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All Journal JFL : Jurnal Farmasi Lampung Jurnal Riset Akuntansi Politala Borneo Journal Of Pharmascientech
Putri, Meilisa
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Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN SEDIAAN MASKER GEL PEEL OFF EKSTRAK ETANOL DAUN PEGAGAN (Centella asiatica (L.) Urban) Putri, Meilisa; Capritasari, Rafiastiana; Wijayatri, Ratna; Ningrum, Yessika Ardian; Pradani, Missya Putri Kurnia
BORNEO JOURNAL OF PHARMASCIENTECH Vol 8 No 2 (2024): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v8i2.612

Abstract

Free radicals damage cellular structures and accelerate the degradation of important elements in the skin, thereby accelerating premature aging. Antioxidants in skin care products can shield cells from harm brought on by oxidative stress. Pegagan leaves (Centella asiatica (L.) Urban) are a natural source of antioxidants. Pegagan leaf ethanolic extract has antioxidant properties and can perhaps be applied in cosmetic products like peel-off mask gel. The objective of this research is to measure the antioxidant behavior of a mask that peels off gel composed of ethanolic extract of Pegagan leaves (Centella asiatica (L.) Urban). This research applies a one-shot case study laboratory experimental method. Pegagan ethanolic extract was utilized in concentrations of F1 (0.5% ) F2 (1%) and F3 (1.5%). The level of antioxidant activity was measured. for three formulae using the DPPH (2,2-diphenyl-1-picrylhydrazyl) technique. Organoleptic, pH measurement, viscosity, homogeneity, spreadability, and drying time are all considered in the physical evaluation of the preparation. Based on evaluation outcomes of the preparations, three formulas met the test requirements with organoleptic test parameters, a drying time of 15-30 minutes, and a pH value between 4.5 and 6.5. For the spreadability test, only F2 meets the test requirements with 5-7 cm, while F1 and F3 do not follow the criteria because the A preparation's spreadability is influenced by viscosity. The thicker the mask gel preparation, the smaller the resulting spreading area. The result examination for antioxidant activity on the ethanolic extract Pegagan leaf showed an IC50 value for F1 of 28.68 ppm, F2 of 38.51 ppm, and F3 of 48.68 ppm. Study shows making the peel-off mask prepared gel Pegagan ethanol extract meets the criteria for a strong antioxidant. The results of this research indicate the quantity of antioxidant function in addition to the outcomes of the physical assessment have an impact on the concentration of pegagan leaf extract in the gel mask that peels off.
PENGARUH KUALITAS PELAYANAN KEPADA KEUNGGULAN BERSAING MELALUI KEPUASAN PELANGGAN SEBAGAI VARIABEL INTERVENING DI JUICECOVERY LAMPUNG Putri, Meilisa; Alam, Iskandar Ali
Jurnal Riset Akuntansi Politala Vol 8 No 1 (2025): Jurnal Riset Akuntansi Politala
Publisher : Pusat Penelitian dan Pengabdian bagi Masyarakat Politeknik Negeri Tanah Laut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34128/jra.v8i1.459

Abstract

This study aims to analyze the factors that have the potential to trigger fraud in financial statements and explore the role of red flags as early indicators of fraud detection. Through a literature review, this study identifies red flags and fraud risk factors that affect audit quality. This literature review covers various perspectives, including international regulations and guidelines such as ISA 240 and SAS 99, as well as empirical studies related to the role of red flags in detecting fraudulent financial reporting. Based on the analysis, red flags play a key role in mitigating the risk of financial information manipulation by detecting financial and operational anomalies that may indicate fraud. The results show that factors such as pressure, opportunity, and rationalization, described in the fraud triangle, contribute significantly to the occurrence of Fraudulent Financial Reporting. This study also underlines the importance of external auditors' knowledge of red flags, which can improve their effectiveness in detecting fraud regardless of demographic factors.
PREDIKSI TOKSISITAS, ANALISIS ADME DAN DOCKING MOLEKULER ASIATICOSIDE TERHADAP PENGHAMBATAN ANGIOTENSIN CONVERTING ENZYME: TOXICITY PREDICTION, ADME ANALYSIS AND MOLECULAR DOCKING OF ASIATICOSIDE AGAINST ANGIOTENSIN CONVERTING ENZYME INHIBITION Capritasari, Rafiastiana; Akrom, Akrom; Setianto, Arif Budi; Putri, Meilisa; Hasna, Elly Rosita; Astuti, Febriana
JFL : Jurnal Farmasi Lampung Vol. 14 No. 1 (2025): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v14i1.2411

Abstract

The presence of risk factors related to the severity of cardiovascular disease is a key consideration in adjunct therapy as an immunostimulant.One of the plants with potential as a cardioprotective immunostimulant is pegagan.Asiaticoside in pegagan leaves can inhibit AT1R and reduce NF-κβ activity.This study aims to predict the interaction of ligands with the receptor of cardioprotective immunostimulant agents.This study uses Molecular Docking simulations with molecular docking using Autodock Tools 1.5.6 and visualization using BIOVIA Discovery Studio Visualizer 24.1.The target macromolecule used is AT1R (PDB 4ZUD) which was downloaded from the PDB.The molecular docking parameters were analyzed based on binding energy.Pharmacokinetic characteristics were evaluated using the SwissADME tool.The binding result of the test ligand molecule to AT1R is -4.50 ±0.595 kcal/mol. The reference ligand has an AT1R binding value of -7.74±0.036 kcal/mol. Validation of the molecular docking method has an RMSD value of 1.857±0.356 Å. The toxicity prediction of the compound Asiatikoside at LD50 4000mg/kg and pharmacokinetic analysis were conducted using the boiled-egg method, which indicates that  Asiatikoside is predicted cannot cross the blood-brain barrier. The ADME prediction results show that the Asiatikoside has 3 parameters that do not meet the bioavailability parameters, namely a molecular weight of 959.12g/mol, TPSA polarity of 315.21A, and flexibility of 10. Conclusion Asiaticosides is predicted to have limitations in terms of oral bioavailability, so special formulations such as nanoencapsulation techniques are needed to help improve its bioavailability Keywords:  Asiaticosides; ACE Inhibition; Molecular Docking
Co-Authors Akrom, Akrom Arif Budi Setianto Astuti, Febriana Capritasari, Rafiastiana Hasna, Elly Rosita Iskandar Ali Alam Ningrum, Yessika Ardian Pradani, Missya Putri Kurnia Wijayatri, Ratna