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All Journal Jurnal Riset Kimia Biology, Medicine, & Natural Product Chemistry Amerta Nutrition SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Jurnal Farmasi Indonesia Journal of Science and Clinical Pharmacy Research
Afriani, Tika
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Uji Aktivitas Antioksidan dan Fenolik Total Fraksi Etil Asetat Daun Sembung (Blumea balsamifera (L.) DC) Rahmi, Azimatur; Afriani, Tika; Hevira, Linda; Widiawati, Wike
Jurnal Riset Kimia Vol 12, No 2 (2021): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.383

Abstract

The aim of this study is to investigate antioxidant activity and total phenolic content of ethyl acetate fraction of Sembung leaves. Sembung (Blumea balsamifera L.) is a plant that has the potential as an antioxidant because it contains secondary metabolites of alkaloids, steroids, flavonoids, saponins, and phenolic compounds. In this study, antioxidant activity was tested by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for free radical scavenging activity assay. Evaluation of total phenolic content was tested by using the Folin-Ciocalteau method. The results showed that the ethyl acetate fraction of Sembung leaves possess showed medium antioxidant activity with IC50 valueof 221.821 compare with reference standard ascorbic acid with IC50 value 68.25 ppm. The ethyl acetate fraction of Sembung leaves has a total phenolic content of 161.101 mg GAE/g. This study provided that Blumea balsamifera leaves possess antioxidant.
Uji Aktivitas Antioksidan Lotion Ekstrak Etanol Daun Pepaya (Carica papaya L.) DEVAHIMER HARSEP ROSI, DEVAHIMER HARSEP ROSI; Afriani, Tika; Alysa Putri, Hasnah
SITAWA : Jurnal Farmasi Sains dan Obat Tradisional Vol. 2 No. 2 (2023): SITAWA : Health, Science and Traditional Medicine Journal
Publisher : LPPM Akademi Farmasi Imam Bonjol Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62018/sitawa.v2i2.66

Abstract

Papaya leaves contain phytochemical including alkaloid, saponin, tannin, flavonoid, triterpenoid, and asiaticoside glycoside. Flavonoid compounds in papaya leaves function as antioxidant that can capture free radicals. This study aims to determine the ethanol extract of papaya leaves can be formulated into lotion preparation and to test the antioxidant activity of these preparation. This study used an experimental method of lotion preparation made with varying concentrations of papaya leaf ethanol extract 2g (F1), 4g (F2), 6g (F3). Physical evaluation include organoleptic test, homogeneity test, pH test, irritation test, spreadability test, and antioxidant activity test. All formulas met the physical evaluation requirements. The papaya leaf ethanol extract lotion has the highest IC50 value, namely at F3 of 44.72 ppm in the very strong antioxidant category.
Isolation and Antibacterial Activity of Sembung (Blumea balsamifera) Leaf Essential Oil L., DC Afriani, Tika; Rahmi, Azimatur; Sari, Mia Darmita
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.361-365

Abstract

Sembung leaf essential oil is a complex mixture in the form of oily yellow liquid with a unique aroma. It contains various volatile components that have antibacterial, antifungal, antioxidant and cytotoxic activities. This study aims to determine the antibacterial activity of essential oil Blumea balsamifera L., DC against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Isolation of essential oil using steam distillation method with 0.21% rendement. Inhibition activity was performed by test tube method with variation concentrations of essential oil were 10%, 20%, 40%, 80%, and 100% for each bacteria. Results of this study showed that the highest antibacterial activity on Escherichia coli at 80% concentration with an inhibition zone diameter of 27.53 mm, 100% concentration for Pseudomonas aeruginosa with an inhibition zone diameter 25.72 mm and 100% concentration for Staphylococcus aureus with inhibition zone diameter 27.31 mm. Essential oil from (Blumea balsamifera) L., DC leaves have a strong activity inhibition category against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.
Evaluation and Antibacterial Activity Test of Peel-off Mask Preparation from Combination of Pegagan Leaves (Centella asiatica (L) Urb.) and Charcoal Powder Utari, Fadhilla Dwi; Hilaliyati, Najmi; Afriani, Tika
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.127-133

