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All Journal Jurnal Riset Kimia Biology, Medicine, & Natural Product Chemistry Amerta Nutrition Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat Indonesian Journal of Pharmaceutical and Clinical Research Journal of Science and Clinical Pharmacy Research
Afriani, Tika
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Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Uji Aktivitas Antioksidan dan Fenolik Total Fraksi Etil Asetat Daun Sembung (Blumea balsamifera (L.) DC) Rahmi, Azimatur; Afriani, Tika; Hevira, Linda; Widiawati, Wike
Jurnal Riset Kimia Vol 12, No 2 (2021): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v12i2.383

Abstract

The aim of this study is to investigate antioxidant activity and total phenolic content of ethyl acetate fraction of Sembung leaves. Sembung (Blumea balsamifera L.) is a plant that has the potential as an antioxidant because it contains secondary metabolites of alkaloids, steroids, flavonoids, saponins, and phenolic compounds. In this study, antioxidant activity was tested by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for free radical scavenging activity assay. Evaluation of total phenolic content was tested by using the Folin-Ciocalteau method. The results showed that the ethyl acetate fraction of Sembung leaves possess showed medium antioxidant activity with IC50 valueof 221.821 compare with reference standard ascorbic acid with IC50 value 68.25 ppm. The ethyl acetate fraction of Sembung leaves has a total phenolic content of 161.101 mg GAE/g. This study provided that Blumea balsamifera leaves possess antioxidant.
Isolation and Antibacterial Activity of Sembung (Blumea balsamifera) Leaf Essential Oil L., DC Afriani, Tika; Rahmi, Azimatur; Sari, Mia Darmita
Biology, Medicine, & Natural Product Chemistry Vol 13, No 2 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.132.361-365

Abstract

Sembung leaf essential oil is a complex mixture in the form of oily yellow liquid with a unique aroma. It contains various volatile components that have antibacterial, antifungal, antioxidant and cytotoxic activities. This study aims to determine the antibacterial activity of essential oil Blumea balsamifera L., DC against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Isolation of essential oil using steam distillation method with 0.21% rendement. Inhibition activity was performed by test tube method with variation concentrations of essential oil were 10%, 20%, 40%, 80%, and 100% for each bacteria. Results of this study showed that the highest antibacterial activity on Escherichia coli at 80% concentration with an inhibition zone diameter of 27.53 mm, 100% concentration for Pseudomonas aeruginosa with an inhibition zone diameter 25.72 mm and 100% concentration for Staphylococcus aureus with inhibition zone diameter 27.31 mm. Essential oil from (Blumea balsamifera) L., DC leaves have a strong activity inhibition category against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.
Evaluation and Antibacterial Activity Test of Peel-off Mask Preparation from Combination of Pegagan Leaves (Centella asiatica (L) Urb.) and Charcoal Powder Utari, Fadhilla Dwi; Hilaliyati, Najmi; Afriani, Tika
Biology, Medicine, & Natural Product Chemistry Vol 13, No 1 (2024)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2024.131.127-133

Abstract

Pegagan leaf (Centella asiatica (L) Urb.) is a plant that contains flavonoids, tannins, triterpenoids, and saponins that function as antibacterials. Pegagan leaf is combined with activated charcoal powder, which has the job of absorbing facial oil, so that it is formulated in the form of a peel off mask to produce a synergistic effect. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the peel-off mask preparation of pegagan leaf extract at concentrations of 1.5%, 2%, and 2.5%. This study uses an experimental method by testing the parameters of the physical evaluation requirements and testing antibacterial activity with the disc method on the peel off mask preparation. The results were evaluated for 28 days, and the results of the organoleptic test were stable, homogeneity stable, pH (5.6–6.2), dry time (16–25 minutes), dispersion (6.1-6.4 cm), and irritation (2 respondents). The effectiveness test against the bacteria Propionibacterium acnes has inhibitory power of 12.3 mm in the strong category. So, it can be concluded that the peel off mask produced has stable physical characteristics and can be used as an antibacterial mask.
Antioxidant Activity Test (DPPH) and Cytotoxicity of Jengkol Peel Ethanol Extract (Pithecellobium jiringa) on Shrimp Larvae (Artemia salina Leach) Wibowo, Glen Arya; Afriani, Tika; Rahmi, Azimatur
Biology, Medicine, & Natural Product Chemistry Vol 12, No 2 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.122.533-537

