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All Journal JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Bali Dermatology Venereology and Aesthetic Journal
Els, Vanessa
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Effectiveness and tolerability of bakuchiol (Psolarea corylifolia) as a dermal anti-aging modality: A systematic review on skin wellness and harmony Limanda, Claudia Felicia; Els, Vanessa; Hernowo, Elliana Freya; Winaya, Ketut Kwartantaya
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 8, Issue 1 (2025)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v8i1.116

Abstract

Skin aging is a natural phenomenon caused by a decline in collagen production that leads to skin thinning, dry and pale skin, wrinkles, and sagging. Skin aging may not contribute to the mortality rate. However, people tend to connect their symbol of inner self to external appearance. Therefore, psychosocial effects such as social anxiety, low self-esteem, and low satisfaction in life will affect their personal and social life. Anti-aging procedures focus on the prevention of damage, replacement of tissues, and skin rejuvenation. Bakuchiol (Psolarea corylifolia) is a novel anti-aging product with antioxidant, anti-inflammatory, and anti-aging properties that is deemed effective and tolerable in skin rejuvenation. This comprehensive review aims to further examine the effectiveness and tolerability of bakuchiol based on previous studies in order to provide new insights into delaying skin aging. A comprehensive literature search was conducted to assess the effectiveness and tolerability of bakuchiol as a dermal anti-aging modality from search engines, PubMed, Google Scholar, CORE, Science Direct, and Cochrane using search terms (“Bakuchiol” OR “Psolarea corylifolia”) AND (“Dermal Aging” OR “Skin Aging”). Bakuchiol proved to have anti-inflammatory and antioxidant properties to maintain youthfulness and skin appearance. Regarding tolerability, bakuchiol has fewer side effects compared to other commonly used modalities. Therefore, bakuchiol (Psolarea corylifolia) is an effective and tolerable modality in the treatment of aging skin.
Nano Drug Delivery System with Resveratrol as Promising Novel Adjuvant Therapy for Diabetic Non-Healing Wounds: A Literature Review Sari, Ni Wayan Puspita; Els, Vanessa; Indrayani, Agung Wiwiek
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.84181

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by increased blood sugar levels (hyperglycemia) and is associated with impaired function of β cells. The uncontrolled and prolonged hyperglycemia in DM can cause complications. One of the most common is diabetic non-healing wounds, the leading cause of disability in people with diabetes, therefore adjuvant therapy is needed. Compounds from natural ingredients are currently getting the spotlight in recent studies conducted to prove their effect on non-healing wounds, such as Resveratrol (RSV). This review aims to discuss the potential of RSV as a novel adjuvant therapy and its delivery system strategy in the case of diabetic non-healing wounds. We conducted an extensive search from three online scientific databases such as ScienceDirect, ResearchGate, and PubMed on February-March 2023. Keywords used are "resveratrol", "diabetic wound healing", and "diabetes mellitus". As a result, 86 studies were reviewed, and only 79 selected studies met all inclusion criteria. The formulation of RSV nanoparticles in oral drug delivery systems and topical administration has shown promise to overcome the limitations of RSV as adjuvant therapy in diabetic non-healing wounds. The best option that we found through this literature review is the nano-oral drug delivery system as it could minimize drug metabolism in the gastrointestinal tract, therefore the drug bioavailability and drug concentration on the target site could be maximized, even though the systemic side effects might occur.
Co-Authors Agung Wiwiek Indrayani Hernowo, Elliana Freya Limanda, Claudia Felicia Sari, Ni Wayan Puspita Winaya, Ketut Kwartantaya