Abstract

Pegagan leaf (Centella asiatica (L) Urb.) is a plant that contains flavonoids, tannins, triterpenoids, and saponins that function as antibacterials. Pegagan leaf is combined with activated charcoal powder, which has the job of absorbing facial oil, so that it is formulated in the form of a peel off mask to produce a synergistic effect. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the peel-off mask preparation of pegagan leaf extract at concentrations of 1.5%, 2%, and 2.5%. This study uses an experimental method by testing the parameters of the physical evaluation requirements and testing antibacterial activity with the disc method on the peel off mask preparation. The results were evaluated for 28 days, and the results of the organoleptic test were stable, homogeneity stable, pH (5.6–6.2), dry time (16–25 minutes), dispersion (6.1-6.4 cm), and irritation (2 respondents). The effectiveness test against the bacteria Propionibacterium acnes has inhibitory power of 12.3 mm in the strong category. So, it can be concluded that the peel off mask produced has stable physical characteristics and can be used as an antibacterial mask.
Antioxidant Activity Test (DPPH) and Cytotoxicity of Jengkol Peel Ethanol Extract (Pithecellobium jiringa) on Shrimp Larvae (Artemia salina Leach) Wibowo, Glen Arya; Afriani, Tika; Rahmi, Azimatur
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.533-537

Abstract

This study aims to determine the antioxidant and cytotoxic activity of the ethanol extract of jengkol peel (Pithecellobium jiringa). Jengkol peel ethanol extract (Pithecellobium jiringa) was obtained by maceration using 70% ethanol as a solvent. In the phytochemical screening test it was found that chemical compounds contained in jengkol peel (Pithecellobium jiringa) including alkaloids, flavonoids, and saponins. The antioxidant activity of the ethanol extract was tested using the 35 ppm DPPH method. The test results on the ethanol extract showed moderate antioxidant activity with an IC50 value of 209.45 µg/mL. The cytotoxic activity of the ethanol extract was tested by the BSLT method using shrimp larvae (Artemia salina L.). The results showed that the ethanol extract of jengkol peel (Pithecellobium jiringa) has cytotoxic activity with LC50 value minimum of 17.875 mg/L and LC50 a maximum of 360.714 mg/L with an average of 180.136 mg/L.
Aktivitas Antioksidan Nanopartikel dari Ekstrak Daun Sembung (Blumea balsamifera L.): Antioxidant Activity of Nanoparticle Modified from Sembung Leaf (Blumea balsamifera L.) Extract Saufani, Iza Ayu; Rahmi, Azimatur; Afriani, Tika; Zikirzi, Widi Urdatullah
Amerta Nutrition Vol. 8 No. 3SP (2024): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 4th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3SP.2024.362-371