Abstract

This study aims to determine the antioxidant and cytotoxic activity of the ethanol extract of jengkol peel (Pithecellobium jiringa). Jengkol peel ethanol extract (Pithecellobium jiringa) was obtained by maceration using 70% ethanol as a solvent. In the phytochemical screening test it was found that chemical compounds contained in jengkol peel (Pithecellobium jiringa) including alkaloids, flavonoids, and saponins. The antioxidant activity of the ethanol extract was tested using the 35 ppm DPPH method. The test results on the ethanol extract showed moderate antioxidant activity with an IC50 value of 209.45 µg/mL. The cytotoxic activity of the ethanol extract was tested by the BSLT method using shrimp larvae (Artemia salina L.). The results showed that the ethanol extract of jengkol peel (Pithecellobium jiringa) has cytotoxic activity with LC50 value minimum of 17.875 mg/L and LC50 a maximum of 360.714 mg/L with an average of 180.136 mg/L.
Aktivitas Antioksidan Nanopartikel dari Ekstrak Daun Sembung (Blumea balsamifera L.): Antioxidant Activity of Nanoparticle Modified from Sembung Leaf (Blumea balsamifera L.) Extract Saufani, Iza Ayu; Rahmi, Azimatur; Afriani, Tika; Zikirzi, Widi Urdatullah
Amerta Nutrition Vol. 8 No. 3SP (2024): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 4th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v8i3SP.2024.362-371

Abstract

Background: Dietary antioxidants are essential to prevent free radical-induced cell damage and maintain the body’s physiological functions. Sembung leaves are rich in polyphenols, which are known to have substantial antioxidant activities. The antioxidant efficacy of Sembung leaves can be enhanced by nanoparticle size. Objectives: To examine the enhancement of antioxidant activity of Sembung leaf (Blumea balsamifera L.) extract modified into nanoparticles. Methods: The extract used was an ethyl acetate fraction extract. The fresh leaves of Sembung ware macerated in 96% ethanol for 24 hours. Ethanol, n-hexan, and ethyl acetate solvents were used to fractionate the ethanolic extract. The extract of the ethyl acetate fraction was modified into nanoparticles through the ionic gelation method. The nanoparticles comprised three formulations, F1 (0.25% chitosan and 10 ml NaTPP solution), F2 (0.50% chitosan and 20 ml NaTPP solution), and F3 (0.75% chitosan and 30 ml NaTPP solution). The antioxidant activity was assessed by lipid peroxidation using ferric thiocyanate (FTC) followed by the thiobarbiturat (TBA) method. A Spectrophotometer UV-Vis was used to analyse the % inhibition values of the samples. Results: The antioxidant activity assay on the sample of ethyl acetate fraction using the FTC method showed 31.25% inhibition, and using the TBA method indicated 17.34% inhibition. Meanwhile, the % inhibition was 23.77% and 40.43% in the nanoparticle sample with the FTC and TBA methods, respectively. Conclusions: This study revealed that nanoparticles of Sembung leaves  can increase antioxidant activities. These findings offer potential applications in the development of existing antioxidant products.
Durian Seed Flour (Durio zibethinus Murr) as an Alternative Medium for Fungal Growth Afriani, Tika; Rahmi, Azimatur; Ramadhani, Putri Agiel; Rahmadaniah, Rahmadaniah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 1 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.141.435-441

Abstract

This study aimed to evaluate the potential of durian seed flour (Durio zibethinus Murr) as an alternative medium for the growth of Candida albicans and Aspergillus niger. The bleaching process utilized sodium metabisulfite at varying concentrations (600 ppm, 800 ppm, 1000 ppm) and immersion durations (15, 20, 25 minutes). The bleached samples were dried at 70℃ for 3 hours. Durian seed flour media were formulated into three variants and compared with Potato Dextrose Agar (PDA) as the control medium. The activity test for Candida albicans used the pour plate method with incubation for 48 hours at 37℃, while Aspergillus niger was tested using the agar block method and incubated for 72 hours under the same conditions. Immersion duration significantly affected the flour's color, with longer durations producing whiter flour. Higher drying temperatures enhanced water evaporation efficiency, resulting in an average moisture content of 10.56%, compliant with national standards. The best medium formulation was F1 (10 g durian seed flour, 2 g sugar, 1.5 g agar, 0.25 g micronutrients, 100 mL distilled water), yielding 3.6 × 10⁷ CFU/mL of Candida albicans colonies and an Aspergillus niger growth diameter of 28.5 mm after 72 hours of incubation. However, sporulation of Aspergillus niger was better on PDA media. Durian seed flour shows potential as an alternative fungal growth medium.
TINGKAT KEPUASAN DOKTER, PETUGAS FARMASI, DAN PASIEN RAWAT JALAN TERHADAP SISTEM PELAYANAN RESEP ELEKTRONIK DI RUMAH SAKIT OTAK DR. Drs. M. HATTA BUKITTINGGI Juliasmi, Riri; Deswati; Afriani, Tika
Journal of Science and Clinical Pharmacy Research Vol. 1 No. 1 (2025): February 2025
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

