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All Journal Acta Neurologica Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Susanto, Billy
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Health Professions Medicine & Pharmacology Neuroscience Public Health

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The Determinants of COVID-19 Vaccine Acceptance in Sumatra Sidarta, Cindy; Kurniawan, Andree; Lugito, Nata P H; Siregar, Jeremia Imanuel; Sungono, Veli; Heriyanto, Rivaldo Steven; Sieto, Novia Lauren; Halim, Devina Adella; Jodhinata, Claudia; Rizki, Saraswati Anindita; Sinaga, Terry Devita; Marcella, Chintya; Wijovi, Felix; Susanto, Billy; Marcella, Elizabeth; Wibowo, Johan; Anurantha, Jonathan Juniard; Imanuelly, Michelle; Indrawan, Michele; Heryadi, Nadia Khoirunnisa
Kesmas Vol. 17, No. 1
Publisher : UI Scholars Hub

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Abstract

In light of the current coronavirus disease 2019 (COVID-19) vaccination programs being implemented worldwide, this study aimed to evaluate the COVID-19 vaccine acceptance survey in Indonesia conducted by the World Health Organization (WHO), the Ministry of Health of the Republic of Indonesia, the National Immunization Technical Advisory Group (NITAG), and the United Nations Children's Fund (UNICEF), published in November 2020. It was found that Sumatra Island having lower COVID-19 vaccine acceptance rates, with Aceh Province displaying the lowest level of vaccine acceptance. Thus, a cross-sectional study was conducted, and a logistic regression analysis was used to identify the factors affecting COVID-19 vaccine acceptance. Out of 368 respondents who participated in the survey, 143 (38.9%) accepted the vaccine, and 225 (61.1%) refused it. Vaccine safety concerns constituted the most reported reason for refusal (43.6%). This study also found that province of residence and basic immunization status were determinants of COVID-19 vaccine acceptance in Sumatra. Concerns regarding vaccine safety might be the reason for the low level of vaccination in Sumatra. Increased education and encouragement from healthcare professionals and regional authority figures can alleviate public concerns and improve vaccine acceptance.
Prognostic Value of Mean Platelet Volume in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis Christina Elsa, Mary; Adinugraha Wijaya, David; Susanto, Billy; Mangara Tua Siahaan, Yusak
Acta Neurologica Indonesia Vol. 4 No. 3 (2026): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v4i3.110

Abstract

Introduction: Acute ischemic stroke (AIS), a significant public health concern, causes severe functional impairments. Mean platelet volume (MPV), a marker of platelet activity, is associated with increased platelet aggregation and elevated thromboxane-A2 and β-thromboglobulin levels, factors linked to heightened stroke risk and potentially its severity. This review aims to evaluate the prognostic value of MPV in predicting functional outcome in acute ischemic stroke patients.  Methods: A comprehensive systematic search of MEDLINE, Google Scholar, ScienceDirect, and Europe PMC databases was conducted using keywords related to MPV, ischemic stroke, and outcome. Cross-sectional, retrospective, and prospective studies from 2016 to 2023 reporting association of MPV with functional outcome measured with modified Rankin scale (mRS) in AIS patients were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS) for cohort studies, and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) for certainty assessment. Discussion: Nine good-quality studies with 1,514 participants and six good-quality studies with 1,030 participants were included in the systematic review and meta-analysis, respectively, with very low certainty based on GRADE. Pooled results demonstrated a significantly lower MPV in the good outcome group than in the poor outcome group at 3-month follow-up (SMD -0.38; 95% CI -0.72, -0.04; p=0.03; I2 84%). Subgroup analysis showed no significant differences in MPV among patients receiving thrombolysis. Conclusion: While lower MPV appeared associated with better outcomes, these findings are insufficient to support its use as a prognostic marker of AIS due to marked heterogeneity and inconsistency. Further studies are warranted to validate its clinical utility.
Co-Authors Adinugraha Wijaya, David Andree Kurniawan Anurantha, Jonathan Juniard Christina Elsa, Mary Halim, Devina Adella Heriyanto, Rivaldo Steven Heryadi, Nadia Khoirunnisa Imanuelly, Michelle Indrawan, Michele Jodhinata, Claudia Johan Wibowo Lugito, Nata P H Mangara Tua Siahaan, Yusak Marcella, Chintya Marcella, Elizabeth Rizki, Saraswati Anindita Sidarta, Cindy Sieto, Novia Lauren Sinaga, Terry Devita Siregar, Jeremia Imanuel Veli Sungono Wijovi, Felix