Abstract

Background: Dietary antioxidants are essential to prevent free radical-induced cell damage and maintain the body’s physiological functions. Sembung leaves are rich in polyphenols, which are known to have substantial antioxidant activities. The antioxidant efficacy of Sembung leaves can be enhanced by nanoparticle size. Objectives: To examine the enhancement of antioxidant activity of Sembung leaf (Blumea balsamifera L.) extract modified into nanoparticles. Methods: The extract used was an ethyl acetate fraction extract. The fresh leaves of Sembung ware macerated in 96% ethanol for 24 hours. Ethanol, n-hexan, and ethyl acetate solvents were used to fractionate the ethanolic extract. The extract of the ethyl acetate fraction was modified into nanoparticles through the ionic gelation method. The nanoparticles comprised three formulations, F1 (0.25% chitosan and 10 ml NaTPP solution), F2 (0.50% chitosan and 20 ml NaTPP solution), and F3 (0.75% chitosan and 30 ml NaTPP solution). The antioxidant activity was assessed by lipid peroxidation using ferric thiocyanate (FTC) followed by the thiobarbiturat (TBA) method. A Spectrophotometer UV-Vis was used to analyse the % inhibition values of the samples. Results: The antioxidant activity assay on the sample of ethyl acetate fraction using the FTC method showed 31.25% inhibition, and using the TBA method indicated 17.34% inhibition. Meanwhile, the % inhibition was 23.77% and 40.43% in the nanoparticle sample with the FTC and TBA methods, respectively. Conclusions: This study revealed that nanoparticles of Sembung leaves  can increase antioxidant activities. These findings offer potential applications in the development of existing antioxidant products.
Uji Aktivitas Antiinflamasi Ekstrak Etanol, Etil Asetat, dan N-heksan Tangkai Daun Kemumu (Colocasia gigantea Hook.f) secara in vitro terhadap Sel Makrofag Peritoneum Rosi, Devahimer Harsep; Qalbi, Abrar Hafidz; Afriani, Tika
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.396

Abstract

Kemumu leaf stalks (Colocasia Gigantea Hook.F) are a plant that has many benefits for society, one of which is anti-inflammatory. Inflammation is process in the body to respond to infection or tissue damage. This study aims to test the anti-inflammatory effectiveness of ethanol extract, n-hexane, and ethyl acetate of kemumu leaf stalks in vitro. Kemumu leaf stalks contain flavonoids, alkaloid and tannin which have anti-inflammatory properties. Anti-inflammatory effectiveness testing was carried out on peritoneal macrophage cells to determine the inhibition of NO production in LPS-stimulated peritoneal macrophage cells by quantifying nitrite accumulation in the culture medium using Griess reagent. This research is an experimental study with 5 dose treatments for each extract with 3 replications. The parameters observed included NO production and the percentage of peritoneal macrophage cell inhibition. The results of statistical tests using One Way Anova showed a significant difference in NO levels between the sample group given the extract and the control sample (p=0.000). From the results of the percentage inhibition of NO production in peritoneal macrophage cells, it shows that ethanol extract of kemumu leaf stalks with concentrations of 50 and 100 µg/ml has the best anti-inflammatory effect, namely with NO production of 4.67 and 1.44 µg/ml respectively, and with respective inhibition 80.32% and 89.01% respectively.
Durian Seed Flour (Durio zibethinus Murr) as an Alternative Medium for Fungal Growth Afriani, Tika; Rahmi, Azimatur; Ramadhani, Putri Agiel; Rahmadaniah, Rahmadaniah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.435-441

Abstract

This study aimed to evaluate the potential of durian seed flour (Durio zibethinus Murr) as an alternative medium for the growth of Candida albicans and Aspergillus niger. The bleaching process utilized sodium metabisulfite at varying concentrations (600 ppm, 800 ppm, 1000 ppm) and immersion durations (15, 20, 25 minutes). The bleached samples were dried at 70℃ for 3 hours. Durian seed flour media were formulated into three variants and compared with Potato Dextrose Agar (PDA) as the control medium. The activity test for Candida albicans used the pour plate method with incubation for 48 hours at 37℃, while Aspergillus niger was tested using the agar block method and incubated for 72 hours under the same conditions. Immersion duration significantly affected the flour's color, with longer durations producing whiter flour. Higher drying temperatures enhanced water evaporation efficiency, resulting in an average moisture content of 10.56%, compliant with national standards. The best medium formulation was F1 (10 g durian seed flour, 2 g sugar, 1.5 g agar, 0.25 g micronutrients, 100 mL distilled water), yielding 3.6 × 10⁷ CFU/mL of Candida albicans colonies and an Aspergillus niger growth diameter of 28.5 mm after 72 hours of incubation. However, sporulation of Aspergillus niger was better on PDA media. Durian seed flour shows potential as an alternative fungal growth medium.
Macroscopic, Microscopic, and Phytochemical Screening Analysis of Medicinal Plants in Nagari Lasi, West Sumatra Afriani, Tika; Rosi, Devahimer Harsep; Mailinda, Winda
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.621-633