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Abstract

Penerapan resep elektronik merupakan salah satu strategi untuk mengurangi kesalahan pengobatan (medication error) guna meningkatkan kualitas pelayanan di rumah sakit. Namun, dalam implementasinya, masih terdapat tantangan terkait interaksi antara teknologi dan sumber daya manusia, serta pengelolaan dan evaluasi yang belum optimal. Peresepan elektronik memungkinkan dokter menulis resep secara digital dan mengirimkannya langsung ke apotek dalam jaringan sistem peresepan elektronik. Penelitian ini bersifat deskriptif analitik dengan metode probability sampling. Sampel penelitian terdiri atas 30 dokter, 35 petugas farmasi, dan 100 pasien rawat jalan yang diberikan kuesioner sebagai alat ukur. Hasil penelitian menunjukkan bahwa tingkat kepuasan terhadap sistem pelayanan resep elektronik di Rumah Sakit Otak Dr. Drs. M. Hatta Bukittinggi sangat tinggi, dengan persentase kepuasan sebesar 90% pada dokter, 88% pada petugas farmasi, dan 86,8% pada pasien rawat jalan. Analisis statistik menunjukkan bahwa tidak terdapat hubungan signifikan antara faktor demografi (jenis kelamin, usia, pendidikan, pekerjaan, dan penghasilan) dengan tingkat kepuasan responden (p > 0,05). Hasil penelitian ini diharapkan dapat menjadi bahan evaluasi untuk meningkatkan efektivitas sistem peresepan elektronik dalam pelayanan kesehatan. Kata kunci : Kepuasan, Resep Elektronik, Dokter, Petugas Farmasi, dan Pasien Rawat Jalan
KAJIAN HUBUNGAN RASIONALITAS PENGGUNAAN OBAT ANTIHIPERTENSI DENGAN LUARAN KLINIS DI PUSKESMAS MALALAK PERIODE APRIL-JUNI 2024: STUDY OF THE RELATION BETWEEN THE RATIONAL USE OF ANTIHYPERTENSIVE DRUGS WITH CLINICAL OUTCOMES AT MALALAK HEALTH CENTER FOR THE PERIOD APRIL - JUNE 2024 kia, Zakiah Nurfitri; Afriani, Tika; Efmisa, Ariesta
Journal of Science and Clinical Pharmacy Research Vol. 1 No. 1 (2025): February 2025
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

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Abstract

Hipertensi adalah keadaan dimana terjadinya peningkatan tekanan darah yang melebihi batas normal yaitu tekanan darah sistolik melebihi 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Tujuan penelitian ini untuk mengetahui hubungan rasionalitas penggunaan obat antihipertensi dengan luaran klinis di Puskesmas Malalak Periode April - Juni 2024. Metode penelitian yang digunakan adalah metode kuantitatif dengan rancangan Cross Sectional dengan pendekatan restrospektif. Populasi dalam penelitian ini adalah seluruh pasien hipertensi di Puskesmas Malalak periode April - Juni 2024 yaitu sebanyak 104 rekam medis pasien. Sampel dalam penelitian ini sebanyak 104 rekam medis pasien. Hasil pada penelitian ini didapatkan karakteristik pasien berdasarkan rekam medik mayoritas berjenis kelamin perempuan 64 pasien (61,5%),usia paling banyak rentang yaitu 41-60 tahun sebanyak 73 pasien (70,2%), diagnosa hipertensi stage 1 sebanyak 59 pasien (56,7%) dan golongan obat Calcium channel blocker (CCB) sebanyak 38 pasien (36,5%) dengan terapi obat Amlodipin. Rasionalitas penggunaan obat antihipertensi menunjukkan 100% tepat pasien, tepat indikasi 100%, tepat obat 93,3% dan tepat dosis 99%. Pasien yang menerima terapi antihipertensi yang rasional sebanyak 96 pasien (92,3 %) dan hasil luaran klinis berupa tercapainya target tekanan darah pasien sebanyak 97 pasien (93,3 %). Penelitian ini menggunakan analisa statistik chi-ssquare menunjukkan terdapat hubungan yang signifikan pada rasionalitas penggunaan obat antihipertensi dengan luaran klinis yaitu dengan nilai p < 0,05. Kata Kunci : Hipertensi, rasionalitas obat antihipertensi , luaran klinis
HUBUNGAN PELAYANAN INFORMASI OBAT TERHADAP TINGKAT KEPATUHAN PASIEN DALAM PENGGUNAAN ANTIBIOTIK DI PUSKESMAS RASIMAH AHMAD KOTA BUKITTINGGI: The Relationship Between Drug Information Services and the Level of Patient Compliance in the Use of Antibiotics at the Rasimah Ahmad Health Center in Bukittinggi City Azqiya, Maharani; Armal, Khairil; Afriani, Tika
Journal of Science and Clinical Pharmacy Research Vol. 1 No. 1 (2025): February 2025
Publisher : LPPM Universitas Mohammad Natsir Bukittinggi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.1144/jscpr.v1i1.275

