association with pregnancy outcomes. Methods: This cohort study was conducted at Dr. Cipto Mangunkusumo General Hospital and Dr. Sander B. Daya Medika Clinic from May 2018 to March 2023. Data were collected using questionnaires and assessments during IVF, focusing on the evaluation of anxiety, depression, and pregnancy outcomes. Chi-square and Fisher’s exact test was used to assess associations between variables, while Friedman ANOVA was used for longitudinal analysis of anxiety and depression scores during IVF. Results: The final analysis comprised 61 participants. The study revealed significant changes in anxiety and depression throughout IVF. Both anxiety (p < 0.001, Kendall’s w = 0.19) and depression levels (p = 0.001, Kendall’s w = 0.121) showed a significant rise across the IVF timeline. There is no statistically significant association between anxiety and depression scores and pregnancy outcomes across three measurement points during IVF (p > 0.05). Conclusion: Anxiety and depression significantly increase during IVF but do not affect clinical pregnancy rates. These findings highlight the importance of mental health screening and psychiatric support during IVF to ensure women’s comfort and enable them to navigate IVF more effectively. Keywords: Anxiety, Depression, Pregnancy Outcomes, Women, In Vitro Fertilization (IVF)
Co-Authors Agiananda, Feranindhya Ana Mira Lubis Aninditha, Tiara Aria Kekalih Bahagia Loebis, Bahagia Brisma, Sinta Elmeida Effendy H, Intan Vindalia Dian Sari IRWANTO Karnasih, Artasya Kusumaningrum, Profitasari Marcellus Simadibrata Natadisastra, Raden Muharram Oktaria Safitri, Dian Prayangga, Regina Puspaseruni, Putri Air Richard Budiman Roestam, Ambar W. Roestam, Ambar W. Samjunanto, Achmad Tinambunan, Iriawan Rembak Velyani, Dyani Pitra Wahmurti, Tuti Wibisono, Sasanto Yahwardiah Siregar Zakiah Zakiah