Abstract

Indonesia is one of the countries titled “Megabiodiversity”, which has a high level of biodiversity, including medicinal plants. Medicinal plants utilize various parts of plants, such as roots, leaves, stems, and fruits for prevention, treatment, and pain relief. Nagari Lasi has great potential in the diversity of medicinal plants, but their utilization by the community is still limited due to a lack of knowledge. This study aims to identify the content of bioactive compounds in medicinal plants through macroscopic, microscopic, and phytochemical screening. The methods include organoleptic observation, macroscopic and microscopic analysis, and phytochemical tests. Of the 150 plant samples, the results showed that 78 samples contained alkaloids, 115 samples contained phenolics, 129 samples contained flavonoids, 75 samples contained steroids, 21 samples contained triterpenoids, and 119 samples contained saponins. This study provides basic information regarding the phytochemical content of medicinal plants in Nagari Lasi as a first step in developing traditional medicine.
TINGKAT KEPUASAN DOKTER, PETUGAS FARMASI, DAN PASIEN RAWAT JALAN TERHADAP SISTEM PELAYANAN RESEP ELEKTRONIK DI RUMAH SAKIT OTAK DR. Drs. M. HATTA BUKITTINGGI Juliasmi, Riri; Deswati; Afriani, Tika
Journal of Science and Clinical Pharmacy Research Vol. 1 No. 1 (2025): February 2025
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penerapan resep elektronik merupakan salah satu strategi untuk mengurangi kesalahan pengobatan (medication error) guna meningkatkan kualitas pelayanan di rumah sakit. Namun, dalam implementasinya, masih terdapat tantangan terkait interaksi antara teknologi dan sumber daya manusia, serta pengelolaan dan evaluasi yang belum optimal. Peresepan elektronik memungkinkan dokter menulis resep secara digital dan mengirimkannya langsung ke apotek dalam jaringan sistem peresepan elektronik. Penelitian ini bersifat deskriptif analitik dengan metode probability sampling. Sampel penelitian terdiri atas 30 dokter, 35 petugas farmasi, dan 100 pasien rawat jalan yang diberikan kuesioner sebagai alat ukur. Hasil penelitian menunjukkan bahwa tingkat kepuasan terhadap sistem pelayanan resep elektronik di Rumah Sakit Otak Dr. Drs. M. Hatta Bukittinggi sangat tinggi, dengan persentase kepuasan sebesar 90% pada dokter, 88% pada petugas farmasi, dan 86,8% pada pasien rawat jalan. Analisis statistik menunjukkan bahwa tidak terdapat hubungan signifikan antara faktor demografi (jenis kelamin, usia, pendidikan, pekerjaan, dan penghasilan) dengan tingkat kepuasan responden (p > 0,05). Hasil penelitian ini diharapkan dapat menjadi bahan evaluasi untuk meningkatkan efektivitas sistem peresepan elektronik dalam pelayanan kesehatan. Kata kunci : Kepuasan, Resep Elektronik, Dokter, Petugas Farmasi, dan Pasien Rawat Jalan
Co-Authors Alysa Putri, Hasnah Azimatur Rahmi Azqiya, Maharani Deswati DEVAHIMER HARSEP ROSI, DEVAHIMER HARSEP ROSI Efmisa, Ariesta Hevira, Linda Hilaliyati, Najmi Iza Ayu Saufani Juliasmi, Riri Khairil Armal kia, Zakiah Nurfitri Mailinda, Winda Qalbi, Abrar Hafidz Rahmadaniah, Rahmadaniah Ramadhani, Putri Agiel Rosi, Devahimer Harsep Sari, Mia Darmita Utari, Fadhilla Dwi Wibowo, Glen Arya Widiawati, Wike Zikirzi, Widi Urdatullah