Abstract

Pelayanan Informasi Obat (PIO) merupakan kegiatan penyediaan dan pemberian informasi, rekomendasi obat yang independen, akurat, tidak bias, terkini dan komprehensif yang dilakukan oleh Apoteker kepada dokter, Apoteker, perawat, profesi kesehatan lainnya serta pasien dan pihak lain di luar Rumah Sakit. Tujuan dari penelitian ini untuk mengetahui hubungan antara pelayanan informasi obat terhadap kepatuhan penggunaan antibiotik di Puskesmas Rasimah Ahmad. Jenis penelitian ini merupakan penelitian dengan rancangan penelitian korelatif dengan cara mengukur dua variabel. Hasil uji analisa univariat menunjukkan yang mengkonsumsi antibiotik terbanyak pada usia 17-25 tahun sebanyak 19 responden dengan persentase (38,0%), jenis kelamin perempuan 28 responden dengan persentase (56,0%), pekerjaan sebagai pelajar 19 responden dengan persentase (38,0%), jenis penyakit adalah demam sebanyak 28 responden dengan persentase (56,0%), jenis antibiotik yang dikonsumsi adalah amoxicillin sebanyak 39 responden dengan persentase (78,0%). Tingkat kepatuhan penggunaan antibiotik di Puskesmas Rasimah Ahmad Kota Bukittinggi tergolong baik, diketahui bahwa dari 50 responden didapatkan 28 responden tergolong patuh dengan persentase (56,0%) lebih dari separuh responden tergolong patuh dalam penggunaan antibiotik. Hasil bivariate menggunakan hasil uji Chi-Square menunjukkan hasil p-value sebesar 0,007 sehingga dapat disimpulkan terdapat hubungan signifikan antara pelayanan informasi obat terhadap tingkat kepatuhan dalam penggunaan antibiotik di Puskesmas Rasimah Ahmad Kota Bukittinggi. Kata kunci : pelayanan informasi obat (PIO), kepatuhan, antibiotik.
Relationship between Patient Knowledge and Attitude Level in the Use of Antibiotic at Tanjung Paku Community Health Center Solok City: Hubungan Tingkat Pengetahuan dan Sikap Pasien dalam Penggunaan Antibiotik di Puskesmas Tanjung Paku Kota Solok Armal, Khairil; Azkia, Nisa; Afriani, Tika
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 2 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i2.13711

Abstract

Low levels of knowledge about the proper use of antibiotics can lead to incorrect usage, which raises the possibility of antibiotic side effects. The goal of this study is to evaluate patient attitudes and knowledge regarding the use of antibiotics at the community health center in Tanjung Paku Solok City. A questionnaire acted as the data collection tool in a cross-sectional study with a descriptive approach and accidental sampling as the sample process. 60 patients who met the inclusion criteria were included in the sample. The Chi Square test, partial T test, simultaneous F test, and multiple linear regression test were used to examine the results. The results revealed that in good category for knowledge is 57 people (95%), in enough category is 3 people (5%), and there is no one in less category. While the results for good category in attitude is 48 people (80%), in enough category is 12 people (20%) and there is no one in less category. It can be stated that the patients of community health center in Tanjung Paku Solok City has knowledge and attitude category in the use of antibiotic is good. The results of the analysis between knowledge and attitude is having a significant relationship (Sig. = 0.039) but has less influence value, and there is no relationship between variables with the sociodemography (age, gender, lastest education, and occupation). And respondent achievement level (TCR) showed that 80% were good at knowledge statements and 70% were good at attitude statements.
Co-Authors Alysa Putri, Hasnah Azimatur Rahmi Azkia, Nisa Azqiya, Maharani Deswati DEVAHIMER HARSEP ROSI, DEVAHIMER HARSEP ROSI Efmisa, Ariesta Farnandi, Rido Harsep Rosi, Devahimer Hevira, Linda Hilaliyati, Najmi Iza Ayu Saufani Juliasmi, Riri Khairil Armal kia, Zakiah Nurfitri Kirana Efmisa, Ariesta Prima Putra, Allans Rahmadaniah, Rahmadaniah Ramadhani, Putri Agiel Sari, Mia Darmita Utari, Fadhilla Dwi Wibowo, Glen Arya Widiawati, Wike Zikirzi, Widi Urdatullah